Published in Proc Natl Acad Sci U S A on December 23, 2013
PTEN function: the long and the short of it. Trends Biochem Sci (2014) 1.29
Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma. Proc Natl Acad Sci U S A (2016) 1.00
PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion. Sci Signal (2015) 0.99
Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations. Elife (2017) 0.97
Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders. Front Mol Neurosci (2014) 0.95
Regulation and function of P-Rex family Rac-GEFs. Small GTPases (2015) 0.92
Melanoma mystery. Elife (2017) 0.79
p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase. J Biol Chem (2015) 0.77
Analysis of intracellular PTEN signaling and secretion. Methods (2014) 0.77
Upregulation of PREX2 promotes the proliferation and migration of hepatocellular carcinoma cells via PTEN-AKT signaling. Oncol Lett (2016) 0.76
Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1. J Biol Chem (2016) 0.75
Mechanistic insights into the role of truncating PREX2 mutations in melanoma. Mol Cell Oncol (2016) 0.75
Interplay between PREX2 mutations and the PI3K pathway and its effect on epigenetic regulation of gene expression in NRAS-mutant melanoma. Small GTPases (2016) 0.75
PREX1 Protein Function Is Negatively Regulated Downstream of Receptor Tyrosine Kinase Activation by p21-activated Kinases (PAKs). J Biol Chem (2016) 0.75
4th international conference on tumor progression and therapeutic resistance: meeting report. Cancer Biol Ther (2015) 0.75
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (1997) 29.34
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell (2006) 20.92
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1998) 17.36
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet (1997) 15.38
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell (1998) 13.98
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol (2005) 10.44
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell (1999) 6.59
Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol (2000) 5.22
Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A (2004) 3.40
Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science (2009) 2.51
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A (2008) 2.34
Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol (2005) 1.93
Direct identification of PTEN phosphorylation sites. FEBS Lett (2002) 1.80
Tumours and tremors: how PTEN regulation underlies both. Br J Cancer (2006) 1.70
Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol (2005) 1.61
RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. Cell (2013) 1.60
Regulation of protein tyrosine phosphatases by reversible oxidation. J Biochem (2011) 1.48
Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus. J Investig Med (1996) 1.45
P-Rex2, a new guanine-nucleotide exchange factor for Rac. FEBS Lett (2004) 1.33
Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation. J Immunol (2002) 1.23
Protein phosphatases and the regulation of mitosis. J Cell Sci (2011) 1.23
P-REX2, a novel PI-3-kinase sensitive Rac exchange factor. FEBS Lett (2004) 1.21
Pleckstrin homology (PH) domains in signal transduction. J Cell Biochem (1994) 1.11
P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proc Natl Acad Sci U S A (2008) 1.07
Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. Prostaglandins Other Lipid Mediat (2005) 1.02
Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis. FEBS J (2012) 0.96
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res (2005) 8.98
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med (2007) 6.55
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. Proc Natl Acad Sci U S A (2007) 5.44
The New York Cancer Project: rationale, organization, design, and baseline characteristics. J Urban Health (2004) 5.21
Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc Natl Acad Sci U S A (2008) 4.13
PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med (2005) 3.96
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat Genet (2007) 3.95
P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell (2002) 3.80
Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab (2008) 3.11
PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity. Science (2012) 3.05
Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A (2008) 2.99
Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell (2005) 2.98
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. Proc Natl Acad Sci U S A (2002) 2.89
A secreted PTEN phosphatase that enters cells to alter signaling and survival. Science (2013) 2.86
OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes (2006) 2.77
PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes. Genes Dev (2005) 2.70
PTEN: from pathology to biology. Trends Cell Biol (2003) 2.69
Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone. J Clin Endocrinol Metab (2007) 2.58
Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry. Nat Methods (2011) 2.56
Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol (2004) 2.54
Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science (2009) 2.51
Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism. Mol Cell (2011) 2.50
Brain networks associated with cognitive reserve in healthy young and old adults. Cereb Cortex (2005) 2.37
