Published in Nature on February 24, 2000
Self-incompatibility in the genus Arabidopsis: characterization of the S locus in the outcrossing A. lyrata and its autogamous relative A. thaliana. Plant Cell (2001) 2.30
ARC1 is an E3 ubiquitin ligase and promotes the ubiquitination of proteins during the rejection of self-incompatible Brassica pollen. Plant Cell (2003) 2.13
Pollen tube development and competitive ability are impaired by disruption of a Shaker K(+) channel in Arabidopsis. Genes Dev (2002) 1.93
The barley stem rust-resistance gene Rpg1 is a novel disease-resistance gene with homology to receptor kinases. Proc Natl Acad Sci U S A (2002) 1.93
Polypeptide hormones. Plant Cell (2002) 1.65
Cellular pathways regulating responses to compatible and self-incompatible pollen in Brassica and Arabidopsis stigmas intersect at Exo70A1, a putative component of the exocyst complex. Plant Cell (2009) 1.62
Identification and characterization of a polymorphic receptor kinase gene linked to the self-incompatibility locus of Arabidopsis lyrata. Genetics (2001) 1.54
Trans-acting small RNA determines dominance relationships in Brassica self-incompatibility. Nature (2010) 1.48
The Papaver self-incompatibility pollen S-determinant, PrpS, functions in Arabidopsis thaliana. Curr Biol (2011) 1.44
Coevolution of the S-locus genes SRK, SLG and SP11/SCR in Brassica oleracea and B. rapa. Genetics (2002) 1.42
Genome-wide survey and expression analysis of Chlamydomonas reinhardtii U-box E3 ubiquitin ligases (CrPUBs) reveal a functional lipid metabolism module. PLoS One (2015) 1.42
Comparative analyses reveal distinct sets of lineage-specific genes within Arabidopsis thaliana. BMC Evol Biol (2010) 1.28
Nucleo-cytoplasmic partitioning of proteins in plants: implications for the regulation of environmental and developmental signalling. Curr Genet (2003) 1.28
The dominance of alleles controlling self-incompatibility in Brassica pollen is regulated at the RNA level. Plant Cell (2002) 1.26
Interaction of calmodulin, a sorting nexin and kinase-associated protein phosphatase with the Brassica oleracea S locus receptor kinase. Plant Physiol (2003) 1.26
Evolutionary expansion, gene structure, and expression of the rice wall-associated kinase gene family. Plant Physiol (2005) 1.24
Two distinct forms of M-locus protein kinase localize to the plasma membrane and interact directly with S-locus receptor kinase to transduce self-incompatibility signaling in Brassica rapa. Plant Cell (2007) 1.19
Evolution of self-compatibility in Arabidopsis by a mutation in the male specificity gene. Nature (2010) 1.18
Balancing selection in the wild: testing population genetics theory of self-incompatibility in the rare species Brassica insularis. Genetics (2005) 1.17
A pollen coat protein, SP11/SCR, determines the pollen S-specificity in the self-incompatibility of Brassica species. Plant Physiol (2001) 1.15
On the origin of self-incompatibility haplotypes: transition through self-compatible intermediates. Genetics (2001) 1.15
Diversity and linkage of genes in the self-incompatibility gene family in Arabidopsis lyrata. Genetics (2003) 1.14
Tissue-specific and developmentally regulated expression of a cluster of tandemly arrayed cell wall-associated kinase-like kinase genes in Arabidopsis. Plant Physiol (2003) 1.12
Transcriptome sequencing and whole genome expression profiling of chrysanthemum under dehydration stress. BMC Genomics (2013) 1.10
Molecular characterisation of the STRUBBELIG-RECEPTOR FAMILY of genes encoding putative leucine-rich repeat receptor-like kinases in Arabidopsis thaliana. BMC Plant Biol (2007) 1.10
Self-incompatibility in the Brassicaceae: receptor-ligand signaling and cell-to-cell communication. Plant Cell (2002) 1.10
Selection at work in self-incompatible Arabidopsis lyrata: mating patterns in a natural population. Genetics (2005) 1.09
Characterization of the SP11/SCR high-affinity binding site involved in self/nonself recognition in brassica self-incompatibility. Plant Cell (2007) 1.07
Post-transcriptional maturation of the S receptor kinase of Brassica correlates with co-expression of the S-locus glycoprotein in the stigmas of two Brassica strains and in transgenic tobacco plants. Plant Physiol (2000) 1.07
The Functions of RNA-Dependent RNA Polymerases in Arabidopsis. Arabidopsis Book (2011) 1.05
Detecting groups of coevolving positions in a molecule: a clustering approach. BMC Evol Biol (2007) 1.03
