Published in J Mol Biol on May 14, 1968
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A subclass of human gamma-A-globulins (gamma-A2) which lacks the disulfied bonds linking heavy and light chains. J Exp Med (1968) 2.98
The disulphide bonds of the heavy chain of rabbit immunoglobulin G. Biochem J (1970) 2.32
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The antibody binding site. Labelling of a specific antibody against the photo-precursor of an aryl nitrene. Biochem J (1972) 1.68
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Partial duplication in the "hinge" region of IgA 1 myeloma proteins. Proc Natl Acad Sci U S A (1972) 1.36
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Amino acid sequence of the protein inhibitor of mitochondrial adenosine triphosphatase. Proc Natl Acad Sci U S A (1981) 1.17
Stability of IgG isotypes in serum. MAbs (2010) 1.17
The molecular defect in a protein (CRA) found in gamma-1 heavy chain disease, and its genetic implications. Proc Natl Acad Sci U S A (1971) 1.13
Protein Hal: partial deletion of a " " immunoglobulin gene(s) and apparent reinitiation at an internal AUG codon. Proc Natl Acad Sci U S A (1973) 1.09
Immunoglobulin lambda-chains. The complete amino acid sequence of a Bence-Jones protein. Biochem J (1968) 1.09
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Lambda2 light chains in normal mouse immunoglobulins. Proc Natl Acad Sci U S A (1978) 1.03
Chain models of 6.6S and 3.9S mouse myeloma gamma A immunoglobulin molecules. Proc Natl Acad Sci U S A (1968) 1.00
Biosynthetic and structural studies of a heavy chain disease protein. J Clin Invest (1969) 1.00
Repetitive hinge region sequences in human IgG3: isolation of an 11,000-dalton fragment. Proc Natl Acad Sci U S A (1975) 0.96
Major coat protein and single-stranded DNA-binding protein of filamentous virus Pf3. Proc Natl Acad Sci U S A (1984) 0.94
Interchain and intrachain disulfide bridges of a human immunoglobulin M: detection of a unique fragment. Proc Natl Acad Sci U S A (1971) 0.86
Intrachain disulphide bridges of rabbit immunoglobulin light chains of allotypes b4 and b5. Biochem J (1972) 0.85
Mutations within a human IgG2 antibody form distinct and homogeneous disulfide isomers but do not affect Fc gamma receptor or C1q binding. Protein Sci (2010) 0.84
A new immunoglobulin variant: gamma3 heavy chain disease protein CHI. Proc Natl Acad Sci U S A (1976) 0.82
Qualitative and quantitative investigations on the reactions of normal and myeloma IgG with antisera to IgG. Clin Exp Immunol (1973) 0.80
The heterogeneity of human immunoglobulins. Biochem J (1968) 0.75
Disulfide Bond Characterization of Endogenous IgG3 Monoclonal Antibodies Using LC-MS: An Investigation of IgG3 Disulfide-mediated Isoforms. Anal Methods (2016) 0.75
Continuous cultures of fused cells secreting antibody of predefined specificity. Nature (1975) 83.56
Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion. Eur J Immunol (1976) 30.70
Antibodies to major histocompatibility antigens produced by hybrid cell lines. Nature (1977) 16.54
Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis. Cell (1978) 14.82
Preparation of monoclonal antibodies: strategies and procedures. Methods Enzymol (1981) 14.45
A possible precursor of immunoglobulin light chains. Nat New Biol (1972) 11.03
Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol (1979) 10.51
Rat monoclonal antitubulin antibodies derived by using a new nonsecreting rat cell line. J Cell Biol (1982) 9.66
Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: differentiation antigens of rat lymphocytes. Cell (1977) 8.46
Complete sequence of constant and 3' noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing. Cell (1978) 8.20
Fusion between immunoglobulin-secreting and nonsecreting myeloma cell lines. Eur J Immunol (1976) 7.64
Rat x rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG. Nature (1979) 5.69
Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. Eur J Immunol (1978) 5.35
Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science (1992) 5.22
A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody. Eur J Immunol (1979) 5.17
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest (2000) 5.07
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science (1990) 4.71
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. Proc Natl Acad Sci U S A (1988) 4.45
Somatic mutation and the maturation of immune response to 2-phenyl oxazolone. Nature (1984) 4.45
Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci Lett (1992) 4.29
Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy. Nat Med (1998) 4.17
Mutation drift and repertoire shift in the maturation of the immune response. Immunol Rev (1987) 4.16
The amino acid sequence of a major nonimmunoglobulin component of some amyloid fibrils. J Clin Invest (1972) 3.96
Man-made antibodies. Nature (1991) 3.88
Origin of antibody variation. Nature (1966) 3.50
Kinetic maturation of an immune response. Nature (1991) 3.26
T-lymphocyte heterogeneity in the rat: separation of functional subpopulations using a monoclonal antibody. J Exp Med (1978) 3.20
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity (1998) 3.16
Linked groups of residues in immunoglobulin k chains. Nature (1967) 3.12
Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell (1994) 3.06
The complete amino acid sequence of a mouse kappa light chain. Biochem J (1972) 2.94
Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proc Natl Acad Sci U S A (1996) 2.79
Molecular events during maturation of the immune response to oxazolone. Nature (1985) 2.78
mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification. Nature (1983) 2.72
Down patients: extracellular preamyloid deposits precede neuritic degeneration and senile plaques. Neurosci Lett (1989) 2.69
Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro. Am J Pathol (1994) 2.66
