ApoA-I deficiency causes both hypertriglyceridemia and increased atherosclerosis in human apoB transgenic mice.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMID 9507992)

Published in J Lipid Res on February 01, 1998

Authors

E Voyiaziakis1, I J Goldberg, A S Plump, E M Rubin, J L Breslow, L S Huang

Author Affiliations

1: Department of Medicine, Columbia University, College of Physicians & Surgeons, New York, NY 10032, USA.

Articles citing this

Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency. Am J Pathol (2000) 1.50

The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis? J Lipid Res (2010) 1.36

Triglycerides and heart disease: still a hypothesis? Arterioscler Thromb Vasc Biol (2011) 1.32

Molecular mechanisms of vascular effects of High-density lipoprotein: alterations in cardiovascular disease. EMBO Mol Med (2012) 1.26

Induction of fatal inflammation in LDL receptor and ApoA-I double-knockout mice fed dietary fat and cholesterol. Am J Pathol (2003) 1.13

Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: a systems biology based approach. Vision Res (2009) 0.95

Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: studies in mice and FH children. Atherosclerosis (2013) 0.94

Prospective study of common variants in the retinoic acid receptor-related orphan receptor α gene and risk of neovascular age-related macular degeneration. Arch Ophthalmol (2010) 0.85

An experimentally robust model of monomeric apolipoprotein A-I created from a chimera of two X-ray structures and molecular dynamics simulations. Biochemistry (2014) 0.84

Dysfunctional HDL containing L159R ApoA-I leads to exacerbation of atherosclerosis in hyperlipidemic mice. Biochim Biophys Acta (2011) 0.83

Beyond genome-wide association studies: the usefulness of mouse genetics in understanding the complex etiology of atherosclerosis. Arterioscler Thromb Vasc Biol (2012) 0.78

Domains of apoE4 required for the biogenesis of apoE-containing HDL. Ann Med (2011) 0.78

THOC5: a novel gene involved in HDL-cholesterol metabolism. J Lipid Res (2013) 0.77

Gene therapy for lipid disorders. Curr Control Trials Cardiovasc Med (2000) 0.77

Proteomic analysis of plasma after branched chain enriched mixture supplementation in mice. J Int Soc Sports Nutr (2013) 0.76

Polymorphisms of mouse apolipoprotein A-II alter its physical and functional nature. PLoS One (2014) 0.76

Treatment of Dyslipidemia in Diabetes: Recent Advances and Remaining Questions. Curr Diab Rep (2017) 0.75

Plasminogen promotes cholesterol efflux by the ABCA1 pathway. JCI Insight (2017) 0.75

Articles by these authors

VISTA : visualizing global DNA sequence alignments of arbitrary length. Bioinformatics (2000) 12.50

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell (1992) 10.97

Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Science (2000) 10.14

An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science (2001) 8.73

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb (1994) 8.54

Active conservation of noncoding sequences revealed by three-way species comparisons. Genome Res (2000) 6.18

Genomic strategies to identify mammalian regulatory sequences. Nat Rev Genet (2001) 5.78

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci U S A (2001) 5.48

Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. N Engl J Med (1993) 5.19

Microarray expression profiling identifies genes with altered expression in HDL-deficient mice. Genome Res (2000) 4.95

AHA Dietary Guidelines: revision 2000: A statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Circulation (2000) 4.80

Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease. Science (1997) 4.25

Detection of sickle cell anaemia and thalassaemias. Nature (1987) 3.94

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev (1994) 3.76

Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. J Lipid Res (1995) 3.73

Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse. Arterioscler Thromb Vasc Biol (1998) 3.66

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration. Neuron (1999) 3.50

The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus. Nature (1998) 3.39

Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc Natl Acad Sci U S A (1994) 3.24

AHA Science Advisory: Wine and your heart: a science advisory for healthcare professionals from the Nutrition Committee, Council on Epidemiology and Prevention, and Council on Cardiovascular Nursing of the American Heart Association. Circulation (2001) 3.21

Mapping the Burkholderia cenocepacia niche response via high-throughput sequencing. Proc Natl Acad Sci U S A (2009) 3.16

ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum. Arterioscler Thromb (1994) 3.11

Low-density lipoprotein subclass patterns and risk of myocardial infarction. JAMA (1988) 3.04

Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice. Science (1990) 3.04

The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron. J Biol Chem (1987) 2.85

Glycosylated hemoglobins and long-term blood glucose control in diabetes mellitus. J Clin Endocrinol Metab (1977) 2.84

Lipoprotein(a) reduction by N-acetylcysteine. Lancet (1991) 2.81

Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome. Nat Genet (1997) 2.81

Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles. J Clin Invest (1992) 2.80

Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Nat Genet (2001) 2.73

Elevating high-density lipoprotein cholesterol in apolipoprotein E-deficient mice remodels advanced atherosclerotic lesions by decreasing macrophage and increasing smooth muscle cell content. Circulation (2001) 2.71

Structure and function of cytochrome bc complexes. Annu Rev Biochem (2000) 2.65

Deletion of a coordinate regulator of type 2 cytokine expression in mice. Nat Immunol (2001) 2.62

Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification. Biochemistry (1981) 2.61

Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes. J Clin Invest (1995) 2.48

Isolation and characterization of the human apolipoprotein A-I gene. Proc Natl Acad Sci U S A (1983) 2.42

Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proc Natl Acad Sci U S A (1998) 2.32

The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating. Science (1998) 2.29

Atherogenesis in transgenic mice expressing human apolipoprotein(a) Nature (1992) 2.28

Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice. J Clin Invest (1995) 2.27

