PubRank

D A Matthews

Author PubWeight™ 102.43‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase. Science 1991 5.42
2 Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate. J Biol Chem 1982 3.84
3 Dihydrofolate reductase: x-ray structure of the binary complex with methotrexate. Science 1977 2.88
4 The mental health of patients with a chief complaint of chronic fatigue. A prospective evaluation and follow-up. Arch Intern Med 1988 2.85
5 Crystal structure of avian dihydrofolate reductase containing phenyltriazine and NADPH. J Biol Chem 1982 2.45
6 Depression and somatization in the chronic fatigue syndrome. Am J Med 1991 2.33
7 The frequency of the chronic fatigue syndrome in patients with symptoms of persistent fatigue. Ann Intern Med 1988 2.11
8 Dihydrofolate reductase from Lactobacillus casei. X-ray structure of the enzyme methotrexate.NADPH complex. J Biol Chem 1978 1.94
9 Synaptic plasma membranes from rat brain synaptosomes: isolation and partial characterization. Biochim Biophys Acta 1971 1.84
10 X-ray crystallographic study of boronic acid adducts with subtilisin BPN' (Novo). A model for the catalytic transition state. J Biol Chem 1975 1.82
11 Identification of variable domains of the attachment (G) protein of subgroup A respiratory syncytial viruses. J Gen Virol 1991 1.79
12 Analysis of respiratory syncytial virus strain variation in successive epidemics in one city. J Clin Microbiol 1994 1.72
13 What makes the patient-doctor relationship therapeutic? Exploring the connexional dimension of medical care. Ann Intern Med 1988 1.64
14 Crystal structure of rat liver dihydropteridine reductase. Proc Natl Acad Sci U S A 1992 1.63
15 In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother 1999 1.63
16 The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation. EMBO J 1999 1.63
17 Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim. J Biol Chem 1985 1.62
18 Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. II. Environment of bound NADPH and implications for catalysis. J Biol Chem 1982 1.61
19 Alpha-delta sleep in patients with a chief complaint of chronic fatigue. South Med J 1994 1.55
20 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements. J Med Chem 1999 1.55
21 Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase. Nat Struct Biol 1994 1.47
22 The low yield of physical examinations and laboratory investigations of patients with chronic fatigue. Am J Med Sci 1990 1.47
23 Structure of the human cytomegalovirus protease catalytic domain reveals a novel serine protease fold and catalytic triad. Cell 1996 1.37
24 An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. I. Magnitude and time course of degeneration. Brain Res 1976 1.36
25 Analysis of relatedness of subgroup A respiratory syncytial viruses isolated worldwide. Virus Res 1992 1.30
26 Crystal structure of a novel trimethoprim-resistant dihydrofolate reductase specified in Escherichia coli by R-plasmid R67. Biochemistry 1986 1.29
27 Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor. Antimicrob Agents Chemother 2005 1.25
28 Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements. J Med Chem 1998 1.24
29 Electrostatic channeling in the bifunctional enzyme dihydrofolate reductase-thymidylate synthase. J Mol Biol 1996 1.23
30 Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones. J Med Chem 1993 1.20
31 Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease. J Med Chem 1996 1.19
32 Dihydrofolate reductase. The stereochemistry of inhibitor selectivity. J Biol Chem 1985 1.17
33 Re-examination of the charge relay system in subtilisin comparison with other serine proteases. J Biol Chem 1977 1.14
34 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies. J Med Chem 1998 1.14
35 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 2. Peptide structure-activity studies. J Med Chem 1998 1.12
36 A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site. Nat Struct Biol 1995 1.12
37 Identification of mutations contributing to the reduced virulence of a modified strain of respiratory syncytial virus. Vaccine 1996 1.11
38 An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. II. Reappearance of morphologically normal synaptic contacts. Brain Res 1976 1.09
39 Escherichia coli thymidylate synthase: amino acid substitutions by suppression of amber nonsense mutations. Proc Natl Acad Sci U S A 1990 1.08
40 Proteolytic release and crystallization of the RNase H domain of human immunodeficiency virus type 1 reverse transcriptase. J Biol Chem 1991 1.04
41 Induced acetylcholinesterase-rich layer in rat dentate gyrus following entorhinal lesions. Brain Res 1972 1.04
42 Structural and mechanistic characteristics of dihydropteridine reductase: a member of the Tyr-(Xaa)3-Lys-containing family of reductases and dehydrogenases. Proc Natl Acad Sci U S A 1994 1.04
43 Mitochondrial protein p32 can accumulate in the nucleus. Biochem Biophys Res Commun 2001 1.03
44 Interaction between herpes simplex virus type 1 IE63 protein and cellular protein p32. J Virol 2000 1.02
45 Chronic fatigue and chronic fatigue syndrome: clinical epidemiology and aetiological classification. Ciba Found Symp 1993 1.00
46 Depression among patients with a chief complaint of chronic fatigue. J Affect Disord 1989 0.99
47 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J Med Chem 1999 0.98
48 An immunocytochemical study of choline acetyltransferase-containing neurons and axon terminals in normal and partially deafferented hippocampal formation. Brain Res 1987 0.95
49 In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother 2007 0.94
