Published in Proc Natl Acad Sci U S A on July 05, 2000
Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci (2001) 11.40
Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. Diabetes (2006) 2.87
Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway. J Neurosci (2005) 2.44
BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses. Exp Brain Res (2009) 1.42
Retracted Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging. J Neurosci (2011) 1.30
Neurotrophins enhance CaMKII activity and rescue amyloid-β-induced deficits in hippocampal synaptic plasticity. J Alzheimers Dis (2010) 0.99
A single Aplysia neurotrophin mediates synaptic facilitation via differentially processed isoforms. Cell Rep (2013) 0.95
BDNF but not NT-4 is required for normal flexion reflex plasticity and function. Proc Natl Acad Sci U S A (2001) 0.93
The best-laid plans go oft awry: synaptogenic growth factor signaling in neuropsychiatric disease. Front Synaptic Neurosci (2014) 0.81
The Role of Astrocytic Aquaporin-4 in Synaptic Plasticity and Learning and Memory. Front Integr Neurosci (2016) 0.78
Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-β on synaptic plasticity. Front Pharmacol (2014) 0.75
Neurotrophic Factors and Their Potential Applications in Tissue Regeneration. Arch Immunol Ther Exp (Warsz) (2015) 0.75
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci (1992) 11.73
Modality-specific retrograde amnesia of fear. Science (1992) 9.36
The role of calcium in neuromuscular facilitation. J Physiol (1968) 9.35
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell (1994) 6.67
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc Natl Acad Sci U S A (1995) 5.25
Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science (1995) 5.19
Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron (1996) 5.19
Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology (Berl) (1997) 5.03
Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell (1997) 4.83
Physiology of the neurotrophins. Annu Rev Neurosci (1996) 4.82
Fear conditioning induces associative long-term potentiation in the amygdala. Nature (1997) 4.80
Neurotrophins and neuronal plasticity. Science (1995) 4.53
Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature (1996) 4.41
Essential role for TrkB receptors in hippocampus-mediated learning. Neuron (1999) 4.20
Molecular cloning and expression of brain-derived neurotrophic factor. Nature (1989) 3.90
Requirement of a critical period of transcription for induction of a late phase of LTP. Science (1994) 3.85
Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell (1994) 3.70
Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature (1994) 3.64
Neurotrophins regulate dendritic growth in developing visual cortex. Neuron (1995) 3.64
Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell (1994) 3.52
Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport. J Neurosci (1997) 3.41
The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning. J Neurosci (1990) 3.13
Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF. Nature (1993) 3.09
The Trk family of neurotrophin receptors. J Neurobiol (1994) 3.06
Neurotrophins and time: different roles for TrkB signaling in hippocampal long-term potentiation. Neuron (1997) 3.03
Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science (1990) 2.91
Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro. Brain Res (1988) 2.77
Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature (1990) 2.69
Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Proc Natl Acad Sci U S A (1995) 2.58
The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell (1991) 2.56
Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth. Neuron (1997) 2.47
The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell (1991) 2.46
trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. Cell (1991) 2.31
Inhibition of ocular dominance column formation by infusion of NT-4/5 or BDNF. Science (1995) 2.30
Learning deficit in BDNF mutant mice. Eur J Neurosci (1997) 2.20
BDNF and NT-4/5 enhance glutamatergic synaptic transmission in cultured hippocampal neurones. Neuroreport (1994) 2.19
Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Proc Natl Acad Sci U S A (1992) 2.14
Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice. Proc Natl Acad Sci U S A (1996) 2.10
Functional interactions of neurotrophins and neurotrophin receptors. Annu Rev Neurosci (1995) 2.09
Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo. J Neurosci (1995) 2.09
Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron (1991) 2.03
Enhancement of neurotransmitter release induced by brain-derived neurotrophic factor in cultured hippocampal neurons. J Neurosci (1998) 1.91
Gene transfer and molecular cloning of the human NGF receptor. Science (1986) 1.91
Hippocampus and context in classical conditioning. Curr Opin Neurobiol (1999) 1.90
Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc Natl Acad Sci U S A (1990) 1.76
Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4. Nature (1995) 1.75
Neurotrophic factors and their receptors. Curr Opin Cell Biol (1995) 1.74
The p75 neurotrophin receptor. J Neurobiol (1994) 1.66
Neurotrophin regulation of synaptic transmission. Curr Opin Neurobiol (1999) 1.66
Naloxone and shock-elicited freezing in the rat. J Comp Physiol Psychol (1979) 1.61
A role for BDNF in the late-phase of hippocampal long-term potentiation. Neuropharmacology (1999) 1.49
Role of neurotrophins in synapse development and plasticity. Rev Neurosci (1998) 1.43
Sensory but not motor neuron deficits in mice lacking NT4 and BDNF. Nature (1995) 1.41
Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses. Neuron (1998) 1.38
Maintenance of long-term potentiation in rat dentate gyrus requires protein synthesis but not messenger RNA synthesis immediately post-tetanization. Neuroscience (1989) 1.37
Acute intrahippocampal infusion of BDNF induces lasting potentiation of synaptic transmission in the rat dentate gyrus. J Neurophysiol (1998) 1.36
LTP is accompanied by commensurate enhancement of auditory-evoked responses in a fear conditioning circuit. Neuron (1995) 1.30
Retrograde signaling in the development and modification of synapses. Physiol Rev (1998) 1.26
Potentiation of developing synapses by postsynaptic release of neurotrophin-4. Neuron (1997) 1.26
Neurotrophin regulation of the developing nervous system: analyses of knockout mice. Rev Neurosci (1998) 1.13
NGF improves spatial memory in aged rodents as a function of age. J Neurosci (1991) 1.06
Reversal of spatial memory impairments in aged rats by nerve growth factor and neurotrophins 3 and 4/5 but not by brain-derived neurotrophic factor. Proc Natl Acad Sci U S A (1994) 1.04
Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits. J Neurosci (1997) 1.04
Synaptic modulation by neurotrophic factors. Prog Brain Res (1996) 0.97
Central neuronal loss and behavioral impairment in mice lacking neurotrophin receptor p75. J Comp Neurol (1999) 0.94
Endogenous neurotrophin-3 regulates short-term plasticity at lateral perforant path-granule cell synapses. J Neurosci (1998) 0.93
Structure-function relationships in the neurotrophin family. J Neurobiol (1994) 0.86
Learning impairment and cholinergic deafferentation after cortical nerve growth factor deprivation. J Neurosci (1997) 0.85
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science (1997) 16.09
Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association. Nat Genet (2001) 13.05
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell (1997) 12.83
The Complex Carbohydrate Structure Database. Trends Biochem Sci (1989) 9.00
A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1. Antimicrob Agents Chemother (2000) 8.54
Oral lesions in sheep and cattle in Dumfries and Galloway. Vet Rec (2001) 7.78
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem (1999) 6.88
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science (2001) 6.84
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature (2000) 5.86
Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae. Genetics (1985) 5.75
Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. Nucleic Acids Res (1985) 5.22
The extent of Down's syndrome screening in Britain in 1991. Lancet (1992) 5.20
Maternal serum screening for Down's syndrome: the effect of routine ultrasound scan determination of gestational age and adjustment for maternal weight. Br J Obstet Gynaecol (1992) 5.11
Control of acid resistance in Escherichia coli. J Bacteriol (1999) 4.93
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A (1999) 4.90
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell (1995) 4.73
Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus. Nature (1986) 4.70
Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor. Cell (1991) 4.66
Genetic evidence for selective transport of opsin and arrestin by kinesin-II in mammalian photoreceptors. Cell (2000) 4.51
