Published in Immunology on February 01, 1998
Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science (2008) 1.97
Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice. Cell (2016) 1.57
Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen-driven affinity selection. Immunology (2005) 1.06
Superior neutralizing antibody response and protection in mice vaccinated with heterologous DNA prime and virus like particle boost against HPAI H5N1 virus. PLoS One (2011) 0.92
Correlation of molecular characteristics, isotype, and in vitro functional activity of human antipneumococcal monoclonal antibodies. Infect Immun (2006) 0.89
Novel viral vectored vaccines for the prevention of influenza. Mol Med (2012) 0.83
IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation process. Arthritis Res (2000) 0.76
Germinal centers. Annu Rev Immunol (1994) 10.85
Intraclonal generation of antibody mutants in germinal centres. Nature (1991) 7.39
Cell selection by antigen in the immune response. Adv Immunol (1969) 6.05
Carrier function in anti-hapten immune responses. I. Enhancement of primary and secondary anti-hapten antibody responses by carrier preimmunization. J Exp Med (1970) 5.71
Mechanism of antigen-driven selection in germinal centres. Nature (1990) 5.26
Somatic mutation and the maturation of immune response to 2-phenyl oxazolone. Nature (1984) 4.45
Mutation drift and repertoire shift in the maturation of the immune response. Immunol Rev (1987) 4.16
Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J (1993) 3.85
Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature (1995) 2.95
Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc Natl Acad Sci U S A (1993) 2.30
Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol Today (1993) 1.93
Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation. Immunol Today (1993) 1.78
The maturation of the immune response. Immunol Today (1993) 1.76
Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen. Eur J Immunol (1992) 1.61
The effect of antigen dose and time after immunization on the amount and affinity of anti-hapten antibody. J Immunol (1968) 1.61
Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes. Proc Natl Acad Sci U S A (1993) 1.46
In situ studies of the germinal center reaction. Adv Immunol (1995) 1.36
Mutation and selection during the secondary response to 2-phenyloxazolone. Proc Natl Acad Sci U S A (1991) 1.35
Development of antibody diversity in single germinal centers: selective expansion of high-affinity variants. Eur J Immunol (1994) 1.20
Somatic mutations in antibodies expressed by germinal centre B cells early after primary immunization. Int Immunol (1990) 1.12
Direct evidence that human follicular dendritic cells (FDC) rescue germinal centre B cells from death by apoptosis. Clin Exp Immunol (1993) 1.09
The effect of carrier and carrier priming on the kinetics and pattern of somatic mutation in the V chi Ox1 gene. Eur J Immunol (1995) 0.82
Continuous cultures of fused cells secreting antibody of predefined specificity. Nature (1975) 83.56
Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion. Eur J Immunol (1976) 30.70
Antibodies to major histocompatibility antigens produced by hybrid cell lines. Nature (1977) 16.54
Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis. Cell (1978) 14.82
Preparation of monoclonal antibodies: strategies and procedures. Methods Enzymol (1981) 14.45
A possible precursor of immunoglobulin light chains. Nat New Biol (1972) 11.03
Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol (1979) 10.51
Rat monoclonal antitubulin antibodies derived by using a new nonsecreting rat cell line. J Cell Biol (1982) 9.66
Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: differentiation antigens of rat lymphocytes. Cell (1977) 8.46
Complete sequence of constant and 3' noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing. Cell (1978) 8.20
Fusion between immunoglobulin-secreting and nonsecreting myeloma cell lines. Eur J Immunol (1976) 7.64
Rat x rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG. Nature (1979) 5.69
Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. Eur J Immunol (1978) 5.35
A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody. Eur J Immunol (1979) 5.17
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. Proc Natl Acad Sci U S A (1988) 4.45
Somatic mutation and the maturation of immune response to 2-phenyl oxazolone. Nature (1984) 4.45
Mutation drift and repertoire shift in the maturation of the immune response. Immunol Rev (1987) 4.16
Man-made antibodies. Nature (1991) 3.88
Origin of antibody variation. Nature (1966) 3.50
Kinetic maturation of an immune response. Nature (1991) 3.26
T-lymphocyte heterogeneity in the rat: separation of functional subpopulations using a monoclonal antibody. J Exp Med (1978) 3.20
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity (1998) 3.16
Linked groups of residues in immunoglobulin k chains. Nature (1967) 3.12
Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell (1994) 3.06
The complete amino acid sequence of a mouse kappa light chain. Biochem J (1972) 2.94
Molecular events during maturation of the immune response to oxazolone. Nature (1985) 2.78
mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification. Nature (1983) 2.72
Structural studies of immunoglobulin G. Nature (1969) 2.63
Variations in the S-S bridges of immunoglobins G: interchain disulfide bridges of gamma G3 myeloma proteins. J Mol Biol (1968) 2.57
An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing. Nature (1980) 2.41
Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc Natl Acad Sci U S A (1993) 2.30
Hybrid hybridomas and their use in immunohistochemistry. Nature (1983) 2.24
Sequence analysis of immunoglobulin light chain messenger RNA. Nature (1974) 2.22
A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6. Nature (1986) 2.22
Detection of substance P in the central nervous system by a monoclonal antibody. Proc Natl Acad Sci U S A (1979) 2.16
Complete sequence of an immunoglobulin mRNA using specific priming and the dideoxynucleotide method of RNA sequencing. Nucleic Acids Res (1981) 2.16
