Published in Nature on February 17, 2000
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol (2003) 4.70
Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors. Proc Natl Acad Sci U S A (2001) 2.77
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol (2007) 2.70
Wnt signaling from development to disease: insights from model systems. Cold Spring Harb Perspect Biol (2009) 2.42
Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity. J Cell Biol (2003) 2.27
Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc Natl Acad Sci U S A (2001) 2.22
Naked cuticle targets dishevelled to antagonize Wnt signal transduction. Genes Dev (2001) 2.16
Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci U S A (2007) 2.15
The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev (2002) 2.02
C-terminal-binding protein directly activates and represses Wnt transcriptional targets in Drosophila. EMBO J (2006) 2.01
Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways. Dev Biol (2007) 1.82
The microRNA miR-8 is a conserved negative regulator of Wnt signaling. Proc Natl Acad Sci U S A (2008) 1.76
Convergence between Wnt-β-catenin and EGFR signaling in cancer. Mol Cancer (2010) 1.74
Roles of Wnt proteins in neural development and maintenance. Curr Opin Neurobiol (2000) 1.68
Wingful, an extracellular feedback inhibitor of Wingless. Genes Dev (2002) 1.48
Casein kinase Iepsilon modulates the signaling specificities of dishevelled. Mol Cell Biol (2004) 1.41
From individual Wnt pathways towards a Wnt signalling network. Philos Trans R Soc Lond B Biol Sci (2008) 1.37
CBP/p300 are bimodal regulators of Wnt signaling. EMBO J (2007) 1.31
Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells. Proc Natl Acad Sci U S A (2004) 1.30
PR72, a novel regulator of Wnt signaling required for Naked cuticle function. Genes Dev (2005) 1.21
Activation of wingless targets requires bipartite recognition of DNA by TCF. Curr Biol (2008) 1.21
Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Mol Cell Proteomics (2008) 1.18
Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane. J Biol Chem (2010) 1.18
Wnt/catenin signaling in adult stem cell physiology and disease. Stem Cell Rev (2014) 1.15
Calcium signaling in vertebrate embryonic patterning and morphogenesis. Dev Biol (2007) 1.14
Drawing lines in the sand: even skipped et al. and parasegment boundaries. Dev Biol (2004) 1.09
Single locus affects embryonic segment polarity and multiple aspects of an adult evolutionary novelty. BMC Biol (2010) 1.08
PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle. Proc Natl Acad Sci U S A (2006) 1.07
Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling. Dev Biol (2007) 1.05
Regulation of wingless signaling by the CKI family in Drosophila limb development. Dev Biol (2006) 1.04
Dickkopf1: a tumor suppressor or metastasis promoter? Int J Cancer (2011) 1.03
Wnt/β-catenin signaling in dermal condensates is required for hair follicle formation. Dev Biol (2013) 1.02
Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors. PLoS One (2013) 1.00
The chromatin remodelers ISWI and ACF1 directly repress Wingless transcriptional targets. Dev Biol (2008) 1.00
Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. Dev Biol (2010) 1.00
The ISWI-containing NURF complex regulates the output of the canonical Wingless pathway. EMBO Rep (2009) 0.99
Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. PLoS One (2009) 0.98
The epigenetic signature of CFTR expression is co-ordinated via chromatin acetylation through a complex intronic element. Biochem J (2007) 0.97
Wnt signaling targets ETO coactivation domain of TAF4/TFIID in vivo. Proc Natl Acad Sci U S A (2008) 0.95
Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway. Mol Syst Biol (2009) 0.94
Structural studies of human Naked2: a biologically active intrinsically unstructured protein. Biochem Biophys Res Commun (2006) 0.94
Regulation of the feedback antagonist naked cuticle by Wingless signaling. Dev Biol (2008) 0.93
Naked1 antagonizes Wnt signaling by preventing nuclear accumulation of β-catenin. PLoS One (2011) 0.92
RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development. Genetics (2005) 0.91
Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6. PLoS One (2009) 0.89
Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. Mol Cell Biol (2007) 0.89
An unconventional nuclear localization motif is crucial for function of the Drosophila Wnt/wingless antagonist Naked cuticle. Genetics (2006) 0.89
