Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNA.

PubWeight™: 2.83‹?› | Rank: Top 1%

🔗 View Article (PMC 109223)

Published in Mol Cell Biol on November 01, 1998

Authors

K Hellmuth1, D M Lau, F R Bischoff, M Künzler, E Hurt, G Simos

Author Affiliations

1: Biochemie-Zentrum Heidelberg, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany.

Articles citing this

(truncated to the top 100)

Transport into and out of the nucleus. Microbiol Mol Biol Rev (2001) 6.36

The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J (1999) 4.49

tRNA biology charges to the front. Genes Dev (2010) 4.07

Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export. EMBO J (2000) 3.76

Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Mol Cell Biol (2002) 3.18

The nuclear pore complex and nuclear transport. Cold Spring Harb Perspect Biol (2010) 2.71

The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. Cell (2011) 2.65

Nuclear export of the small ribosomal subunit requires the ran-GTPase cycle and certain nucleoporins. Genes Dev (1999) 2.56

Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA. EMBO J (2002) 2.56

Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export. J Cell Biol (2000) 2.48

The role of exportin-t in selective nuclear export of mature tRNAs. EMBO J (1998) 2.40

An aminoacylation-dependent nuclear tRNA export pathway in yeast. Genes Dev (2000) 2.38

A novel in vivo assay reveals inhibition of ribosomal nuclear export in ran-cycle and nucleoporin mutants. J Cell Biol (1999) 2.37

Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA export. Mol Cell (2009) 2.25

A novel complex of membrane proteins required for formation of a spherical nucleus. EMBO J (1998) 2.19

CRM1-mediated recycling of snurportin 1 to the cytoplasm. J Cell Biol (1999) 2.08

Nuclear tRNA aminoacylation and its role in nuclear export of endogenous tRNAs in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1999) 2.05

Importin-beta-like nuclear transport receptors. Genome Biol (2001) 2.03

Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase. Mol Cell Biol (1999) 1.83

Possibility of cytoplasmic pre-tRNA splicing: the yeast tRNA splicing endonuclease mainly localizes on the mitochondria. Mol Biol Cell (2003) 1.80

The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins. J Cell Biol (2001) 1.78

Coordination of tRNA nuclear export with processing of tRNA. RNA (1999) 1.74

The nucleoporin nup153 plays a critical role in multiple types of nuclear export. Mol Biol Cell (1999) 1.71

A nuclear AAA-type ATPase (Rix7p) is required for biogenesis and nuclear export of 60S ribosomal subunits. EMBO J (2001) 1.69

Arginine methyltransferase affects interactions and recruitment of mRNA processing and export factors. Genes Dev (2004) 1.66

The budding yeast nuclear envelope adjacent to the nucleolus serves as a membrane sink during mitotic delay. Curr Biol (2012) 1.65

Nuclear import of the TATA-binding protein: mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting. J Cell Biol (1999) 1.55

Yeast nuclear envelope subdomains with distinct abilities to resist membrane expansion. Mol Biol Cell (2006) 1.48

Role of nuclear pools of aminoacyl-tRNA synthetases in tRNA nuclear export. Mol Biol Cell (2001) 1.43

An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1. EMBO J (2010) 1.42

Ran-dependent nuclear export mediators: a structural perspective. EMBO J (2011) 1.42

Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export. J Cell Biol (2001) 1.41

Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha. Mol Cell Biol (2000) 1.34

A Los1p-independent pathway for nuclear export of intronless tRNAs in Saccharomycescerevisiae. Proc Natl Acad Sci U S A (2002) 1.34

The nucleoporin Nup60p functions as a Gsp1p-GTP-sensitive tether for Nup2p at the nuclear pore complex. J Cell Biol (2001) 1.32

Exportin-5 orthologues are functionally divergent among species. Nucleic Acids Res (2006) 1.29

Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Mol Cell Biol (2000) 1.29

Regulation of tRNA bidirectional nuclear-cytoplasmic trafficking in Saccharomyces cerevisiae. Mol Biol Cell (2009) 1.28

Nucleo-cytoplasmic partitioning of proteins in plants: implications for the regulation of environmental and developmental signalling. Curr Genet (2003) 1.28

Functional analyses of interacting factors involved in both pre-mRNA splicing and cell cycle progression in Saccharomyces cerevisiae. RNA (2000) 1.25