A good practice guide to the administration of substances and removal of blood, including routes and volumes. J Appl Toxicol (2001) 4.39
Single-molecule studies of DNA mechanics. Curr Opin Struct Biol (2000) 4.39
Activation of memory circuits during cue-elicited cocaine craving. Proc Natl Acad Sci U S A (1996) 4.31
SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol (2000) 4.30
Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest (1987) 4.26
Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease. Neurology (2007) 3.97
Analysis of yeast protein kinases using protein chips. Nat Genet (2000) 3.94
Classification, nomenclature, and database development for hepatitis C virus (HCV) and related viruses: proposals for standardization. International Committee on Virus Taxonomy. Arch Virol (1998) 3.77
A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet (2000) 3.63
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell (1999) 3.58
Statistical power and optimal design for multisite randomized trials. Psychol Methods (2000) 3.58
Olfactory deficits in patients with mild cognitive impairment predict Alzheimer's disease at follow-up. Am J Psychiatry (2000) 3.54
Bone lead as a biological marker in epidemiologic studies of chronic toxicity: conceptual paradigms. Environ Health Perspect (1998) 3.51
Assessment of commercial laboratories performing hair mineral analysis. JAMA (2001) 3.42
Disrupted circadian rhythms in VIP- and PHI-deficient mice. Am J Physiol Regul Integr Comp Physiol (2003) 3.37
Temperate Bacteriophage Which Causes the Production of a New Major Outer Membrane Protein by Escherichia coli. J Virol (1975) 3.11
Size and shape effects in the biodistribution of intravascularly injected particles. J Control Release (2009) 3.08
CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling. Oncogene (2011) 3.08
Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science (2001) 2.97
Clinical and molecular cytogenetic characterisation of a newly recognised microdeletion syndrome involving 2p15-16.1. J Med Genet (2006) 2.97
Lead exposure and intelligence in 7-year-old children: the Yugoslavia Prospective Study. Environ Health Perspect (1997) 2.88
Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science (1998) 2.83
Functional deficits in patients with mild cognitive impairment: prediction of AD. Neurology (2002) 2.79
The biological lifetime of nitric oxide: implications for the perivascular dynamics of NO and O2. Proc Natl Acad Sci U S A (2001) 2.75
The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins. Mol Biol Cell (1999) 2.75
Retrohoming of a bacterial group II intron: mobility via complete reverse splicing, independent of homologous DNA recombination. Cell (1998) 2.74
AIDS and self-organization among intravenous drug users. Int J Addict (1987) 2.73
Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild-type viruses. Hum Gene Ther (1999) 2.73
A transmission/disequilibrium test that allows for genotyping errors in the analysis of single-nucleotide polymorphism data. Am J Hum Genet (2001) 2.68
The National Health Service needs a voice of its own. J R Soc Med (2000) 2.65
Accreditation in transoesophageal echocardiography: statement from the Association of Cardiothoracic Anaesthetists and the British Society of Echocardiography Joint TOE Accreditation Committee. Br J Anaesth (2003) 2.64
A functional mitotic spindle prepared from mammalian cells in culture. Proc Natl Acad Sci U S A (1974) 2.64
Study of 962 patients indicates progressive muscular atrophy is a form of ALS. Neurology (2009) 2.60
Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53. Genes Dev (1994) 2.54
Retrotransposition of a bacterial group II intron. Nature (2000) 2.51
Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases. Cochrane Database Syst Rev (2007) 2.47
Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains. J Biol Chem (2000) 2.43
Additional educational needs in children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry (2001) 2.40
Serum screening for Down's syndrome between 8 and 14 weeks of pregnancy. International Prenatal Screening Research Group. Br J Obstet Gynaecol (1996) 2.40
Treatment of advanced breast cancer with sterically stabilized liposomal doxorubicin: results of a multicenter phase II trial. J Clin Oncol (1997) 2.39
Prognostic indicators for AIDS and infectious disease death in HIV-infected injection drug users: plasma viral load and CD4+ cell count. JAMA (1998) 2.37
