Published in J Biol Chem on December 18, 1998
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J (2000) 41.48
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell (2003) 17.55
Autophagy as a regulated pathway of cellular degradation. Science (2000) 17.27
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol (2001) 13.98
Eaten alive: a history of macroautophagy. Nat Cell Biol (2010) 8.83
Autophagic programmed cell death by selective catalase degradation. Proc Natl Acad Sci U S A (2006) 4.81
Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. Mol Biol Cell (1999) 4.68
Atg8 controls phagophore expansion during autophagosome formation. Mol Biol Cell (2008) 4.41
The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell (2008) 4.25
The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell (2008) 3.72
Dissection of autophagosome biogenesis into distinct nucleation and expansion steps. J Cell Biol (2000) 3.64
Autophagy in the eukaryotic cell. Eukaryot Cell (2002) 3.61
The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep (2008) 3.52
Leaf senescence and starvation-induced chlorosis are accelerated by the disruption of an Arabidopsis autophagy gene. Plant Physiol (2002) 3.47
Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes. Nat Cell Biol (2011) 3.45
Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal (2010) 3.35
Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J Clin Invest (2006) 3.34
An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol (2009) 3.29
Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy. Plant Cell (2004) 3.17
The machinery of macroautophagy. Cell Res (2013) 3.13
The autophagosome: origins unknown, biogenesis complex. Nat Rev Mol Cell Biol (2013) 3.04
ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell (2010) 2.83
Vacuolar localization of oligomeric alpha-mannosidase requires the cytoplasm to vacuole targeting and autophagy pathway components in Saccharomyces cerevisiae. J Biol Chem (2001) 2.58
Piecemeal microautophagy of nucleus in Saccharomyces cerevisiae. Mol Biol Cell (2003) 2.48
Class III phosphoinositide 3-kinase--Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes. Biochem J (2003) 2.45
Autophagosome precursor maturation requires homotypic fusion. Cell (2011) 2.39
Control of autophagy as a therapy for neurodegenerative disease. Nat Rev Neurol (2011) 2.38
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell (2011) 2.34
Apg5p functions in the sequestration step in the cytoplasm-to-vacuole targeting and macroautophagy pathways. Mol Biol Cell (2000) 2.33
Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris. Mol Biol Cell (2001) 2.21
Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. Mol Biol Cell (2008) 2.08
Apg2 is a novel protein required for the cytoplasm to vacuole targeting, autophagy, and pexophagy pathways. J Biol Chem (2001) 1.99
Hepatitis C virus genotype 1a growth and induction of autophagy. J Virol (2007) 1.96
Regulation of innate immune responses by autophagy-related proteins. J Cell Biol (2010) 1.94
Endolysosomal proteolysis and its regulation. Biochem J (2002) 1.93
Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration. PLoS One (2009) 1.84
Degradation of oxidized proteins by autophagy during oxidative stress in Arabidopsis. Plant Physiol (2006) 1.84
p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways. J Biol Chem (2011) 1.82
Autophagy regulation by nutrient signaling. Cell Res (2013) 1.81
Autophagy in yeast: mechanistic insights and physiological function. Microbiol Mol Biol Rev (2001) 1.78
The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis. Elife (2013) 1.66
Porphyromonas gingivalis traffics to autophagosomes in human coronary artery endothelial cells. Infect Immun (2001) 1.65
Analysis of the role of autophagy in replication of herpes simplex virus in cell culture. J Virol (2007) 1.63
Transcriptome profiling of the response of Arabidopsis suspension culture cells to Suc starvation. Plant Physiol (2004) 1.57
Integration of clearance mechanisms: the proteasome and autophagy. Cold Spring Harb Perspect Biol (2010) 1.52
Disruption of neuronal autophagy by infected microglia results in neurodegeneration. PLoS One (2008) 1.50
Historical landmarks of autophagy research. Cell Res (2013) 1.49
Autophagy, a guardian against neurodegeneration. Semin Cell Dev Biol (2010) 1.45
The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy. Immunity (2014) 1.34
Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy. J Cell Biol (2002) 1.33
Cardioprotection requires taking out the trash. Basic Res Cardiol (2009) 1.32
Autophagy-physiology and pathophysiology. Histochem Cell Biol (2008) 1.31
Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major. Autophagy (2009) 1.26
Crohn disease: a current perspective on genetics, autophagy and immunity. Autophagy (2011) 1.26
The interplay between autophagy and ROS in tumorigenesis. Front Oncol (2012) 1.17