Variations in amino-acid sequence near the disulphide bridges of Bence-Jones proteins. Nature (1966) 2.14
Intracellular immunoglobulin chain synthesis in non-secreting variants of a mouse myeloma: detection of inactive light-chain messenger RNA. J Mol Biol (1974) 2.14
Developmental regulation of IgM secretion: the role of the carboxy-terminal cysteine. Cell (1990) 2.12
Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain. Biochem J (1970) 2.11
Two classes of CD1 genes. Eur J Immunol (1989) 2.11
Structure and biological properties of immunoglobulins. Adv Immunol (1967) 2.08
The dynamic nature of the antibody repertoire. Immunol Rev (1988) 2.08
Somatic hypermutation. Curr Opin Immunol (1995) 2.08
Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography. Proc Natl Acad Sci U S A (2001) 1.99
Conformational isomerism and the diversity of antibodies. Proc Natl Acad Sci U S A (1994) 1.99
Original and artificial antibodies. Nature (1992) 1.97
Monoclonal antibodies as probes for differentiation and tumor-associated antigens: a Forssman specificity on teratocarcinoma stem cells. Cell (1978) 1.97
Structure and evolution of immunoglobulins. Prog Biophys Mol Biol (1970) 1.96
Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol Today (1993) 1.93
Reshaping human antibodies: grafting an antilysozyme activity. Science (1988) 1.92
Three rat monoclonal antibodies to human C3. Immunology (1980) 1.91
Molecular analysis of spontaneous somatic mutants. Nature (1977) 1.90
The disulphide bridges of immunoglobulin kappa-chains. Biochem J (1966) 1.89
Nonsense mutations inhibit RNA splicing in a cell-free system: recognition of mutant codon is independent of protein synthesis. Cell (1996) 1.88
Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing. EMBO J (1994) 1.87
The amino acid sequence around the reactive serine residue in alkaline phosphatase from Escherichia coli. Biochem J (1964) 1.83
Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes. EMBO J (1991) 1.83
Letter: Fusion of two immunoglobulin-producing myeloma cells. Nature (1973) 1.83
Regulation of membrane IgM expression in secretory B cells: translational and post-translational events. EMBO J (1987) 1.82
Continuous cultures of fused cells secreting antibody of predefined specificity. 1975. J Immunol (2005) 1.80
Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature (1995) 1.80
Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens. Proc Natl Acad Sci U S A (1986) 1.77
Affinity maturation leads to differential expression of multiple copies of a kappa light-chain transgene. Nature (1993) 1.75
Secretion of immunoglobulin M assembly intermediates in the presence of reducing agents. Nature (1990) 1.74
Russell bodies: a general response of secretory cells to synthesis of a mutant immunoglobulin which can neither exit from, nor be degraded in, the endoplasmic reticulum. J Cell Biol (1991) 1.70
Codon bias targets mutation. Nature (1995) 1.69
Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination. Proc Natl Acad Sci U S A (2001) 1.69
Control of HLA-A,B,C synthesis and expression in interferon-treated cells. EMBO J (1982) 1.69
Monoclonal antibodies as tools to analyze the serological and genetic complexities of major transplantation antigens. Immunol Rev (1979) 1.67
Partial deletion in the heavy chain disease protein ZUC. Nature (1969) 1.65
Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. Proc Natl Acad Sci U S A (1987) 1.57
Activation of memory and virgin B cell clones in hyperimmune animals. Eur J Immunol (1987) 1.54
Anti-oxazolone hybridomas and the structure of the oxazolone idiotype. J Immunol (1983) 1.52
Monitoring and interpreting the intrinsic features of somatic hypermutation. Immunol Rev (1998) 1.51
Sequence and evolution of the human T-cell antigen receptor beta-chain genes. Proc Natl Acad Sci U S A (1985) 1.50
Subpopulations of normal and leukemic human thymocytes: an analysis with the use of monoclonal antibodies. J Natl Cancer Inst (1980) 1.50
A small polypeptide different from beta2-microglobin associated with a human cell surface antigen. Nature (1979) 1.49
Translation of messenger RNA for immunoglobulin light chains in a cell-free system from Krebs II ascites cells. FEBS Lett (1972) 1.49
Purification and sequence of messenger RNA for immunoglobulin light chains. Nat New Biol (1973) 1.46
Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes. Proc Natl Acad Sci U S A (1993) 1.46
Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers. EMBO J (1997) 1.46
Disulphide bridges of immunoglobin G-1 heavy chains. Nature (1967) 1.44
Recovery of the genome of murine sarcoma virus (MSV) after infection of cells with nuclear DNA from MSV transformed non-virus producing cells. Eur J Cancer (1973) 1.44
Expression of spleen cell immunoglobulin phenotype in hybrids with myeloma cell lines. Somatic Cell Genet (1981) 1.42
Mouse CD1 is distinct from and co-exists with TL in the same thymus. EMBO J (1988) 1.41
Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51. Proc Natl Acad Sci U S A (1991) 1.41
A myeloma hybrid producing antibody specific for an allotypic determinant on "IgD-like" molecules of the mouse. Eur J Immunol (1977) 1.41
Non-allelic nature of the basic sequences of normal immunoglobulin K chains. Nature (1969) 1.38
Studies on polysome-membrane interactions in mouse myeloma cells. Eur J Biochem (1974) 1.36
Mutation and selection during the secondary response to 2-phenyloxazolone. Proc Natl Acad Sci U S A (1991) 1.35
The genetic basis of antibody specificity. Annu Rev Microbiol (1970) 1.31
C-terminal half of immunoglobulin lambda-chains. Nature (1967) 1.30
The targeting of somatic hypermutation. Semin Immunol (1996) 1.29
Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease. Proc Natl Acad Sci U S A (2000) 1.28
The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially. EMBO J (2001) 1.28
The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron. Eur J Immunol (1994) 1.27
Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1. EMBO J (1988) 1.26
Serum beta 2-microglobulin binds to a T-cell differentiation antigen and increases its expression. Nature (1984) 1.25