Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells.

PubWeight™: 2.71‹?› | Rank: Top 1%

🔗 View Article (PMID 10936180)

Published in J Neurochem on September 01, 2000

Authors

M Encinas1, M Iglesias, Y Liu, H Wang, A Muhaisen, V Ceña, C Gallego, J X Comella

Author Affiliations

1: Grup de Neurobiologia Molecular, Department de Ciències Mèdiques Bàsiques, Facultat de Medicina, Universitat de Lleida, Lleida, Catalonia, Spain.

Articles citing this

(truncated to the top 100)

A human peripheral blood monocyte-derived subset acts as pluripotent stem cells. Proc Natl Acad Sci U S A (2003) 2.09

MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets. Mol Cell Biol (2009) 2.08

A specific LSD1/KDM1A isoform regulates neuronal differentiation through H3K9 demethylation. Mol Cell (2015) 1.84

RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation. Cell (2017) 1.39

Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models. Methods Enzymol (2009) 1.36

Nrf2 promotes neuronal cell differentiation. Free Radic Biol Med (2009) 1.22

Neuroimmunity and the blood-brain barrier: molecular regulation of leukocyte transmigration and viral entry into the nervous system with a focus on neuroAIDS. J Neuroimmune Pharmacol (2006) 1.21

Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β. Protein Cell (2010) 1.19

Tissue-specific control of brain-enriched miR-7 biogenesis. Genes Dev (2013) 1.18

Haplotype-specific expression of the N-terminal exons 2 and 3 at the human MAPT locus. Neurobiol Aging (2007) 1.18

Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling. J Immunol (2010) 1.17

Nontelomeric TRF2-REST interaction modulates neuronal gene silencing and fate of tumor and stem cells. Curr Biol (2008) 1.14

Basic helix-loop-helix proteins bind to TrkB and p21(Cip1) promoters linking differentiation and cell cycle arrest in neuroblastoma cells. Mol Cell Biol (2004) 1.13

Considerations for the use of SH-SY5Y neuroblastoma cells in neurobiology. Methods Mol Biol (2013) 1.12

MicroRNAs-10a and -10b contribute to retinoic acid-induced differentiation of neuroblastoma cells and target the alternative splicing regulatory factor SFRS1 (SF2/ASF). J Biol Chem (2010) 1.11

The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation. Cell Cycle (2014) 1.08

The COPI vesicle complex binds and moves with survival motor neuron within axons. Hum Mol Genet (2011) 1.08

WW domain-containing oxidoreductase promotes neuronal differentiation via negative regulation of glycogen synthase kinase 3β. Cell Death Differ (2011) 1.05

TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells. Oncogene (2010) 1.04

Differentiated neuroblastoma cells provide a highly efficient model for studies of productive varicella-zoster virus infection of neuronal cells. J Virol (2011) 1.01

Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2. J Biol Chem (2010) 1.01

ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. PLoS One (2010) 0.98

Expression of microtubule-associated protein 2 in benign and malignant melanocytes: implications for differentiation and progression of cutaneous melanoma. Am J Pathol (2001) 0.97

Evidence for neuroprotective properties of human umbilical cord blood cells after neuronal hypoxia in vitro. BMC Neurosci (2008) 0.96

Differential effect of membrane cholesterol removal on mu- and delta-opioid receptors: a parallel comparison of acute and chronic signaling to adenylyl cyclase. J Biol Chem (2009) 0.96

Cannabinoid receptors CB1 and CB2 form functional heteromers in brain. J Biol Chem (2012) 0.96

TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons. Proc Natl Acad Sci U S A (2013) 0.95

The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain. Hum Mol Genet (2010) 0.95

Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth. J Neurochem (2010) 0.94

XRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cells. Nucleic Acids Res (2008) 0.94

Microglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cells. PLoS Pathog (2009) 0.94

