Published in J Virol on March 01, 1999
Revealing domain structure through linker-scanning analysis of the murine leukemia virus (MuLV) RNase H and MuLV and human immunodeficiency virus type 1 integrase proteins. J Virol (2006) 1.03
Assembly and catalysis of concerted two-end integration events by Moloney murine leukemia virus integrase. J Virol (2001) 0.88
Subcellular localization of feline immunodeficiency virus integrase and mapping of its karyophilic determinant. J Virol (2003) 0.86
A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain. Nucleic Acids Res (2010) 0.83
Refined solution structure of the dimeric N-terminal HHCC domain of HIV-2 integrase. J Biomol NMR (2000) 0.82
Transcription factor YY1 interacts with retroviral integrases and facilitates integration of moloney murine leukemia virus cDNA into the host chromosomes. J Virol (2010) 0.77
X-ray Crystal Structure of the N-Terminal Region of Moloney Murine Leukemia Virus Integrase and its Implications for Viral DNA Recognition. Proteins (2017) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. Biopolymers (1983) 99.69
Calculation of protein extinction coefficients from amino acid sequence data. Anal Biochem (1989) 29.15
Nucleotide sequence of Moloney murine leukaemia virus. Nature (1981) 24.82
Spectroscopic determination of tryptophan and tyrosine in proteins. Biochemistry (1967) 21.79
Retroviral DNA integration: structure of an integration intermediate. Cell (1988) 8.48
Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein. Proc Natl Acad Sci U S A (1989) 8.13
The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro. Cell (1990) 7.99
The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro. Cell (1990) 7.19
Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes. Proc Natl Acad Sci U S A (1986) 6.94
The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration. J Virol (1989) 6.83
Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases. Mol Cell Biol (1992) 6.77
Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases. Science (1994) 6.69
HIV-1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer. Cell (1991) 6.54
Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro. J Virol (1992) 6.07
Structure of the termini of DNA intermediates in the integration of retroviral DNA: dependence on IN function and terminal DNA sequence. Cell (1989) 6.04
The galvanization of biology: a growing appreciation for the roles of zinc. Science (1996) 5.67
Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature (1995) 5.48
Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus. Science (1992) 4.97
Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex. EMBO J (1993) 4.39
Retroviral integrase domains: DNA binding and the recognition of LTR sequences. Nucleic Acids Res (1991) 4.39
Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication. J Virol (1995) 4.27
Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding. Proc Natl Acad Sci U S A (1993) 3.99
Determination of protein secondary structure in solution by vacuum ultraviolet circular dichroism. J Mol Biol (1980) 3.60
Mutational analysis of the integrase protein of human immunodeficiency virus type 2. Proc Natl Acad Sci U S A (1992) 3.55
Identification of amino acid residues critical for endonuclease and integration activities of HIV-1 IN protein in vitro. Virology (1992) 3.43
Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein. Nucleic Acids Res (1993) 3.42
Complementation between HIV integrase proteins mutated in different domains. EMBO J (1993) 3.32
Zinc finger domains: hypotheses and current knowledge. Annu Rev Biophys Biophys Chem (1990) 3.31
Characterization of human immunodeficiency virus type 1 integrase expressed in Escherichia coli and analysis of variants with amino-terminal mutations. J Virol (1993) 3.28
Solution structure of the N-terminal zinc binding domain of HIV-1 integrase. Nat Struct Biol (1997) 2.81
Solution structure of the DNA binding domain of HIV-1 integrase. Biochemistry (1995) 2.69
Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro. J Biol Chem (1993) 2.69
The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding. J Virol (1994) 2.56
The DNA-binding domain of HIV-1 integrase has an SH3-like fold. Nat Struct Biol (1995) 2.53
Structural implications of spectroscopic characterization of a putative zinc finger peptide from HIV-1 integrase. J Biol Chem (1992) 2.52
