Published in Am J Respir Cell Mol Biol on September 13, 2012
mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects. FASEB J (2013) 0.94
Vitamin C: a novel regulator of neutrophil extracellular trap formation. Nutrients (2013) 0.86
Autophagy is essential for ultrafine particle-induced inflammation and mucus hyperproduction in airway epithelium. Autophagy (2016) 0.86
Targeting the Intracellular Environment in Cystic Fibrosis: Restoring Autophagy as a Novel Strategy to Circumvent the CFTR Defect. Front Pharmacol (2013) 0.84
Streptococcus pneumoniae induces autophagy through the inhibition of the PI3K-I/Akt/mTOR pathway and ROS hypergeneration in A549 cells. PLoS One (2015) 0.82
CFTR activity and mitochondrial function. Redox Biol (2013) 0.79
Co-localization of iron binding on silica with p62/sequestosome1 (SQSTM1) in lung granulomas of mice with acute silicosis. J Clin Biochem Nutr (2014) 0.79
Apelin inhibits the proliferation and migration of rat PASMCs via the activation of PI3K/Akt/mTOR signal and the inhibition of autophagy under hypoxia. J Cell Mol Med (2014) 0.78
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The crucial role of vitamin C and its transporter (SVCT2) in bone marrow stromal cell autophagy and apoptosis. Stem Cell Res (2015) 0.76
Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis. Mol Med (2013) 0.76
Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice. Am J Respir Cell Mol Biol (2016) 0.75
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J (2000) 41.48
mTOR signaling in growth control and disease. Cell (2012) 29.21
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem (2007) 21.73
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In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell (2003) 17.55
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol (2011) 15.71
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31
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Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell (2004) 12.71
How to interpret LC3 immunoblotting. Autophagy (2007) 12.30
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Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol (2008) 9.37
Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science (2006) 9.17
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol (2010) 9.02
Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol (2006) 8.89
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Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell (2010) 8.29
A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat Cell Biol (2009) 7.84
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol (2009) 7.35
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol (2008) 7.16
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell (2008) 7.14
Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes. J Cell Sci (2006) 6.98
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The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol (2010) 5.95
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Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol (2008) 5.52
Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease. Nat Cell Biol (2008) 5.50
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ (2006) 5.18
A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. J Biol Chem (1998) 5.07
Monitoring autophagic degradation of p62/SQSTM1. Methods Enzymol (2009) 4.74
3D tomography reveals connections between the phagophore and endoplasmic reticulum. Autophagy (2009) 4.17
The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes. Autophagy (2005) 4.08
The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy (2005) 4.02
DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep (2009) 3.69
Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties. Immunity (2010) 3.62
Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett (2006) 3.49
Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum Mol Genet (2005) 3.45
Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes. Traffic (2006) 2.98
Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers. Proc Am Thorac Soc (2006) 2.77
Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent. Proc Natl Acad Sci U S A (2011) 2.73
Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PLoS One (2008) 2.67
Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes. Cell Struct Funct (2008) 2.47
Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism. Cell Microbiol (2006) 2.40
Modulation of intracellular ROS levels by TIGAR controls autophagy. EMBO J (2009) 2.31
Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition. Nat Cell Biol (2010) 2.29
ER-phagy: selective autophagy of the endoplasmic reticulum. Autophagy (2007) 2.21
Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis. Autophagy (2011) 2.06
Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med (2010) 1.93
