Published in Nature on July 30, 1998
Rho GTPases and their effector proteins. Biochem J (2000) 8.89
A functional genomic analysis of cell morphology using RNA interference. J Biol (2003) 5.99
Clostridium difficile toxins: mechanism of action and role in disease. Clin Microbiol Rev (2005) 5.69
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J (2007) 5.31
Activity of Rho-family GTPases during cell division as visualized with FRET-based probes. J Cell Biol (2003) 3.85
Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. J Cell Biol (1999) 3.77
PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. J Cell Biol (2002) 3.51
Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc Natl Acad Sci U S A (2000) 3.44
Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. J Cell Biol (1999) 3.43
Terminal cytokinesis events uncovered after an RNAi screen. Curr Biol (2004) 2.99
The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis. EMBO J (2000) 2.50
RhoE binds to ROCK I and inhibits downstream signaling. Mol Cell Biol (2003) 2.46
Cytokinesis in eukaryotes. Microbiol Mol Biol Rev (2002) 2.43
Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. J Cell Biol (2000) 2.36
Dissecting the role of Rho-mediated signaling in contractile ring formation. Mol Biol Cell (2005) 2.33
Extracellular matrix and integrin signalling: the shape of things to come. Biochem J (1999) 2.28
PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation. Biochem J (2005) 2.19
Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. Mol Cell Biol (1999) 2.19
Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J Cell Biol (1999) 2.17
Citron kinase, a Rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin II. Mol Biol Cell (2003) 2.17
The small GTP-binding protein rho regulates cortical activities in cultured cells during division. J Cell Biol (1999) 2.09
Myosin phosphatase target subunit: Many roles in cell function. Biochem Biophys Res Commun (2007) 2.08
KIF14 and citron kinase act together to promote efficient cytokinesis. J Cell Biol (2006) 2.06
Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2. J Cell Biol (1999) 1.96
Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac. J Cell Biol (2004) 1.94
An essential role for a membrane lipid in cytokinesis. Regulation of contractile ring disassembly by redistribution of phosphatidylethanolamine. J Cell Biol (2000) 1.89
mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells. Mol Biol Cell (2008) 1.78
Enucleation of human erythroblasts involves non-muscle myosin IIB. Blood (2011) 1.76
Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes. Dev Cell (2012) 1.76
The human kinesin-like protein RB6K is under tight cell cycle control and is essential for cytokinesis. Mol Cell Biol (2001) 1.75
The nonmuscle myosin regulatory light chain gene mlc-4 is required for cytokinesis, anterior-posterior polarity, and body morphology during Caenorhabditis elegans embryogenesis. J Cell Biol (1999) 1.73
Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Proc Natl Acad Sci U S A (2005) 1.73
lncRNA directs cooperative epigenetic regulation downstream of chemokine signals. Cell (2014) 1.59
Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family. Mol Biol Cell (2000) 1.58
The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. Mol Cell Biol (2003) 1.52
Cytokinesis mediated through the recruitment of cortexillins into the cleavage furrow. EMBO J (1999) 1.44
Citron kinase controls abscission through RhoA and anillin. Mol Biol Cell (2011) 1.37
Untying the Gordian knot of cytokinesis. Role of small G proteins and their regulators. J Cell Biol (2000) 1.36
The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals. Mol Cell Biol (2005) 1.34
Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins. EMBO J (2001) 1.28
Rho kinase's role in myosin recruitment to the equatorial cortex of mitotic Drosophila S2 cells is for myosin regulatory light chain phosphorylation. PLoS One (2006) 1.28
Proliferating versus differentiating stem and cancer cells exhibit distinct midbody-release behaviour. Nat Commun (2011) 1.26
A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95. Biochemistry (2007) 1.25
RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts. J Biol Chem (2011) 1.23
Activation of rho through a cross-link with polyamines catalyzed by Bordetella dermonecrotizing toxin. EMBO J (2000) 1.22
Drosophila citron kinase is required for the final steps of cytokinesis. Mol Biol Cell (2004) 1.21
CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis. J Cell Biol (2012) 1.20
Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis. EMBO J (2007) 1.19
Defects in nuclear pore assembly lead to activation of an Aurora B-mediated abscission checkpoint. J Cell Biol (2010) 1.18
Rho and anillin-dependent control of mDia2 localization and function in cytokinesis. Mol Biol Cell (2010) 1.17
Defining the protein-protein interaction network of the human hippo pathway. Mol Cell Proteomics (2013) 1.14
The ESCRT machinery: from the plasma membrane to endosomes and back again. Crit Rev Biochem Mol Biol (2014) 1.12
Inhibition of cytokinesis by a lipid metabolite, psychosine. J Cell Biol (2000) 1.12
Rho GTPases in animal cell cytokinesis: an occupation by the one percent. Cytoskeleton (Hoboken) (2012) 1.11
Overexpression of RhoA induces preneoplastic transformation of primary mammary epithelial cells. Cancer Res (2009) 1.06
Understanding cytokinesis failure. Adv Exp Med Biol (2010) 1.06
Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis. Mol Cell Biol (2002) 1.05
Rho kinases regulate corneal epithelial wound healing. Am J Physiol Cell Physiol (2008) 1.04
Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis. J Cell Biol (2011) 1.01
Embryonic morphogenesis in Caenorhabditis elegans integrates the activity of LET-502 Rho-binding kinase, MEL-11 myosin phosphatase, DAF-2 insulin receptor and FEM-2 PP2c phosphatase. Genetics (2000) 1.01
Identification and functional analysis of epigenetically silenced microRNAs in colorectal cancer cells. PLoS One (2011) 1.00
Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells. Small GTPases (2014) 1.00
Control over the morphology and segregation of Zebrafish germ cell granules during embryonic development. BMC Dev Biol (2008) 0.99
The midbody ring scaffolds the abscission machinery in the absence of midbody microtubules. J Cell Biol (2013) 0.98
Mitochondria localize to the cleavage furrow in mammalian cytokinesis. PLoS One (2013) 0.93
The Rho-related protein Rnd1 inhibits Ca2+ sensitization of rat smooth muscle. J Physiol (1999) 0.93
Tissue-specific control of midbody microtubule stability by Citron kinase through modulation of TUBB3 phosphorylation. Cell Death Differ (2015) 0.93
Citron kinase controls a molecular network required for midbody formation in cytokinesis. Proc Natl Acad Sci U S A (2013) 0.93
Deficiency in myosin light-chain phosphorylation causes cytokinesis failure and multipolarity in cancer cells. Oncogene (2010) 0.93
Citron kinase, a RhoA effector, enhances HIV-1 virion production by modulating exocytosis. Traffic (2006) 0.91
Negative control of keratinocyte differentiation by Rho/CRIK signaling coupled with up-regulation of KyoT1/2 (FHL1) expression. Proc Natl Acad Sci U S A (2005) 0.91
ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules. EMBO Rep (2016) 0.91
The protein tyrosine phosphatase PTP-BL associates with the midbody and is involved in the regulation of cytokinesis. Mol Biol Cell (2003) 0.90
p27(Kip1) controls cytokinesis via the regulation of citron kinase activation. J Clin Invest (2012) 0.90
APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis. PLoS One (2011) 0.89
Targeting and clustering citron to synapses. Mol Cell Neurosci (2005) 0.89
Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis. Elife (2016) 0.88
Opposing actions of septins and Sticky on Anillin promote the transition from contractile to midbody ring. J Cell Biol (2013) 0.88
Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos. Cancer Metastasis Rev (2013) 0.87
Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly. Am J Hum Genet (2016) 0.87
PKN delays mitotic timing by inhibition of Cdc25C: possible involvement of PKN in the regulation of cell division. Proc Natl Acad Sci U S A (2001) 0.87
Focal adhesion components are essential for mammalian cell cytokinesis. Cell Cycle (2008) 0.86
Defective dendrite elongation but normal fertility in mice lacking the Rho-like GTPase activator Dbl. Mol Cell Biol (2002) 0.86
Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines. Cell Rep (2016) 0.86
Cell cycle regulation of Rho signaling pathways. Cell Cycle (2012) 0.85
RanBPM regulates the progression of neuronal precursors through M-phase at the surface of the neocortical ventricular zone. Dev Neurobiol (2010) 0.85
Molecular pathways: induction of polyploidy as a novel differentiation therapy for leukemia. Clin Cancer Res (2013) 0.84
Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells. Immunol Rev (2013) 0.83
Cell migration regulates the kinetics of cytokinesis. Cell Cycle (2011) 0.83
Myosin light chain kinases and phosphatase in mitosis and cytokinesis. Arch Biochem Biophys (2011) 0.83
Kinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzone. Semin Cell Dev Biol (2010) 0.83
Myotonic dystrophy kinase-related Cdc42-binding kinases (MRCK), the ROCK-like effectors of Cdc42 and Rac1. Small GTPases (2015) 0.83
Eph-mediated tyrosine phosphorylation of citron kinase controls abscission. J Cell Biol (2016) 0.83
The effects of Rho-associated kinase inhibitor Y-27632 on primary human corneal endothelial cells propagated using a dual media approach. Sci Rep (2015) 0.83
Drosophila sticky/citron kinase is a regulator of cell-cycle progression, genetically interacts with Argonaute 1 and modulates epigenetic gene silencing. Genetics (2008) 0.81
The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer. J Mol Med (Berl) (2014) 0.80
Metabolic actions of Rho-kinase in periphery and brain. Trends Endocrinol Metab (2013) 0.79
Cross-regulation between Aurora B and Citron kinase controls midbody architecture in cytokinesis. Open Biol (2016) 0.79
Non-muscle myosin IIB is essential for cytokinesis during male meiotic cell divisions. Dev Biol (2012) 0.79
Phosphorylation of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) at threonine 544 by aurora B kinase promotes the binding of polo-like kinase 1 to MyoGEF. J Biol Chem (2014) 0.78
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature (1997) 14.91
Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol (2001) 9.73
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science (1999) 7.12
Cooperation between mDia1 and ROCK in Rho-induced actin reorganization. Nat Cell Biol (1999) 5.84
Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature (1989) 5.21
International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev (1994) 5.11