Structures of the tRNA export factor in the nuclear and cytosolic states. Nature (2009) 1.23

Curing of the [URE3] prion by Btn2p, a Batten disease-related protein. EMBO J (2008) 1.22

Transfer RNA post-transcriptional processing, turnover, and subcellular dynamics in the yeast Saccharomyces cerevisiae. Genetics (2013) 1.20

RNA length defines RNA export pathway. Genes Dev (2004) 1.18

Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1. Mol Cell Biol (2000) 1.18

Cellular dynamics of tRNAs and their genes. FEBS Lett (2010) 1.17

Inorganic phosphate deprivation causes tRNA nuclear accumulation via retrograde transport in Saccharomyces cerevisiae. Genetics (2007) 1.12

The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast Ran binding protein 1 (Yrb1p). Mol Biol Cell (2001) 1.12

Cex1p is a novel cytoplasmic component of the Saccharomyces cerevisiae nuclear tRNA export machinery. EMBO J (2007) 1.10

Nucleus-specific and cell cycle-regulated degradation of mitogen-activated protein kinase scaffold protein Ste5 contributes to the control of signaling competence. Mol Cell Biol (2008) 1.10

Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p. EMBO Rep (2003) 1.09

The intracellular location of two aminoacyl-tRNA synthetases depends on complex formation with Arc1p. EMBO J (2001) 1.07

Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway. Mol Cell Biol (2000) 1.06

Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism. Genetics (2004) 1.04

The nuclear tRNA aminoacylation-dependent pathway may be the principal route used to export tRNA from the nucleus in Saccharomyces cerevisiae. Biochem J (2004) 1.04

Vesicle trafficking maintains nuclear shape in Saccharomyces cerevisiae during membrane proliferation. J Cell Biol (2010) 1.04

RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro. Mol Cell Biol (2000) 1.03

Retrograde transfer RNA nuclear import provides a new level of tRNA quality control in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2013) 1.01

PAUSED, a putative exportin-t, acts pleiotropically in Arabidopsis development but is dispensable for viability. Plant Physiol (2003) 1.00

tRNAs: cellular barcodes for amino acids. FEBS Lett (2010) 0.99

Nucleo-cytoplasmic transport of proteins and RNA in plants. Plant Cell Rep (2010) 0.98

The yeast nucleoporin Nup53p specifically interacts with Nic96p and is directly involved in nuclear protein import. Mol Biol Cell (2000) 0.98

Transfer RNA travels from the cytoplasm to organelles. Wiley Interdiscip Rev RNA (2011) 0.98

Significantly higher activity of a cytoplasmic hammerhead ribozyme than a corresponding nuclear counterpart: engineered tRNAs with an extended 3' end can be exported efficiently and specifically to the cytoplasm in mammalian cells. Nucleic Acids Res (2001) 0.97

Cloning and characterization of the Schizosaccharomyces pombe tRNA:pseudouridine synthase Pus1p. Nucleic Acids Res (2000) 0.94

Utp9p facilitates Msn5p-mediated nuclear reexport of retrograded tRNAs in Saccharomyces cerevisiae. Mol Biol Cell (2009) 0.94

Minimum requirements for the function of eukaryotic translation initiation factor 2. Genetics (2001) 0.93

Scyl1 facilitates nuclear tRNA export in mammalian cells by acting at the nuclear pore complex. Mol Biol Cell (2010) 0.92

Maf1 protein, repressor of RNA polymerase III, indirectly affects tRNA processing. J Biol Chem (2011) 0.92

Protein arginine methylation in Candida albicans: role in nuclear transport. Eukaryot Cell (2007) 0.90

Rsp5 ubiquitin ligase modulates translation accuracy in yeast Saccharomyces cerevisiae. RNA (2005) 0.90

Have tRNA, will travel. Proc Natl Acad Sci U S A (2005) 0.89

The yeast hnRNP-like protein Hrp1/Nab4 sccumulates in the cytoplasm after hyperosmotic stress: a novel Fps1-dependent response. Mol Biol Cell (2003) 0.89

Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defects. Genetics (2001) 0.88

Coordination of tRNA transcription with export at nuclear pore complexes in budding yeast. Genes Dev (2014) 0.88

Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains. Mol Cell Biol (2002) 0.88

