Signaling events induced by lipopolysaccharide-activated toll-like receptor 2.

PubWeight™: 1.51‹?› | Rank: Top 4%

🔗 View Article (PMID 10395652)

Published in J Immunol on July 15, 1999

Authors

R B Yang1, M R Mark, A L Gurney, P J Godowski

Author Affiliations

1: Department of Molecular Biology, Genentech, Inc., San Francisco, CA 94080, USA.

Articles citing this

Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun (2000) 5.65

Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock. Clin Microbiol Rev (2003) 3.70

Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J Clin Invest (2001) 3.04

Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J Clin Invest (2003) 2.89

The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J (2000) 2.82

Toll-related receptors and the control of antimicrobial peptide expression in Drosophila. Proc Natl Acad Sci U S A (2000) 2.45

Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol (2002) 2.14

Accessory molecules for Toll-like receptors and their function. Nat Rev Immunol (2012) 2.00

Toll-like receptors in central nervous system glial inflammation and homeostasis. J Neurosci Res (2006) 1.91

Micrococci and peptidoglycan activate TLR2-->MyD88-->IRAK-->TRAF-->NIK-->IKK-->NF-kappaB signal transduction pathway that induces transcription of interleukin-8. Infect Immun (2001) 1.59

Toll-like receptors confer responsiveness to lipopolysaccharide from Porphyromonas gingivalis in human gingival fibroblasts. Infect Immun (2000) 1.33

Toll-like receptors: molecular mechanisms of the mammalian immune response. Immunology (2000) 1.27

Hepatic and renal cytochrome p450 gene regulation during citrobacter rodentium infection in wild-type and toll-like receptor 4 mutant mice. Drug Metab Dispos (2005) 1.17

Upregulation of toll-like receptor 2 gene expression in macrophage response to peptidoglycan and high concentration of lipopolysaccharide is involved in NF-kappa b activation. Infect Immun (2001) 1.12

Understanding Streptococcus suis serotype 2 infection in pigs through a transcriptional approach. BMC Genomics (2011) 1.06

Activation of interleukin-1 receptor-associated kinase by gram-negative flagellin. Infect Immun (2001) 1.03

Bench-to-bedside review: Toll-like receptors and their role in septic shock. Crit Care (2002) 1.01

TRAF6-dependent mitogen-activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii. Infect Immun (2004) 0.97

Gram-positive and gram-negative bacteria do not trigger monocytic cytokine production through similar intracellular pathways. Infect Immun (2001) 0.97

Molecular events of bacterial-induced maturation of dendritic cells. J Clin Immunol (2000) 0.92

The chemokine CCL2 is required for control of murine gastric Salmonella enterica infection. Infect Immun (2005) 0.90

Mycobacterium tuberculosis 6-kDa early secreted antigenic target (ESAT-6) protein downregulates lipopolysaccharide induced c-myc expression by modulating the extracellular signal regulated kinases 1/2. BMC Immunol (2007) 0.89

Endothelial cells are main producers of interleukin 8 through Toll-like receptor 2 and 4 signaling during bacterial infection in leukopenic cancer patients. Clin Diagn Lab Immunol (2003) 0.85

Toll-like receptors 2 and 4 and their mutations in patients with otitis media and middle ear effusion. Clin Exp Otorhinolaryngol (2008) 0.85

Differential expression of toll-like receptor 3 and 5 in ileal pouch mucosa of ulcerative colitis patients. Int J Colorectal Dis (2006) 0.83

Induction of keratinocyte growth factor 1 Expression by lipopolysaccharide is regulated by CD-14 and toll-like receptors 2 and 4. Infect Immun (2002) 0.83

Effects of sevoflurane postconditioning on cell death, inflammation and TLR expression in human endothelial cells exposed to LPS. J Transl Med (2013) 0.81

Selective inhibition of inhibitory kappa B kinase-beta abrogates induction of nitric oxide synthase in lipopolysaccharide-stimulated rat aortic smooth muscle cells. Br J Pharmacol (2005) 0.80

Toll-like receptors, cytokines & nitric oxide synthase in patients with otitis media with effusion. Indian J Med Res (2013) 0.79

Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue. Immunology (2003) 0.78

Metalloproteinase-dependent TLR2 ectodomain shedding is involved in soluble toll-like receptor 2 (sTLR2) production. PLoS One (2014) 0.78

Articles by these authors

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science (1999) 8.63

Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science (1999) 7.75

Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol (2001) 6.62

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature (1998) 6.49

Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA. Cell (1986) 4.66

Induction of direct antimicrobial activity through mammalian toll-like receptors. Science (2001) 4.46

Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat Immunol (2001) 4.13

Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. Nat Immunol (2000) 3.96

WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc Natl Acad Sci U S A (1998) 3.73

Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement. Nature (1987) 3.42

Transcriptional control of herpesvirus gene expression: gene functions required for positive and negative regulation. Proc Natl Acad Sci U S A (1986) 3.28

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature (1994) 3.13

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Nature (1998) 2.98

IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J (2001) 2.84

Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J Biol Chem (2000) 2.73

IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. J Biol Chem (2001) 2.50

Glucocorticoid receptor mutants that define a small region sufficient for enhancer activation. Science (1987) 2.33

Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2. J Immunol (2001) 2.24

Toll-like receptor 4, but not toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharides. J Immunol (2000) 2.16