High levels of human apolipoprotein A-I in transgenic mice result in increased plasma levels of small high density lipoprotein (HDL) particles comparable to human HDL3. J Biol Chem (1989) 2.17

Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction. Circulation (1997) 2.10

Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production. J Clin Invest (1996) 2.10

Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia. J Clin Invest (1995) 2.05

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. J Lipid Res (1982) 2.01

Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo. J Clin Invest (1986) 1.96

Noninvasive In vivo high-resolution magnetic resonance imaging of atherosclerotic lesions in genetically engineered mice. Circulation (1998) 1.94

Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice. J Clin Invest (1994) 1.93

Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII. Proc Natl Acad Sci U S A (1984) 1.91

AHA Dietary Guidelines: revision 2000: A statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Stroke (2000) 1.90

Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase. Proc Natl Acad Sci U S A (1997) 1.85

Lower plasma levels and accelerated clearance of high density lipoprotein (HDL) and non-HDL cholesterol in scavenger receptor class B type I transgenic mice. J Biol Chem (1999) 1.85

Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis. Nature (1989) 1.85

Genetic background determines the extent of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol (1999) 1.84

An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3' untranslated region polymorphisms. Proc Natl Acad Sci U S A (1993) 1.83

Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy. Proc Natl Acad Sci U S A (2000) 1.82

An inherited polymorphism in the human apolipoprotein A-I gene locus related to the development of atherosclerosis. Nature (1983) 1.80

Biliary cholesterol excretion: a novel mechanism that regulates dietary cholesterol absorption. Proc Natl Acad Sci U S A (1998) 1.73

Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region. Genome Res (1997) 1.69

Methylation changes in the apolipoprotein AI gene during embryonic development of the mouse. Proc Natl Acad Sci U S A (1991) 1.68

Direct visualization of lipid deposition and reverse lipid transport in a perfused artery : roles of VLDL and HDL. Circ Res (2000) 1.67

Epidemiology and factor analysis of obesity, type II diabetes, hypertension, and dyslipidemia (syndrome X) on the Island of Kosrae, Federated States of Micronesia. Hum Hered (2001) 1.67

Linkage of human apolipoproteins A-I and C-III genes. Nature (1983) 1.66

Isolation and characterization of cDNA clones for human apolipoprotein A-I. Proc Natl Acad Sci U S A (1982) 1.66

Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences. J Clin Invest (1992) 1.66

Human apolipoprotein CIII gene expression is regulated by positive and negative cis-acting elements and tissue-specific protein factors. J Biol Chem (1988) 1.64

Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile. J Biol Chem (1999) 1.64

Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice. J Biol Chem (1991) 1.63

Lipoprotein lipase expression exclusively in liver. A mouse model for metabolism in the neonatal period and during cachexia. J Clin Invest (1998) 1.63

Protein composition determines the anti-atherogenic properties of HDL in transgenic mice. Nature (1993) 1.62

Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p. Genes Dev (1999) 1.56

Apolipoprotein B-gene DNA polymorphisms associated with myocardial infarction. N Engl J Med (1986) 1.55

Plasma Ip(a) concentration is inversely correlated with the ratio of Kringle IV/Kringle V encoding domains in the apo(a) gene. J Clin Invest (1989) 1.55

Macrophages and smooth muscle cells express lipoprotein lipase in human and rabbit atherosclerotic lesions. Proc Natl Acad Sci U S A (1991) 1.55

Orphan receptor HNF-4 and bZip protein C/EBP alpha bind to overlapping regions of the apolipoprotein B gene promoter and synergistically activate transcription. J Biol Chem (1993) 1.54

Human apolipoprotein E isoprotein subclasses are genetically determined. Am J Hum Genet (1981) 1.54

Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene. J Biol Chem (1985) 1.54

Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics. J Biol Chem (2000) 1.52

Characterization of the major apolipoproteins secreted by two human hepatoma cell lines. Biochemistry (1981) 1.51

Increased prebeta-high density lipoprotein, apolipoprotein AI, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes. J Clin Invest (1996) 1.49

Induced mutant mice expressing lipoprotein lipase exclusively in muscle have subnormal triglycerides yet reduced high density lipoprotein cholesterol levels in plasma. J Biol Chem (1997) 1.49

Hypobetalipoproteinemia due to an apolipoprotein B gene exon 21 deletion derived by Alu-Alu recombination. J Biol Chem (1989) 1.47

Type of alcoholic beverage and risk of myocardial infarction. Am J Cardiol (1999) 1.46

Synthesis, intracellular processing, and signal peptide of human apolipoprotein E. J Biol Chem (1984) 1.45

Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil. J Clin Invest (1987) 1.45

HMG CoA reductase inhibitors lower LDL cholesterol without reducing Lp(a) levels. Circulation (1989) 1.43

Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility. Proc Natl Acad Sci U S A (1996) 1.42

Expression of human apolipoprotein B and assembly of lipoprotein(a) in transgenic mice. Proc Natl Acad Sci U S A (1994) 1.42

Increased apo A-I and apo A-II fractional catabolic rate in patients with low high density lipoprotein-cholesterol levels with or without hypertriglyceridemia. J Clin Invest (1991) 1.42

Elevated high density lipoprotein cholesterol levels correlate with decreased apolipoprotein A-I and A-II fractional catabolic rate in women. J Clin Invest (1989) 1.40

Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: correlation with changes in plasma triglyceride levels. J Lipid Res (1994) 1.40

Human HDL cholesterol levels are determined by apoA-I fractional catabolic rate, which correlates inversely with estimates of HDL particle size. Effects of gender, hepatic and lipoprotein lipases, triglyceride and insulin levels, and body fat distribution. Arterioscler Thromb (1994) 1.40

ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes. J Lipid Res (1997) 1.39