Crystal structure of the ectodomain of human transferrin receptor.

Forging a field: the golden age of iron biology. Blood (2008) 3.83

Canine and feline parvoviruses can use human or feline transferrin receptors to bind, enter, and infect cells. J Virol (2001) 2.08

The natural host range shift and subsequent evolution of canine parvovirus resulted from virus-specific binding to the canine transferrin receptor. J Virol (2003) 1.84

Intracellular iron transport and storage: from molecular mechanisms to health implications. Antioxid Redox Signal (2008) 1.73

The homodimer of prostate-specific membrane antigen is a functional target for cancer therapy. Proc Natl Acad Sci U S A (2003) 1.71

Mouse transferrin receptor 1 is the cell entry receptor for mouse mammary tumor virus. Proc Natl Acad Sci U S A (2002) 1.65

A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. Proc Natl Acad Sci U S A (2005) 1.65

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms. Nat Rev Mol Cell Biol (2012) 1.58

Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer. EMBO J (2006) 1.55

Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase. Proc Natl Acad Sci U S A (2005) 1.49

Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses. Proc Natl Acad Sci U S A (2008) 1.47

Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses. Nat Struct Mol Biol (2010) 1.46

Mechanism for multiple ligand recognition by the human transferrin receptor. PLoS Biol (2003) 1.41

Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses. PLoS Pathog (2009) 1.37

Glutamate carboxypeptidase II in diagnosis and treatment of neurologic disorders and prostate cancer. Curr Med Chem (2012) 1.34

The long history of iron in the Universe and in health and disease. Biochim Biophys Acta (2011) 1.33

Asymmetric binding of transferrin receptor to parvovirus capsids. Proc Natl Acad Sci U S A (2007) 1.30

Residues in the apical domain of the feline and canine transferrin receptors control host-specific binding and cell infection of canine and feline parvoviruses. J Virol (2003) 1.24

Dual host-virus arms races shape an essential housekeeping protein. PLoS Biol (2013) 1.22

Purified feline and canine transferrin receptors reveal complex interactions with the capsids of canine and feline parvoviruses that correspond to their host ranges. J Virol (2006) 1.18

The PA domain: a protease-associated domain. Protein Sci (2000) 1.16

How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH. Proc Natl Acad Sci U S A (2011) 1.12

Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3. Proc Natl Acad Sci U S A (2009) 1.11

Human growth hormone-transferrin fusion protein for oral delivery in hypophysectomized rats. J Control Release (2009) 1.10

Structures of host range-controlling regions of the capsids of canine and feline parvoviruses and mutants. J Virol (2003) 1.10

Different mechanisms of antibody-mediated neutralization of parvoviruses revealed using the Fab fragments of monoclonal antibodies. Virology (2007) 1.09

The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane. J Biol Chem (2008) 1.09

The protease-associated domain and C-terminal extension are required for zymogen processing, sorting within the secretory pathway, and activity of tomato subtilase 3 (SlSBT3). J Biol Chem (2009) 1.07

Cancer-cell-phenotype-dependent differential intracellular trafficking of unconjugated quantum dots. Small (2009) 1.07

Evolutionary reconstructions of the transferrin receptor of Caniforms supports canine parvovirus being a re-emerged and not a novel pathogen in dogs. PLoS Pathog (2012) 1.05

Subcellular localization of herpes simplex virus type 1 UL51 protein and role of palmitoylation in Golgi apparatus targeting. J Virol (2003) 1.05

Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses. Curr Opin Microbiol (2011) 1.03

Evidence that His349 acts as a pH-inducible switch to accelerate receptor-mediated iron release from the C-lobe of human transferrin. J Biol Inorg Chem (2010) 1.03

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin. Oncogene (2011) 1.03

Early steps in cell infection by parvoviruses: host-specific differences in cell receptor binding but similar endosomal trafficking. J Virol (2009) 1.01

Structure of the streptococcal cell wall C5a peptidase. Proc Natl Acad Sci U S A (2005) 1.00

Kinetics of iron release from transferrin bound to the transferrin receptor at endosomal pH. Biochim Biophys Acta (2011) 1.00

Single-cell FRET imaging of transferrin receptor trafficking dynamics by Sfp-catalyzed, site-specific protein labeling. Chem Biol (2005) 0.99

Receptor complexes cotransported via polarized endocytic pathways form clusters with distinct organizations. Mol Biol Cell (2007) 0.99

Exploring transferrin-receptor interactions at the single-molecule level. Biophys J (2007) 0.97

Parvovirus infection of cells by using variants of the feline transferrin receptor altering clathrin-mediated endocytosis, membrane domain localization, and capsid-binding domains. J Virol (2004) 0.96