Retroviral integrase functions as a multimer and can turn over catalytically. J Biol Chem (1992) 2.48
Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity. Proc Natl Acad Sci U S A (1996) 2.46
Genetic analysis of the human immunodeficiency virus type 1 integrase protein. J Virol (1994) 2.26
Methods to estimate the conformation of proteins and polypeptides from circular dichroism data. Anal Biochem (1996) 2.22
High-resolution structure of the catalytic domain of avian sarcoma virus integrase. J Mol Biol (1995) 2.16
Poly(pro)II helices in globular proteins: identification and circular dichroic analysis. Biochemistry (1994) 2.06
Characterization of the minimal DNA-binding domain of the HIV integrase protein. Nucleic Acids Res (1994) 1.98
The N-terminal region of HIV-1 integrase is required for integration activity, but not for DNA-binding. Biochem Biophys Res Commun (1992) 1.93
Photo-cross-linking studies suggest a model for the architecture of an active human immunodeficiency virus type 1 integrase-DNA complex. Biochemistry (1998) 1.83
Localization of DNA binding activity of HIV-1 integrase to the C-terminal half of the protein. AIDS Res Hum Retroviruses (1992) 1.82
Characterization of a DNA binding domain in the C-terminus of HIV-1 integrase by deletion mutagenesis. Nucleic Acids Res (1993) 1.79
Analysis of mutations in the integration function of Moloney murine leukemia virus: effects on DNA binding and cutting. J Virol (1990) 1.75
Zn2+ promotes the self-association of human immunodeficiency virus type-1 integrase in vitro. Biochemistry (1997) 1.69
Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking. Biochemistry (1997) 1.68
An essential interaction between distinct domains of HIV-1 integrase mediates assembly of the active multimer. J Biol Chem (1995) 1.67
Defining nucleic acid-binding properties of avian retrovirus integrase by deletion analysis. J Virol (1991) 1.62
Targeting of retroviral integrase by fusion to a heterologous DNA binding domain: in vitro activities and incorporation of a fusion protein into viral particles. Virology (1996) 1.45
Characterization of the forward and reverse integration reactions of the Moloney murine leukemia virus integrase protein purified from Escherichia coli. J Biol Chem (1993) 1.44
The solution structure of the amino-terminal HHCC domain of HIV-2 integrase: a three-helix bundle stabilized by zinc. Curr Biol (1997) 1.44
Formation of a stable complex between the human immunodeficiency virus integrase protein and viral DNA. Nucleic Acids Res (1994) 1.40
Integrase mutants of human immunodeficiency virus type 1 with a specific defect in integration. J Virol (1994) 1.33
Role of the His-Cys finger of Moloney murine leukemia virus integrase protein in integration and disintegration. J Virol (1993) 1.25
Zinc stimulates Mg2+-dependent 3'-processing activity of human immunodeficiency virus type 1 integrase in vitro. Biochemistry (1996) 1.14
Juxtaposition of two viral DNA ends in a bimolecular disintegration reaction mediated by multimers of human immunodeficiency virus type 1 or murine leukemia virus integrase. J Virol (1994) 1.08
Rous sarcoma virus integrase protein: mapping functions for catalysis and substrate binding. J Virol (1994) 1.03
Viral long terminal repeat substrate binding characteristics of the human immunodeficiency virus type 1 integrase. J Biol Chem (1994) 1.03
Functional domains of Moloney murine leukemia virus integrase defined by mutation and complementation analysis. J Virol (1996) 1.01
Characterization of the DNA-binding activity of HIV-1 integrase using a filter binding assay. Biochem Biophys Res Commun (1995) 0.92
Coordinated disintegration reactions mediated by Moloney murine leukemia virus integrase. J Virol (1996) 0.82
Implication of a central cysteine residue and the HHCC domain of Moloney murine leukemia virus integrase protein in functional multimerization. J Virol (1998) 0.82
Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front. Oncogene (2001) 4.40
Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes. Biochim Biophys Acta (1977) 2.65
Mucosal iodine staining improves endoscopic visualization of squamous dysplasia and squamous cell carcinoma of the esophagus in Linxian, China. Cancer (1998) 2.39
