Published in Nature on February 15, 2001
Assembly of the working draft of the human genome with GigAssembler. Genome Res (2001) 8.23
From silencing to gene expression: real-time analysis in single cells. Cell (2004) 7.73
Mining the draft human genome. Nature (2001) 5.81
A high quality draft consensus sequence of the genome of a heterozygous grapevine variety. PLoS One (2007) 5.62
Millions of years of evolution preserved: a comprehensive catalog of the processed pseudogenes in the human genome. Genome Res (2003) 5.49
Alu-containing exons are alternatively spliced. Genome Res (2002) 5.45
Modeling gene and genome duplications in eukaryotes. Proc Natl Acad Sci U S A (2005) 5.00
Major events in the genome evolution of vertebrates: paranome age and size differ considerably between ray-finned fishes and land vertebrates. Proc Natl Acad Sci U S A (2004) 3.13
Human RNA "rumor" viruses: the search for novel human retroviruses in chronic disease. Microbiol Mol Biol Rev (2008) 3.07
Protein family expansions and biological complexity. PLoS Comput Biol (2006) 2.69
Evidence that rice and other cereals are ancient aneuploids. Plant Cell (2003) 2.62
Legume genome evolution viewed through the Medicago truncatula and Lotus japonicus genomes. Proc Natl Acad Sci U S A (2006) 2.61
Global levels of histone modifications predict prognosis in different cancers. Am J Pathol (2009) 2.28
An ancient genome duplication contributed to the abundance of metabolic genes in the moss Physcomitrella patens. BMC Evol Biol (2007) 2.17
TFCat: the curated catalog of mouse and human transcription factors. Genome Biol (2009) 2.06
The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome. Nat Rev Urol (2010) 1.94
Duplicate genes and robustness to transient gene knock-downs in Caenorhabditis elegans. Proc Biol Sci (2004) 1.94
Continued colonization of the human genome by mitochondrial DNA. PLoS Biol (2004) 1.93
Identification, phylogeny, and evolution of retroviral elements based on their envelope genes. J Virol (2001) 1.91
Nonrandom divergence of gene expression following gene and genome duplications in the flowering plant Arabidopsis thaliana. Genome Biol (2006) 1.85
Genome-wide identification of potential plant E2F target genes. Plant Physiol (2005) 1.85
Pattern and timing of gene duplication in animal genomes. Genome Res (2001) 1.79
Dntf-2r, a young Drosophila retroposed gene with specific male expression under positive Darwinian selection. Genetics (2003) 1.79
Comprehensive analysis of human endogenous retrovirus transcriptional activity in human tissues with a retrovirus-specific microarray. J Virol (2005) 1.76
Human heterochromatin proteins form large domains containing KRAB-ZNF genes. Genome Res (2006) 1.72
Human gene organization driven by the coordination of replication and transcription. Genome Res (2007) 1.71
Transposable elements re-wire and fine-tune the transcriptome. PLoS Genet (2013) 1.70
Complex genomic rearrangements lead to novel primate gene function. Genome Res (2005) 1.62
Endogenous retroviruses in the human genome sequence. Genome Biol (2001) 1.60
Terminal-repeat retrotransposons in miniature (TRIM) are involved in restructuring plant genomes. Proc Natl Acad Sci U S A (2001) 1.51
The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors. J Virol (2002) 1.49
Analysis of 41 plant genomes supports a wave of successful genome duplications in association with the Cretaceous-Paleogene boundary. Genome Res (2014) 1.42
Signatures of domain shuffling in the human genome. Genome Res (2002) 1.39
Sequence similarity network reveals common ancestry of multidomain proteins. PLoS Comput Biol (2008) 1.19
Genomic insights into the Ixodes scapularis tick vector of Lyme disease. Nat Commun (2016) 1.18
A tale of tails: insights into the coordination of 3' end processing during homologous recombination. Bioessays (2009) 1.14
Epigenetic silencing may aid evolution by gene duplication. J Mol Evol (2003) 1.11
Rapid and asymmetric divergence of duplicate genes in the human gene coexpression network. BMC Bioinformatics (2006) 1.10
Identification of novel regulatory modules in dicotyledonous plants using expression data and comparative genomics. Genome Biol (2006) 1.08
Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2',5'-oligoadenylate synthetase from prostate cancer cells. Nucleic Acids Res (2006) 1.07
Protein coding potential of retroviruses and other transposable elements in vertebrate genomes. Nucleic Acids Res (2005) 1.06
The duplicated genes database: identification and functional annotation of co-localised duplicated genes across genomes. PLoS One (2012) 1.05
A first generation BAC-based physical map of the Asian seabass (Lates calcarifer). PLoS One (2010) 1.05