Retinoic acid-induced differentiation increases the rate of oxygen consumption and enhances the spare respiratory capacity of mitochondria in SH-SY5Y cells. Mech Ageing Dev (2012) 0.93

A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration. BMC Genomics (2012) 0.93

Ethyl acetate extract of germinated brown rice attenuates hydrogen peroxide-induced oxidative stress in human SH-SY5Y neuroblastoma cells: role of anti-apoptotic, pro-survival and antioxidant genes. BMC Complement Altern Med (2013) 0.93

Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria. Cell Mol Life Sci (2010) 0.93

Retinoic acid reduces human neuroblastoma cell migration and invasiveness: effects on DCX, LIS1, neurofilaments-68 and vimentin expression. BMC Cancer (2008) 0.92

Nicotinamide N-methyltransferase expression in SH-SY5Y neuroblastoma and N27 mesencephalic neurones induces changes in cell morphology via ephrin-B2 and Akt signalling. Cell Death Dis (2013) 0.91

Alternative polyadenylation and miR-34 family members regulate tau expression. J Neurochem (2013) 0.91

Closing the phenotypic gap between transformed neuronal cell lines in culture and untransformed neurons. J Neurosci Methods (2008) 0.91

Optimising parameters for the differentiation of SH-SY5Y cells to study cell adhesion and cell migration. BMC Res Notes (2013) 0.91

Identification and classification of genes regulated by phosphatidylinositol 3-kinase- and TRKB-mediated signalling pathways during neuronal differentiation in two subtypes of the human neuroblastoma cell line SH-SY5Y. BMC Res Notes (2008) 0.90

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines. Neurobiol Dis (2012) 0.90

Modulation of BK channel by MicroRNA-9 in neurons after exposure to HIV and methamphetamine. J Neuroimmune Pharmacol (2013) 0.89

Maturation-dependent responses of human neuronal cells to western equine encephalitis virus infection and type I interferons. Virology (2007) 0.89

Trimeric tau is toxic to human neuronal cells at low nanomolar concentrations. Int J Cell Biol (2013) 0.89

Effects of IKAP/hELP1 deficiency on gene expression in differentiating neuroblastoma cells: implications for familial dysautonomia. PLoS One (2011) 0.89

Neurogenic maturation of human dental pulp stem cells following neurosphere generation induces morphological and electrophysiological characteristics of functional neurons. Stem Cells Dev (2014) 0.89

Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-β prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes. J Neurosci Res (2011) 0.88

Nanoporous peptide particles for encapsulating and releasing neurotrophic factors in an animal model of neurodegeneration. Adv Mater (2012) 0.88

Protective role of STAT3 in NMDA and glutamate-induced neuronal death: negative regulatory effect of SOCS3. PLoS One (2012) 0.87

TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6. Mol Neurodegener (2011) 0.87

Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern. Dev Biol (2013) 0.86

StearoylCoA desaturase-5: a novel regulator of neuronal cell proliferation and differentiation. PLoS One (2012) 0.86

Nontelomeric splice variant of telomere repeat-binding factor 2 maintains neuronal traits by sequestering repressor element 1-silencing transcription factor. Proc Natl Acad Sci U S A (2011) 0.86

Toxic Oligomeric Alpha-Synuclein Variants Present in Human Parkinson's Disease Brains Are Differentially Generated in Mammalian Cell Models. Biomolecules (2015) 0.86

Charcot-Marie-Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilaments. Acta Neuropathol (2013) 0.85

Neuronal toxicity in HIV CNS disease. Future Virol (2012) 0.85

Microglial responses to dopamine in a cell culture model of Parkinson's disease. Neurobiol Aging (2008) 0.85

Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease. Proc Natl Acad Sci U S A (2014) 0.85

A monoclonal antibody TrkB receptor agonist as a potential therapeutic for Huntington's disease. PLoS One (2014) 0.85

ORF7 of varicella-zoster virus is a neurotropic factor. J Virol (2012) 0.85

Comprehensive cytogenomic profile of the in vitro neuronal model SH-SY5Y. Neurogenetics (2012) 0.84

