Published in Nat Cell Biol on December 01, 1999
Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell (2007) 13.04
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell (2004) 11.33
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev (2002) 8.31
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev (2001) 6.15
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev (2003) 5.91
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Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell (2010) 2.96
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Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci U S A (2007) 2.67
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Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc Natl Acad Sci U S A (2005) 2.58
Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell (2012) 2.39
Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. J Cell Biol (2003) 2.38
A hormone-dependent module regulating energy balance. Cell (2011) 2.30
The Drosophila cyclin D-Cdk4 complex promotes cellular growth. EMBO J (2000) 2.19
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Phosphoinositide 3-kinase signaling in the vertebrate retina. J Lipid Res (2010) 1.15
A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Genes Dev (2008) 1.14
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Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling. Mol Cell Biol (2013) 0.93
dAkt kinase controls follicle cell size during Drosophila oogenesis. Dev Dyn (2005) 0.93
Insulin delays the progression of Drosophila cells through G2/M by activating the dTOR/dRaptor complex. EMBO J (2006) 0.93
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Centrosome misorientation mediates slowing of the cell cycle under limited nutrient conditions in Drosophila male germline stem cells. Mol Biol Cell (2012) 0.87
Regulation of the activity of the tumor suppressor PTEN by thioredoxin in Drosophila melanogaster. Exp Cell Res (2007) 0.86
Insulin stimulates translocation of human GLUT4 to the membrane in fat bodies of transgenic Drosophila melanogaster. PLoS One (2013) 0.85
Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling. Mol Cell Biol (2005) 0.85
Developmental control of lateralized neuron size in the nematode Caenorhabditis elegans. Neural Dev (2010) 0.84
FOXO-independent suppression of programmed cell death by the PI3K/Akt signaling pathway in Drosophila. Dev Genes Evol (2006) 0.84
Defective prolactin signaling impairs pancreatic β-cell development during the perinatal period. Am J Physiol Endocrinol Metab (2013) 0.83
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Exercise and dietary change ameliorate high fat diet induced obesity and insulin resistance via mTOR signaling pathway. J Exerc Nutrition Biochem (2016) 0.78
Akt1 protects against germ cell apoptosis in the postnatal mouse testis following lactational exposure to 6-N-propylthiouracil. Reprod Toxicol (2010) 0.78
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Insulin exerts direct, IGF-1 independent actions in growth plate chondrocytes. Bone Res (2014) 0.77
The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster. BMB Rep (2016) 0.77
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The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila. PLoS One (2016) 0.75
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Roles of NlAKTIP in the Growth and Eclosion of the Rice Brown Planthopper, Nilaparvata lugens Stål, as Revealed by RNA Interference. Int J Mol Sci (2015) 0.75
Ohgata, the Single Drosophila Ortholog of Human Cereblon, Regulates Insulin Signaling-dependent Organismic Growth. J Biol Chem (2016) 0.75
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The FOXO transcription factor controls insect growth and development by regulating juvenile hormone degradation in the silkworm, Bombyx mori. J Biol Chem (2017) 0.75
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