Published in J Clin Invest on June 01, 1999
Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proc Natl Acad Sci U S A (2005) 1.92
Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E. Proc Natl Acad Sci U S A (2001) 1.51
Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo. J Bone Miner Res (2013) 1.47
Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength? World J Diabetes (2014) 1.44
Apolipoprotein E gene polymorphism and risk of type 2 diabetes and cardiovascular disease. Cardiovasc Diabetol (2016) 1.43
Anatomical differences and atherosclerosis in apolipoprotein E-deficient mice with 129/SvEv and C57BL/6 genetic backgrounds. Atherosclerosis (2007) 1.42
A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med (2004) 1.28
Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond. J Lipid Res (2008) 1.26
ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain. Neurobiol Aging (2007) 1.24
Genetic modifiers of atherosclerosis in mice. Arterioscler Thromb Vasc Biol (2000) 1.22
Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease. Cardiovasc Diabetol (2012) 1.21
A practical approach to using mice in atherosclerosis research. Clin Biochem Rev (2004) 1.16
Presence of oestrogen receptor type beta in human retina. Br J Ophthalmol (2001) 1.15
Molecular mechanism of apolipoprotein E binding to lipoprotein particles. Biochemistry (2009) 1.11
Differential modulation of diet-induced obesity and adipocyte functionality by human apolipoprotein E3 and E4 in mice. Int J Obes (Lond) (2008) 1.05
Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice. Neurobiol Aging (2010) 1.04
Effect of apolipoprotein E on the cerebral load of latent herpes simplex virus type 1 DNA. J Virol (2006) 0.97
Genetically altering Abeta distribution from the brain to the vasculature ameliorates tau pathology. Brain Pathol (2008) 0.96
Human apolipoprotein E4 targeted replacement in mice reveals increased susceptibility to sleep disruption and intermittent hypoxia. Am J Physiol Regul Integr Comp Physiol (2012) 0.95
Apolipoprotein E and cholesterol in aging and disease in the brain. Future Lipidol (2008) 0.94
Apolipoprotein E4 in macrophages enhances atherogenesis in a low density lipoprotein receptor-dependent manner. J Biol Chem (2007) 0.94
Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress. J Biol Chem (2012) 0.93
Acrolein consumption induces systemic dyslipidemia and lipoprotein modification. Toxicol Appl Pharmacol (2009) 0.92
Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in mice. Behav Pharmacol (2010) 0.92
Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice. Arterioscler Thromb Vasc Biol (2008) 0.90
Effect of human apolipoprotein E genotype on the pathogenesis of experimental ocular HSV-1. Exp Eye Res (2008) 0.88
Estrogen metabolism within the lung and its modulation by tobacco smoke. Carcinogenesis (2012) 0.88
APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice. J Alzheimers Dis (2010) 0.88
Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner. Neurobiol Dis (2014) 0.87
Expression of the human apoE2 isoform in adipocytes: altered cellular processing and impaired adipocyte lipogenesis. J Lipid Res (2011) 0.85
Human apolipoprotein E genotypes differentially modify house dust mite-induced airway disease in mice. Am J Physiol Lung Cell Mol Physiol (2011) 0.85
Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels. Arterioscler Thromb Vasc Biol (2013) 0.85
The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice. PLoS One (2011) 0.85
Impaired adipogenic response to thiazolidinediones in mice expressing human apolipoproteinE4. FASEB J (2010) 0.85
Apolipoprotein E4 exaggerates diabetic dyslipidemia and atherosclerosis in mice lacking the LDL receptor. Diabetes (2011) 0.84
Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele. J Neuroinflammation (2013) 0.84
CNF1 increases brain energy level, counteracts neuroinflammatory markers and rescues cognitive deficits in a murine model of Alzheimer's disease. PLoS One (2013) 0.83
Human APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer model. Hum Mol Genet (2013) 0.83
Apolipoprotein E4 domain interaction accelerates diet-induced atherosclerosis in hypomorphic Arg-61 apoe mice. Arterioscler Thromb Vasc Biol (2012) 0.82
Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice. Mol Neurodegener (2015) 0.82
Genetics of lipid traits and relationship to coronary artery disease. Curr Cardiol Rep (2013) 0.82
Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice. Acta Neuropathol Commun (2014) 0.81
ApoE isoform-dependent deficits in extinction of contextual fear conditioning. Genes Brain Behav (2012) 0.81
A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice. Neural Plast (2016) 0.81
ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations. PLoS Comput Biol (2015) 0.81
The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. Neuroscience (2010) 0.81
Ultrastructural studies in APP/PS1 mice expressing human ApoE isoforms: implications for Alzheimer's disease. Int J Clin Exp Pathol (2012) 0.81
The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice. PLoS One (2016) 0.80
Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease. J Neuropathol Exp Neurol (2015) 0.80
ApoE polymorphism may determine low-density lipoprotein cholesterol level in association with obesity and metabolic syndrome in postmenopausal Korean women. Yonsei Med J (2011) 0.79
Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease. Mol Neurodegener (2010) 0.79
Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice. Sci Rep (2015) 0.79
Adenosine triphosphate concentrations are higher in the brain of APOE3- compared to APOE4-targeted replacement mice and can be modulated by curcumin. Genes Nutr (2014) 0.79
Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction. Cardiol Res Pract (2015) 0.78
Diabetic atherosclerosis in APOE*4 mice: synergy between lipoprotein metabolism and vascular inflammation. J Lipid Res (2012) 0.78
ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model. Sci Rep (2016) 0.78
ApoE2 Exaggerates PTSD-Related Behavioral, Cognitive, and Neuroendocrine Alterations. Neuropsychopharmacology (2015) 0.77
APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations. Ann Neurol (2016) 0.77
Isoform-dependent effects of apoE on doublecortin-positive cells and microtubule-associated protein 2 immunoreactivity following (137)Cs irradiation. Radiat Environ Biophys (2010) 0.77
Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome. Sci Rep (2017) 0.76
ApoE knockout and knockin mice: the history of their contribution to the understanding of atherogenesis. J Lipid Res (2016) 0.76
Metabolic shifts toward fatty-acid usage and increased thermogenesis are associated with impaired adipogenesis in mice expressing human APOE4. Int J Obes (Lond) (2016) 0.76
Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice. Mol Neurodegener (2016) 0.76
Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer's disease. Front Aging Neurosci (2015) 0.75
Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory. Neurobiol Learn Mem (2015) 0.75
Identification of a Nuclear Respiratory Factor 1 Recognition Motif in the Apolipoprotein E Variant APOE4 linked to Alzheimer's Disease. Sci Rep (2017) 0.75
Apolipoprotein E isotype-dependent modulation of microRNA-146a in plasma and brain. Neuroreport (2016) 0.75
Mouse models of atherosclerosis: a historical perspective and recent advances. Lipids Health Dis (2017) 0.75
Lipoprotein(a) Mass Levels Increase Significantly According to APOE Genotype: An Analysis of 431 239 Patients. Arterioscler Thromb Vasc Biol (2017) 0.75
The Apoe(-/-) mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction. J Transl Med (2016) 0.75
ERβ and ApoE isoforms interact to regulate BDNF-5-HT2A signaling and synaptic function in the female brain. Alzheimers Res Ther (2017) 0.75
Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res (1990) 14.82
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science (1988) 13.54
Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science (1992) 11.83
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell (1992) 10.97
Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clin Chem (1982) 9.77
Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. J Biol Chem (1974) 9.02
Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis (1988) 6.01
Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis (1987) 5.00
Apolipoprotein E: structure-function relationships. Adv Protein Chem (1994) 3.46
Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem (1997) 3.04
Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site. J Biol Chem (1982) 2.71
Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. J Biol Chem (1990) 2.42
Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity. Proc Natl Acad Sci U S A (1992) 2.23
Abnormal in vivo metabolism of apolipoprotein E4 in humans. J Clin Invest (1986) 1.98
Electron microscopy of negatively stained lipoproteins. Methods Enzymol (1986) 1.73
Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apolipoprotein B, and cholesterol metabolism. Am J Hum Genet (1988) 1.68
Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. J Clin Invest (1998) 1.61
Apolipoprotein E alleles and risk of coronary disease. A meta-analysis. Arterioscler Thromb Vasc Biol (1996) 1.60
Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3. J Biol Chem (1986) 1.50
Lipoproteins and atherosclerosis. A look back and a look ahead. Arteriosclerosis (1983) 1.45
NIH conference. Type III hyperlipoproteinemia: diagnosis, molecular defects, pathology, and treatment. Ann Intern Med (1983) 1.36
Rapid fluorometric assay of LDL receptor activity by DiI-labeled LDL. J Lipid Res (1993) 1.33
Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E. J Clin Invest (1987) 1.33
Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor. J Clin Invest (1998) 1.25
Chylomicron assembly and catabolism: role of apolipoproteins and receptors. Biochim Biophys Acta (1996) 1.23
Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice. J Clin Invest (1998) 1.21
Method to measure apolipoprotein B-48 and B-100 secretion rates in an individual mouse: evidence for a very rapid turnover of VLDL and preferential removal of B-48- relative to B-100-containing lipoproteins. J Lipid Res (1996) 1.19
Apobec-1 and apolipoprotein B mRNA editing. Biochim Biophys Acta (1997) 1.09
Influence of apolipoprotein E polymorphism on apolipoprotein B-100 metabolism in normolipemic subjects. J Clin Invest (1991) 1.03
Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than e4. J Biol Chem (1998) 1.00
Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages. J Clin Invest (1998) 1.00
In vivo cholesterol kinetics in apolipoprotein E-deficient and control mice. J Lipid Res (1995) 0.89
Prolonged postprandial responses of lipids and apolipoproteins in triglyceride-rich lipoproteins of individuals expressing an apolipoprotein epsilon 4 allele. J Clin Invest (1996) 0.88
Apolipoprotein (apo) E genotype and apoE concentration determine binding of normal very low density lipoproteins to HepG2 cell surface receptors. J Lipid Res (1996) 0.88
Rapid determination of apolipoprotein E phenotypes from whole plasma by automated isoelectric focusing using PhastSystem and immunofixation. J Lipid Res (1994) 0.88
Role of apolipoprotein E in hepatic lipase catalyzed hydrolysis of phospholipid in high-density lipoproteins. Biochemistry (1992) 0.84
Characterization of a monoclonal antibody that binds to apolipoprotein E and to lipoprotein of human plasma containing apo E. Applications to ELISA quantification of plasma apo E. J Immunoassay (1988) 0.82
Apolipoprotein E modulates low density lipoprotein retention by lipoprotein lipase anchored to the subendothelial matrix. J Biol Chem (1993) 0.81
Close encounters with apolipoprotein E receptors. Curr Opin Lipidol (1996) 0.79
All-atom empirical potential for molecular modeling and dynamics studies of proteins. J Phys Chem B (1998) 54.00
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science (1992) 11.83
A comparison of sustained-release bupropion and placebo for smoking cessation. N Engl J Med (1997) 9.73
Urban residential environments and senior citizens' longevity in megacity areas: the importance of walkable green spaces. J Epidemiol Community Health (2002) 7.79
Targetted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature (1988) 6.12
Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (1996) 5.94
Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci U S A (1992) 5.75
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc Natl Acad Sci U S A (1997) 5.54
Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science (1997) 5.13
Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400. Nature (1989) 5.02
Action spectra for phytochrome A- and B-specific photoinduction of seed germination in Arabidopsis thaliana. Proc Natl Acad Sci U S A (1996) 4.48
Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression. Arterioscler Thromb (1994) 3.75
Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest (1998) 3.71
Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature (1997) 3.66
Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci U S A (1995) 3.54
Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia. Proc Natl Acad Sci U S A (1995) 3.51
Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci U S A (1995) 3.46
Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science (1988) 3.40
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. J Clin Invest (2001) 3.24
Targeted mutation of the Hprt gene in mouse embryonic stem cells. Proc Natl Acad Sci U S A (1988) 3.20
Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem (1997) 3.04
The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin. Nat Genet (2001) 3.01
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc Natl Acad Sci U S A (1997) 2.99
Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus. Am J Pathol (2000) 2.98
The S receptor kinase determines self-incompatibility in Brassica stigma. Nature (2000) 2.96
Single-copy transgenic mice with chosen-site integration. Proc Natl Acad Sci U S A (1996) 2.84
The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response? Am J Gastroenterol (2010) 2.74
Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression. EMBO J (1998) 2.74
Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex. Neuron (1998) 2.73
Direct ligand-receptor complex interaction controls Brassica self-incompatibility. Nature (2001) 2.69
Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice. Neuron (1996) 2.62
Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci U S A (1989) 2.59
The pollen determinant of self-incompatibility in Brassica campestris. Proc Natl Acad Sci U S A (2000) 2.50
The effect of tetraethylammonium chloride on potassium permeability in the smooth muscle cell membrane of canine trachea. J Physiol (1981) 2.45
Prefrontal and cingulate unit activity during timing behavior in the monkey. Brain Res (1979) 2.41
Ampulla cardiomyopathy ('Takotusbo' cardiomyopathy)--reversible left ventricular dysfunction: with ST segment elevation. Jpn Circ J (2000) 2.39
Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase. Infect Immun (1999) 2.38
A coagulation factor IX-deficient mouse model for human hemophilia B. Blood (1997) 2.36
Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis (1999) 2.35
Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazer. J Neurosci (1999) 2.27
Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A beta1-42(43) in Alzheimer's disease: a study in Japan. Ann Neurol (1998) 2.25
Flat neoplastic lesions of the colon and rectum detected by high-resolution video endoscopy and chromoscopy. Gastrointest Endosc (1995) 2.22
The evolution of multigene families: human haptoglobin genes. Annu Rev Genet (1986) 2.21
Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc Natl Acad Sci U S A (1998) 2.17
Mental-physical co-morbidity and its relationship with disability: results from the World Mental Health Surveys. Psychol Med (2008) 2.15
Delay activity of orbital and lateral prefrontal neurons of the monkey varying with different rewards. Cereb Cortex (2000) 2.15
Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption. J Exp Med (1999) 2.13
Genomic organization of the S locus: Identification and characterization of genes in SLG/SRK region of S(9) haplotype of Brassica campestris (syn. rapa). Genetics (1999) 2.12
Recombination and balanced chromosome polymorphism suggested by DNA sequences 5' to the human delta-globin gene. Proc Natl Acad Sci U S A (1983) 2.11
Laparoscopic observations of congenital anomalies of the liver. Gastrointest Endosc (1998) 2.10
Targeted disruption of the apolipoprotein C-III gene in mice results in hypotriglyceridemia and protection from postprandial hypertriglyceridemia. J Biol Chem (1994) 2.09
Vitreoretinal surgery after inadvertent globe penetration during local ocular anesthesia. Ophthalmology (1998) 2.09
Statistical analysis of the 5' untranslated region of human mRNA using "Oligo-Capped" cDNA libraries. Genomics (2000) 2.09
Duplication within the haptoglobin Hp2 gene. Nature (1984) 2.08
An autopsy case of troglitazone-induced fulminant hepatitis. Diabetes Care (1998) 2.08
Purified poloxamer 188 for treatment of acute vaso-occlusive crisis of sickle cell disease: A randomized controlled trial. JAMA (2001) 2.06
Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats. J Neurosci Res (2002) 2.06
Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut (2008) 2.05