Nkd1 functions as a passive antagonist of Wnt signaling. PLoS One (2013) 0.89
Wnt signaling inhibits adrenal steroidogenesis by cell-autonomous and non-cell-autonomous mechanisms. Mol Endocrinol (2014) 0.88
Down-regulation of NKD1 increases the invasive potential of non-small-cell lung cancer and correlates with a poor prognosis. BMC Cancer (2011) 0.86
Small molecules and stem cells. Potency and lineage commitment: the new quest for the fountain of youth. J Med Chem (2010) 0.86
Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling. Dev Biol (2008) 0.86
Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol (2013) 0.85
Epigenetic silencing of NKD2, a major component of Wnt signaling, promotes breast cancer growth. Oncotarget (2015) 0.85
Robustness and stability of the gene regulatory network involved in DV boundary formation in the Drosophila wing. PLoS One (2007) 0.84
Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterning. Development (2008) 0.84
TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer. Sci Rep (2015) 0.84
Wnt ligand-dependent activation of the negative feedback regulator Nkd1. Mol Biol Cell (2015) 0.83
Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled. Exp Mol Med (2009) 0.83
Regulation of Stem Cell Proliferation and Cell Fate Specification by Wingless/Wnt Signaling Gradients Enriched at Adult Intestinal Compartment Boundaries. PLoS Genet (2016) 0.82
Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation. J Cell Sci (2010) 0.81
Wnt signaling cross-talks with JH signaling by suppressing Met and gce expression. PLoS One (2011) 0.81
NKD1 down-regulation is associated with poor prognosis in breast invasive ductal carcinoma. Int J Clin Exp Pathol (2015) 0.80
Coop functions as a corepressor of Pangolin and antagonizes Wingless signaling. Genes Dev (2010) 0.80
Cell-autonomous, myristyl-independent activity of the Drosophila Wnt/Wingless antagonist Naked cuticle (Nkd). Dev Biol (2007) 0.80
The ADP-ribose polymerase Tankyrase regulates adult intestinal stem cell proliferation during homeostasis in Drosophila. Development (2016) 0.80
FGF2 mediates hepatic progenitor cell formation during human pluripotent stem cell differentiation by inducing the WNT antagonist NKD1. Genes Dev (2015) 0.77
Identification of genes differentially expressed in dorsal and ventral chick midbrain during early development. BMC Dev Biol (2009) 0.76
Zfp703 Is a Wnt/β-Catenin Feedback Suppressor Targeting the β-Catenin/Tcf1 Complex. Mol Cell Biol (2016) 0.76
Wnt signaling and cellular metabolism in osteoblasts. Cell Mol Life Sci (2016) 0.75
Silencing the Honey Bee (Apis mellifera) Naked Cuticle Gene (nkd) Improves Host Immune Function and Reduces Nosema ceranae Infections. Appl Environ Microbiol (2016) 0.75
Rnf25/AO7 positively regulates wnt signaling via disrupting Nkd1-Axin inhibitory complex independent of its ubiquitin ligase activity. Oncotarget (2016) 0.75
Brinker possesses multiple mechanisms for repression because its primary co-repressor, Groucho, may be unavailable in some cell types. Development (2013) 0.75
Wnt Signaling in Normal and Malignant Stem Cells. Curr Stem Cell Rep (2016) 0.75
Reversal of hyperactive Wnt signaling-dependent adipocyte defects by peptide boronic acids. Proc Natl Acad Sci U S A (2017) 0.75
A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues. G3 (Bethesda) (2017) 0.75
Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing. PLoS Genet (2017) 0.75
Altered neural cell fates and medulloblastoma in mouse patched mutants. Science (1997) 11.44
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature (2000) 10.04
Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science (1995) 8.31
Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science (1996) 8.06
Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron (1999) 7.80
brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2. Cell (1992) 7.63
Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell (1985) 6.93
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem (2001) 6.85
Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins. Nature (1984) 6.79
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature (1999) 6.37
Sequence and genomic organization of Norwalk virus. Virology (1993) 6.25
opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster. Cell (1985) 5.71
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature (1996) 5.69