Nucleotides of the tRNA D-stem that play an important role in nuclear-tRNA export in Saccharomyces cerevisiae. Biochem J (2000) 0.87

A Crm1p-independent nuclear export path for the mRNA-associated protein, Npl3p/Mtr13p. Proc Natl Acad Sci U S A (1999) 0.87

Utp8p is a nucleolar tRNA-binding protein that forms a complex with components of the nuclear tRNA export machinery in Saccharomyces cerevisiae. Mol Biol Cell (2007) 0.87

Reconstitution of nuclear protein export in isolated nuclear envelopes. J Cell Biol (2002) 0.86

The ins and outs of nuclear re-export of retrogradely transported tRNAs in Saccharomyces cerevisiae. Nucleus (2010) 0.86

Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1p. Mol Biol Cell (2011) 0.86

Functional insights of nucleocytoplasmic transport in plants. Front Plant Sci (2014) 0.85

Nutrient stress does not cause retrograde transport of cytoplasmic tRNA to the nucleus in evolutionarily diverse organisms. Mol Biol Cell (2011) 0.84

P-body components, Dhh1 and Pat1, are involved in tRNA nuclear-cytoplasmic dynamics. RNA (2011) 0.84

Kap120 functions as a nuclear import receptor for ribosome assembly factor Rpf1 in yeast. Mol Cell Biol (2006) 0.82

Quality Control Pathways for Nucleus-Encoded Eukaryotic tRNA Biosynthesis and Subcellular Trafficking. Mol Cell Biol (2015) 0.82

In vivo biochemical analyses reveal distinct roles of β-importins and eEF1A in tRNA subcellular traffic. Genes Dev (2015) 0.82

RNA Export through the NPC in Eukaryotes. Genes (Basel) (2015) 0.82

Separate responses of karyopherins to glucose and amino acid availability regulate nucleocytoplasmic transport. Mol Biol Cell (2014) 0.81

Protein kinase A is part of a mechanism that regulates nuclear reimport of the nuclear tRNA export receptors Los1p and Msn5p. Eukaryot Cell (2013) 0.80

Structural basis for the nuclear export activity of Importin13. EMBO J (2013) 0.80

Specific sequences within arginine-glycine-rich domains affect mRNA-binding protein function. Nucleic Acids Res (2009) 0.79

Cytosolic Hsp70 and co-chaperones constitute a novel system for tRNA import into the nucleus. Elife (2015) 0.79

Crystal structure of Cex1p reveals the mechanism of tRNA trafficking between nucleus and cytoplasm. Nucleic Acids Res (2013) 0.78

Role of Rsp5 ubiquitin ligase in biogenesis of rRNA, mRNA and tRNA in yeast. RNA Biol (2015) 0.77

Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation. PLoS One (2012) 0.77

Post-translational modification directs nuclear and hyphal tip localization of Candida albicans mRNA-binding protein Slr1. Mol Microbiol (2017) 0.76

Characterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni. Parasitol Res (2013) 0.76

Nucleocytoplasmic shuttling of tRNAs and implication of the cytosolic Hsp70 system in tRNA import. Nucleus (2015) 0.75

Articles cited by this

(truncated to the top 100)

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics (1989) 105.30

New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene (1988) 42.65

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell (1993) 33.20

High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier. Curr Genet (1989) 31.80

Getting started with yeast. Methods Enzymol (1991) 26.67

A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae. Nucleic Acids Res (1993) 21.52

pEMBL: a new family of single stranded plasmids. Nucleic Acids Res (1983) 19.19

CRM1 is an export receptor for leucine-rich nuclear export signals. Cell (1997) 18.60

A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site. Proc Natl Acad Sci U S A (1982) 11.42

CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature (1997) 10.49

Exportin 1 (Crm1p) is an essential nuclear export factor. Cell (1997) 10.32

The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell (1995) 9.98

Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. Nat Genet (1997) 9.60

Nucleocytoplasmic transport. Science (1996) 8.76

Nucleocytoplasmic transport: signals, mechanisms and regulation. Nature (1997) 7.47

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell (1995) 6.97

Evidence for a role of CRM1 in signal-mediated nuclear protein export. Science (1997) 6.60

Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor. Cell (1997) 6.28

A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. Cell (1995) 6.19

A novel receptor-mediated nuclear protein import pathway. Cell (1996) 6.04

Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA. Genes Dev (1992) 5.84

Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. EMBO J (1997) 5.61

Identification of different roles for RanGDP and RanGTP in nuclear protein import. EMBO J (1996) 5.53

The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. EMBO J (1997) 5.08

Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Proc Natl Acad Sci U S A (1995) 5.04

Nuclear export of different classes of RNA is mediated by specific factors. J Cell Biol (1994) 4.99

A yeast nucleolar protein related to mammalian fibrillarin is associated with small nucleolar RNA and is essential for viability. EMBO J (1989) 4.91

The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88. EMBO J (1997) 4.65

RanGAP1 induces GTPase activity of nuclear Ras-related Ran. Proc Natl Acad Sci U S A (1994) 4.58

The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex. Cell (1995) 4.55

A family of versatile centromeric vectors designed for use in the sectoring-shuffle mutagenesis assay in Saccharomyces cerevisiae. Gene (1988) 4.50

A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores. Cell (1996) 4.37

A novel class of RanGTP binding proteins. J Cell Biol (1997) 4.36

The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export. Curr Biol (1997) 4.35

Proofreading and aminoacylation of tRNAs before export from the nucleus. Science (1998) 4.08

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex. EMBO J (1997) 4.06

Identification of a tRNA-specific nuclear export receptor. Mol Cell (1998) 3.94

A cap-binding protein complex mediating U snRNA export. Nature (1995) 3.89

A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export. Genes Dev (1996) 3.78

Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science (1996) 3.70

A distinct nuclear import pathway used by ribosomal proteins. Cell (1997) 3.66

A new subclass of nucleoporins that functionally interact with nuclear pore protein NSP1. EMBO J (1992) 3.57

Identification of a nuclear export receptor for tRNA. Curr Biol (1998) 3.49

Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. J Cell Biol (1997) 3.36

An RNA-export mediator with an essential nuclear export signal. Nature (1996) 3.33

tRNA transport from the nucleus in a eukaryotic cell: carrier-mediated translocation process. Proc Natl Acad Sci U S A (1983) 3.31

Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1. EMBO J (1995) 3.27

A conditional allele of the novel repeat-containing yeast nucleoporin RAT7/NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes. J Cell Biol (1995) 3.19

Purification of NSP1 reveals complex formation with 'GLFG' nucleoporins and a novel nuclear pore protein NIC96. EMBO J (1993) 3.04

Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export. EMBO J (1998) 3.02

Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily. EMBO J (1993) 3.00

Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. Proc Natl Acad Sci U S A (1995) 3.00

Nuclear pore proteins are involved in the biogenesis of functional tRNA. EMBO J (1996) 2.90

Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export. EMBO J (1998) 2.90

Nuclear export receptors: from importin to exportin. Cell (1997) 2.82

Nuclear export signals and the fast track to the cytoplasm. Cell (1995) 2.77

From nucleoporins to nuclear pore complexes. Curr Opin Cell Biol (1997) 2.75

A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. J Cell Biol (1997) 2.74

Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export. Science (1997) 2.74

Inhibition of Ran guanosine triphosphatase-dependent nuclear transport by the matrix protein of vesicular stomatitis virus. Science (1997) 2.72

Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p. EMBO J (1998) 2.71

A yeast RNA-binding protein shuttles between the nucleus and the cytoplasm. Mol Cell Biol (1994) 2.66

Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta. J Cell Sci (1997) 2.60

Nucleocytoplasmic transport of macromolecules. Microbiol Mol Biol Rev (1997) 2.51

The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm. Proc Natl Acad Sci U S A (1995) 2.48

A novel nucleoskeletal-like protein located at the nuclear periphery is required for the life cycle of Saccharomyces cerevisiae. EMBO J (1988) 2.42

tRNA nuclear transport: defining the critical regions of human tRNAimet by point mutagenesis. Cell (1985) 2.41

RanBP1 is crucial for the release of RanGTP from importin beta-related nuclear transport factors. FEBS Lett (1997) 2.41

Processing of intervening sequences: a new yeast mutant which fails to excise intervening sequences from precursor tRNAs. Cell (1980) 2.37

Functional interaction of Nic96p with a core nucleoporin complex consisting of Nsp1p, Nup49p and a novel protein Nup57p. EMBO J (1995) 2.35

GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization. Mol Cell Biol (1993) 2.30

The GLFG repetitive region of the nucleoporin Nup116p interacts with Kap95p, an essential yeast nuclear import factor. J Cell Biol (1995) 2.27

A conditional yeast mutant deficient in mRNA transport from nucleus to cytoplasm. Proc Natl Acad Sci U S A (1992) 2.21

The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases. EMBO J (1996) 2.20

The vertebrate GLFG nucleoporin, Nup98, is an essential component of multiple RNA export pathways. J Cell Biol (1997) 2.19

NUP2, a novel yeast nucleoporin, has functional overlap with other proteins of the nuclear pore complex. Mol Biol Cell (1993) 2.15

A channeled tRNA cycle during mammalian protein synthesis. Proc Natl Acad Sci U S A (1995) 2.13

A distinct and parallel pathway for the nuclear import of an mRNA-binding protein. J Cell Biol (1997) 2.08

The nuclear transport factor karyopherin beta binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating protein. J Biol Chem (1996) 2.08

Cloning and characterization of LOS1, a Saccharomyces cerevisiae gene that affects tRNA splicing. Mol Cell Biol (1987) 2.00

Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant. Mol Biol Cell (1994) 1.99

Mutants in a yeast Ran binding protein are defective in nuclear transport. EMBO J (1995) 1.97

Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins. J Biol Chem (1997) 1.96

A GTPase controlling nuclear trafficking: running the right way or walking RANdomly? Cell (1996) 1.95

A G protein involved in nucleocytoplasmic transport: the role of Ran. Trends Biochem Sci (1994) 1.91

RNA transport. Annu Rev Neurosci (1997) 1.91

Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus. EMBO J (1997) 1.91

A novel nuclear pore protein Nup82p which specifically binds to a fraction of Nsp1p. J Cell Biol (1995) 1.90

Diverse effects of the guanine nucleotide exchange factor RCC1 on RNA transport. Science (1995) 1.89

Signal-mediated import of bacteriophage T7 RNA polymerase into the Saccharomyces cerevisiae nucleus and specific transcription of target genes. Mol Cell Biol (1990) 1.84

Cloning and characterization of human karyopherin beta3. Proc Natl Acad Sci U S A (1997) 1.63

Molecular architecture of the yeast nuclear pore complex: localization of Nsp1p subcomplexes. J Cell Biol (1998) 1.57

A conserved domain within Arc1p delivers tRNA to aminoacyl-tRNA synthetases. Mol Cell (1998) 1.57

Site-directed mutagenesis using a double-stranded DNA fragment as a PCR primer. Nucleic Acids Res (1990) 1.54

Supramolecular organization of the mammalian translation system. Proc Natl Acad Sci U S A (1994) 1.54

Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis. EMBO J (1995) 1.48

A nuclear import pathway for a protein involved in tRNA maturation. J Cell Biol (1997) 1.45

Yeast nucleoporin mutants are defective in pre-tRNA splicing. Mol Cell Biol (1996) 1.43

Inhibition of mRNA export in vertebrate cells by nuclear export signal conjugates. Proc Natl Acad Sci U S A (1997) 1.29

The Saccharomyces cerevisiae LOS1 gene involved in pre-tRNA splicing encodes a nuclear protein that behaves as a component of the nuclear matrix. J Biol Chem (1993) 1.23

Articles by these authors

Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor. Cell (1997) 6.28

Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. EMBO J (1997) 5.61

The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans. Nature (2000) 5.57

Identification of different roles for RanGDP and RanGTP in nuclear protein import. EMBO J (1996) 5.53

The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J (1999) 4.49

A novel class of RanGTP binding proteins. J Cell Biol (1997) 4.36

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex. EMBO J (1997) 4.06

Identification of a 60S preribosomal particle that is closely linked to nuclear export. Mol Cell (2001) 3.95

Identification of a tRNA-specific nuclear export receptor. Mol Cell (1998) 3.94

Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export. EMBO J (2000) 3.76

Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores. Mol Cell Biol (1998) 3.66

Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p. Mol Cell Biol (2001) 3.60

Mammalian nuclei contain foci which are highly enriched in components of the pre-mRNA splicing machinery. EMBO J (1991) 3.49

Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p. Nature (2001) 3.35

Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis. Mol Cell Biol (1997) 2.95

Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1. Biochemistry (1995) 2.91

From nucleoporins to nuclear pore complexes. Curr Opin Cell Biol (1997) 2.75

Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p. EMBO J (1998) 2.71

A cytochrome f/b6 complex of five polypeptides with plastoquinol-plastocyanin-oxidoreductase activity from spinach chloroplasts. Eur J Biochem (1981) 2.51

Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export. J Cell Biol (2000) 2.48

An aminoacylation-dependent nuclear tRNA export pathway in yeast. Genes Dev (2000) 2.38

Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Cell (2001) 2.38

RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase. Mol Cell Biol (1999) 2.37

A novel in vivo assay reveals inhibition of ribosomal nuclear export in ran-cycle and nucleoporin mutants. J Cell Biol (1999) 2.37

The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1. EMBO J (1999) 2.31

Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import. Mol Cell Biol (1999) 2.27

The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis. Mol Cell (2001) 2.25

Structure and assembly of the Nup84p complex. J Cell Biol (2000) 2.22

A novel complex of membrane proteins required for formation of a spherical nucleus. EMBO J (1998) 2.19

Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes. EMBO J (2000) 2.18

Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly. Mol Biol Cell (1997) 2.08

CRM1-mediated recycling of snurportin 1 to the cytoplasm. J Cell Biol (1999) 2.08

Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking. Annu Rev Genet (1997) 2.08

Nup116p and nup100p are interchangeable through a conserved motif which constitutes a docking site for the mRNA transport factor gle2p. EMBO J (1998) 1.91

Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus. EMBO J (1997) 1.91

Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of psi 38 and psi 39 in tRNA anticodon loop. J Biol Chem (1998) 1.82

Two functionally distinct domains generated by in vivo cleavage of Nup145p: a novel biogenesis pathway for nucleoporins. EMBO J (1997) 1.78

RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae. J Biol Chem (1995) 1.77

Coordination of tRNA nuclear export with processing of tRNA. RNA (1999) 1.74

Reconstitution of nuclear protein transport with semi-intact yeast cells. J Cell Biol (1993) 1.73

A nuclear AAA-type ATPase (Rix7p) is required for biogenesis and nuclear export of 60S ribosomal subunits. EMBO J (2001) 1.69

The lamin B receptor (LBR) provides essential chromatin docking sites at the nuclear envelope. EMBO J (1996) 1.59

Comparative aspects of quinol-cytochrome c/plastocyanin oxidoreductases. Biochim Biophys Acta (1983) 1.57

The yeast tRNA:pseudouridine synthase Pus1p displays a multisite substrate specificity. RNA (1998) 1.55

RanBP3 influences interactions between CRM1 and its nuclear protein export substrates. EMBO Rep (2001) 1.46

Intron-dependent enzymatic formation of modified nucleosides in eukaryotic tRNAs: a review. Biochimie (1997) 1.44

Binding of lamin A to polynucleosomes. J Biol Chem (1991) 1.44

Mlp2p, a component of nuclear pore attached intranuclear filaments, associates with nic96p. J Biol Chem (2000) 1.44

Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export. J Cell Biol (2001) 1.41

A nuclear envelope-associated kinase phosphorylates arginine-serine motifs and modulates interactions between the lamin B receptor and other nuclear proteins. J Biol Chem (1996) 1.39

Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1. Mol Cell Biol (1997) 1.36

Review: transport of tRNA out of the nucleus-direct channeling to the ribosome? J Struct Biol (2000) 1.34

Cse1p is involved in export of yeast importin alpha from the nucleus. Mol Cell Biol (1998) 1.33

A cytochrome b/c1 complex with ubiquinol--cytochrome c2 oxidoreductase activity from Rhodopseudomonas sphaeroides GA. Eur J Biochem (1982) 1.27

The Nsp1p carboxy-terminal domain is organized into functionally distinct coiled-coil regions required for assembly of nucleoporin subcomplexes and nucleocytoplasmic transport. Mol Cell Biol (2001) 1.26

Human RanBP3, a group of nuclear RanGTP binding proteins. FEBS Lett (1998) 1.25

Pus1p-dependent tRNA pseudouridinylation becomes essential when tRNA biogenesis is compromised in yeast. J Biol Chem (2001) 1.25