Circular dichroism and optical rotatory dispersion of proteins and polypeptides. Methods Enzymol (1973) 2.32
Histological precursors of oesophageal squamous cell carcinoma: results from a 13 year prospective follow up study in a high risk population. Gut (2005) 2.31
Analysis of retroviral pol gene products with antisera raised against fusion proteins produced in Escherichia coli. J Virol (1986) 2.18
Deciphering the design of the tropomyosin molecule. Proc Natl Acad Sci U S A (2001) 2.14
Mutational analysis of the envelope gene of Moloney murine leukemia virus. J Virol (1993) 2.08
Purification and characterization of murine retroviral reverse transcriptase expressed in Escherichia coli. J Biol Chem (1985) 2.02
Analysis of long terminal repeat circle junctions of human immunodeficiency virus type 1. J Virol (1990) 1.80
Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region. Biophys J (2001) 1.77
Mutational analysis of the N-linked glycosylation sites of the SU envelope protein of Moloney murine leukemia virus. J Virol (1992) 1.64
Loss of annexin 1 correlates with early onset of tumorigenesis in esophageal and prostate carcinoma. Cancer Res (2000) 1.50
Clearing of melanoma in situ with intralesional interferon alfa in a patient with xeroderma pigmentosum. Arch Dermatol (1994) 1.46
Characterization of the forward and reverse integration reactions of the Moloney murine leukemia virus integrase protein purified from Escherichia coli. J Biol Chem (1993) 1.44
Specificity of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H in removal of the minus-strand primer, tRNA(Lys3). J Biol Chem (1992) 1.44
CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation. J Immunol (1996) 1.42
Analysis of bacteriophage phi X174 gene A protein-mediated termination and reinitiation of phi X DNA synthesis. II. Structural characterization of the covalent phi X A protein-DNA complex. J Biol Chem (1984) 1.41
Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples. Am J Pathol (1994) 1.36
Risk factors for oesophageal squamous dysplasia in adult inhabitants of a high risk region of China. Gut (2005) 1.32
High levels of carcinogenic polycyclic aromatic hydrocarbons present within food from Linxian, China may contribute to that region's high incidence of oesophageal cancer. Eur J Cancer (1998) 1.30
Strongyloides stercoralis: eosinophil-dependent immune-mediated killing of third stage larvae in BALB/cByJ mice. Exp Parasitol (1996) 1.27
RNase H cleavage of tRNAPro mediated by M-MuLV and HIV-1 reverse transcriptases. Virology (1997) 1.25
Role of the His-Cys finger of Moloney murine leukemia virus integrase protein in integration and disintegration. J Virol (1993) 1.25
Adaptation of an osmotically fragile L-form of Streptococcus pyogenes to physiological osmotic conditions and its ability to destroy human heart cells in tissue culture. Infect Immun (1976) 1.24
Studies of esophageal balloon cytology in Linxian, China. Cancer Epidemiol Biomarkers Prev (1997) 1.23
Contributions of DNA polymerase subdomains to the RNase H activity of human immunodeficiency virus type 1 reverse transcriptase. J Virol (1994) 1.21
Allelic loss in esophageal squamous cell carcinoma patients with and without family history of upper gastrointestinal tract cancer. Clin Cancer Res (1999) 1.20
Purification and characterization of an active human immunodeficiency virus type 1 RNase H domain. J Virol (1993) 1.19
Identification of novel regions of allelic loss from a genomewide scan of esophageal squamous-cell carcinoma in a high-risk Chinese population. Genes Chromosomes Cancer (2000) 1.19
Strongyloides stercoralis: protective immunity to third-stage larvae inBALB/cByJ mice. Exp Parasitol (1995) 1.17
Frequent inactivation of the TP53 gene in esophageal squamous cell carcinoma from a high-risk population in China. Clin Cancer Res (2001) 1.14
Development of a urinary biomarker of human exposure to deoxynivalenol. Food Chem Toxicol (2003) 1.12
Second-site changes affect viability of amphotropic/ecotropic chimeric enveloped murine leukemia viruses. J Virol (2000) 1.09
Dihydrofolate reductase. Purification and characterization of the enzyme from an amethopterin-resistant mutant of Escherichia coli. Biochemistry (1972) 1.08
Divalent cation modulation of the ribonuclease functions of human immunodeficiency virus reverse transcriptase. Biochemistry (1995) 1.07