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev (1996) 4.94
Pairwise end sequencing: a unified approach to genomic mapping and sequencing. Genomics (1995) 4.83
Translational control of protein synthesis in response to heat shock in D. melanogaster cells. Cell (1980) 4.82
The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development. Cell (1991) 4.63
Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila. Proc Natl Acad Sci U S A (1984) 4.59
Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem (1999) 4.56
The molecular organization of the Antennapedia locus of Drosophila. Cell (1983) 4.50
Five SWI/SNF gene products are components of a large multisubunit complex required for transcriptional enhancement. Proc Natl Acad Sci U S A (1994) 4.49
Filamin, a new high-molecular-weight protein found in smooth muscle and non-muscle cells. Proc Natl Acad Sci U S A (1975) 4.38
Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci U S A (1995) 4.22
Right 25 bp terminus sequence of the nopaline T-DNA is essential for and determines direction of DNA transfer from agrobacterium to the plant genome. Cell (1984) 4.09
Basal cell carcinomas in mice overexpressing sonic hedgehog. Science (1997) 3.84
A mini binary vector series for plant transformation. Plant Mol Biol (1999) 3.75
Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene (2009) 3.64
Intracellular distributions of mechanochemical proteins in cultured fibroblasts. Proc Natl Acad Sci U S A (1977) 3.63
Patterns of gene expression during Drosophila mesoderm development. Science (2001) 3.48
Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res (1998) 3.44
What determines the specificity of action of Drosophila homeodomain proteins? Cell (1990) 3.34
Activation of the Wnt signaling pathway: a molecular mechanism for lithium action. Dev Biol (1997) 3.03
Localization of the fushi tarazu protein during Drosophila embryogenesis. Cell (1985) 3.00
Titin: major myofibrillar components of striated muscle. Proc Natl Acad Sci U S A (1979) 2.96
Homeotic gene Antennapedia mRNA contains 5'-noncoding sequences that confer translational initiation by internal ribosome binding. Genes Dev (1992) 2.94
Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. J Mol Biol (1999) 2.92
The developmental biology of brain tumors. Annu Rev Neurosci (2001) 2.82
Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway. Cell (1997) 2.81
Regulation of microvillus structure: calcium-dependent solation and cross-linking of actin filaments in the microvilli of intestinal epithelial cells. J Cell Biol (1980) 2.72
The Drosophila snr1 and brm proteins are related to yeast SWI/SNF proteins and are components of a large protein complex. Mol Biol Cell (1995) 2.67
Molecular targets of lithium action. Annu Rev Pharmacol Toxicol (2001) 2.63
Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis. EMBO J (2000) 2.55
Recruitment of a hedgehog regulatory circuit in butterfly eyespot evolution. Science (1999) 2.55
An approach to nearest neighbor analysis of membrane proteins. Application to the human erythrocyte membrane of a method employing cleavable cross-linkages. J Biol Chem (1974) 2.53
Quantitation of dihydropyrimidine dehydrogenase expression by real-time reverse transcription polymerase chain reaction. Anal Biochem (2000) 2.53
Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases. Mol Cell (2001) 2.44
Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers. Anal Chem (2001) 2.42
Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat Med (1999) 2.39
Translational control in lysates of Drosophila melanogaster cells. Proc Natl Acad Sci U S A (1981) 2.37
Sarcomere-associated cytoskeletal lattices in striated muscle. Review and hypothesis. Cell Muscle Motil (1985) 2.30
The circadian pattern of the development of ventricular fibrillation in patients with Brugada syndrome. Eur Heart J (1999) 2.28
Site-Specific Nick in the T-DNA Border Sequence as a Result of Agrobacterium vir Gene Expression. Science (1987) 2.26
The prospero gene specifies cell fates in the Drosophila central nervous system. Cell (1991) 2.21
Development of a real-time PCR method for Firmicutes and Bacteroidetes in faeces and its application to quantify intestinal population of obese and lean pigs. Lett Appl Microbiol (2008) 2.19
Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning. Development (1996) 2.18
Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome. Eur Heart J (2002) 2.17