Functional evolution of the vertebrate Myb gene family: B-Myb, but neither A-Myb nor c-Myb, complements Drosophila Myb in hemocytes. Genetics (2004) 1.04
Human endogenous retroviruses: transposable elements with potential? Clin Exp Immunol (2004) 1.03
Phylogenetic analysis of Ciona intestinalis gene superfamilies supports the hypothesis of successive gene expansions. J Mol Evol (2004) 1.02
Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions. Mob DNA (2010) 1.00
Human endogenous retroviruses and cancer prevention: evidence and prospects. BMC Cancer (2013) 0.99
A scale of functional divergence for yeast duplicated genes revealed from analysis of the protein-protein interaction network. Genome Biol (2004) 0.98
A novel chimeric gene, siren, with retroposed promoter sequence in the Drosophila bipectinata complex. Genetics (2005) 0.96
ParaDB: a tool for paralogy mapping in vertebrate genomes. Nucleic Acids Res (2003) 0.96
Novel PAX6 binding sites in the human genome and the role of repetitive elements in the evolution of gene regulation. Genome Res (2002) 0.96
Tandemly arrayed genes in vertebrate genomes. Comp Funct Genomics (2008) 0.95
TARGeT: a web-based pipeline for retrieving and characterizing gene and transposable element families from genomic sequences. Nucleic Acids Res (2009) 0.95
Exonization of active mouse L1s: a driver of transcriptome evolution? BMC Genomics (2007) 0.94
Bs1, a new chimeric gene formed by retrotransposon-mediated exon shuffling in maize. Plant Physiol (2010) 0.93
Exploring the plant transcriptome through phylogenetic profiling. Plant Physiol (2005) 0.92
Deconstruction of the (paleo)polyploid grapevine genome based on the analysis of transposition events involving NBS resistance genes. PLoS One (2012) 0.91
Haplotype analysis of the human endogenous retrovirus locus HERV-K(HML-2.HOM) and its evolutionary implications. J Mol Evol (2005) 0.91
Human cytomegalovirus (HCMV) induces human endogenous retrovirus (HERV) transcription. Retrovirology (2013) 0.91
Association of an allele on chromosome 9 and abdominal aortic aneurysm. Atherosclerosis (2010) 0.91
Human endogenous retroviral long terminal repeat sequences as cell type-specific promoters in retroviral vectors. J Virol (2009) 0.88
Design and characterization of two-dye and three-dye binary fluorescent probes for mRNA detection. Tetrahedron (2007) 0.88
Sequence space coverage, entropy of genomes and the potential to detect non-human DNA in human samples. BMC Genomics (2008) 0.87
LIA5 is required for nuclear reorganization and programmed DNA rearrangements occurring during tetrahymena macronuclear differentiation. PLoS One (2013) 0.87
Enigmatic orthology relationships between Hox clusters of the African butterfly fish and other teleosts following ancient whole-genome duplication. Mol Biol Evol (2014) 0.86
Molecular evolution and functional divergence of the bestrophin protein family. BMC Evol Biol (2008) 0.86
A novel human-specific splice isoform alters the critical C-terminus of Survival Motor Neuron protein. Sci Rep (2016) 0.86
RAD59 and RAD1 cooperate in translocation formation by single-strand annealing in Saccharomyces cerevisiae. Curr Genet (2009) 0.84
Transposable elements in Coffea (Gentianales: Rubiacea) transcripts and their role in the origin of protein diversity in flowering plants. Mol Genet Genomics (2008) 0.84
LTR retrotransposon-gene associations in Drosophila melanogaster. J Mol Evol (2006) 0.84
Rapid divergence and diversification of mammalian duplicate gene functions. BMC Evol Biol (2015) 0.84
Phylogenetics in the bioinformatics culture of understanding. Comp Funct Genomics (2004) 0.82
Gene tree correction for reconciliation and species tree inference. Algorithms Mol Biol (2012) 0.82
Transcriptional interference networks coordinate the expression of functionally related genes clustered in the same genomic loci. Front Genet (2012) 0.82
The shape of human gene family phylogenies. BMC Evol Biol (2006) 0.81
GalEa retrotransposons from galatheid squat lobsters (Decapoda, Anomura) define a new clade of Ty1/copia-like elements restricted to aquatic species. Mol Genet Genomics (2007) 0.81
Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells. Oncotarget (2016) 0.81
Gain of a New Exon by a Lineage-Specific Alu Element-Integration Event in the BCS1L Gene during Primate Evolution. Mol Cells (2015) 0.80
Genome-wide analysis of adaptive molecular evolution in the carnivorous plant Utricularia gibba. Genome Biol Evol (2015) 0.80
Phylogenetics and evolution of Su(var)3-9 SET genes in land plants: rapid diversification in structure and function. BMC Evol Biol (2011) 0.80
Species-specific duplications driving the recent expansion of NBS-LRR genes in five Rosaceae species. BMC Genomics (2015) 0.80
A fast algorithm for determining the best combination of local alignments to a query sequence. BMC Bioinformatics (2004) 0.80
