Published in Mol Cell Biol on March 01, 2000
Integrin signalling adaptors: not only figurants in the cancer story. Nat Rev Cancer (2010) 2.94
Integrins in invasive growth. J Clin Invest (2002) 1.96
CAS proteins in normal and pathological cell growth control. Cell Mol Life Sci (2009) 1.84
Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent. Oncogene (2010) 1.19
The nucleocytoplasmic shuttling protein CIZ reduces adult bone mass by inhibiting bone morphogenetic protein-induced bone formation. J Exp Med (2005) 1.08
Identifying genes that regulate bone remodeling as potential therapeutic targets. J Exp Med (2005) 0.96
A brief review of bone adaptation to unloading. Genomics Proteomics Bioinformatics (2008) 0.93
Regulation of nucleocytoplasmic trafficking by cell adhesion receptors and the cytoskeleton. J Cell Biol (2001) 0.92
Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness. Mol Biol Cell (2011) 0.90
Nmp4/CIZ suppresses parathyroid hormone-induced increases in trabecular bone. J Cell Physiol (2009) 0.90
The adaptor proteins p140CAP and p130CAS as molecular hubs in cell migration and invasion of cancer cells. Am J Cancer Res (2011) 0.87
A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signaling. BMC Cell Biol (2002) 0.87
CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics. Cell Mol Life Sci (2013) 0.86
The application of modular protein domains in proteomics. FEBS Lett (2012) 0.82
Nmp4/CIZ inhibits mechanically induced beta-catenin signaling activity in osteoblasts. J Cell Physiol (2010) 0.82
Nmp4/CIZ: road block at the intersection of PTH and load. Bone (2009) 0.82
Immortalization and characterization of osteoblast cell lines generated from wild-type and Nmp4-null mouse bone marrow stromal cells using murine telomerase reverse transcriptase (mTERT). J Cell Physiol (2012) 0.80
Nmp4/CIZ closes the parathyroid hormone anabolic window. Crit Rev Eukaryot Gene Expr (2012) 0.77
Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis. Mol Endocrinol (2015) 0.77
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members. Gene (2015) 0.76
Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression. J Biol Chem (2016) 0.75
The role of focal adhesion anchoring domains of CAS in mechanotransduction. Sci Rep (2017) 0.75
EP300-ZNF384 fusion gene product up-regulates GATA3 gene expression and induces hematopoietic stem cell gene expression signature in B-cell precursor acute lymphoblastic leukemia cells. Int J Hematol (2017) 0.75
Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. Mamm Genome (2004) 0.75
Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners. Sci Rep (2017) 0.75
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell (1986) 42.45
CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res (1987) 15.65
Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell (1989) 7.21
Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J Cell Biol (1989) 6.55
Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell (1991) 6.48
Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp Cell Res (1998) 6.11
12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region. Mol Cell Biol (1987) 4.86
Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression. J Biol Chem (1994) 4.28
CAS/Crk coupling serves as a "molecular switch" for induction of cell migration. J Cell Biol (1998) 4.22
The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors. Oncogene (1999) 3.95
Transcriptional activation modulated by homopolymeric glutamine and proline stretches. Science (1994) 3.92
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J (1994) 3.88
Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site. Mol Cell Biol (1991) 3.54
Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nat Genet (1998) 3.38
Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration. J Cell Biol (1998) 2.97
Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change. Science (1998) 2.95
Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Mol Cell Biol (1996) 2.94
Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol Cell Biol (1997) 2.83
Activation of Rac1 by a Crk SH3-binding protein, DOCK180. Genes Dev (1998) 2.82
p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase. J Biol Chem (1996) 2.77
Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts. Mol Cell Biol (1986) 2.74
Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Proc Natl Acad Sci U S A (1998) 2.73
Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas. Proc Natl Acad Sci U S A (1995) 2.67
Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin. J Cell Biol (1995) 2.45
Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint. EMBO J (1998) 2.38
The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors. Proc Natl Acad Sci U S A (1986) 2.28
Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs. J Biol Chem (1995) 2.25
Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport. Proc Natl Acad Sci U S A (1996) 2.19
Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix. J Biol Chem (1995) 2.17
Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus. J Cell Biol (1997) 2.01
Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins. J Biol Chem (1997) 1.96
Adhesion-induced tyrosine phosphorylation of the p130 src substrate. J Cell Sci (1995) 1.95
Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase. J Biol Chem (1996) 1.90
Nuclear export of actin: a novel mechanism regulating the subcellular localization of a major cytoskeletal protein. EMBO J (1998) 1.89
Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins. J Cell Biol (1995) 1.82
Requirements for localization of p130cas to focal adhesions. Mol Cell Biol (1997) 1.76
The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas. J Biol Chem (1997) 1.69
Changes in cell shape correlate with collagenase gene expression in rabbit synovial fibroblasts. J Cell Biol (1984) 1.67
Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas). J Biol Chem (1996) 1.58
Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing. J Clin Invest (1993) 1.56
Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1(I) gene expression. J Biol Chem (1995) 1.56
Structure and expression of the human gene for the matrix metalloproteinase matrilysin. J Biol Chem (1994) 1.55
Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial? Cell (1998) 1.53
The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway. Proc Natl Acad Sci U S A (1998) 1.46
CMS: an adapter molecule involved in cytoskeletal rearrangements. Proc Natl Acad Sci U S A (1999) 1.42
CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription. Mol Cell Biol (1997) 1.36
cDNAs with long CAG trinucleotide repeats from human brain. Hum Genet (1997) 1.28
Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition. Oncogene (1997) 1.26
Transcriptional regulation of human stromelysin. J Biol Chem (1989) 1.26
Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G. J Biol Chem (1998) 1.18
Evi-1 raises AP-1 activity and stimulates c-fos promoter transactivation with dependence on the second zinc finger domain. J Biol Chem (1994) 1.13
Differential regulation of interstitial collagenase (MMP-1) gene expression by ETS transcription factors. Oncogene (1997) 1.06
Integrin-mediated signal transduction in cells lacking focal adhesion kinase p125FAK. FEBS Lett (1998) 1.05
Of the GATA-binding proteins, only GATA-4 selectively regulates the human interleukin-5 gene promoter in interleukin-5-producing cells which express multiple GATA-binding proteins. Mol Cell Biol (1995) 1.01
Characterization, partial purification, and peptide sequencing of p130,the main phosphoprotein associated with v-Crk oncoprotein. J Biol Chem (1994) 1.00
Augmentation of metalloproteinase (gelatinase) activity secreted from Rous sarcoma virus-infected cells correlates with transforming activity of src. Oncogene (1995) 0.91
src-related tyrosine kinases regulate transcriptional activation of the interstitial collagenase gene, MMP-1, in interleukin-1-stimulated synovial fibroblasts. Arthritis Rheum (1996) 0.89
An epidermal growth factor receptor-leukocyte tyrosine kinase chimeric receptor generates ligand-dependent growth signals through the Ras signaling pathway. J Biol Chem (1995) 0.83
Identification and mapping of 26 human testis mRNAs containing CAG/CTG repeats. Mamm Genome (1998) 0.78
A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature (1988) 27.60
CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science (1997) 13.67
The effect of adrenalin on the gaseous metabolism of the isolated mammalian heart. J Physiol (1914) 8.89
A dipole mode in the tropical Indian Ocean. Nature (1999) 8.42
The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science (1992) 7.49
Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature (2000) 6.70
Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates. J Biol Chem (1968) 6.28
Purification and properties of bacterial chondroitinases and chondrosulfatases. J Biol Chem (1968) 5.66
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature (1997) 5.55
Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest (1999) 5.30
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ (2006) 5.18
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron (1996) 4.12
Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci U S A (1998) 3.99
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J (1994) 3.88
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest (1998) 3.76
Transplantation of anergic histoincompatible bone marrow allografts. N Engl J Med (1999) 3.72
Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium. Nature (2000) 3.61
Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nat Genet (1998) 3.38
Replication and plaque formation of mouse hepatitis virus (MHV-2) in mouse cell line DBT culture. Arch Gesamte Virusforsch (1974) 3.24
Total synthesis of taxol. Nature (1994) 3.22
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nat Genet (2001) 3.14
Cellular applications of 31P and 13C nuclear magnetic resonance. Science (1979) 3.14
Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases. Curr Biol (1995) 3.12
Sarin poisoning in Tokyo subway. Lancet (1995) 3.06
Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. Nat Immunol (2001) 2.97
Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Mol Cell Biol (1996) 2.94
cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol (2000) 2.83
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet (1999) 2.81
High resolution 31P nuclear magnetic resonance studies of intact yeast cells. Proc Natl Acad Sci U S A (1975) 2.72
Nonsense mutation of glucokinase gene in late-onset non-insulin-dependent diabetes mellitus. Lancet (1992) 2.71