50 Development of cholinergic innervation in the hippocampal formation of the rat. I. Histochemical demonstration of acetylcholinesterase activity. Dev Biol 1974 0.92
51 Dihydrofolate reductase from Lactobacillus casei. Stereochemistry of NADPH binding. J Biol Chem 1979 0.89
52 The nucleotide sequences of intergenic regions between nine genes of pneumonia virus of mice establish the physical order of these genes in the viral genome. Virus Res 1991 0.89
53 Frequent polymerase errors observed in a restricted area of clones derived from the attachment (G) protein gene of respiratory syncytial virus. J Virol 1993 0.87
54 Precursor of human adenovirus core polypeptide Mu targets the nucleolus and modulates the expression of E2 proteins. J Gen Virol 2004 0.87
55 Synaptic rearrangement in the dentate gyrus: histochemical evidence of adjustments after lesions in immature and adult rats. Proc Natl Acad Sci U S A 1973 0.87
56 Species-specific second antibodies reduce spurious staining in immunocytochemistry. J Histochem Cytochem 1984 0.86
57 Preliminary x-ray diffraction characterization of crystalline rat liver dihydropteridine reductase. J Biol Chem 1986 0.86
58 Development of cholinergic innervation in the hippocampal formation of the rat. II. Quantitative changes in choline acetyltransferase and acetylcholinesterase activities. Dev Biol 1974 0.84
59 Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett 2000 0.84
60 Chronic fatigue syndromes in clinical practice. Psychother Psychosom 1992 0.84
61 Religious commitment and health status. Arch Fam Med 1999 0.83
62 Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement. J Biol Chem 1992 0.83
63 Interpretation of nuclear magnetic resonance spectra for Lactobacillus casei dihydrofolate reductase based on the X-ray structure of the enzyme-methotrexate-NADPH complex. Biochemistry 1979 0.82
64 Somatization disorder in patients with chronic fatigue. Psychosomatics 1989 0.82
65 Serologic specificities of brain subcellular organelles. I. Antisera to synaptosomal fractions. J Immunol 1972 0.81
66 Panic disorder among patients with chronic fatigue. South Med J 1991 0.81
67 Dr. Marjory Warren and the origin of British geriatrics. J Am Geriatr Soc 1984 0.80
68 Effect of patient gender on evaluation of intern performance. Arch Intern Med 1989 0.80
69 Enhanced cationic liposome-mediated transfection using the DNA-binding peptide mu (mu) from the adenovirus core. Gene Ther 2001 0.80
70 Yeast connection among 100 patients with chronic fatigue. Am J Med 1989 0.79
71 Proton magnetic resonance studies on Escherichia coli dihydrofolate reductase. Assignment of histidine C-2 protons in binary complexes with folates on the basis of the crystal structure with methotrexate and on chemical modifications. J Biol Chem 1979 0.79
72 Screening for somatization disorder in patients with chronic fatigue. Gen Hosp Psychiatry 1989 0.79
73 Genomic mapping and evolution of human GABA(A) receptor subunit gene clusters. Mamm Genome 1999 0.79
74 Substance use disorders in patients with chronic fatigue. Hosp Community Psychiatry 1991 0.77
75 Genetically-associated variations in the development of hippocampal pyramidal neurons may produce differences in mossy fiber connectivity. J Comp Neurol 1977 0.77
76 Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis. J Med Chem 1992 0.77
77 Isolation of rat brain subcellular fraction enriched in putative neurotransmitter receptors and synaptic junctions. Neurochem Res 1980 0.77
78 Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase. J Med Chem 1997 0.77
79 Depression and chronic fatigue. Indications for psychiatric consultation. Prim Care 1991 0.77
80 Food intolerance in patients with chronic fatigue. Int J Eat Disord 1993 0.76
81 Substituted benzamide inhibitors of human rhinovirus 3C protease: structure-based design, synthesis, and biological evaluation. J Med Chem 2000 0.76
82 Standards, guidelines and so on ... Health Libr Rev 1990 0.75
83 Medical subspecialty training and interest in cost containment education. J Gen Intern Med 1987 0.75
84 Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase. J Med Chem 1996 0.75
85 The pathophysiology of chronic fatigue syndrome: confirmations, contradictions, and conjectures. Int J Psychiatry Med 1992 0.75
86 Standards, guidelines and so on .... Health Libr Rev 1990 0.75
87 Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett 2001 0.75
88 The house officer's changing world. N Engl J Med 1987 0.75
89 Nuclear perturbations following adenovirus infection. Curr Top Microbiol Immunol 2003 0.75
90 Crystal structure of a monoclinic form of dihydropteridine reductase from rat liver. Acta Crystallogr D Biol Crystallogr 1994 0.75
91 An appraisal of goals for residency training in internal medicine. J Med Educ 1985 0.75
92 How much practice makes perfect? A quantitative measure of the experience needed to achieve procedural competence. Med Teach 1990 0.75
93 Nitrate and bisulfide: monitoring and patterns in Onondaga Lake, New York, following implementation of nitrification treatment. Water Environ Res 2009 0.75
94 Quantitative relationships of five putative neurotransmitter receptor sites in rat hippocampal formation. J Neurochem 1980 0.75
95 Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids. Bioorg Med Chem Lett 1999 0.75
96 Definition of the chronic fatigue syndrome. Ann Intern Med 1988 0.75
97 Two crystal structures of rat liver dihydropteridine reductase. Adv Exp Med Biol 1993 0.75
98 A quantitative measure of consumer preferences in health care delivery. Med Care 1986 0.75