Published in J Virol on May 01, 2000
GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS. J Virol (2006) 1.86
Ribavirin induces error-prone replication of GB virus B in primary tamarin hepatocytes. J Virol (2001) 1.50
Development of a primary tamarin hepatocyte culture system for GB virus-B: a surrogate model for hepatitis C virus. J Virol (2000) 1.24
Identification of residues in the dengue virus type 2 NS2B cofactor that are critical for NS3 protease activation. J Virol (2004) 1.19
Development of a GB virus B marmoset model and its validation with a novel series of hepatitis C virus NS3 protease inhibitors. J Virol (2004) 1.16
Chronic hepatitis associated with GB virus B persistence in a tamarin after intrahepatic inoculation of synthetic viral RNA. Proc Natl Acad Sci U S A (2003) 1.11
In vivo analysis of the 3' untranslated region of GB virus B after in vitro mutagenesis of an infectious cDNA clone: persistent infection in a transfected tamarin. J Virol (2004) 1.07
Cell clones selected from the Huh7 human hepatoma cell line support efficient replication of a subgenomic GB virus B replicon. J Virol (2002) 0.93
Virus-specific T-cell immunity correlates with control of GB virus B infection in marmosets. J Virol (2007) 0.89
Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335. J Biol Chem (2011) 0.84
A cooperative interaction between nontranslated RNA sequences and NS5A protein promotes in vivo fitness of a chimeric hepatitis C/GB virus B. PLoS One (2009) 0.82
Hep3B human hepatoma cells support replication of the wild-type and a 5'-end deletion mutant GB virus B replicon. J Virol (2003) 0.81
Modeling HCV disease in animals: virology, immunology and pathogenesis of HCV and GBV-B infections. Front Microbiol (2014) 0.80
Antiviral activity and host gene induction by tamarin and marmoset interferon-alpha and interferon-gamma in the GBV-B primary hepatocyte culture model. Virology (2009) 0.79
Infection of Common Marmosets with GB Virus B Chimeric Virus Encoding the Major Nonstructural Proteins NS2 to NS4A of Hepatitis C Virus. J Virol (2016) 0.75
Changes in immune cell populations in the periphery and liver of GBV-B-infected and convalescent tamarins (Saguinus labiatus). Virus Res (2013) 0.75
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science (1989) 37.89
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science (1999) 24.31
The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Engl J Med (1999) 16.35
Randomised, double-blind, placebo-controlled trial of interferon alpha-2b with and without ribavirin for chronic hepatitis C. The Swedish Study Group. Lancet (1998) 14.31
Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N Engl J Med (1989) 8.10
Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science (1997) 7.53
Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites. J Virol (1993) 6.36
Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee. Proc Natl Acad Sci U S A (1997) 6.09
Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding. Structure (1998) 5.83
Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J (1996) 5.47
Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J Virol (1993) 5.41
Lack of protective immunity against reinfection with hepatitis C virus. Science (1992) 4.94
Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. J Virol (1997) 4.71
Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins. J Virol (1991) 4.63
Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA. J Virol (1996) 4.59
Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J Virol (1993) 4.57
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat Struct Biol (1999) 4.37
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell (1996) 4.12
Structure of the hepatitis C virus RNA helicase domain. Nat Struct Biol (1997) 3.80
Classification, nomenclature, and database development for hepatitis C virus (HCV) and related viruses: proposals for standardization. International Committee on Virus Taxonomy. Arch Virol (1998) 3.77
Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins. J Virol (1994) 3.51
Long-term histologic improvement and loss of detectable intrahepatic HCV RNA in patients with chronic hepatitis C and sustained response to interferon-alpha therapy. Ann Intern Med (1997) 3.49
Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes. J Virol (1993) 3.37
Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase. Structure (1999) 3.37
Identification of two flavivirus-like genomes in the GB hepatitis agent. Proc Natl Acad Sci U S A (1995) 3.30
C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity. Biochem Biophys Res Commun (1995) 3.09
Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses. J Virol (1994) 3.06
Pestivirus gene expression: protein p80 of bovine viral diarrhea virus is a proteinase involved in polyprotein processing. Virology (1991) 3.06
An infectious molecular clone of a Japanese genotype 1b hepatitis C virus. Hepatology (1999) 3.00
