Published in Curr Opin Neurobiol on June 01, 2000
Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A (2003) 7.60
Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc Natl Acad Sci U S A (2003) 2.14
A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules. J Cell Biol (2004) 1.90
Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation. Proc Natl Acad Sci U S A (2005) 1.67
A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol (2006) 1.66
Winding through the WNT pathway during cellular development and demise. Histol Histopathol (2006) 1.50
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Wnt-5a/JNK signaling promotes the clustering of PSD-95 in hippocampal neurons. J Biol Chem (2009) 1.38
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The primary cilium as a Hedgehog signal transduction machine. Methods Cell Biol (2009) 1.35
Mechanistic insights into diabetes mellitus and oxidative stress. Curr Med Chem (2007) 1.25
Vital elements of the Wnt-Frizzled signaling pathway in the nervous system. Curr Neurovasc Res (2005) 1.21
Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling. J Biol Chem (2008) 1.20
Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Neurobiol Dis (2010) 1.17
Multilineage potential of stable human mesenchymal stem cell line derived from fetal marrow. PLoS One (2007) 1.14
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A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection. Mol Neurodegener (2011) 1.13
Erythropoietin: elucidating new cellular targets that broaden therapeutic strategies. Prog Neurobiol (2008) 1.13
Synaptic Wnt signaling-a contributor to major psychiatric disorders? J Neurodev Disord (2011) 1.06
Hand in glove: brain and skull in development and dysmorphogenesis. Acta Neuropathol (2013) 1.04
Triple play: promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus. Biomed Pharmacother (2008) 1.02
GSK3beta in ethanol neurotoxicity. Mol Neurobiol (2009) 1.01
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Ror1-Ror2 complexes modulate synapse formation in hippocampal neurons. Neuroscience (2009) 0.95
Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair. Eur J Neurosci (2013) 0.95
The carboxyl-terminal domain of connexin43 is a negative modulator of neuronal differentiation. J Biol Chem (2010) 0.94
Nucleus- and cell-specific gene expression in monkey thalamus. Proc Natl Acad Sci U S A (2007) 0.89
LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Hum Mol Genet (2012) 0.89
Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model. Neuropsychopharmacology (2011) 0.86
Expression of the diabetes-associated gene TCF7L2 in adult mouse brain. J Comp Neurol (2009) 0.86
WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation. PLoS One (2013) 0.86
Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase. Front Mol Neurosci (2012) 0.86
Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson's disease. J Mol Cell Biol (2014) 0.85
Genetic and protein changes of E-cadherin in meningiomas. J Cancer Res Clin Oncol (2009) 0.83
Subchronic treatment with fluoxetine and ketanserin increases hippocampal brain-derived neurotrophic factor, β-catenin and antidepressant-like effects. Br J Pharmacol (2012) 0.83
Therapeutic promise and principles: metabotropic glutamate receptors. Oxid Med Cell Longev (2010) 0.82
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The cellular story of dishevelleds. Croat Med J (2014) 0.81
Genetic and molecular alterations across medulloblastoma subgroups. J Mol Med (Berl) (2015) 0.81
Midbrain dopaminergic development in vivo and in vitro from embryonic stem cells. J Anat (2005) 0.81
Wnt/Glycogen Synthase Kinase 3β/β-catenin Signaling Activation Mediated Sevoflurane Preconditioning-induced Cardioprotection. Chin Med J (Engl) (2015) 0.80
Neural crest stem cell-specific deletion of the Pygopus2 gene modulates hair follicle development. Stem Cell Rev (2014) 0.79
Molecular subtyping and improved treatment of neurodevelopmental disease. Genome Med (2016) 0.79
The wnt pathway in mood disorders. Curr Neuropharmacol (2012) 0.79
Modelling of a targeted nanotherapeutic 'stroma' to deliver the cytokine LIF, or XAV939, a potent inhibitor of Wnt-β-catenin signalling, for use in human fetal dopaminergic grafts in Parkinson's disease. Dis Model Mech (2014) 0.78
Discovery of new candidate genes related to brain development using protein interaction information. PLoS One (2015) 0.78
Neurodevelopment in schizophrenia: the role of the wnt pathways. Curr Neuropharmacol (2013) 0.77
The role of GSK3beta in the development of the central nervous system. Front Biol (Beijing) (2012) 0.77
Exploring the heterogeneity of neural social indices for genetically distinct etiologies of autism. J Neurodev Disord (2017) 0.76
Involvement of the Wnt signaling pathway and cell apoptosis in the rat hippocampus following cerebral ischemia/reperfusion injury. Neural Regen Res (2013) 0.76
Kruppel-Like Factor 4 Regulates Granule Cell Pax6 Expression and Cell Proliferation in Early Cerebellar Development. PLoS One (2015) 0.76
Genetic perspective of retinoblastoma: From present to future. Indian J Ophthalmol (2016) 0.75
Motor Function Deficits Following Chronic Prenatal Ethanol Exposure are Linked to Impairments in Insulin/IGF, Notch and Wnt Signaling in the Cerebellum. J Diabetes Metab (2013) 0.75
Arsenic inhibits stem cell differentiation by altering the interplay between the Wnt3a and Notch signaling pathways. Toxicol Rep (2016) 0.75
Activation of muscarinic receptors inhibits glutamate-induced GSK-3β overactivation in PC12 cells. Acta Pharmacol Sin (2013) 0.75