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J (1996) 5.09
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J (1997) 5.03
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol (2000) 4.80
Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell (1993) 4.46
p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett (1997) 4.31
The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs. Nature (1989) 4.13
An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat Med (1999) 3.76
Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J Cell Biol (1994) 3.65
Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase. J Biol Chem (1989) 3.47
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett (1996) 3.46
Prostaglandin D2 as a mediator of allergic asthma. Science (2000) 3.19
Safe right subclavian vein puncture: the importance of pressing the skin with the left thumb. Am J Emerg Med (1993) 3.07
Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature (1997) 3.07
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science (1996) 2.99
Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem (2000) 2.99
Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice. Nat Med (2001) 2.98
cDNA cloning and structure of mouse putative Ah receptor. Biochem Biophys Res Commun (1992) 2.93
Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. J Biol Chem (1996) 2.92
Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. Nature (1993) 2.91
Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature (1998) 2.88
Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron (1996) 2.86
Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J Cell Biol (1998) 2.81
Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. Int Immunol (1997) 2.79
PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression. Mol Cell (1998) 2.75
A novel negative selection for homologous recombinants using diphtheria toxin A fragment gene. Anal Biochem (1993) 2.74
A rho-like protein is involved in the organisation of the contractile ring in dividing sand dollar eggs. Zygote (1993) 2.71
Tumor angiogenesis in human lung adenocarcinoma. Cancer (1994) 2.59
Evaluation of monensin toxicity in the horse. J Am Vet Med Assoc (1976) 2.56
A novel partner for the GTP-bound forms of rho and rac. FEBS Lett (1995) 2.52
Structural and mechanistic insights into the interaction between Rho and mammalian Dia. Nature (2005) 2.52
Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas. Br J Cancer (1998) 2.48
Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity. Diabetes (1999) 2.47
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol (1997) 2.44
Parthenogenetic activation of oocytes in c-mos-deficient mice. Nature (1994) 2.40
Does superoxide underlie the pathogenesis of hypertension? Proc Natl Acad Sci U S A (1991) 2.39
Transformation mediated by RhoA requires activity of ROCK kinases. Curr Biol (1999) 2.39
Dependence of cyclin E-CDK2 kinase activity on cell anchorage. Science (1996) 2.38
Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways. Proc Natl Acad Sci U S A (1989) 2.38
Failure of parturition in mice lacking the prostaglandin F receptor. Science (1997) 2.27
Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1. Nat Cell Biol (2001) 2.27
Cloning and expression of cDNA for a human thromboxane A2 receptor. Nature (1991) 2.26
Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho. J Cell Biol (1993) 2.26
ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. J Biol Chem (1993) 2.20
A detailed linkage map of medaka, Oryzias latipes: comparative genomics and genome evolution. Genetics (2000) 2.19
Rho effectors and reorganization of actin cytoskeleton. FEBS Lett (1997) 2.19
Use and properties of ROCK-specific inhibitor Y-27632. Methods Enzymol (2000) 2.19
Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics. Clin Pharmacol Ther (1992) 2.18
Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2). Proc Natl Acad Sci U S A (1999) 2.15
Subtotal corpectomy versus laminoplasty for multilevel cervical spondylotic myelopathy: a long-term follow-up study over 10 years. Spine (Phila Pa 1976) (2001) 2.14
N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest (2000) 2.13
Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor. Nature (1995) 2.09
Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo. Nat Genet (1996) 2.09
Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow. Oncogene (2000) 2.08
The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology (2000) 2.08
Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice. Biochem Biophys Res Commun (1998) 2.04
Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation. J Biol Chem (2000) 2.04
Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39. Mol Cell Biol (1995) 2.03
Walking speed as a good predictor for the onset of functional dependence in a Japanese rural community population. Age Ageing (2000) 1.99
Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds. J Biol Chem (2001) 1.99
Studies of prevalence of Japanese cedar pollinosis among the residents in a densely cultivated area. Ann Allergy (1987) 1.92
Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations. Pharmacogenetics (1997) 1.92
Urinary protein as measured with a pyrogallol red-molybdate complex, manually and in a Hitachi 726 automated analyzer. Clin Chem (1986) 1.92
Accuracy and performance of the Terumo ES-H51, a new portable blood pressure monitor. Am J Hypertens (1994) 1.92