Autophagy in vascular disease. Proc Am Thorac Soc (2010) 1.16
Molecular mechanisms of autophagy in the cardiovascular system. Circ Res (2015) 1.10
Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells. Br J Pharmacol (2011) 1.10
Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. J Clin Invest (2015) 1.08
Autophagy in tumor suppression and cancer therapy. Crit Rev Eukaryot Gene Expr (2011) 1.08
mir-30d Regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells. Biochem Biophys Res Commun (2012) 1.08
Eat your heart out: Role of autophagy in myocardial ischemia/reperfusion. Autophagy (2008) 1.06
Liver autophagy: much more than just taking out the trash. Nat Rev Gastroenterol Hepatol (2013) 1.05
Intertwined pathways of programmed cell death in immunity. Immunol Rev (2010) 1.04
TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic. EMBO J (2015) 1.02
Coibamide A induces mTOR-independent autophagy and cell death in human glioblastoma cells. PLoS One (2013) 1.01
RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms. PLoS Pathog (2014) 1.01
Drosophila as a model system to study autophagy. Semin Immunopathol (2010) 0.99
Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay. Elife (2016) 0.97
Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer. Pharmacol Rev (2014) 0.96
WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma. Cell Death Dis (2013) 0.94
Intestinal epithelium and autophagy: partners in gut homeostasis. Front Immunol (2013) 0.94
Type I interferons induce autophagy in certain human cancer cell lines. Autophagy (2013) 0.94
Herpesviruses and autophagy: catch me if you can! Viruses (2010) 0.94
The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection. Immunity (2015) 0.93
Quantitative proteomics reveals the induction of mitophagy in tumor necrosis factor-α-activated (TNFα) macrophages. Mol Cell Proteomics (2013) 0.90
Modulation of translation and induction of autophagy by bacterial exoproducts. Med Microbiol Immunol (2012) 0.90
Autophagy and apoptosis act as partners to induce germ cell death after heat stress in mice. PLoS One (2012) 0.89
SUMO1 promotes Aβ production via the modulation of autophagy. Autophagy (2015) 0.89
RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. Autophagy (2014) 0.89
Regulation and functional significance of autophagy in respiratory cell biology and disease. Am J Respir Cell Mol Biol (2012) 0.89
Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy. Autophagy (2015) 0.88
Impact of cellular autophagy on viruses: Insights from hepatitis B virus and human retroviruses. J Biomed Sci (2012) 0.86
Tumor suppressor gene PDCD4 negatively regulates autophagy by inhibiting the expression of autophagy-related gene ATG5. Autophagy (2013) 0.85
Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis. Blood (2015) 0.85
Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1. J Biol Chem (2015) 0.84
Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression. Cell Rep (2014) 0.84
Vaccinia virus leads to ATG12–ATG3 conjugation and deficiency in autophagosome formation. Autophagy (2011) 0.83
Autophagy signal transduction by ATG proteins: from hierarchies to networks. Cell Mol Life Sci (2015) 0.83
Impact of Autophagy on Chemotherapy and Radiotherapy Mediated Tumor Cytotoxicity: "To Live or not to Live". Front Oncol (2011) 0.83
Autophagy in Plasmodium, a multifunctional pathway? Comput Struct Biotechnol J (2013) 0.82
Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101). BMC Cancer (2015) 0.82
An overview of macroautophagy in yeast. J Mol Biol (2016) 0.81
Skeletal muscle homeostasis in duchenne muscular dystrophy: modulating autophagy as a promising therapeutic strategy. Front Aging Neurosci (2014) 0.81
Level of macroautophagy drives senescent keratinocytes into cell death or neoplastic evasion. Cell Death Dis (2014) 0.81
Elucidating the composition and conservation of the autophagy pathway in photosynthetic eukaryotes. Autophagy (2015) 0.80
A putative polypeptide N-acetylgalactosaminyltransferase/Williams-Beuren syndrome chromosome region 17 (WBSCR17) regulates lamellipodium formation and macropinocytosis. J Biol Chem (2012) 0.80
Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins. BMC Cell Biol (2013) 0.80
Autophagic program is regulated by miR-325. Cell Death Differ (2014) 0.80
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J (2000) 41.48
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol (2001) 13.98
Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett (1993) 13.48
A protein conjugation system essential for autophagy. Nature (1998) 12.71
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem (1998) 10.77
A ubiquitin-like system mediates protein lipidation. Nature (2000) 10.61
Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol (2000) 9.61
Formation process of autophagosome is traced with Apg8/Aut7p in yeast. J Cell Biol (1999) 9.33
Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct Funct (1998) 9.18
The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J (2001) 8.84
Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction. J Cell Biol (1992) 8.33
Vacuolar import of proteins and organelles from the cytoplasm. Annu Rev Cell Dev Biol (1999) 7.75
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol (2001) 7.68
The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J Cell Biol (2000) 7.48
Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep (2001) 7.13
Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun (1995) 5.89
Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome. J Cell Biol (1997) 5.57
Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae. Gene (1997) 5.53
Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization. J Cell Biol (1994) 5.41
Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole. Proc Natl Acad Sci U S A (1996) 4.97
Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. Mol Biol Cell (1999) 4.68
Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways. J Cell Biol (2000) 4.30
Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole. J Cell Biol (2001) 4.25
The mouse SKD1, a homologue of yeast Vps4p, is required for normal endosomal trafficking and morphology in mammalian cells. Mol Biol Cell (2000) 4.22
Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway. EMBO J (1999) 3.97
Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. J Biol Chem (1998) 3.93
Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae. Gene (1997) 3.88
Aminopeptidase I is targeted to the vacuole by a nonclassical vesicular mechanism. J Cell Biol (1997) 3.81
Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast. EMBO J (1999) 3.70
Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion. Mol Biol Cell (2001) 3.41
Intravenous recombinant tissue plasminogen activator in acute carotid artery territory stroke. Neurology (1992) 3.40
Immunostaining of skeletal and cardiac muscle surface membrane with antibody against Duchenne muscular dystrophy peptide. Nature (1988) 3.25
Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting. J Biol Chem (2000) 3.25
Properties of H+-translocating adenosine triphosphatase in vacuolar membranes of SAccharomyces cerevisiae. J Biol Chem (1981) 2.81
Exploring the molecular basis for variability among patients with Becker muscular dystrophy: dystrophin gene and protein studies. Am J Hum Genet (1991) 2.79
Analysis of the membrane structures involved in autophagy in yeast by freeze-replica method. Cell Struct Funct (1995) 2.69
Calcium transport driven by a proton motive force in vacuolar membrane vesicles of Saccharomyces cerevisiae. J Biol Chem (1983) 2.62
Occurrence of tetrodotoxin and anhydrotetrodotoxin in Vibrio sp. isolated from the intestines of a xanthid crab, Atergatis floridus. J Biochem (1986) 2.56
Purification and properties of H+-translocating, Mg2+-adenosine triphosphatase from vacuolar membranes of Saccharomyces cerevisiae. J Biol Chem (1985) 2.54
Active transport of basic amino acids driven by a proton motive force in vacuolar membrane vesicles of Saccharomyces cerevisiae. J Biol Chem (1981) 2.51
Genes for directing vacuolar morphogenesis in Saccharomyces cerevisiae. I. Isolation and characterization of two classes of vam mutants. J Biol Chem (1992) 2.45
Apg5p functions in the sequestration step in the cytoplasm-to-vacuole targeting and macroautophagy pathways. Mol Biol Cell (2000) 2.33
Autophagy in yeast: a TOR-mediated response to nutrient starvation. Curr Top Microbiol Immunol (2004) 2.27
Mosaic expression of dystrophin in symptomatic carriers of Duchenne's muscular dystrophy. N Engl J Med (1989) 2.19
Genetic mutations in exons 3 and 4 of the pancreatic secretory trypsin inhibitor in patients with pancreatitis. J Gastroenterol (2001) 2.17
Structural and functional analyses of APG5, a gene involved in autophagy in yeast. Gene (1996) 2.06
Vam3p, a new member of syntaxin related protein, is required for vacuolar assembly in the yeast Saccharomyces cerevisiae. J Cell Sci (1997) 2.05
Nucleotide sequence of the CLS4 (CDC24) gene of Saccharomyces cerevisiae. Gene (1987) 2.00
DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. Cell Death Differ (2008) 1.99
Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae. J Biol Chem (1997) 1.97
Calcium-sensitive cls4 mutant of Saccharomyces cerevisiae with a defect in bud formation. J Bacteriol (1986) 1.87
Three-dimensional analysis of morphogenesis induced by mating pheromone alpha factor in Saccharomyces cerevisiae. J Cell Sci (1989) 1.85
The anticancer drug imatinib induces cellular autophagy. Leukemia (2007) 1.84
Apg2p functions in autophagosome formation on the perivacuolar structure. J Biol Chem (2001) 1.82
A protein conjugation system in yeast with homology to biosynthetic enzyme reaction of prokaryotes. J Biol Chem (2000) 1.82