The ARC1 E3 ligase gene is frequently deleted in self-compatible Brassicaceae species and has a conserved role in Arabidopsis lyrata self-pollen rejection. Plant Cell (2012) 1.02
Involvement of a cell wall-associated kinase, WAKL4, in Arabidopsis mineral responses. Plant Physiol (2005) 1.01
Preservation of a pseudogene by gene conversion and diversifying selection. Genetics (2008) 1.01
Isolation and characterization of kinase interacting protein 1, a pollen protein that interacts with the kinase domain of PRK1, a receptor-like kinase of petunia. Plant Physiol (2001) 1.00
Plant sexual reproduction during climate change: gene function in natura studied by ecological and evolutionary systems biology. Ann Bot (2011) 0.99
Self-incompatibility in Brassica: the elusive pollen S gene is identified! Plant Cell (2000) 0.99
Evidence that intragenic recombination contributes to allelic diversity of the S-RNase gene at the self-incompatibility (S) locus in Petunia inflata. Plant Physiol (2001) 0.97
The different mechanisms of sporophytic self-incompatibility. Philos Trans R Soc Lond B Biol Sci (2003) 0.96
Comparison of the genome structure of the self-incompatibility (S) locus in interspecific pairs of S haplotypes. Genetics (2006) 0.95
The beginning of a seed: regulatory mechanisms of double fertilization. Front Plant Sci (2014) 0.94
Sporophytic self-incompatibility genes and mating system variation in Arabis alpina. Ann Bot (2011) 0.94
Actin dynamics in papilla cells of Brassica rapa during self- and cross-pollination. Plant Physiol (2007) 0.92
Thiol-based redox regulation in sexual plant reproduction: new insights and perspectives. Front Plant Sci (2013) 0.92
Intrahaplotype polymorphism at the Brassica S locus. Genetics (2001) 0.90
Characterization of salicylic acid-induced genes in Chinese cabbage. Plant Cell Rep (2003) 0.90
Microstructure of a Brassica rapa genome segment homoeologous to the resistance gene cluster on Arabidopsis chromosome 4. Breed Sci (2012) 0.89
Selection at work in self-incompatible Arabidopsis lyrata. II. Spatial distribution of S haplotypes in Iceland. Genetics (2008) 0.87
Effects of recombination on hitchhiking diversity in the Brassica self-incompatibility locus complex. Genetics (2007) 0.86
Diversification and alteration of recognition specificity of the pollen ligand SP11/SCR in self-incompatibility of Brassica and Raphanus. Plant Cell (2004) 0.86
S-LOCUS EARLY FLOWERING 3 is exclusively present in the genomes of short-styled buckwheat plants that exhibit heteromorphic self-incompatibility. PLoS One (2012) 0.85
Recent loss of self-incompatibility by degradation of the male component in allotetraploid Arabidopsis kamchatica. PLoS Genet (2012) 0.85
Molecular genetics, physiology and biology of self-incompatibility in Brassicaceae. Proc Jpn Acad Ser B Phys Biol Sci (2012) 0.84
Molecular characterization of Lal2, an SRK-like gene linked to the S-locus in the wild mustard Leavenworthia alabamica. Genetics (2008) 0.84
Genomic organization of the S core region and the S flanking regions of a class-II S haplotype in Brassica rapa. Mol Genet Genomics (2003) 0.83
Self-incompatibility in Brassicaceae: identification and characterization of SRK-like sequences linked to the S-locus in the tribe Biscutelleae. G3 (Bethesda) (2014) 0.83
Altered Expression of PERK Receptor Kinases in Arabidopsis Leads to Changes in Growth and Floral Organ Formation. Plant Signal Behav (2006) 0.83
NaStEP: a proteinase inhibitor essential to self-incompatibility and a positive regulator of HT-B stability in Nicotiana alata pollen tubes. Plant Physiol (2012) 0.82
A conserved role for the ARC1 E3 ligase in Brassicaceae self-incompatibility. Front Plant Sci (2014) 0.82
Time-lapse imaging of self- and cross-pollinations in Brassica rapa. Ann Bot (2013) 0.82
In planta assessment of the role of thioredoxin h proteins in the regulation of S-locus receptor kinase signaling in transgenic Arabidopsis. Plant Physiol (2013) 0.81
The S haplotypes lacking SLG in the genome of Brassica rapa. Plant Cell Rep (2003) 0.81
Self-incompatibility in Brassicaceae crops: lessons for interspecific incompatibility. Breed Sci (2014) 0.81
Plant biology. A social stigma. Nature (2000) 0.80
S-genotype identification based on allele-specific PCR in Japanese pear. Breed Sci (2015) 0.78
Structural basis for specific self-incompatibility response in Brassica. Cell Res (2016) 0.77
Isolation and characterization of a J domain protein that interacts with ARC1 from ornamental kale (Brassica oleracea var. acephala). Plant Cell Rep (2015) 0.77