A loop in the N-lobe of human serum transferrin is critical for binding to the transferrin receptor as revealed by mutagenesis, isothermal titration calorimetry, and epitope mapping. J Mol Recognit (2009) 0.95

Binding site on the transferrin receptor for the parvovirus capsid and effects of altered affinity on cell uptake and infection. J Virol (2010) 0.94

A structural comparison of human serum transferrin and human lactoferrin. Biometals (2007) 0.94

Limited transferrin receptor clustering allows rapid diffusion of canine parvovirus into clathrin endocytic structures. J Virol (2012) 0.93

Crystal structure of a putative methyltransferase from Mycobacterium tuberculosis: misannotation of a genome clarified by protein structural analysis. J Bacteriol (2003) 0.91

Host-specific parvovirus evolution in nature is recapitulated by in vitro adaptation to different carnivore species. PLoS Pathog (2014) 0.91

Cells under siege: viral glycoprotein interactions at the cell surface. J Struct Biol (2011) 0.91

Incorporation of 5-hydroxytryptophan into transferrin and its receptor allows assignment of the pH induced changes in intrinsic fluorescence when iron is released. Biochim Biophys Acta (2008) 0.89

Transferrin-mediated cellular iron delivery. Curr Top Membr (2012) 0.86

Molecular evolution of the transferrin receptor/glutamate carboxypeptidase II family. J Mol Evol (2006) 0.86

Structure and dynamics of drug carriers and their interaction with cellular receptors: focus on serum transferrin. Adv Drug Deliv Rev (2012) 0.84

Can uranium follow the iron-acquisition pathway? Interaction of uranyl-loaded transferrin with receptor 1. J Biol Inorg Chem (2009) 0.84

Structure-based mutagenesis reveals critical residues in the transferrin receptor participating in the mechanism of pH-induced release of iron from human serum transferrin. Biochemistry (2012) 0.83

Cholesterol-sensitive modulation of transcytosis. Mol Biol Cell (2007) 0.83

Gallium uptake by transferrin and interaction with receptor 1. J Biol Inorg Chem (2006) 0.83

A computational study of the open and closed forms of the N-lobe human serum transferrin apoprotein. Biophys J (2003) 0.82

Characterization of a single b-type heme, FAD, and metal binding sites in the transmembrane domain of six-transmembrane epithelial antigen of the prostate (STEAP) family proteins. J Biol Chem (2015) 0.81

From structure of the complex to understanding of the biology. Acta Crystallogr D Biol Crystallogr (2006) 0.81

Structural and functional studies on the stalk of the transferrin receptor. Biochem Biophys Res Commun (2009) 0.81

Ionic residues of human serum transferrin affect binding to the transferrin receptor and iron release. Biochemistry (2012) 0.81

A human blood-brain barrier transcytosis assay reveals antibody transcytosis influenced by pH-dependent receptor binding. PLoS One (2014) 0.81

Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe. Sci Rep (2012) 0.80

Characterization of the interaction between diferric transferrin and transferrin receptor 2 by functional assays and atomic force microscopy. J Mol Biol (2010) 0.79

Multiplex detection of homo- and heterodimerization of g protein-coupled receptors by proximity biotinylation. PLoS One (2014) 0.79

Single Mutations in the VP2 300 Loop Region of the Three-Fold Spike of the Carnivore Parvovirus Capsid Can Determine Host Range. J Virol (2015) 0.79

Soluble form of canine transferrin receptor inhibits canine parvovirus infection in vitro and in vivo. Biomed Res Int (2013) 0.78

A novel rat model of hereditary hemochromatosis due to a mutation in transferrin receptor 2. Comp Med (2013) 0.78

The placenta: the forgotten essential organ of iron transport. Nutr Rev (2016) 0.77

CD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression. J Biol Chem (2015) 0.77

The therapeutic and diagnostic potential of the prostate specific membrane antigen/glutamate carboxypeptidase II (PSMA/GCPII) in cancer and neurological disease. Br J Pharmacol (2016) 0.76

Structural and biochemical characterization of a novel aminopeptidase from human intestine. J Biol Chem (2015) 0.75

Atomic structure of the ectodomain from HIV-1 gp41. Nature (1997) 16.31

The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution. Nature (1995) 12.25