Characterization of chimeras between the ecotropic Moloney murine leukemia virus and the amphotropic 4070A envelope proteins. J Virol (1996) 1.07
The transcriptional form of the phosphoprotein of vesicular stomatitis virus is a trimer: structure and stability. Biochemistry (1996) 1.05
Cytotoxicity and inhibition of normal collagen synthesis in mouse fibroblasts by lipoteichoic acid from Streptococcus pyogenes type 12. Infect Immun (1983) 1.04
Analysis of cysteine mutations on the transmembrane protein of Moloney murine leukemia virus. Virology (1995) 1.03
Functional domains of Moloney murine leukemia virus integrase defined by mutation and complementation analysis. J Virol (1996) 1.01
A heuristic proposal for understanding steroidogenic processes. Endocr Rev (1984) 1.01
Development of a recombinant antigen vaccine against infection with the filarial worm Onchocerca volvulus. Infect Immun (2001) 1.01
Effects of two familial hypertrophic cardiomyopathy-causing mutations on alpha-tropomyosin structure and function. Biochemistry (1997) 1.01
High frequency allelic loss on chromosome 17p13.3-p11.1 in esophageal squamous cell carcinomas from a high incidence area in northern China. Carcinogenesis (2000) 1.01
RNA capping by the vaccinia virus guanylyltransferase. Structure of enzyme-guanylate intermediate. J Biol Chem (1984) 1.00
Polycyclic aromatic hydrocarbons identified in soot extracts from domestic coal-burning stoves of Henan Province, China. Environ Sci Technol (2001) 0.99
RNase H requirements for the second strand transfer reaction of human immunodeficiency virus type 1 reverse transcription. J Virol (1999) 0.97
Influence of substrate structure on disintegration activity of Moloney murine leukemia virus integrase. J Virol (1993) 0.97
Expression of cyclooxygenase-2 in human squamous cell carcinoma of the esophagus; an immunohistochemical survey. Anticancer Res (1999) 0.97
A calorimetric study of the folding-unfolding of an alpha-helix with covalently closed N and C-terminal loops. J Mol Biol (1999) 0.97
Alteration of tropomyosin function and folding by a nemaline myopathy-causing mutation. Biophys J (2000) 0.96
Replacement of the octadecenoic acid growth-requirement for Acholeplasma laidlawii A by cis-9,10-methylenehexadecanoic acid, a cyclopropane fatty acid. J Gen Microbiol (1974) 0.96
The effects of deletion of the amino-terminal helix on troponin C function and stability. J Biol Chem (1994) 0.94
Ov-ASP-1, the Onchocerca volvulus homologue of the activation associated secreted protein family is immunostimulatory and can induce protective anti-larval immunity. Parasite Immunol (2004) 0.94
Morphological changes and pathology of mouse glomeruli infected with a streptococcal L-form or exposed to lipoteichoic acid. Infect Immun (1983) 0.94
Structural specificity effects of trivalent polyamine analogues on the stabilization and conformational plasticity of triplex DNA. Biochem J (1996) 0.93
Strongyloides stercoralis: role of antibody and complement in immunity to the third stage of larvae in BALB/cByJ mice. Exp Parasitol (1996) 0.91
Analysis of mutations within the cytoplasmic domain of the Moloney murine leukemia virus transmembrane protein. Virology (1997) 0.91
Functional characterization of the N termini of murine leukemia virus envelope proteins. J Virol (2001) 0.91
Circular dichroism studies of dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli. Biochemistry (1972) 0.91
Detection of the von Hippel-Lindau gene deletion in cytologic specimens using microdissection and the polymerase chain reaction. Acta Cytol (1994) 0.89
Dihydrofolate reductase from a resistant subline of the L1210 lymphoma. Purification by affinity chromatography and ultraviolet difference spectrophotometric and circular dichroic studies. Biochemistry (1977) 0.89
von Hippel-Lindau disease gene deletion detected in microdissected sporadic human colon carcinoma specimens. Hum Pathol (1996) 0.88
Assembly and catalysis of concerted two-end integration events by Moloney murine leukemia virus integrase. J Virol (2001) 0.88
Expression of cyclooxygenase-2 in human adenocarcinomas of the gastric cardia and corpus. Oncol Rep (1999) 0.87
Common genetic variants of TP53 and BRCA2 in esophageal cancer patients and healthy individuals from low and high risk areas of northern China. Cancer Detect Prev (2003) 0.87