Cell type-specific transcriptome of Brassicaceae stigmatic papilla cells from a combination of laser microdissection and RNA sequencing. Plant Cell Physiol (2013) 0.77
Involvement of MLPK Pathway in Intraspecies Unilateral Incompatibility Regulated by a Single Locus With Stigma and Pollen Factors. G3 (Bethesda) (2013) 0.76
Helitron-like transposons contributed to the mating system transition from out-crossing to self-fertilizing in polyploid Brassica napus L. Sci Rep (2016) 0.76
Physiological and genetic analysis of CO2-induced breakdown of self-incompatibility in Brassica rapa. J Exp Bot (2013) 0.76
Commonalities and differences between Brassica and Arabidopsis self-incompatibility. Hortic Res (2014) 0.76
Variability of the self-incompatibility reaction in Brassica oleracea L. with S 15 haplotype. Sex Plant Reprod (2009) 0.76
Exogenous selection rather than cytonuclear incompatibilities shapes asymmetrical fitness of reciprocal Arabidopsis hybrids. Ecol Evol (2015) 0.76
The Pollen Coat Proteome: At the Cutting Edge of Plant Reproduction. Proteomes (2016) 0.75
Pollen recognition during the self-incompatibility response in plants. Genome Biol (2002) 0.75
Over-expression of an S-domain receptor-like kinase extracellular domain improves panicle architecture and grain yield in rice. J Exp Bot (2015) 0.75
Development of self-compatible B. rapa by RNAi-mediated S locus gene silencing. PLoS One (2012) 0.75
Genome-wide analysis of lectin receptor-like kinases in Populus. BMC Genomics (2016) 0.75
PCP-B class pollen coat proteins are key regulators of the hydration checkpoint in Arabidopsis thaliana pollen-stigma interactions. New Phytol (2016) 0.75
Time-Course Transcriptome Analysis of Compatible and Incompatible Pollen-Stigma Interactions in Brassica napus L. Front Plant Sci (2017) 0.75
Identification of a novel MLPK homologous gene MLPKn1 and its expression analysis in Brassica oleracea. Plant Reprod (2016) 0.75
Dynamic N-glycoproteome analysis of maize seedling leaves during de-etiolation using Concanavalin A lectin affinity chromatography and a nano-LC-MS/MS-based iTRAQ approach. Plant Cell Rep (2017) 0.75
All-atom empirical potential for molecular modeling and dynamics studies of proteins. J Phys Chem B (1998) 54.00
Urban residential environments and senior citizens' longevity in megacity areas: the importance of walkable green spaces. J Epidemiol Community Health (2002) 7.79
Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science (1997) 5.13
Action spectra for phytochrome A- and B-specific photoinduction of seed germination in Arabidopsis thaliana. Proc Natl Acad Sci U S A (1996) 4.48
Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature (1997) 3.66
A coordinated change in chemokine responsiveness guides plasma cell movements. J Exp Med (2001) 3.36
Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation. J Immunol (1987) 3.30
The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin. Nat Genet (2001) 3.01
The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response? Am J Gastroenterol (2010) 2.74
Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression. EMBO J (1998) 2.74
Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex. Neuron (1998) 2.73
Direct ligand-receptor complex interaction controls Brassica self-incompatibility. Nature (2001) 2.69
Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice. Neuron (1996) 2.62
The pollen determinant of self-incompatibility in Brassica campestris. Proc Natl Acad Sci U S A (2000) 2.50
The effect of tetraethylammonium chloride on potassium permeability in the smooth muscle cell membrane of canine trachea. J Physiol (1981) 2.45
Prefrontal and cingulate unit activity during timing behavior in the monkey. Brain Res (1979) 2.41
Ampulla cardiomyopathy ('Takotusbo' cardiomyopathy)--reversible left ventricular dysfunction: with ST segment elevation. Jpn Circ J (2000) 2.39
Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. J Cell Biol (2000) 2.36
Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazer. J Neurosci (1999) 2.27
Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A beta1-42(43) in Alzheimer's disease: a study in Japan. Ann Neurol (1998) 2.25
Flat neoplastic lesions of the colon and rectum detected by high-resolution video endoscopy and chromoscopy. Gastrointest Endosc (1995) 2.22
Mental-physical co-morbidity and its relationship with disability: results from the World Mental Health Surveys. Psychol Med (2008) 2.15
Delay activity of orbital and lateral prefrontal neurons of the monkey varying with different rewards. Cereb Cortex (2000) 2.15