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science (1998) 11.23

Three-dimensional structure of the tyrosine kinase c-Src. Nature (1997) 7.62

The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex. Cell (1992) 6.47

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature (1995) 6.16

Structure of simian virus 40 at 3.8-A resolution. Nature (1991) 5.96

Structure of an IkappaBalpha/NF-kappaB complex. Cell (1998) 5.67

DNA recognition by GAL4: structure of a protein-DNA complex. Nature (1992) 5.60

Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Mol Cell (1999) 5.09

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains. Nature (1990) 4.70

Recognition of a DNA operator by the repressor of phage 434: a view at high resolution. Science (1988) 4.60

Structure and mechanism of DNA topoisomerase II. Nature (1996) 4.56

Retrovirus envelope domain at 1.7 angstrom resolution. Nat Struct Biol (1996) 4.49

Structure of the reovirus core at 3.6 A resolution. Nature (2000) 4.28

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell (2000) 4.21

Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. Nature (1995) 4.08

DNA arrangement in isometric phage heads. Nature (1977) 3.98

Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements. Nat Struct Biol (1999) 3.72

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA. Nature (1998) 3.71

The Florida "truth" anti-tobacco media evaluation: design, first year results, and implications for planning future state media evaluations. Tob Control (2001) 3.69

Diffraction methods for biological macromolecules. Oscillation method with large unit cells. Methods Enzymol (1985) 3.68

Protein organization in clathrin trimers. Cell (1981) 3.55

Structure of small virus-like particles assembled from the L1 protein of human papillomavirus 16. Mol Cell (2000) 3.44

Structure of murine polyomavirus complexed with an oligosaccharide receptor fragment. Nature (1994) 3.35

Structure of the NF-kappa B p50 homodimer bound to DNA. Nature (1995) 3.33

Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer. Genes Dev (1994) 3.30

Recoverin: a calcium sensitive activator of retinal rod guanylate cyclase. Science (1991) 3.27

Structural basis for membrane fusion by enveloped viruses. Mol Membr Biol (1999) 3.26

Molecular organization of a recombinant subviral particle from tick-borne encephalitis virus. Mol Cell (2001) 3.23

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. Nature (1993) 3.14

Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin. Proc Natl Acad Sci U S A (2000) 3.09

Influence of a counteradvertising media campaign on initiation of smoking: the Florida "truth" campaign. Am J Public Health (2001) 3.09

Structure of the repressor-operator complex of bacteriophage 434. Nature (1987) 3.00

Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA. Nature (1990) 2.97

The structure of simian virus 40 refined at 3.1 A resolution. Structure (1996) 2.96

The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1995) 2.95

Tomato bushy stunt virus at 2.9 A resolution. Nature (1978) 2.87

Structure and assembly of turnip crinkle virus. II. Mechanism of reassembly in vitro. J Mol Biol (1986) 2.77

Is there a single pathway for the folding of a polypeptide chain? Proc Natl Acad Sci U S A (1985) 2.62

Crystal structure of the repetitive segments of spectrin. Science (1993) 2.61

Crystal structures of murine polyomavirus in complex with straight-chain and branched-chain sialyloligosaccharide receptor fragments. Structure (1996) 2.49

Effect of non-contacted bases on the affinity of 434 operator for 434 repressor and Cro. Nature (1987) 2.49

The effect of membrane fixed charges on diffusion potentials and streaming potentials. J Physiol (1966) 2.38

Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion. Oncogene (2011) 2.36

Assembly of the head of bacteriophage P22: x-ray diffraction from heads, proheads and related structures. J Mol Biol (1976) 2.32

SHORT INTEGUMENT (SIN1), a gene required for ovule development in Arabidopsis, also controls flowering time. Development (1996) 2.28

High-resolution structure of a polyomavirus VP1-oligosaccharide complex: implications for assembly and receptor binding. EMBO J (1997) 2.20

Sindbis virus glycoproteins form a regular icosahedral surface lattice. J Virol (1975) 2.15

The industry manipulation attitudes of smokers and nonsmokers. J Public Health Manag Pract (2000) 2.14

The human immunodeficiency virus gp120 binding site on CD4: delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure. J Exp Med (1992) 2.13

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res (2013) 2.12

Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker. Cell (1998) 2.10

DNA twisting and the affinity of bacteriophage 434 operator for bacteriophage 434 repressor. Proc Natl Acad Sci U S A (1988) 2.08

Interaction of polyomavirus internal protein VP2 with the major capsid protein VP1 and implications for participation of VP2 in viral entry. EMBO J (1998) 2.06

Prospective study of quality of life before and after coronary artery bypass grafting. BMJ (1991) 2.03

Using the UK primary care Quality and Outcomes Framework to audit health care equity: preliminary data on diabetes management. J Public Health (Oxf) (2006) 2.02

A phage repressor-operator complex at 7 A resolution. Nature (1985) 2.00

The structural organization of DNA packaged within the heads of T4 wild-type, isometric and giant bacteriophages. Cell (1978) 1.99