The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Cell (1996) 2.81
Transcripts of a chimeric cDNA clone of hepatitis C virus genotype 1b are infectious in vivo. Virology (1998) 2.76
Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing. J Virol (1995) 2.76
Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol (1998) 2.62
Studies on the transmission of human viral hepatitis to marmoset monkeys. I. Transmission of disease, serial passages, and description of liver lesions. J Exp Med (1967) 2.41
Genomic organization of GB viruses A and B: two new members of the Flaviviridae associated with GB agent hepatitis. J Virol (1995) 2.38
Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli. J Virol (1999) 2.37
A new RNA helicase isolated from HeLa cells that catalytically translocates in the 3' to 5' direction. J Biol Chem (1992) 2.33
RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region. J Biol Chem (1998) 2.29
A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro. J Virol (1995) 2.26
Pestivirus NS3 (p80) protein possesses RNA helicase activity. J Virol (1995) 2.06
Toward a surrogate model for hepatitis C virus: An infectious molecular clone of the GB virus-B hepatitis agent. Virology (1999) 1.95
Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form. Protein Sci (1998) 1.90
Hepatitis C virus persistence in human hematopoietic cells injected into SCID mice. Hepatology (1998) 1.74
Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition. Proc Natl Acad Sci U S A (1994) 1.57
Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus. J Virol (1998) 1.54
Expression, isolation, and characterization of the hepatitis C virus ATPase/RNA helicase. Arch Biochem Biophys (1995) 1.45
Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system. J Virol (1996) 1.38
Recent developments in HIV protease inhibitor therapy. Antiviral Res (1998) 1.33
Activity of purified hepatitis C virus protease NS3 on peptide substrates. J Virol (1996) 1.32
Identification of the sequence on NS4A required for enhanced cleavage of the NS5A/5B site by hepatitis C virus NS3 protease. J Virol (1996) 1.31
Mutational analysis of the GB virus B internal ribosome entry site. J Virol (2000) 1.29
A central hydrophobic domain of the hepatitis C virus NS4A protein is necessary and sufficient for the activation of the NS3 protease. J Gen Virol (1996) 1.29
GB virus B and hepatitis C virus NS3 serine proteases share substrate specificity. J Virol (1997) 1.24
Evolutionary relationship of hepatitis C, pesti-, flavi-, plantviruses, and newly discovered GB hepatitis agents. FEBS Lett (1996) 1.23
Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor. J Gen Virol (1999) 1.21
Generation of transmissible hepatitis C virions from a molecular clone in chimpanzees. Virology (1999) 1.18
A novel recombinant single-chain hepatitis C virus NS3-NS4A protein with improved helicase activity. Protein Sci (1999) 1.15
Immunity in chimpanzees chronically infected with hepatitis C virus: role of minor quasispecies in reinfection. J Virol (1998) 1.09
Serine protease of hepatitis C virus expressed in insect cells as the NS3/4A complex. Biochemistry (1998) 1.07
Modulation of hepatitis C virus NS3 protease and helicase activities through the interaction with NS4A. Biochemistry (1999) 1.06
Hepatitis G virus encodes protease activities which can effect processing of the virus putative nonstructural proteins. J Virol (1998) 1.06
Nucleoside triphosphatase and RNA helicase activities associated with GB virus B nonstructural protein 3. Virology (1999) 1.00
Superinfection by homotypic virus in hepatitis C virus carriers: studies on patients with post-transfusion hepatitis. J Med Virol (1996) 0.99
Identification of a novel sequence at the 3' end of the GB virus B genome. J Virol (1999) 0.93
Human immunodeficiency virus protease inhibitors. Pharmacotherapy (1999) 0.93
Chimeric Sindbis viruses dependent on the NS3 protease of hepatitis C virus. J Virol (1997) 0.93
Cross-genotypic interaction between hepatitis C virus NS3 protease domains and NS4A cofactors. J Hepatol (2000) 0.92
Generation of a novel poliovirus with a requirement of hepatitis C virus protease NS3 activity. Virology (1996) 0.89
Hepatitis C. Seroprevalence of hepatitis C virus (HCV) in a population sample. Wkly Epidemiol Rec (1996) 0.88
The conformation of hepatitis C virus NS3 proteinase with and without NS4A: a structural basis for the activation of the enzyme by its cofactor. Clin Diagn Virol (1998) 0.85
Construction of hepatitis C-SIN virus recombinants with replicative dependency on hepatitis C virus serine protease activity. J Virol Methods (1997) 0.83
Selection of functional variants of the NS3-NS4A protease of hepatitis C virus by using chimeric sindbis viruses. J Virol (1999) 0.82
Transgenic mouse expressing a full-length hepatitis C virus cDNA. Jpn J Cancer Res (1998) 0.81
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell (1997) 16.78
Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat Med (1996) 12.11