A nested-PCR-based schizodeme method for identifying Leishmania kinetoplast minicircle classes directly from clinical samples and its application to the study of the epidemiology of Leishmania tropica in Pakistan. J Clin Microbiol (1998) 2.35
Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence. Proc Natl Acad Sci U S A (1985) 2.34
Estrogen-related receptor alpha 1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements. Mol Endocrinol (1997) 2.34
Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene. Genes Dev (1998) 2.29
Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactions. EMBO J (1992) 2.29
Patterns of differentiation and hybridization in North American wolflike canids, revealed by analysis of microsatellite loci. Mol Biol Evol (1994) 2.28
Hormone receptors: studies on the interaction of estrogen with the uterus. Recent Prog Horm Res (1968) 2.28
An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat Genet (1995) 2.26
The Yugoslavia Prospective Lead Study: contributions of prenatal and postnatal lead exposure to early intelligence. Neurotoxicol Teratol (2001) 2.25
NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation. Oncogene (2011) 2.22
Identification of Harper-Cawston factor as thymidine phosphorylase and removal from media of substances interfering with susceptibility testing to sulfonamides and diaminopyrimidines. Antimicrob Agents Chemother (1975) 2.22
Transfusion-associated graft-versus-host disease in immunocompetent patients: report of a fatal case associated with transfusion of blood from a second-degree relative, and a survey of predisposing factors. Transfusion (1993) 2.22
GDNF signalling through the Ret receptor tyrosine kinase. Nature (1996) 2.21
Severe adverse life events and depressive symptoms among women with, or at risk for, HIV infection in four cities in the United States of America. AIDS (1999) 2.20
The natural history of treated and untreated primary hyperparathyroidism: the parathyroid epidemiology and audit research study. QJM (2011) 2.20
Ginsenoside-Rd improves outcome of acute ischaemic stroke - a randomized, double-blind, placebo-controlled, multicenter trial. Eur J Neurol (2012) 2.18
Randomized phase II study of two gemcitabine schedules for patients with impaired performance status (Karnofsky performance status </= 70) and advanced non-small-cell lung cancer. J Clin Oncol (2005) 2.17
An association between type 1 diabetes and idiopathic generalized epilepsy. Ann Neurol (2006) 2.15
Measurement and characterization of postischemic free radical generation in the isolated perfused heart. J Biol Chem (1989) 2.14
Observations in the Haight-Ashbury Medical Clinic of San Francisco. Health problems in a "hippie" subculture. Clin Pediatr (Phila) (1968) 2.12
An epidemiological study of insomnia among the Japanese general population. Sleep (2000) 2.09
Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors. Ann N Y Acad Sci (2001) 2.09
Ribonuclease P: function and variation. J Biol Chem (1990) 2.07
Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway. Oncogene (2007) 2.07
SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling. Proc Natl Acad Sci U S A (1999) 2.06
Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction. Evaluation of its role in nitric oxide generation in anoxic tissues. J Biol Chem (2001) 2.06
Delayed dark-adaptation and lipofuscin accumulation in abcr+/- mice: implications for involvement of ABCR in age-related macular degeneration. Invest Ophthalmol Vis Sci (2001) 2.05
Reelin gene alleles and susceptibility to autism spectrum disorders. Mol Psychiatry (2002) 2.05
Biological properties of a CD4 immunoadhesin. Nature (1990) 2.05
Social networks, social support, and mortality among older people in Japan. J Gerontol (1994) 2.01
Predicting global atmospheric ice nuclei distributions and their impacts on climate. Proc Natl Acad Sci U S A (2010) 2.00
Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Development (1999) 2.00
Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci U S A (2004) 1.99
Differential distribution of 5HT1D- and 5HT1B-immunoreactivity within the human trigemino-cerebrovascular system: implications for the discovery of new antimigraine drugs. Cephalalgia (1997) 1.99
Insulin resistance in uremia. J Clin Invest (1981) 1.98
The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides. Diabetes (2004) 1.96
DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila. Cell (1996) 1.94