Genomic organization of the S locus: Identification and characterization of genes in SLG/SRK region of S(9) haplotype of Brassica campestris (syn. rapa). Genetics (1999) 2.12
Laparoscopic observations of congenital anomalies of the liver. Gastrointest Endosc (1998) 2.10
Statistical analysis of the 5' untranslated region of human mRNA using "Oligo-Capped" cDNA libraries. Genomics (2000) 2.09
An autopsy case of troglitazone-induced fulminant hepatitis. Diabetes Care (1998) 2.08
Purified poloxamer 188 for treatment of acute vaso-occlusive crisis of sickle cell disease: A randomized controlled trial. JAMA (2001) 2.06
Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats. J Neurosci Res (2002) 2.06
Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut (2008) 2.05
Phylogenetic relationships between toxic and non-toxic strains of the genus Microcystis based on 16S to 23S internal transcribed spacer sequence. FEMS Microbiol Lett (1999) 2.04
"Exon-shuffling" maps control of antibody- and T-cell-recognition sites to the NH2-terminal domain of the class II major histocompatibility polypeptide A beta. Proc Natl Acad Sci U S A (1985) 1.93
Isolation and structure of bacterial sex pheromone, cPD1. Science (1984) 1.92
Ataxia with oculomotor apraxia type 2: clinical, biological and genotype/phenotype correlation study of a cohort of 90 patients. Brain (2009) 1.91
Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur J Neurosci (1998) 1.90
Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. Immunity (1997) 1.89
Needs-based planning: the case of Manitoba. CMAJ (1997) 1.87
Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes. Proc Natl Acad Sci U S A (1999) 1.85
Apo E structure determines VLDL clearance and atherosclerosis risk in mice. J Clin Invest (1999) 1.85
Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators. Science (1999) 1.85
Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord. J Neurosci (1997) 1.84
The prgQ gene of the Enterococcus faecalis tetracycline resistance plasmid pCF10 encodes a peptide inhibitor, iCF10. J Bacteriol (1994) 1.81
Stereochemistry of chitin hydrolysis by a plant chitinase/lysozyme and X-ray structure of a complex with allosamidin: evidence for substrate assisted catalysis. Biochemistry (1995) 1.80
Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. Mol Cell (2000) 1.78
Two-step regulation of left-right asymmetric expression of Pitx2: initiation by nodal signaling and maintenance by Nkx2. Mol Cell (2001) 1.77
Photoisomerization of retinal at 13-ene is important for phototaxis of Chlamydomonas reinhardtii: simultaneous measurements of phototactic and photophobic responses. Biochem Biophys Res Commun (1991) 1.77
Per anum intersphincteric rectal dissection with direct coloanal anastomosis for lower rectal cancer: the ultimate sphincter-preserving operation. Dis Colon Rectum (1997) 1.76
Intensive expansion of natural killer T cells in the early phase of hepatocyte regeneration after partial hepatectomy in mice and its association with sympathetic nerve activation. Hepatology (2000) 1.76
Schwannoma of the esophagus: a case exhibiting high 18F-fluorodeoxyglucose uptake in positron emission tomography imaging. Dis Esophagus (2009) 1.75
Ultrahigh-speed optical coherence tomography imaging and visualization of the embryonic avian heart using a buffered Fourier Domain Mode Locked laser. Opt Express (2007) 1.75
Striking sequence similarity in inter- and intra-specific comparisons of class I SLG alleles from Brassica oleracea and Brassica campestris: implications for the evolution and recognition mechanism. Proc Natl Acad Sci U S A (1997) 1.75
Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis. J Cell Biol (1988) 1.75
Isolation and structure of the bacterial sex pheromone, cAD1, that induces plasmid transfer in Streptococcus faecalis. FEBS Lett (1984) 1.73
Predictive factors for metachronous recurrence of early gastric cancer after endoscopic treatment. J Clin Gastroenterol (1999) 1.73
Expression and localization of Drosophila melanogaster hsp70 cognate proteins. Mol Cell Biol (1986) 1.72
Effects of cyclopiazonic acid, a novel Ca(2+)-ATPase inhibitor, on contractile responses in skinned ileal smooth muscle. Br J Pharmacol (1992) 1.71
Irinotecan (CPT-11) and characteristic mucosal changes in the mouse ileum and cecum. J Natl Cancer Inst (1995) 1.71
4D embryonic cardiography using gated optical coherence tomography. Opt Express (2006) 1.71