Crystal structure of the extracellular segment of integrin alpha Vbeta3. Science (2001) 8.12
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol (1997) 6.61
The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat Med (2000) 5.73
X-ray structure determination of fully hydrated L alpha phase dipalmitoylphosphatidylcholine bilayers. Biophys J (1996) 5.60
Association of diabetes mellitus and chronic hepatitis C virus infection. Hepatology (1999) 4.59
Secondary structure of the 5' nontranslated regions of hepatitis C virus and pestivirus genomic RNAs. Nucleic Acids Res (1992) 4.58
Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses. J Virol (1987) 4.49
Distinctive nucleotide sequences adjacent to multiple initiation and termination sites of an early vaccinia virus gene. Cell (1981) 4.42
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat Struct Biol (1999) 4.37
VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest (2000) 4.36
Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J Exp Med (2000) 4.33
Survival by time of day of hemodialysis in an elderly cohort. JAMA (2001) 4.09
Measurement of chain tilt angle in fully hydrated bilayers of gel phase lecithins. Biophys J (1993) 4.08
Structure of the hepatitis C virus RNA helicase domain. Nat Struct Biol (1997) 3.80
A human 88-kD membrane glycoprotein (CD36) functions in vitro as a receptor for a cytoadherence ligand on Plasmodium falciparum-infected erythrocytes. J Clin Invest (1989) 3.71
Activated antigen-specific CD8+ T cells persist in the lungs following recovery from respiratory virus infections. J Immunol (2001) 3.68
Insulin-like growth factor II receptor as a multifunctional binding protein. Nature (1987) 3.52
Direct mapping of adeno-associated virus capsid proteins B and C: a possible ACG initiation codon. Proc Natl Acad Sci U S A (1985) 3.31
Transcription of the hepatitis B surface antigen gene in cultured murine cells initiates within the presurface region. J Virol (1984) 3.30
The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold. J Mol Biol (1999) 3.25
A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells. Proc Natl Acad Sci U S A (1996) 3.25
A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD. Neurology (2001) 3.25
Synthesis of hepatitis B surface antigen in mammalian cells: expression of the entire gene and the coding region. J Virol (1983) 3.24
The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science (1999) 3.23
Radioimmunofocus assay for quantitation of hepatitis A virus in cell cultures. J Clin Microbiol (1983) 3.20
Protection from respiratory virus infections can be mediated by antigen-specific CD4(+) T cells that persist in the lungs. J Exp Med (2001) 3.19
A reticulocyte-binding protein complex of Plasmodium vivax merozoites. Cell (1992) 3.19
Stability of a stem-loop involving the initiator AUG controls the efficiency of internal initiation of translation on hepatitis C virus RNA. RNA (1996) 3.14
Structural requirements for initiation of translation by internal ribosome entry within genome-length hepatitis C virus RNA. Virology (1996) 3.14
A phylogenetically conserved stem-loop structure at the 5' border of the internal ribosome entry site of hepatitis C virus is required for cap-independent viral translation. J Virol (1999) 3.13
Relationship of a putative receptor protein kinase from maize to the S-locus glycoproteins of Brassica. Nature (1990) 3.11
Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen. N Engl J Med (2001) 3.02
An infectious molecular clone of a Japanese genotype 1b hepatitis C virus. Hepatology (1999) 3.00
Atrophy and intestinal metaplasia one year after cure of H. pylori infection: a prospective, randomized study. Gastroenterology (2000) 2.99
Molecular cloning and characterization of hepatitis A virus cDNA. Proc Natl Acad Sci U S A (1983) 2.92
Type A viral hepatitis. New developments in an old disease. N Engl J Med (1985) 2.86
Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonresponders. Gastroenterology (2000) 2.83
The 5' nontranslated region of hepatitis A virus RNA: secondary structure and elements required for translation in vitro. J Virol (1991) 2.83
Transcription of hepatitis B virus by RNA polymerase II. Mol Cell Biol (1983) 2.81
New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a. J Clin Microbiol (1997) 2.78
Incompletely base-paired flip-flop terminal loops link the two DNA strands of the vaccinia virus genome into one uninterrupted polynucleotide chain. Cell (1982) 2.76
SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells. Antimicrob Agents Chemother (2006) 2.75
The nucleotide sequence of chromosome I from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1995) 2.74
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene (2007) 2.68
Calcium entry blockers and activators: conformational and structural determinants of dihydropyrimidine calcium channel modulators. J Med Chem (1995) 2.68