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene (1999) 2.66
Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell (1998) 2.64
Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10. Nat Genet (2000) 2.60
High-resolution 31P nuclear magnetic resonance studies of metabolism in aerobic Escherichia coli cells. Proc Natl Acad Sci U S A (1977) 2.58
The codon CUG is read as serine in an asporogenic yeast Candida cylindracea. Nature (1989) 2.57
Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. Science (1999) 2.56
Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit. Neuron (1997) 2.54
Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis. J Biol Chem (1998) 2.51
Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest (1997) 2.44
Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells. FEBS Lett (1988) 2.44
Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. J Biol Chem (1998) 2.42
Nucleotide sequence comparison of the mycobacterial dnaJ gene and PCR-restriction fragment length polymorphism analysis for identification of mycobacterial species. Int J Syst Bacteriol (1994) 2.42
An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease. Nature (1997) 2.42
Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome. J Am Coll Cardiol (1996) 2.42
Rhamnolipids produced by Pseudomonas aeruginosa grown on n-paraffin (mixture of C 12 , C 13 and C 14 fractions). J Antibiot (Tokyo) (1971) 2.39
1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells. J Clin Invest (1984) 2.39
Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase. J Clin Invest (1998) 2.36
Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron (1997) 2.34
Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons. J Biol Chem (1999) 2.27
The absence of "heme-heme" interactions in hemoglobin. Science (1969) 2.26
Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs. J Biol Chem (1995) 2.25
Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Cell (1998) 2.25
Retracted A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. EMBO J (2001) 2.21
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone. Nature (1997) 2.20
13C NMR studies of gluconeogenesis in rat liver cells: utilization of labeled glycerol by cells from euthyroid and hyperthyroid rats. Proc Natl Acad Sci U S A (1979) 2.19
Advanced protein glycosylation induces transendothelial human monocyte chemotaxis and secretion of platelet-derived growth factor: role in vascular disease of diabetes and aging. Proc Natl Acad Sci U S A (1990) 2.18
A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes. Mol Cell Biol (1996) 2.18
The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3. Nature (1998) 2.18
Imaging at high magnetic fields: initial experiences at 4 T. Magn Reson Q (1993) 2.14
Analysis of genomic and intracellular viral RNAs of small plaque mutants of mouse hepatitis virus, JHM strain. Virology (1984) 2.13
Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J (1994) 2.12
ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1. Nat Cell Biol (2001) 2.11
Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets. Diabetologia (1993) 2.11
Matrix/integrin interaction activates the mitogen-activated protein kinase, p44erk-1 and p42erk-2. J Biol Chem (1995) 2.09
Cbfa1 isoforms exert functional differences in osteoblast differentiation. J Biol Chem (1999) 2.06
Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science (1999) 2.06
Angiotensin II type 1A receptor knockout mice display less left ventricular remodeling and improved survival after myocardial infarction. Circulation (1999) 2.06
Determination of relative CMRO2 from CBF and BOLD changes: significant increase of oxygen consumption rate during visual stimulation. Magn Reson Med (1999) 2.06
Pressure overload induces cardiac hypertrophy in angiotensin II type 1A receptor knockout mice. Circulation (1998) 2.05
Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy. Circulation (2001) 2.04
Successful pregnancy after allogeneic bone marrow transplantation following conditioning with total body irradiation. Bone Marrow Transplant (1995) 2.01
Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods. J Biol Chem (1999) 2.00
Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes. Hum Mol Genet (2001) 2.00
31P nuclear magnetic resonance studies of Ehrlich ascites tumor cells. Proc Natl Acad Sci U S A (1977) 1.97
Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J Clin Invest (1995) 1.95
Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol Cell Biol (1996) 1.95
Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. Proc Natl Acad Sci U S A (1999) 1.95
The nature of spatiotemporal changes in cerebral hemodynamics as manifested in functional magnetic resonance imaging. Magn Reson Med (1997) 1.94
Causes of maternal mortality in Japan. JAMA (2000) 1.92
Dynamic mapping of the human visual cortex by high-speed magnetic resonance imaging. Proc Natl Acad Sci U S A (1992) 1.92
Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4. Mol Cell Biol (1999) 1.91
Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur J Neurosci (1998) 1.90
Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase. J Biol Chem (1996) 1.90
Interaction of phytoestrogens with estrogen receptors alpha and beta. Biol Pharm Bull (2001) 1.90