Structure of cCF10, a peptide sex pheromone which induces conjugative transfer of the Streptococcus faecalis tetracycline resistance plasmid, pCF10. J Biol Chem (1988) 1.70
Peptidal Sex Hormones Inducing Conjugation Tube Formation in Compatible Mating-Type Cells of Tremella mesenterica. Science (1981) 1.70
Molecular cloning and characterization of complementary DNA encoding for ferredoxin-dependent glutamate synthase in maize leaf. J Biol Chem (1991) 1.69
Restoration of prehension with the double free muscle technique following complete avulsion of the brachial plexus. Indications and long-term results. J Bone Joint Surg Am (2000) 1.68
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67
A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation. EMBO J (2000) 1.67
Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J Biol Chem (1995) 1.66
Glial cells express N-CAM/D2-CAM-like polypeptides in vitro. Nature (1985) 1.66
Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency. Biochem J (2000) 1.63
CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression. Nucleic Acids Res (2001) 1.62
Purification and some properties of staphylococcal alpha-toxin. Jpn J Exp Med (1974) 1.62
Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Galphaq. Proc Natl Acad Sci U S A (1997) 1.62
Randomized controlled trial of laparoscopic versus open colectomy for advanced colorectal cancer. Surg Endosc (2003) 1.61
Optical pacing of the embryonic heart. Nat Photonics (2010) 1.61
Blockade of Ca-activated K conductance by apamin in rat sympathetic neurones. Br J Pharmacol (1986) 1.61
Functional expression of costimulatory molecule CD86 on epithelial cells in the inflamed colonic mucosa. Gastroenterology (1999) 1.61
Intraspinal cyst communicating with the intervertebral disc in the lumbar spine: discal cyst. Spine (Phila Pa 1976) (2001) 1.60
Structural components of Sendai virus. Serological and physicochemical characterization of hemagglutinin subunit associated with neuraminidase activity. Virology (1973) 1.60
Dissecting the protein kinase C/MAP kinase signalling pathway of Saccharomyces cerevisiae. Cell Mol Biol Res (1994) 1.59
A call for action from the National Forum on Health. CMAJ (1997) 1.59
Gadolinium-enhanced three-dimensional magnetization-prepared rapid gradient-echo (3D MP-RAGE) imaging is superior to spin-echo imaging in delineating brain metastases. Acta Radiol (2008) 1.58
Junction of the cystic duct with the left hepatic duct: report of a case discovered during laparoscopic cholecystectomy. Surg Laparosc Endosc (1996) 1.58
Temporal and spatial variations in structural protein expression during the progression from stunned to hibernating myocardium. Circulation (2004) 1.56
Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56
Mutational spectrum of the CHAC gene in patients with chorea-acanthocytosis. Eur J Hum Genet (2002) 1.56
Ca2+ images and K+ current during depolarization in smooth muscle cells of the guinea-pig vas deferens and urinary bladder. J Physiol (1998) 1.54
Effectiveness of interferon-alpha therapy in chronic hepatitis C is associated with the amount of interferon-alpha receptor mRNA in the liver. J Hepatol (1997) 1.54
RNA transcripts for I-J polypeptides are apparently not encoded between the I-A and I-E subregions of the murine major histocompatibility complex. Proc Natl Acad Sci U S A (1983) 1.54
An assessment of local curability of endoscopic surgery in early gastric cancer without satisfaction of current therapeutic indications. Endoscopy (1998) 1.53
Modeling, synthesis and biological activity of novel antifungal agents (1). Bioorg Med Chem Lett (1998) 1.52
Malignant transformation of pleomorphic xanthoastrocytoma. Acta Neurochir (Wien) (2005) 1.52
Associations of various gene polymorphisms with toxicity in colorectal cancer patients receiving oral uracil and tegafur plus leucovorin: a prospective study. Ann Oncol (2010) 1.52
Expression of the vesicular glutamate transporters-1 and -2 in adult mouse dorsal root ganglia and spinal cord and their regulation by nerve injury. Neuroscience (2007) 1.51
CSF hypocretin levels in Guillain-Barré syndrome and other inflammatory neuropathies. Neurology (2003) 1.50
Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif. Oncogene (1997) 1.50
Constructing a local district telepathology network in Japan. Diagnosis of intraoperative frozen sections via telepathology over an integrated service digital network and the National Television Standard Committee System. Anal Quant Cytol Histol (1999) 1.50