Adherence of Streptococcus agalactiae to synchronously growing human cell monolayers without lipoteichoic acid involvement. Infect Immun (1988) 0.86
Analysis of bacteriophage phi X174 gene A protein-mediated termination and reinitiation of phi X DNA synthesis. I. Characterization of the termination and reinitiation reactions. J Biol Chem (1984) 0.86
Evidence for two reduced triphosphopyridine nucleotide binding sites on dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli. J Biol Chem (1973) 0.85
Enzyme ligand complexes: spectroscopic studies. CRC Crit Rev Biochem (1975) 0.84
Modulation of the kinetics of cholesterol side-chain cleavage by an activator and by an inhibitor isolated from the cytosol of the cortex of bovine adrenals. Proc Natl Acad Sci U S A (1983) 0.83
Mutations in the N- and D-helices of the N-domain of troponin C affect the C-domain and regulatory function. Biophys J (1999) 0.83
Proton magnetic resonance studies of human hemoglobin. Histidine titrations. Biochim Biophys Acta (1972) 0.83
Strongyloides stercoralis: complete life cycle in SCID mice. Exp Parasitol (1995) 0.83
Coordinated disintegration reactions mediated by Moloney murine leukemia virus integrase. J Virol (1996) 0.82
Substitution of Asp114 or Arg116 in the fingers domain of moloney murine leukemia virus reverse transcriptase affects interactions with the template-primer resulting in decreased processivity. J Mol Biol (2001) 0.82
Implication of a central cysteine residue and the HHCC domain of Moloney murine leukemia virus integrase protein in functional multimerization. J Virol (1998) 0.82
Dihydrofolate reductase from a methotrexate-resistant Escherichia coli. J Biol Chem (1974) 0.82
Differential effects of C-terminal molecular tagged integrase on replication competent moloney murine leukemia virus. Virology (2000) 0.81
Allelic loss on chromosome bands 13q11-q13 in esophageal squamous cell carcinoma. Genes Chromosomes Cancer (2001) 0.81
Analysis of a temperature-sensitive mutation affecting the integration protein of Moloney murine leukemia virus. Virology (1993) 0.81
Specificity of priming reaction of HIV-1 reverse transcriptase, 2'-OH or 3'-OH. J Biol Chem (1994) 0.81
Mutational analysis of the N-terminus of Moloney murine leukemia virus integrase. Virology (2001) 0.81
Sequence requirements for removal of tRNA by an isolated human immunodeficiency virus type 1 RNase H domain. J Virol (1998) 0.81
Modification of specific lysine residues in E. coli methionyl-tRNA synthetase by crosslinking to E. coli formylmethionine tRNA. Biochem Biophys Res Commun (1984) 0.80
Effect of streptococcal lipoteichoic acid on prolyl hydroxylase activity as related to collagen formation in mouse fibroblast monolayers. Infect Immun (1985) 0.80
Conformational dynamics of estrogen receptors alpha and beta as revealed by intrinsic tryptophan fluorescence and circular dichroism. J Mol Endocrinol (2005) 0.80
Effect of polyanions on lysosomes and lysosomal enzymes of rat liver in vitro. Hoppe Seylers Z Physiol Chem (1974) 0.80
A comparative study of the aerosolized bronchodilators, isoproterenol, metaproterenol and terbutaline in asthma. Ann Allergy (1977) 0.79
Plasma immunotherapy in a child with acquired immunodeficiency syndrome. Pediatr Infect Dis J (1993) 0.79
Effects of hyperthermia on bone. I. Heating rate patterns induced by microwave irradiation in bone and muscle phantoms. Int J Hyperthermia (1993) 0.79
Effects of phospholipid and detergent on the substrate specificity of adrenal cytochrome P-450scc. Substrate binding and kinetics of cholesterol side chain oxidation. J Biol Chem (1981) 0.78
Strongyloides stercoralis host-adapted third-stage larvae are the target of eosinophil-associated immune-mediated killing in mice. J Parasitol (1998) 0.78
Circular dichroism studies of dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli B, MB 1428: ternary complexes. Biochim Biophys Acta (1975) 0.78
Covalent coupling of the variable loop of the elongator methionine tRNA to a specific lysine residue in Escherichia coli methionyl-tRNA synthetase. Biochemistry (1987) 0.78
Effects of temperature and concentration on bovine lens alpha-crystallin secondary structure: a circular dichroism spectroscopic study. Int J Biol Macromol (1997) 0.78
Further evidence that there is more than one adrenal 21-hydroxylase system. J Steroid Biochem (1987) 0.77