Published in Proc Natl Acad Sci U S A on September 25, 2001
PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci U S A (2003) 4.46
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med (2006) 3.78
The role of RNAi and microRNAs in animal virus replication and antiviral immunity. Genes Dev (2009) 3.30
PUMA, a potent killer with or without p53. Oncogene (2008) 3.09
p53 and E2f: partners in life and death. Nat Rev Cancer (2009) 3.06
Hypoxia and defective apoptosis drive genomic instability and tumorigenesis. Genes Dev (2004) 2.69
PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell Stem Cell (2008) 2.68
An Epstein-Barr virus-encoded microRNA targets PUMA to promote host cell survival. J Exp Med (2008) 2.68
BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Blood (2005) 2.54
In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Mol Cell Biol (2004) 2.50
Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. J Cell Biol (2003) 2.42
BH3-only proteins in apoptosis and beyond: an overview. Oncogene (2008) 2.13
PUMA is critical for neonatal cardiomyocyte apoptosis induced by endoplasmic reticulum stress. Cardiovasc Res (2006) 2.08
Chlamydia inhibit host cell apoptosis by degradation of proapoptotic BH3-only proteins. J Exp Med (2004) 1.89
JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis. J Biol Chem (2009) 1.82
In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute. Cell Death Differ (2008) 1.81
Dichloroacetate induces apoptosis in endometrial cancer cells. Gynecol Oncol (2008) 1.79
Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis. Cell Death Differ (2009) 1.75
The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage. Proc Natl Acad Sci U S A (2007) 1.73
Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis. Mol Cell Biol (2008) 1.72
Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice. Proc Natl Acad Sci U S A (2007) 1.58
The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia. Leukemia (2007) 1.56
p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion. Gut (2006) 1.56
Lysosomal destabilization in p53-induced apoptosis. Proc Natl Acad Sci U S A (2002) 1.54
Glucocorticoids in T cell apoptosis and function. Cell Mol Life Sci (2006) 1.48
Sp1 and p73 activate PUMA following serum starvation. Carcinogenesis (2008) 1.46
Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis. Oncogene (2009) 1.43
Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies. Nat Rev Cancer (2016) 1.42
Role of virus-encoded microRNAs in herpesvirus biology. Trends Microbiol (2009) 1.41
Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a. Proc Natl Acad Sci U S A (2006) 1.37
The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis: identification of the nuclear pore complex as a potential target of the JNK pathway. J Cell Biol (2005) 1.32
Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite. Mol Cell Biol (2005) 1.25
Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation. Blood (2010) 1.24
The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells. Proc Natl Acad Sci U S A (2006) 1.23
The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment. Genes Cancer (2011) 1.23
Morpholino artifacts provide pitfalls and reveal a novel role for pro-apoptotic genes in hindbrain boundary development. Dev Biol (2010) 1.22
p53 suppresses Src-induced podosome and rosette formation and cellular invasiveness through the upregulation of caldesmon. Mol Cell Biol (2009) 1.19
Pharmacological manipulation of Bcl-2 family members to control cell death. J Clin Invest (2005) 1.19
BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection. Proc Natl Acad Sci U S A (2008) 1.18
The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells. Blood (2007) 1.18
PUMA promotes Bax translocation by both directly interacting with Bax and by competitive binding to Bcl-X L during UV-induced apoptosis. Mol Biol Cell (2009) 1.16
Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3. Chem Biol (2013) 1.15
PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01. Mol Cancer Ther (2010) 1.13
In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury. J Cereb Blood Flow Metab (2011) 1.11
Phosphorylation of Puma modulates its apoptotic function by regulating protein stability. Cell Death Dis (2010) 1.10
The p53 tumor suppressor protein regulates hematopoietic stem cell fate. J Cell Physiol (2011) 1.08
The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in β-amyloid-induced neuron death. J Biol Chem (2014) 1.06
Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia. Glia (2013) 1.04
Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma. FASEB J (2009) 1.03
BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina. Mol Neurodegener (2011) 1.02
Coupling endoplasmic reticulum stress to the cell-death program: a novel HSP90-independent role for the small chaperone protein p23. Cell Death Differ (2006) 1.02
Epstein-Barr virus in Burkitt's lymphoma: a role for latent membrane protein 2A. Cell Cycle (2010) 1.02
Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites. Nucleic Acids Res (2008) 1.01
Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils. Expert Opin Ther Targets (2012) 1.01
Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia. Stroke (2008) 1.01
DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis. J Zhejiang Univ Sci B (2007) 0.99
DNA repair and cell cycle biomarkers of radiation exposure and inflammation stress in human blood. PLoS One (2012) 0.97
Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation. Blood (2009) 0.96
E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation. BMC Cancer (2007) 0.95
Therapeutic efficacy of PUMA for malignant glioma cells regardless of p53 status. Hum Gene Ther (2005) 0.95
Characterisation of p53 status at the gene, chromosomal and protein levels in oesophageal adenocarcinoma. Br J Cancer (2003) 0.94
Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death. Cell Death Differ (2011) 0.93
Host-Cell Survival and Death During Chlamydia Infection. Curr Immunol Rev (2007) 0.93
Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity. Proc Natl Acad Sci U S A (2012) 0.93
p53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors. Blood (2007) 0.93
Slug suppression induces apoptosis via Puma transactivation in rheumatoid arthritis fibroblast-like synoviocytes treated with hydrogen peroxide. Exp Mol Med (2010) 0.92
Cell metabolism: an essential link between cell growth and apoptosis. Biochim Biophys Acta (2010) 0.92
Microglia-derived TNFα induces apoptosis in neural precursor cells via transcriptional activation of the Bcl-2 family member Puma. Cell Death Dis (2013) 0.91
Regulation of bim in glucocorticoid-mediated osteoblast apoptosis. J Cell Physiol (2008) 0.91
Programmed cell death during neuronal development: the sympathetic neuron model. Cell Death Differ (2014) 0.90
Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies? Cell Death Dis (2014) 0.89
The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by Bcl-x(L) and Mcl-1. Mol Med (2011) 0.88
The p53-target gene puma drives neutrophil-mediated protection against lethal bacterial sepsis. PLoS Pathog (2010) 0.87
p16INK4A sensitizes human leukemia cells to FAS- and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2. J Biol Chem (2009) 0.87
Intestinal stem cells and their roles during mucosal injury and repair. J Surg Res (2010) 0.86
Gene bi-targeting by viral and human miRNAs. BMC Bioinformatics (2010) 0.85
Overexpression of peroxisomal testis-specific 1 protein induces germ cell apoptosis and leads to infertility in male mice. Mol Biol Cell (2011) 0.85
Slug promotes survival during metastasis through suppression of Puma-mediated apoptosis. Cancer Res (2014) 0.85
PUMA Cooperates with p21 to Regulate Mammary Epithelial Morphogenesis and Epithelial-To-Mesenchymal Transition. PLoS One (2013) 0.84
BH3-only proteins and their effects on cancer. Adv Exp Med Biol (2010) 0.83
PUMA mediates the combinational therapy of 5-FU and NVP-BEZ235 in colon cancer. Oncotarget (2015) 0.83
Ex vivo induction of mRNA in human whole blood as a new platform of drug and dietary supplement development. Pharm Res (2008) 0.83
BH3-based fusion artificial peptide induces apoptosis and targets human colon cancer. Mol Ther (2009) 0.82
p53-Dependent transcriptional responses to interleukin-3 signaling. PLoS One (2012) 0.81
Molecular mechanisms of hexavalent chromium-induced apoptosis in human bronchoalveolar cells. Am J Respir Cell Mol Biol (2005) 0.81
BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus. Cell Death Dis (2010) 0.81
Enhanced Expression of Radiation-induced Leukocyte CDKN1A mRNA in Multiple Primary Breast Cancer Patients: Potential New Marker of Cancer Susceptibility. Biomark Insights (2009) 0.80
β-Arrestin2 encourages inflammation-induced epithelial apoptosis through ER stress/PUMA in colitis. Mucosal Immunol (2014) 0.80
Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons. J Neurochem (2010) 0.80
Vitamin D/VDR signaling pathway ameliorates 2,4,6-trinitrobenzene sulfonic acid-induced colitis by inhibiting intestinal epithelial apoptosis. Int J Mol Med (2015) 0.80
PUMA mediates ER stress-induced apoptosis in portal hypertensive gastropathy. Cell Death Dis (2014) 0.79
Therapeutic targeting of HES1 transcriptional programs in T-ALL. Blood (2015) 0.79
Sp1 is involved in H2O2-induced PUMA gene expression and apoptosis in colorectal cancer cells. J Exp Clin Cancer Res (2008) 0.78
Lipopolysaccharide (LPS) potentiates hydrogen peroxide toxicity in T98G astrocytoma cells by suppression of anti-oxidative and growth factor gene expression. BMC Genomics (2008) 0.78
Retinal transcriptome profiling at transcription start sites: a cap analysis of gene expression early after axonal injury. BMC Genomics (2014) 0.78
Regulation of Apoptosis by HER2 in Breast Cancer. J Carcinog Mutagen (2013) 0.78
Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt's lymphoma B cells. Oncotarget (2015) 0.77
Occupational health assessment of chromite toxicity among Indian miners. Indian J Occup Environ Med (2011) 0.77
Functional Cross-Talking between Differentially Expressed and Alternatively Spliced Genes in Human Liver Cancer Cells Treated with Berberine. PLoS One (2015) 0.77
HER2 phosphorylates and destabilizes pro-apoptotic PUMA, leading to antagonized apoptosis in cancer cells. PLoS One (2013) 0.77
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