Naked cuticle targets dishevelled to antagonize Wnt signal transduction. Genes Dev (2001) 2.16
A network of transverse and longitudinal intermediate filaments is associated with sarcomeres of adult vertebrate skeletal muscle. J Cell Biol (1983) 2.16
Vertebrate homeobox gene nomenclature. Cell (1992) 2.15
Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3. J Biol Chem (1997) 2.12
Fluorescent localization of contractile proteins in tissue culture cells. Methods Enzymol (1982) 2.12
Filamin, a new high-molecular-weight protein found in smooth muscle and nonmuscle cells. Purification and properties of chicken gizzard filamin. Biochemistry (1977) 2.11
The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell (1989) 2.10
Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol (2000) 2.08
Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc Natl Acad Sci U S A (1992) 2.07
Hemodynamic predictors of myocardial oxygen consumption during static and dynamic exercise. Circulation (1974) 2.01
Structure of transcripts from the homeotic Antennapedia gene of Drosophila melanogaster: two promoters control the major protein-coding region. Mol Cell Biol (1986) 2.00
Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome. J Invest Dermatol (1998) 2.00
Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo. EMBO J (1997) 1.96
Zygotically active genes that affect the spatial expression of the fushi tarazu segmentation gene during early Drosophila embryogenesis. Cell (1986) 1.96
VirD proteins of Agrobacterium tumefaciens are required for the formation of a covalent DNA--protein complex at the 5' terminus of T-strand molecules. EMBO J (1988) 1.93
Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog. Nat Med (1997) 1.93
Comparative genomics of the human and mouse T cell receptor loci. Immunity (2001) 1.92
Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. Dev Biol (2001) 1.87
Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events. Mol Biol Cell (2001) 1.87
Interaction of filamin with f-actin in solution. Proc Natl Acad Sci U S A (1977) 1.87
A mixture model with random-effects components for clustering correlated gene-expression profiles. Bioinformatics (2006) 1.85
Nebulin as a length regulator of thin filaments of vertebrate skeletal muscles: correlation of thin filament length, nebulin size, and epitope profile. J Cell Biol (1991) 1.85
Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity. Development (1993) 1.85
Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors. Cancer Res (1997) 1.83
Power to detect linkage based on multiple sets of data in the presence of locus heterogeneity: comparative evaluation of model-based linkage methods for affected sib pair data. Hum Hered (2001) 1.82
Homeotic genes regulate the spatial expression of putative growth factors in the visceral mesoderm of Drosophila embryos. Development (1990) 1.82
Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil. Clin Cancer Res (1999) 1.82
Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development (1996) 1.80
A sequence-specific DNA-binding protein that activates fushi tarazu segmentation gene expression. Genes Dev (1990) 1.79
A Drosophila growth factor homolog, decapentaplegic, regulates homeotic gene expression within and across germ layers during midgut morphogenesis. Development (1990) 1.79
Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila. Development (1998) 1.78
The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identity. Development (1999) 1.77
Passive tension and stiffness of vertebrate skeletal and insect flight muscles: the contribution of weak cross-bridges and elastic filaments. Biophys J (1993) 1.75
Localized right ventricular morphological abnormalities detected by electron-beam computed tomography represent arrhythmogenic substrates in patients with the Brugada syndrome. Eur Heart J (2001) 1.71
Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1. Oncogene (2006) 1.69
Molecular genetics of Drosophila neurogenesis. Cold Spring Harb Symp Quant Biol (1985) 1.68
The localization and regulation of Antennapedia protein expression in Drosophila embryos. Cell (1986) 1.67
Nucleated polymerization of actin from the membrane-associated ends of microvillar filaments in the intestinal brush border. J Cell Biol (1982) 1.65
Incorporating language phenotypes strengthens evidence of linkage to autism. Am J Med Genet (2001) 1.65