The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex. Biochem J (1993) 2.66
Structural studies of immunoglobulin G. Nature (1969) 2.63
A stop-codon mutation in the BRI gene associated with familial British dementia. Nature (1999) 2.46
Human amyloidosis, Alzheimer disease and related disorders. Lab Invest (1988) 2.44
An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing. Nature (1980) 2.41
The disulphide bonds of the heavy chain of rabbit immunoglobulin G. Biochem J (1970) 2.32
Alpha chain disease. Ann N Y Acad Sci (1971) 2.31
Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc Natl Acad Sci U S A (1993) 2.30
Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals. Neurosci Lett (1988) 2.26
Hybrid hybridomas and their use in immunohistochemistry. Nature (1983) 2.24
Differences between vascular and plaque core amyloid in Alzheimer's disease. J Neurochem (1988) 2.24
Sequence analysis of immunoglobulin light chain messenger RNA. Nature (1974) 2.22
A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6. Nature (1986) 2.22
In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to Alzheimer's disease beta-protein. Biochem Biophys Res Commun (1986) 2.16
Detection of substance P in the central nervous system by a monoclonal antibody. Proc Natl Acad Sci U S A (1979) 2.16
Complete sequence of an immunoglobulin mRNA using specific priming and the dideoxynucleotide method of RNA sequencing. Nucleic Acids Res (1981) 2.16
Variations in amino-acid sequence near the disulphide bridges of Bence-Jones proteins. Nature (1966) 2.14
Intracellular immunoglobulin chain synthesis in non-secreting variants of a mouse myeloma: detection of inactive light-chain messenger RNA. J Mol Biol (1974) 2.14
Developmental regulation of IgM secretion: the role of the carboxy-terminal cysteine. Cell (1990) 2.12
Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain. Biochem J (1970) 2.11
Two classes of CD1 genes. Eur J Immunol (1989) 2.11
A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. Proc Natl Acad Sci U S A (2000) 2.11
Structure and biological properties of immunoglobulins. Adv Immunol (1967) 2.08
The dynamic nature of the antibody repertoire. Immunol Rev (1988) 2.08
Somatic hypermutation. Curr Opin Immunol (1995) 2.08
Isolation and partial characterization of SAA-an amyloid-related protein from human serum. J Immunol (1976) 2.05
Apolipoprotein J (clusterin) and Alzheimer's disease. Microsc Res Tech (2000) 2.00
Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography. Proc Natl Acad Sci U S A (2001) 1.99
Conformational isomerism and the diversity of antibodies. Proc Natl Acad Sci U S A (1994) 1.99
Monoclonal antibodies as probes for differentiation and tumor-associated antigens: a Forssman specificity on teratocarcinoma stem cells. Cell (1978) 1.97
Original and artificial antibodies. Nature (1992) 1.97
Fate of cerebrospinal fluid-borne amyloid beta-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries. J Neurochem (1996) 1.96
Structure and evolution of immunoglobulins. Prog Biophys Mol Biol (1970) 1.96
Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP. Proc Natl Acad Sci U S A (1996) 1.94
Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol Today (1993) 1.93
Reshaping human antibodies: grafting an antilysozyme activity. Science (1988) 1.92
Three rat monoclonal antibodies to human C3. Immunology (1980) 1.91
Molecular analysis of spontaneous somatic mutants. Nature (1977) 1.90
The disulphide bridges of immunoglobulin kappa-chains. Biochem J (1966) 1.89
Nonsense mutations inhibit RNA splicing in a cell-free system: recognition of mutant codon is independent of protein synthesis. Cell (1996) 1.88
Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing. EMBO J (1994) 1.87
Preferential association of kappa IIIb light chains with monoclonal human IgM kappa autoantibodies. J Immunol (1983) 1.87
A 25-kDa NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein. J Biol Chem (1987) 1.86
Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. Biochem J (2000) 1.84
The amino acid sequence around the reactive serine residue in alkaline phosphatase from Escherichia coli. Biochem J (1964) 1.83
Letter: Fusion of two immunoglobulin-producing myeloma cells. Nature (1973) 1.83
Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes. EMBO J (1991) 1.83
Primary structure of the "hinge" region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit. J Biol Chem (1977) 1.83
Regulation of membrane IgM expression in secretory B cells: translational and post-translational events. EMBO J (1987) 1.82
Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid. Biochem Biophys Res Commun (1993) 1.80
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Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature (1995) 1.80
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Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens. Proc Natl Acad Sci U S A (1986) 1.77
Affinity maturation leads to differential expression of multiple copies of a kappa light-chain transgene. Nature (1993) 1.75
Secretion of immunoglobulin M assembly intermediates in the presence of reducing agents. Nature (1990) 1.74
Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58. EMBO J (1991) 1.74
Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation. Biochem Biophys Res Commun (1996) 1.73
Nucleotide sequence of the small double-stranded RNA segment of bacteriophage phi 6: novel mechanism of natural translational control. J Virol (1986) 1.72
Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E. Biochem J (1995) 1.72
Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells. J Biol Chem (2000) 1.71
Russell bodies: a general response of secretory cells to synthesis of a mutant immunoglobulin which can neither exit from, nor be degraded in, the endoplasmic reticulum. J Cell Biol (1991) 1.70
Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis. Lab Invest (1988) 1.70