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood (2005) 2.35
Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle (2009) 2.31
Phosphoinositide 3-kinase-dependent activation of Rac. FEBS Lett (2003) 2.11
Association of life activities with cerebral blood flow in Alzheimer disease: implications for the cognitive reserve hypothesis. Arch Neurol (2003) 2.08
Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects. J Clin Endocrinol Metab (2008) 2.07
BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer. Cancer Res (2008) 2.06
Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing. J Exp Med (2006) 2.01
Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice. Curr Biol (2005) 2.00
The clinically important difference on the unified Parkinson's disease rating scale. Arch Neurol (2010) 1.98
P-Rex1 regulates neutrophil function. Curr Biol (2005) 1.97
PI3Kβ plays a critical role in neutrophil activation by immune complexes. Sci Signal (2011) 1.95
Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation. Am J Physiol Endocrinol Metab (2010) 1.94
The evolution of disability in Parkinson disease. Mov Disord (2008) 1.85
Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. Nat Cell Biol (2006) 1.76
Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action. Am J Physiol Endocrinol Metab (2009) 1.75
Pioglitazone improves insulin sensitivity through reduction in muscle lipid and redistribution of lipid into adipose tissue. Am J Physiol Endocrinol Metab (2005) 1.75
Thrombospondin-1 is an adipokine associated with obesity, adipose inflammation, and insulin resistance. Diabetes (2007) 1.67
Adipose tissue extracellular matrix and vascular abnormalities in obesity and insulin resistance. J Clin Endocrinol Metab (2011) 1.65
The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration. Cancer Res (2008) 1.63
Cognitive reserve modulates functional brain responses during memory tasks: a PET study in healthy young and elderly subjects. Neuroimage (2003) 1.62
The PX domain: a new phosphoinositide-binding module. J Cell Sci (2002) 1.60
Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma. Neuro Oncol (2007) 1.53
Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro. Blood (2006) 1.53
Reduced expression of PTEN correlates with breast cancer progression. Hum Pathol (2002) 1.53
Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression. Am J Physiol Endocrinol Metab (2005) 1.52
The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment. J Lipid Res (2006) 1.50
Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits. J Biol Chem (2004) 1.49
Covariance PET patterns in early Alzheimer's disease and subjects with cognitive impairment but no dementia: utility in group discrimination and correlations with functional performance. Neuroimage (2004) 1.49
Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation. Diabetes (2006) 1.48
HLTF gene silencing in human colon cancer. Proc Natl Acad Sci U S A (2002) 1.43
3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma. Cancer Res (2009) 1.43
Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation. J Clin Endocrinol Metab (2006) 1.42
Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase. J Biol Chem (2007) 1.41
Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion. Am J Physiol Endocrinol Metab (2003) 1.38
Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity. Am J Physiol Endocrinol Metab (2004) 1.36
Adiponectin translation is increased by the PPARgamma agonists pioglitazone and omega-3 fatty acids. Am J Physiol Endocrinol Metab (2008) 1.33
P-Rex2, a new guanine-nucleotide exchange factor for Rac. FEBS Lett (2004) 1.33
Global gene expression profiles of subcutaneous adipose and muscle from glucose-tolerant, insulin-sensitive, and insulin-resistant individuals matched for BMI. Diabetes (2011) 1.31
Prevalence of anxiety disorders and anxiety subtypes in patients with Parkinson's disease. Mov Disord (2009) 1.30
Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice. Proc Natl Acad Sci U S A (2002) 1.30
Randomized clinical trial of 3 types of physical exercise for patients with Parkinson disease. JAMA Neurol (2013) 1.30
SCFAs induce mouse neutrophil chemotaxis through the GPR43 receptor. PLoS One (2011) 1.28
PTEN loss inhibits CHK1 to cause double stranded-DNA breaks in cells. Cell Cycle (2005) 1.26
SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets. J Biol Chem (2004) 1.25
Divergent effects of peroxisome proliferator-activated receptor gamma agonists and tumor necrosis factor alpha on adipocyte ApoE expression. J Biol Chem (2004) 1.24
Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities. J Biol Chem (2002) 1.23
The molecular basis of the differential subcellular localization of FYVE domains. J Biol Chem (2004) 1.23
The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils. Blood (2011) 1.23
The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancer. Oncogene (2005) 1.23
Ectopic fat accumulation and metabolic syndrome. Diabetes Obes Metab (2007) 1.22
PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation. EMBO J (2006) 1.22
Gab2-mediated signaling promotes melanoma metastasis. Am J Pathol (2009) 1.21
Pioglitazone induces apoptosis of macrophages in human adipose tissue. J Lipid Res (2006) 1.19