Identification of synergistic signals initiating inner ear development. Science (2000) 2.15

Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. Proc Natl Acad Sci U S A (2000) 2.06

RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J (1994) 2.04

Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood (1996) 2.03

The toll of innate immunity on microbial pathogens. N Engl J Med (1999) 1.98

Mutations in the major DNA-binding protein gene of herpes simplex virus type 1 result in increased levels of viral gene expression. J Virol (1983) 1.98

Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Proc Natl Acad Sci U S A (1997) 1.89

Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice. J Immunol (2001) 1.89

FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. Cytokine (1999) 1.83

Identification of a herpes simplex virus function that represses late gene expression from parental viral genomes. J Virol (1985) 1.79

Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10. J Immunol (2000) 1.77

Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation. Oncogene (1997) 1.70

Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding. EMBO J (1992) 1.68

The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP). Mol Cell Biol (1990) 1.67

Reevaluation of the roles of protein S and Gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3. Cell (1995) 1.67

Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr Biol (1999) 1.63

Acinar cells of the pancreas are a target of interleukin-22. J Interferon Cytokine Res (2001) 1.57

Relative roles of CCAAT/enhancer-binding protein beta and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP). J Biol Chem (1993) 1.54

Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium. J Clin Invest (1994) 1.51

Characterization of herpes simplex virus 2 temperature-sensitive mutants whose lesions map in or near the coding sequences for the major DNA-binding protein. J Virol (1983) 1.51

Cyclic AMP induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription is mediated by multiple promoter elements. J Biol Chem (1991) 1.49

Identification of Gas6 as a growth factor for human Schwann cells. J Neurosci (1996) 1.45

In vivo response of hepatocytes to growth factors requires an initial priming stimulus. Hepatology (1994) 1.38

Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2. J Cell Biol (1996) 1.19

Ecdysteroid-dependent regulation of genes in mammalian cells by a Drosophila ecdysone receptor and chimeric transactivators. Proc Natl Acad Sci U S A (1992) 1.14

rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain. J Biol Chem (1994) 1.11

Identification of a thyroid hormone response element in the phosphoenolpyruvate carboxykinase (GTP) gene. Evidence for synergistic interaction between thyroid hormone and cAMP cis-regulatory elements. J Biol Chem (1991) 1.05

Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution. Structure (1998) 1.01

Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity. J Biol Chem (1994) 1.00

Ligand-regulated nonspecific inactivation of receptor function: a versatile mechanism for signal transduction. Cold Spring Harb Symp Quant Biol (1988) 0.99

Generation and characterization of a competitive antagonist of human hepatocyte growth factor, HGF/NK1. J Biol Chem (1993) 0.98

Macrophage stimulating protein (MSP) binds to its receptor via the MSP beta chain. J Biol Chem (1997) 0.97

Expression and characterization of hepatocyte growth factor receptor-IgG fusion proteins. Effects of mutations in the potential proteolytic cleavage site on processing and ligand binding. J Biol Chem (1992) 0.96

Mutational analysis and molecular modeling of the N-terminal kringle-containing domain of hepatocyte growth factor identifies amino acid side chains important for interaction with the c-Met receptor. Protein Eng (1994) 0.96

Antisense transcripts and protein binding motifs within the Wilms tumour (WT1) locus. Oncogene (1994) 0.94

Modulation of megakaryocytopoiesis by human macrophage-stimulating protein, the ligand for the RON receptor. J Immunol (1996) 0.89

Reduction of alpha-naphthylisothiocyanate-induced hepatotoxicity by recombinant human hepatocyte growth factor. Endocrinology (1992) 0.86

The pharmacokinetics, tissue localization, and metabolic processing of recombinant human hepatocyte growth factor after intravenous administration in rats. Endocrinology (1994) 0.81

Short-term primary culture of acinar-intercalated duct complexes from rat submandibular glands. In Vitro Cell Dev Biol (1986) 0.79

Development of neurotrophic factor therapy for Alzheimer's disease. Ciba Found Symp (1996) 0.79

Effect of parasympathetic denervation on acetylcholine levels in the rat parotid gland. Is there an extraneuronal pool of acetylcholine? Life Sci (1983) 0.78

New branches on the neuregulin family tree. Mol Psychiatry (1998) 0.78

Effect of clonidine on secretion of fluid and ions by the parotid and submandibular glands of the rat. Arch Oral Biol (1987) 0.77

Amino acid uptake in denervated rat parotid gland: I. Preparation and evaluation of a lobule system for in vitro studies. J Pharmacol Exp Ther (1987) 0.75

Surface morphology of normal and enzymatically treated rat parotid gland. Scan Electron Microsc (1981) 0.75

Growth hormone receptor and binding protein. Recent Prog Horm Res (1990) 0.75

The promoter regulatory regions of the genes for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) from the chicken and the rat have different species-specific roles in gluconeogenesis. J Nutr (1997) 0.75

Plant eats plant: sap-feeding witchweeds and other parasitic angiosperms. Biologist (London) (2000) 0.75

Amino acid uptake in the rat parotid gland: II. Effects of surgical sympathectomy and parasympathectomy. J Pharmacol Exp Ther (1987) 0.75

Modulation of hormone response elements by promoter environment. Trends Endocrinol Metab (2008) 0.75