Pexophagy: autophagic degradation of peroxisomes. Biochim Biophys Acta (2006) 1.93
Mitophagy. Biochim Biophys Acta (2009) 1.92
Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema. Proc Natl Acad Sci U S A (2010) 1.82
AMP-activated protein kinase and autophagy. Autophagy (2007) 1.66
Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and -independent mechanisms. J Immunol (2011) 1.65
Autophagy in idiopathic pulmonary fibrosis. PLoS One (2012) 1.45
Identification of an autophagy defect in smokers' alveolar macrophages. J Immunol (2010) 1.36
Intracellular survival of Burkholderia cenocepacia in macrophages is associated with a delay in the maturation of bacteria-containing vacuoles. Cell Microbiol (2006) 1.35
Cigarette smoke: protection of alveolar macrophages by glutathione and cysteine. Science (1968) 1.29
Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy (2011) 1.20
Hyperoxia-induced LC3B interacts with the Fas apoptotic pathway in epithelial cell death. Am J Respir Cell Mol Biol (2011) 1.15
Outcome of Burkholderia cepacia colonisation in an adult cystic fibrosis centre. Thorax (2002) 1.08
Investigating autophagy: quantitative morphometric analysis using electron microscopy. Autophagy (2010) 1.01
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol (2010) 9.02
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev (2006) 7.76
Mechanisms of cell death in oxidative stress. Antioxid Redox Signal (2007) 3.33
Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med (2012) 2.92
Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. J Exp Med (2006) 2.92
Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. J Exp Med (2006) 2.77
Autophagy in human health and disease. N Engl J Med (2013) 2.73
Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PLoS One (2008) 2.67
Inhaled carbon monoxide confers antiinflammatory effects against ventilator-induced lung injury. Am J Respir Crit Care Med (2004) 2.60
Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A (2004) 2.42
Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1. Autophagy (2008) 2.38
Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. J Biol Chem (2009) 2.33
An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med (2013) 2.23
Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance. Mol Cell Biochem (2002) 2.16
Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med (2003) 2.15
Heme oxygenase-1: the "emerging molecule" has arrived. Am J Respir Cell Mol Biol (2002) 2.12
CO as a cellular signaling molecule. Annu Rev Pharmacol Toxicol (2006) 2.03
Inhaled hydrogen sulfide protects against ventilator-induced lung injury. Anesthesiology (2010) 2.02
Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy. Am J Respir Cell Mol Biol (2009) 1.94
Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med (2010) 1.93
Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1. J Biol Chem (2003) 1.83
Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema. Proc Natl Acad Sci U S A (2010) 1.82
Brief inhalation of low-dose carbon monoxide protects rodents and swine from postoperative ileus. Crit Care Med (2005) 1.73
Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death. Am J Respir Cell Mol Biol (2006) 1.69
Carbon monoxide prevents ventilator-induced lung injury via caveolin-1. Crit Care Med (2009) 1.68
The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1. J Immunol (2009) 1.66
Carbon monoxide and bilirubin: potential therapies for pulmonary/vascular injury and disease. Am J Respir Cell Mol Biol (2006) 1.65
Inhaled carbon monoxide suppresses the development of postoperative ileus in the murine small intestine. Gastroenterology (2003) 1.59
Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase-dependent nitric oxide generation. Circulation (2009) 1.58
Caveolae compartmentalization of heme oxygenase-1 in endothelial cells. FASEB J (2004) 1.54
Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation. J Biol Chem (2006) 1.53
Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem (2002) 1.52
Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet (2009) 1.52
Caveolin-1 confers antiinflammatory effects in murine macrophages via the MKK3/p38 MAPK pathway. Am J Respir Cell Mol Biol (2005) 1.51
Heme oxygenase-1: redox regulation of a stress protein in lung and cell culture models. Antioxid Redox Signal (2005) 1.49
Carbon monoxide inhalation protects rat intestinal grafts from ischemia/reperfusion injury. Am J Pathol (2003) 1.47
Heme oxygenase-1: from bench to bedside. Am J Respir Crit Care Med (2005) 1.47
Gene expression profiling of target genes in ventilator-induced lung injury. Physiol Genomics (2006) 1.45
Autophagy in idiopathic pulmonary fibrosis. PLoS One (2012) 1.45
Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects. Am J Pathol (2003) 1.43
Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet (2011) 1.42
Protective functions of heme oxygenase-1 and carbon monoxide in the respiratory system. Antioxid Redox Signal (2007) 1.41
Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. PLoS One (2008) 1.41
Carbon monoxide: to boldly go where NO has gone before. Sci STKE (2004) 1.40
Heme oxygenase-1: molecular mechanisms of gene expression in oxygen-related stress. Antioxid Redox Signal (2002) 1.40
Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway. J Biol Chem (2003) 1.39
Cellular and humoral autoreactivity in idiopathic pulmonary fibrosis. J Immunol (2007) 1.39
Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1. J Exp Med (2003) 1.39
Pathways of cell signaling in hyperoxia. Free Radic Biol Med (2003) 1.39
Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease. Free Radic Biol Med (2009) 1.38
Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium. Am J Respir Cell Mol Biol (2003) 1.36
Heme oxygenase-1 and carbon monoxide in pulmonary medicine. Respir Res (2003) 1.33
Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clin Invest (2013) 1.29
Caveolin-1 expression by means of p38beta mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide. Proc Natl Acad Sci U S A (2005) 1.29
Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1. J Immunol (2005) 1.28
The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease. PLoS One (2009) 1.28
Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med (2012) 1.27
Carbon monoxide modulates endotoxin-induced production of granulocyte macrophage colony-stimulating factor in macrophages. Am J Respir Cell Mol Biol (2002) 1.27
Autophagy: a critical regulator of cellular metabolism and homeostasis. Mol Cells (2013) 1.24
Carbon monoxide protects against ventilator-induced lung injury via PPAR-gamma and inhibition of Egr-1. Am J Respir Crit Care Med (2008) 1.23
Carbon monoxide activates autophagy via mitochondrial reactive oxygen species formation. Am J Respir Cell Mol Biol (2011) 1.23
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD. J Clin Invest (2014) 1.23
Autophagy in the lung. Proc Am Thorac Soc (2010) 1.22
Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy (2011) 1.20
Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver. FASEB J (2004) 1.19
Protective effect of carbon monoxide in transplantation. J Cell Mol Med (2006) 1.19
Caveolin-1: a critical regulator of lung injury. Am J Physiol Lung Cell Mol Physiol (2010) 1.17
Carbon monoxide suppresses bleomycin-induced lung fibrosis. Am J Pathol (2005) 1.17
CCAAT/enhancer-binding protein mediates carbon monoxide-induced suppression of cyclooxygenase-2. Am J Respir Cell Mol Biol (2006) 1.17
Insulin-like growth factor-binding protein-5 induces pulmonary fibrosis and triggers mononuclear cellular infiltration. Am J Pathol (2006) 1.17
Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol (2009) 1.16
Autophagy in vascular disease. Proc Am Thorac Soc (2010) 1.16
Functional significance of apoptosis in chronic obstructive pulmonary disease. COPD (2007) 1.16
Hyperoxia-induced LC3B interacts with the Fas apoptotic pathway in epithelial cell death. Am J Respir Cell Mol Biol (2011) 1.15
Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo. Transl Res (2008) 1.14
TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema. Am J Physiol Lung Cell Mol Physiol (2012) 1.13
Discovery of the gene signature for acute lung injury in patients with sepsis. Physiol Genomics (2009) 1.10
Carbon monoxide promotes Fas/CD95-induced apoptosis in Jurkat cells. J Biol Chem (2004) 1.10
Carbon monoxide inhibits human airway smooth muscle cell proliferation via mitogen-activated protein kinase pathway. Am J Respir Cell Mol Biol (2002) 1.09
Ex vivo carbon monoxide prevents cytochrome P450 degradation and ischemia/reperfusion injury of kidney grafts. Kidney Int (2008) 1.09
Insulin-like growth factor binding protein 5 induces skin fibrosis: A novel murine model for dermal fibrosis. Arthritis Rheum (2006) 1.09
TGF-beta1 stimulates HO-1 via the p38 mitogen-activated protein kinase in A549 pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol (2002) 1.09
MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production. Am J Physiol Lung Cell Mol Physiol (2007) 1.09
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. J Clin Invest (2015) 1.09
Autophagy in pulmonary diseases. Annu Rev Physiol (2011) 1.07
Heat-shock proteins: new keys to the development of cytoprotective therapies. Expert Opin Ther Targets (2006) 1.06
Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis. Autophagy (2011) 1.06
Inhaled carbon monoxide accelerates resolution of inflammation via unique proresolving mediator-heme oxygenase-1 circuits. J Immunol (2013) 1.06
CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema. Am J Pathol (2008) 1.06
Carbon monoxide ameliorates renal cold ischemia-reperfusion injury with an upregulation of vascular endothelial growth factor by activation of hypoxia-inducible factor. Transplantation (2008) 1.05
Carbon monoxide in sepsis. Antioxid Redox Signal (2007) 1.05