Moringin activates Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune encephalomyelitis. Drug Des Devel Ther (2016) 0.75
Review of the neuroanatomic landscape implicated in glucose sensing and regulation of nutrient signaling: immunophenotypic localization of diabetes gene Tcf7l2 in the developing murine brain. J Chem Neuroanat (2012) 0.75
Long-term influence of prenatal high sucrose intake on learning and memory of aged rat offspring with oxidative stress and disruptions in NMDARs/Wnt signaling in hippocampus. Brain Res (2017) 0.75
Distinct patterns of gene expression induced by viral oncogenes in human embryonic brain cells. Cell Mol Neurobiol (2003) 0.75
beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J (1997) 12.97
Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol (1998) 9.24
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature (1998) 8.02
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev (1999) 6.56
Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell (1998) 4.49
Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling. Cell (2000) 4.35
The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Curr Biol (1999) 4.06
The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Nature (1999) 4.01
The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. Oncogene (1999) 3.36
Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer. Nature (2000) 3.35
Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell (1997) 3.23
The role of RhoA in tissue polarity and Frizzled signalling. Nature (1997) 3.22
A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature (1999) 3.22
The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature (1999) 3.19
Wnt signalling required for expansion of neural crest and CNS progenitors. Nature (1997) 3.11
The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. Development (1998) 3.07
Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature (1997) 3.04
Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus. J Cell Biol (1996) 2.86
A local Wnt-3a signal is required for development of the mammalian hippocampus. Development (2000) 2.75
Control of neural crest cell fate by the Wnt signalling pathway. Nature (1998) 2.71
A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A (1997) 2.70
WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans. Cell (1999) 2.69
The Wnt/Wg signal transducer beta-catenin controls fibronectin expression. Mol Cell Biol (1999) 2.68
Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells. J Biol Chem (1999) 2.67
Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A. Dev Biol (1997) 2.66
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature (1998) 2.56
Inhibition of beta-catenin-mediated transactivation by cadherin derivatives. Proc Natl Acad Sci U S A (1998) 2.55
Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Cell (1997) 2.40
Differential nuclear translocation and transactivation potential of beta-catenin and plakoglobin. J Cell Biol (1998) 2.38
Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proc Natl Acad Sci U S A (1997) 2.36
naked cuticle encodes an inducible antagonist of Wnt signalling. Nature (2000) 2.35
MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. Nature (1999) 2.32
Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function. Proc Natl Acad Sci U S A (1999) 2.25
Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. Genes Dev (1999) 2.24
The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila. Nature (1999) 2.22
Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium. J Cell Sci (1998) 2.10
A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans. Development (1999) 2.03
Molecular modification of N-cadherin in response to synaptic activity. Neuron (2000) 2.02
Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development (2000) 2.01
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WNT targets. Repression and activation. Trends Genet (1999) 1.91
Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway. Genes Dev (2000) 1.87
Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development. Cell (1998) 1.82
The novel tyrosine kinase ZAK1 activates GSK3 to direct cell fate specification. Cell (1999) 1.81
WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons. Dev Biol (1997) 1.68
Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell. Genes Dev (1999) 1.67
Excess beta-catenin promotes accumulation of transcriptionally active p53. EMBO J (1999) 1.63
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Wnt signalling in Caenorhabditis elegans: regulating repressors and polarizing the cytoskeleton. Trends Cell Biol (2000) 1.50
sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney. Dev Dyn (1998) 1.37
Head in the WNT: the molecular nature of Spemann's head organizer. Trends Genet (1999) 1.31
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Regulation of neurotrophin-3 expression by epithelial-mesenchymal interactions: the role of Wnt factors. Science (1999) 1.19
SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development (2000) 1.19
Expression of Pax-3 in the lateral neural plate is dependent on a Wnt-mediated signal from posterior nonaxial mesoderm. Dev Biol (1999) 1.18
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Identification of an evolutionarily conserved 110 base-pair cis-acting regulatory sequence that governs Wnt-1 expression in the murine neural plate. Development (1998) 1.17
Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick development. Dev Biol (2000) 1.14
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