Substrate specificities of active transport systems for amino acids in vacuolar-membrane vesicles of Saccharomyces cerevisiae. Evidence of seven independent proton/amino acid antiport systems. J Biol Chem (1984) 1.82
Dynamic aspects of vacuolar and cytosolic amino acid pools of Saccharomyces cerevisiae. J Bacteriol (1988) 1.67
Geranylgeranylated SNAREs are dominant inhibitors of membrane fusion. J Cell Biol (2000) 1.66
The C-terminal region of an Apg7p/Cvt2p is required for homodimerization and is essential for its E1 activity and E1-E2 complex formation. J Biol Chem (2001) 1.60
The AtVAM3 encodes a syntaxin-related molecule implicated in the vacuolar assembly in Arabidopsis thaliana. J Biol Chem (1997) 1.60
Mutants of Saccharomyces cerevisiae with defective vacuolar function. J Bacteriol (1988) 1.60
The frequency of patients with dystrophin abnormalities in a limb-girdle patient population. Neurology (1991) 1.59
Acidification of vacuoles is required for autophagic degradation in the yeast, Saccharomyces cerevisiae. J Biochem (1997) 1.57
Muscle-specific calpain, p94, is degraded by autolysis immediately after translation, resulting in disappearance from muscle. J Biol Chem (1993) 1.52
Neuroleptic malignant syndrome: caffeine contracture of single muscle fibers and muscle pathology. Neurology (1988) 1.51
Mutational analysis of Csc1/Vps4p: involvement of endosome in regulation of autophagy in yeast. Cell Struct Funct (1997) 1.50
Hereditary muscular atrophy with ataxia, retinitis pigmentosa, and diabetes mellitus. A clinical report of a family. Neurology (1968) 1.49
Rotavirus NSP4 induces a novel vesicular compartment regulated by calcium and associated with viroplasms. J Virol (2006) 1.49
A rapid and simplified method for the preparation of lysosomal membranes from rat liver. J Biochem (1983) 1.48
Isolation and characterization of Ca2+-sensitive mutants of Saccharomyces cerevisiae. J Gen Microbiol (1986) 1.48
The late stages of autophagy: how does the end begin? Cell Death Differ (2009) 1.47
Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells. J Biol Chem (2000) 1.46
Solubilization and purification of alpha-mannosidase, a marker enzyme of vacuolar membranes in Saccharomyces cerevisiae. J Biol Chem (1988) 1.44
Nationwide survey of neurologic manifestations of acquired immunodeficiency syndrome in Japan. Intern Med (1997) 1.40
Dystrophin diagnosis: comparison of dystrophin abnormalities by immunofluorescence and immunoblot analyses. Proc Natl Acad Sci U S A (1989) 1.40
Genetic study of the role of calcium ions in the cell division cycle of Saccharomyces cerevisiae: a calcium-dependent mutant and its trifluoperazine-dependent pseudorevertants. Mol Gen Genet (1984) 1.35
Abnormal localization of laminin subunits in muscular dystrophies. J Neurol Sci (1993) 1.29
Immunologic derangement in myotonic dystrophy--abnormal contact sensitization to dinitrochlorobenzene. J Neurol Sci (1980) 1.29
An arginine/histidine exchange transport system in vacuolar-membrane vesicles of Saccharomyces cerevisiae. J Biol Chem (1984) 1.26
Heavy chain binding protein (BiP/GRP78) and endoplasmin are exported from the endoplasmic reticulum in rat exocrine pancreatic cells, similar to protein disulfide-isomerase. Arch Biochem Biophys (1992) 1.21
Pathophysiology of muscle fiber necrosis induced by bupivacaine hydrochloride (Marcaine). Acta Neuropathol (1983) 1.21
Biogenesis of vacuolar membrane glycoproteins of yeast Saccharomyces cerevisiae. J Biol Chem (1990) 1.20
Identification of elastase as a secretory protease from cultured rat microglia. J Neurochem (1992) 1.18
Inhibition of epoxide derivatives on chicken calcium-activated neutral protease (CANP) in vitro and in vivo. J Biochem (1980) 1.18
Smoking-related changes in the background lung of specimens resected for lung cancer: a semiquantitative study with correlation to postoperative course. Histopathology (2008) 1.18
Vacuolar ion channel of the yeast, Saccharomyces cerevisiae. J Biol Chem (1987) 1.17
Specific induction of Ca2+ transport activity in MATa cells of Saccharomyces cerevisiae by a mating pheromone, alpha factor. J Biol Chem (1985) 1.14
Molecular cloning and functional analysis of three subunits of yeast proteasome. Mol Cell Biol (1991) 1.10
Purification of yeast vacuolar membrane H+-ATPase and enzymological discrimination of three ATP-driven proton pumps in Saccharomyces cerevisiae. Methods Enzymol (1988) 1.08
A clinical and histological study of Ullrich's disease (congenital atonic-sclerotic muscular dystrophy). Neuropediatrics (1981) 1.08
Frequency of occurrence, morphology, and causes of congenital malformation of limbs in the Japanese monkey. Ecotoxicol Environ Saf (1979) 1.05
Absence of extraocular muscle pathology in Duchenne's muscular dystrophy: role for calcium homeostasis in extraocular muscle sparing. J Exp Med (1995) 1.05