Dlx2 homeobox gene transcriptional regulation of Trkb neurotrophin receptor expression during mouse retinal development. Nucleic Acids Res (2007) 0.84

The expression of the human neuronal alpha3 Na+,K+-ATPase subunit gene is regulated by the activity of the Sp1 and NF-Y transcription factors. Biochem J (2005) 0.84

Proteolytic control of neurite outgrowth inhibitor NOGO-A by the cAMP/PKA pathway. Proc Natl Acad Sci U S A (2014) 0.83

BDNF and the maturation of posttranscriptional regulatory networks in human SH-SY5Y neuroblast differentiation. Front Cell Neurosci (2014) 0.83

Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways. J Biol Chem (2009) 0.82

Differential Expression of Tyrosine Hydroxylase Protein and Apoptosis-Related Genes in Differentiated and Undifferentiated SH-SY5Y Neuroblastoma Cells Treated with MPP(.). Neurol Res Int (2015) 0.82

The SMN protein is a key regulator of nuclear architecture in differentiating neuroblastoma cells. Traffic (2009) 0.82

Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: implications for Parkinson's disease. Exp Neurol (2014) 0.82

Characterization of Differentiated SH-SY5Y as Neuronal Screening Model Reveals Increased Oxidative Vulnerability. J Biomol Screen (2016) 0.81

Constitutive activity of the A2A adenosine receptor and compartmentalised cyclic AMP signalling fine-tune noradrenaline release. Purinergic Signal (2012) 0.81

Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation. J Neuropathol Exp Neurol (2011) 0.81

Inhibition of neuronal cell death after retinoic acid-induced down-regulation of P2X7 nucleotide receptor expression. Mol Cell Biochem (2009) 0.81

Prolyl isomerase Pin1 and protein kinase HIPK2 cooperate to promote cortical neurogenesis by suppressing Groucho/TLE:Hes1-mediated inhibition of neuronal differentiation. Cell Death Differ (2013) 0.81

TIRFM and pH-sensitive GFP-probes to evaluate neurotransmitter vesicle dynamics in SH-SY5Y neuroblastoma cells: cell imaging and data analysis. J Vis Exp (2015) 0.80

Expression of URG4/URGCP, Cyclin D1, Bcl-2, and Bax genes in retinoic acid treated SH-SY5Y human neuroblastoma cells. Contemp Oncol (Pozn) (2013) 0.80

Identification of small molecule inhibitors of beta-amyloid cytotoxicity through a cell-based high-throughput screening platform. J Biomol Screen (2008) 0.80

The SH-SY5Y cell line in Parkinson's disease research: a systematic review. Mol Neurodegener (2017) 0.79

The cellular distribution and Ser262 phosphorylation of tau protein are regulated by BDNF in vitro. PLoS One (2014) 0.79

Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism. PLoS One (2012) 0.79

Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth. J Clin Invest (2014) 0.78

A novel disorder reveals clathrin heavy chain-22 is essential for human pain and touch development. Brain (2015) 0.78

N-acetylaspartate (NAA) induces neuronal differentiation of SH-SY5Y neuroblastoma cell line and sensitizes it to chemotherapeutic agents. Oncotarget (2016) 0.78

Eicosapentaenoic acid (EPA) increases cell viability and expression of neurotrophin receptors in retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cells. Eur J Nutr (2008) 0.78

Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway. Nat Commun (2016) 0.78

The Na+/H+ exchanger NHE6 modulates endosomal pH to control processing of amyloid precursor protein in a cell culture model of Alzheimer disease. J Biol Chem (2015) 0.78

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line. J Vis Exp (2016) 0.77

A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation. PLoS One (2013) 0.77

Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis. Mol Neurobiol (2015) 0.77

Ameliorative effects of a combination of baicalin, jasminoidin and cholic acid on ibotenic acid-induced dementia model in rats. PLoS One (2013) 0.77

MPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells. Cell Death Discov (2017) 0.76

Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases. J Neuroinflammation (2016) 0.76

Functional switching of ATM: sensor of DNA damage in proliferating cells and mediator of Akt survival signal in post-mitotic human neuron-like cells. Chin J Cancer (2012) 0.76

Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism. Oncotarget (2015) 0.76

Modulation of tau phosphorylation by environmental copper. Transl Neurodegener (2014) 0.76

Morphological Differentiation Towards Neuronal Phenotype of SH-SY5Y Neuroblastoma Cells by Estradiol, Retinoic Acid and Cholesterol. Neurochem Res (2015) 0.76

IKAP/hELP1 down-regulation in neuroblastoma cells causes enhanced cell adhesion mediated by contactin overexpression. Cell Adh Migr (2011) 0.76

DNA Targeting Sequence Improves Magnetic Nanoparticle-Based Plasmid DNA Transfection Efficiency in Model Neurons. Int J Mol Sci (2015) 0.76

Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways. Cell Death Dis (2014) 0.76

Articles by these authors

(truncated to the top 100)

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity (2000) 16.03

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science (1997) 13.61

LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell (2001) 11.99

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature (2000) 11.49

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med (2000) 7.38

Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest (2001) 7.20

Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol (1997) 6.61

Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med (1999) 6.27

Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein. Science (1997) 6.10

Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci U S A (1996) 6.00

Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base. Pharmacogenomics J (2001) 5.94

Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell (1996) 5.45

Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes. Biophys J (2001) 5.28

HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol (2000) 4.96

The urea reduction ratio and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis. N Engl J Med (1993) 4.88

HMG-1 as a mediator of acute lung inflammation. J Immunol (2000) 4.78

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc Natl Acad Sci U S A (2001) 4.62

Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science (1999) 4.61

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A (2001) 4.58

Diffusion of the Interspecies Electron Carriers H(2) and Formate in Methanogenic Ecosystems and Its Implications in the Measurement of K(m) for H(2) or Formate Uptake. Appl Environ Microbiol (1989) 4.53

The cpr5 mutant of Arabidopsis expresses both NPR1-dependent and NPR1-independent resistance. Plant Cell (1997) 4.47

Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity (2000) 4.44

Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol (2001) 4.39

Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques (1994) 4.24

Evolutionary analyses of the human genome. Nature (2001) 4.13

Gene expression profiles during the initial phase of salt stress in rice. Plant Cell (2001) 4.11

Junction adhesion molecule is a receptor for reovirus. Cell (2001) 4.00

Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex. Genes Dev (1998) 3.84

Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. J Biol Chem (2000) 3.75

Quantum ground state and single-phonon control of a mechanical resonator. Nature (2010) 3.71

Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol (1985) (1999) 3.65

Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury. J Biol Chem (1996) 3.65

Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol (2001) 3.63

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates. Proc Natl Acad Sci U S A (1997) 3.59

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med (1999) 3.57

Response regulator output in bacterial chemotaxis. EMBO J (1998) 3.40

Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY. Cell (1997) 3.32

Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors. Mol Ther (2000) 3.32

Requirement for math5 in the development of retinal ganglion cells. Genes Dev (2001) 3.26

Alternative gene form discovery and candidate gene selection from gene indexing projects. Genome Res (1998) 3.26

A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature (1997) 3.26

Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. Nature (2000) 3.26

Hyperexpression of mitogen-activated protein kinase in human breast cancer. J Clin Invest (1997) 3.26

Proto-oncogene PML controls genes devoted to MHC class I antigen presentation. Nature (1998) 3.22

Deletion of the K(V)1.1 potassium channel causes epilepsy in mice. Neuron (1998) 3.18

Termination of Medi-Cal benefits. A follow-up study one year later. N Engl J Med (1986) 3.16