Structure of a phage 434 Cro/DNA complex. Nature (1988) 1.98

The phage 434 Cro/OR1 complex at 2.5 A resolution. J Mol Biol (1991) 1.94

Arabidopsis floral homeotic gene BELL (BEL1) controls ovule development through negative regulation of AGAMOUS gene (AG). Proc Natl Acad Sci U S A (1994) 1.94

Location and distribution of the light chains in clathrin trimers. Proc Natl Acad Sci U S A (1983) 1.90

X-ray diffraction from microtubules. J Mol Biol (1971) 1.84

A stable latent reservoir for HIV-1 in resting CD4(+) T lymphocytes in infected children. J Clin Invest (2000) 1.81

The flavivirus envelope protein E: isolation of a soluble form from tick-borne encephalitis virus and its crystallization. J Virol (1991) 1.80

Climate change and the integrity of science. Science (2010) 1.80

Structural models of human apolipoprotein A-I: a critical analysis and review. Biochim Biophys Acta (2001) 1.80

Use of a low-literacy patient education tool to enhance pneumococcal vaccination rates. A randomized controlled trial. JAMA (1999) 1.79

Solution structure of the DNA-binding domain of Cd2-GAL4 from S. cerevisiae. Nature (1992) 1.79

Cooperative assembly of simian virus 40 T-antigen hexamers on functional halves of the replication origin. J Virol (1991) 1.78

DNA transport by a type II topoisomerase: direct evidence for a two-gate mechanism. Proc Natl Acad Sci U S A (1996) 1.77

Structure of the regulatory domains of the Src-family tyrosine kinase Lck. Nature (1994) 1.77

Structure and assembly of turnip crinkle virus. I. X-ray crystallographic structure analysis at 3.2 A resolution. J Mol Biol (1986) 1.76

Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex. Proc Natl Acad Sci U S A (1998) 1.67

Structure of the amino-terminal domain of phage 434 repressor at 2.0 A resolution. J Mol Biol (1989) 1.67

sin 1, a mutation affecting female fertility in Arabidopsis, interacts with mod 1, its recessive modifier. Genetics (1994) 1.66

Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2. Nature (1996) 1.65

Structure of tomato busy stunt virus IV. The virus particle at 2.9 A resolution. J Mol Biol (1983) 1.64

Idiopathic urethritis in male children. Br J Urol (1987) 1.63

Clathrin, cages, and coated vesicles. Cell (1983) 1.62

Crystal structure of a PPR1-DNA complex: DNA recognition by proteins containing a Zn2Cys6 binuclear cluster. Genes Dev (1994) 1.62

Interactions among the major and minor coat proteins of polyomavirus. J Virol (1994) 1.58

HIV seroincidence and correlates of seroconversion in a cohort of male factory workers in Harare, Zimbabwe. AIDS (1996) 1.57

Pharmacokinetics of 18F-labeled fluconazole in healthy human subjects by positron emission tomography. Antimicrob Agents Chemother (1993) 1.55

Delineation of two functional regions of transcription factor TFIIB. Proc Natl Acad Sci U S A (1993) 1.55

Hexagonal glycoprotein arrays from Sindbis virus membranes. J Virol (1978) 1.54

DNA sequence preferences of GAL4 and PPR1: how a subset of Zn2 Cys6 binuclear cluster proteins recognizes DNA. Mol Cell Biol (1996) 1.54

Genetic and structural analysis of a virulence determinant in polyomavirus VP1. J Virol (1995) 1.52

Crystallization of the reovirus type 3 Dearing core. Crystal packing is determined by the lambda 2 protein. J Mol Biol (1990) 1.51

Breast conserving surgery for breast cancer: single institutional experience from Southern India. Indian J Cancer (2012) 1.50

Conserved residues make similar contacts in two repressor-operator complexes. Science (1990) 1.48

Discrimination between sialic acid-containing receptors and pseudoreceptors regulates polyomavirus spread in the mouse. J Virol (1999) 1.47

Structural similarities between topoisomerases that cleave one or both DNA strands. Proc Natl Acad Sci U S A (1998) 1.47

Papillomavirus capsid protein expression in Escherichia coli: purification and assembly of HPV11 and HPV16 L1. J Mol Biol (2001) 1.46

Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes. Nat Struct Biol (1996) 1.46

Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110. J Biol Chem (1993) 1.45

Configuration of clathrin trimers: evidence from electron microscopy. J Ultrastruct Mol Struct Res (1986) 1.44

Structural domains of clathrin heavy chains. J Cell Biol (1984) 1.43