Phylogenetic relationships between toxic and non-toxic strains of the genus Microcystis based on 16S to 23S internal transcribed spacer sequence. FEMS Microbiol Lett (1999) 2.04
Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. J Clin Invest (2001) 2.03
Hepatic failure in a case of multiple myeloma-associated amyloidosis (kappa-AL) J Gastroenterol (1995) 2.01
A mouse model for beta 0-thalassemia. Proc Natl Acad Sci U S A (1995) 2.01
Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element. J Biol Chem (1985) 2.00
Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption. J Clin Invest (1994) 1.98
The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. Proc Natl Acad Sci U S A (1994) 1.97
Accurate modification of a chromosomal plasmid by homologous recombination in human cells. Proc Natl Acad Sci U S A (1987) 1.93
Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice. J Clin Invest (1994) 1.93
Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proc Natl Acad Sci U S A (2005) 1.92
Ataxia with oculomotor apraxia type 2: clinical, biological and genotype/phenotype correlation study of a cohort of 90 patients. Brain (2009) 1.91
Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur J Neurosci (1998) 1.90
Blockade of Angiotensin II type-1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation. Kidney Int (2006) 1.87
Needs-based planning: the case of Manitoba. CMAJ (1997) 1.87
Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes. Proc Natl Acad Sci U S A (1999) 1.85
Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators. Science (1999) 1.85
Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord. J Neurosci (1997) 1.84
Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)Apoe(-/-) mice are ameliorated by enalapril treatment. J Clin Invest (2000) 1.84
Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. Mol Cell (2000) 1.78
Two-step regulation of left-right asymmetric expression of Pitx2: initiation by nodal signaling and maintenance by Nkx2. Mol Cell (2001) 1.77
Photoisomerization of retinal at 13-ene is important for phototaxis of Chlamydomonas reinhardtii: simultaneous measurements of phototactic and photophobic responses. Biochem Biophys Res Commun (1991) 1.77
Per anum intersphincteric rectal dissection with direct coloanal anastomosis for lower rectal cancer: the ultimate sphincter-preserving operation. Dis Colon Rectum (1997) 1.76
Ultrahigh-speed optical coherence tomography imaging and visualization of the embryonic avian heart using a buffered Fourier Domain Mode Locked laser. Opt Express (2007) 1.75
Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis. J Cell Biol (1988) 1.75
TNF-alpha causes reversible in vivo systemic vascular barrier dysfunction via NO-dependent and -independent mechanisms. Am J Physiol (1997) 1.73
Predictive factors for metachronous recurrence of early gastric cancer after endoscopic treatment. J Clin Gastroenterol (1999) 1.73
Expression and localization of Drosophila melanogaster hsp70 cognate proteins. Mol Cell Biol (1986) 1.72
Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene. Nat Genet (2000) 1.71
Effects of cyclopiazonic acid, a novel Ca(2+)-ATPase inhibitor, on contractile responses in skinned ileal smooth muscle. Br J Pharmacol (1992) 1.71
4D embryonic cardiography using gated optical coherence tomography. Opt Express (2006) 1.71
Irinotecan (CPT-11) and characteristic mucosal changes in the mouse ileum and cecum. J Natl Cancer Inst (1995) 1.71
Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I. Proc Natl Acad Sci U S A (1992) 1.71
Targeted disruption of the mouse sphingolipid activator protein gene: a complex phenotype, including severe leukodystrophy and wide-spread storage of multiple sphingolipids. Hum Mol Genet (1996) 1.70
Cutting edge: Role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans. J Immunol (1999) 1.69
Molecular cloning and characterization of complementary DNA encoding for ferredoxin-dependent glutamate synthase in maize leaf. J Biol Chem (1991) 1.69
Restoration of prehension with the double free muscle technique following complete avulsion of the brachial plexus. Indications and long-term results. J Bone Joint Surg Am (2000) 1.68
A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation. EMBO J (2000) 1.67
Characterization and expression of the complementary DNA encoding rat histidine decarboxylase. Proc Natl Acad Sci U S A (1990) 1.66