Purification and characterization of a DNA-dependent RNA polymerase from vaccinia virions. J Biol Chem (1980) 2.66
The size and conformation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virions. J Virol (1996) 2.65
The rhinovirus type 14 genome contains an internally located RNA structure that is required for viral replication. RNA (1998) 2.61
Assignment of the genome segments of bluetongue virus type 1 to the proteins which they encode. Virology (1984) 2.60
Infectious RNA transcripts from Ross River virus cDNA clones and the construction and characterization of defined chimeras with Sindbis virus. Virology (1991) 2.57
Molecular epidemiology of human hepatitis A virus defined by an antigen-capture polymerase chain reaction method. Proc Natl Acad Sci U S A (1990) 2.52
Complete nucleotide sequence of a cell culture-adapted variant of hepatitis A virus: comparison with wild-type virus with restricted capacity for in vitro replication. Virology (1988) 2.51
Maturation cleavage required for infectivity of a nodavirus. J Virol (1992) 2.50
SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo. Proc Natl Acad Sci U S A (2001) 2.49
Randomized phase III study 306: adjunctive perampanel for refractory partial-onset seizures. Neurology (2012) 2.45
RNA- and DNA-binding activities in hepatitis B virus capsid protein: a model for their roles in viral replication. J Virol (1992) 2.42
Mutagenesis of the 3' nontranslated region of Sindbis virus RNA. J Virol (1990) 2.42
Randomised comparison between adrenaline injection alone and adrenaline injection plus heat probe treatment for actively bleeding ulcers. BMJ (1997) 2.42
Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli. J Virol (1999) 2.37
Protein covalently linked to foot-and-mouth disease virus RNA. Nature (1977) 2.35
Location of the initiation site for protein synthesis on foot-and-mouth disease virus RNA by in vitro translation of defined fragments of the RNA. J Virol (1980) 2.34
Assembly of viral particles in Xenopus oocytes: pre-surface-antigens regulate secretion of the hepatitis B viral surface envelope particle. Proc Natl Acad Sci U S A (1986) 2.28
Small-bowel perforations related to endoscopic retrograde cholangiopancreatography (ERCP) in patients with Billroth II gastrectomy. Endoscopy (1999) 2.24
All foot and mouth disease virus serotypes initiate protein synthesis at two separate AUGs. Nucleic Acids Res (1987) 2.22
A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase. Virology (2001) 2.21
Synthetic nano-scale fibrous extracellular matrix. J Biomed Mater Res (1999) 2.21
Frequency of illness associated with epidemic hepatitis A virus infections in adults. Am J Epidemiol (1985) 2.20
De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase. J Virol (2000) 2.19
A complex translational program generates multiple novel proteins from the latently expressed kaposin (K12) locus of Kaposi's sarcoma-associated herpesvirus. J Virol (1999) 2.16
Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases. Nat Commun (2013) 2.10
Oocyst-transmitted toxoplasmosis associated with ingestion of contaminated water. N Engl J Med (1982) 2.07
A re-appraisal of the biochemical map of foot-and-mouth disease virus RNA. J Gen Virol (1978) 2.06
Cell cycle regulation of hepatitis C virus internal ribosomal entry site-directed translation. Gastroenterology (2000) 2.05
Obesity as a predictor of poor antibody response to hepatitis B plasma vaccine. JAMA (1985) 2.03
The replication of picornaviruses. J Gen Virol (1979) 2.03
Two Plasmodium falciparum genes express merozoite proteins that are related to Plasmodium vivax and Plasmodium yoelii adhesive proteins involved in host cell selection and invasion. Proc Natl Acad Sci U S A (2000) 2.00
Low efficiency of the 5' nontranslated region of hepatitis A virus RNA in directing cap-independent translation in permissive monkey kidney cells. J Virol (1994) 2.00
Hepatitis B virus capsid particles are assembled from core-protein dimer precursors. Proc Natl Acad Sci U S A (1992) 1.98
Evidence that hepatitis D virus needs hepatitis B virus to cause hepatocellular damage. Am J Clin Pathol (1992) 1.98
Transmission of hepatitis A virus among recently captured Panamanian owl monkeys. J Med Virol (1982) 1.94
Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus. Antimicrob Agents Chemother (1997) 1.94
Comparisons between the structures of HCV and Rep helicases reveal structural similarities between SF1 and SF2 super-families of helicases. Protein Sci (1998) 1.93
Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule. Proc Natl Acad Sci U S A (2001) 1.92
Clinical characteristics and MR imaging features of nonalcoholic Wernicke encephalopathy. AJNR Am J Neuroradiol (2008) 1.92
Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells. Science (1995) 1.92
Factors predictive of a beneficial response to therapy of hepatitis C. Hepatology (1997) 1.90
Atomic resolution imaging of a carbon nanotube from diffraction intensities. Science (2003) 1.90