An association between renal cell carcinoma and lymphoid malignancies. A case series of eight patients. Cancer (1996) 3.12

Subsequent pulmonary embolism: risk after a negative helical CT pulmonary angiogram--prospective comparison with scintigraphy. Radiology (2000) 3.06

IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J (1998) 2.99

Activation of a mitogen-activated protein kinase pathway is involved in disease resistance in tobacco. Proc Natl Acad Sci U S A (2001) 2.98

Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest (1997) 2.93

Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions. EMBO J (1993) 2.92

Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles. J Virol (1997) 2.91

Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export. EMBO J (1998) 2.90

Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem (2000) 2.89

A floral transmitting tissue-specific glycoprotein attracts pollen tubes and stimulates their growth. Cell (1995) 2.85

Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol (2001) 2.85

Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene (2012) 2.82

Structure of the adenylyl cyclase catalytic core. Nature (1997) 2.81

Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. Intern Med J (2012) 2.81

Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity. J Virol (2001) 2.79

MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene (2007) 2.79

Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat Immunol (2000) 2.78

Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution. Acta Crystallogr D Biol Crystallogr (1999) 2.77

Interlocked feedback loops contribute to the robustness of the Neurospora circadian clock. Proc Natl Acad Sci U S A (2001) 2.77

Ecology. Giant pandas in a changing landscape. Science (2001) 2.73

Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol (2001) 2.73

Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions. Br J Anaesth (2013) 2.70

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene (2007) 2.68

Effect of peer led programme for asthma education in adolescents: cluster randomised controlled trial. BMJ (2001) 2.67

Adhesion formation after previous caesarean section-a meta-analysis and systematic review. BJOG (2010) 2.66

The regulation of reactive oxygen species production during programmed cell death. J Cell Biol (1998) 2.62

Strongly enhanced current densities in superconducting coated conductors of YBa2Cu3O7-x + BaZrO3. Nat Mater (2004) 2.61

The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci (1998) 2.58

The C termini of Arabidopsis cryptochromes mediate a constitutive light response. Cell (2000) 2.53

Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. Cancer Res (2001) 2.53

Nitric oxide and cutaneous active vasodilation during heat stress in humans. J Appl Physiol (1985) (1998) 2.53

Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature (2000) 2.51

Integrin activation by R-ras. Cell (1996) 2.50

The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J (1998) 2.50

Uncoupling PR gene expression from NPR1 and bacterial resistance: characterization of the dominant Arabidopsis cpr6-1 mutant. Plant Cell (1998) 2.48

On the use of thiol-modifying agents to determine channel topology. Neuropharmacology (1996) 2.47

Zinc inhibition of mitochondrial aconitase and its importance in citrate metabolism of prostate epithelial cells. J Biol Chem (1997) 2.47

Increased thermal stability of proteins in the presence of naturally occurring osmolytes. Biochemistry (1992) 2.47

Profiling serine hydrolase activities in complex proteomes. Biochemistry (2001) 2.46

High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Arthritis Rheum (2002) 2.45

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci U S A (1999) 2.42

A theoretical solution for the frictionless rolling contact of cylindrical biphasic articular cartilage layers. J Biomech (1995) 2.42

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Oncogene (2012) 2.41

On sample size calculation in bioequivalence trials. J Pharmacokinet Pharmacodyn (2001) 2.40

A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis. Neurology (2011) 2.39

GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development (1997) 2.38

Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37

Design of allele-specific inhibitors to probe protein kinase signaling. Curr Biol (1998) 2.36

Establishment, maintenance and description of cell lines from the tick Ixodes scapularis. J Parasitol (1994) 2.36

Fire and flood management of coastal swamp enabled first rice paddy cultivation in east China. Nature (2007) 2.36

Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron (1997) 2.34

Discovering molecular pathways from protein interaction and gene expression data. Bioinformatics (2003) 2.32

Phylogeny of the Simbu serogroup of the genus Bunyavirus. J Gen Virol (2001) 2.30