Nup192p is a conserved nucleoporin with a preferential location at the inner site of the nuclear membrane. J Biol Chem (1999) 1.22

Genes and transcripts for the polypeptides of the cytochrome b6/f complex from spinach thylakoid membranes. EMBO J (1983) 1.21

Lamins and lamin-associated proteins. Curr Opin Cell Biol (1994) 1.16

Mitotic phosphorylation of the lamin B receptor by a serine/arginine kinase and p34(cdc2). J Biol Chem (1997) 1.16

Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. J Biol Chem (2000) 1.15

Amino acid and adenine cross-pathway regulation act through the same 5'-TGACTC-3' motif in the yeast HIS7 promoter. J Biol Chem (1996) 1.13

A lectin-mediated resistance of higher fungi against predators and parasites. Mol Ecol (2011) 1.12

The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast Ran binding protein 1 (Yrb1p). Mol Biol Cell (2001) 1.12

Anterior cruciate ligament tears: MR imaging-based diagnosis in a pediatric population. Radiology (1999) 1.11

Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid. J Lipid Res (1995) 1.09

The intracellular location of two aminoacyl-tRNA synthetases depends on complex formation with Arc1p. EMBO J (2001) 1.07

Arc1p organizes the yeast aminoacyl-tRNA synthetase complex and stabilizes its interaction with the cognate tRNAs. J Biol Chem (2000) 1.06

Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway. Mol Cell Biol (2000) 1.06

Hypoxia inducible factor-1 alpha and vascular endothelial growth factor in biopsies of small cell lung carcinoma. Lung (2009) 1.05

Identification of the polypeptides in the cytochrome b6/f complex from spinach chloroplasts with redox-center-carrying subunits. J Bioenerg Biomembr (1982) 1.04

The thermolability of nuclear protein import in tsBN2 cells is suppressed by microinjected Ran-GTP or Ran-GDP, but not by RanQ69L or RanT24N. J Cell Sci (1996) 1.03

Nup116p associates with the Nup82p-Nsp1p-Nup159p nucleoporin complex. J Biol Chem (2000) 1.03

Nuclear RNA export in yeast. FEBS Lett (1999) 1.01

Transfer RNA biogenesis: A visa to leave the nucleus. Curr Biol (1999) 0.96

Yeast nuclear pore complex assembly defects determined by nuclear envelope reconstruction. J Struct Biol (2000) 0.95

Cloning and characterization of the Schizosaccharomyces pombe tRNA:pseudouridine synthase Pus1p. Nucleic Acids Res (2000) 0.94

The two 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase isoenzymes from Saccharomyces cerevisiae show different kinetic modes of inhibition. Arch Microbiol (1998) 0.94

Yeast Ran-binding protein Yrb1p is required for efficient proteolysis of cell cycle regulatory proteins Pds1p and Sic1p. J Biol Chem (2000) 0.92

MHP1, an essential gene in Saccharomyces cerevisiae required for microtubule function. J Cell Biol (1996) 0.92

Structural differences in the minimal catalytic domains of the GTPase-activating proteins p120GAP and neurofibromin. J Biol Chem (1996) 0.91

In vitro and in vivo evidence that protein and U1 snRNP nuclear import in somatic cells differ in their requirement for GTP-hydrolysis, Ran/TC4 and RCC1. Nucleic Acids Res (1996) 0.90

Targeting of Ran: variation on a common theme? J Cell Sci (2001) 0.89

Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defects. Genetics (2001) 0.88

Modifications of low-density lipoprotein induced by arterial proteoglycans and chondroitin-6-sulfate. Biochim Biophys Acta (1991) 0.87

Molecular analysis of the yeast SER1 gene encoding 3-phosphoserine aminotransferase: regulation by general control and serine repression. Curr Genet (1995) 0.87

Structural requirements of quinone coenzymes for endogenous and dye-mediated coupled electron transport in bacterial photosynthesis. J Bioenerg Biomembr (1980) 0.86

Vectorial redox reactions of physiological quinones. I. Requirement of a minimum length of the isoprenoid side chain. Biochim Biophys Acta (1979) 0.85

Regulation of the yeast HIS7 gene by the global transcription factor Abf1p. Mol Gen Genet (1997) 0.85