Obesity and cancer: the role of vitamin D. BMC Cancer (2014) 0.79
Divergent long-terminal-repeat retrotransposon families in the genome of Paragonimus westermani. Korean J Parasitol (2003) 0.79
The rarity of gene shuffling in conserved genes. Genome Biol (2005) 0.79
Defining the function of a prolactin gene family member. Proc Natl Acad Sci U S A (2004) 0.79
Protein subcellular relocalization increases the retention of eukaryotic duplicate genes. Genome Biol Evol (2013) 0.79
The prevalence of gene duplications and their ancient origin in Rhodobacter sphaeroides 2.4.1. BMC Microbiol (2010) 0.79
Infertile Finnish Yorkshire boars carry a full-length LINE-1 retrotransposon within the KPL2 gene. Mol Genet Genomics (2007) 0.78
Exploiting a Reference Genome in Terms of Duplications: The Network of Paralogs and Single Copy Genes in Arabidopsis thaliana. Biology (Basel) (2013) 0.78
Characterization and potential functional significance of human-chimpanzee large INDEL variation. Mob DNA (2011) 0.78
Evolutionary course of CsRn1 long-terminal-repeat retrotransposon and its heterogeneous integrations into the genome of the liver fluke, Clonorchis sinensis. Korean J Parasitol (2003) 0.78
Rad59 regulates association of Rad52 with DNA double-strand breaks. Microbiologyopen (2012) 0.78
Pseudogenes. Comp Funct Genomics (2012) 0.77
Protein connectivity and protein complexity promotes human gene duplicability in a mutually exclusive manner. DNA Res (2010) 0.77
Phylogenomic analysis reveals extensive phylogenetic mosaicism in the human GPCR superfamily. Evol Bioinform Online (2007) 0.77
Whole Genome Duplications Shaped the Receptor Tyrosine Kinase Repertoire of Jawed Vertebrates. Genome Biol Evol (2016) 0.76
The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans. Virulence (2014) 0.76
The DNA damage checkpoint allows recombination between divergent DNA sequences in budding yeast. DNA Repair (Amst) (2011) 0.76
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
A general approach to single-nucleotide polymorphism discovery. Nat Genet (1999) 13.39
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell (2001) 11.99
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature (2000) 11.49
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med (2000) 7.38
Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest (2001) 7.20
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol (1997) 6.61
Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med (1999) 6.27
Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein. Science (1997) 6.10
Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci U S A (1996) 6.00
Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell (1996) 5.45
Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase. Science (1996) 5.08
HMG-1 as a mediator of acute lung inflammation. J Immunol (2000) 4.78
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc Natl Acad Sci U S A (2001) 4.62
Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science (1999) 4.61
Gene expression profiles during the initial phase of salt stress in rice. Plant Cell (2001) 4.11
Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer. Proc Natl Acad Sci U S A (1998) 3.89
Quantum ground state and single-phonon control of a mechanical resonator. Nature (2010) 3.71
Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med (1999) 3.57
Requirement for math5 in the development of retinal ganglion cells. Genes Dev (2001) 3.26
A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature (1997) 3.26
Alternative gene form discovery and candidate gene selection from gene indexing projects. Genome Res (1998) 3.26
Hyperexpression of mitogen-activated protein kinase in human breast cancer. J Clin Invest (1997) 3.26
Deletion of the K(V)1.1 potassium channel causes epilepsy in mice. Neuron (1998) 3.18
Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci U S A (2001) 3.16
An association between renal cell carcinoma and lymphoid malignancies. A case series of eight patients. Cancer (1996) 3.12
The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine. Antimicrob Agents Chemother (1993) 3.00
A floral transmitting tissue-specific glycoprotein attracts pollen tubes and stimulates their growth. Cell (1995) 2.85
Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol (2001) 2.85
Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. Intern Med J (2012) 2.81
Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity. J Virol (2001) 2.79
MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene (2007) 2.79
Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat Immunol (2000) 2.78
Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution. Acta Crystallogr D Biol Crystallogr (1999) 2.77
Ecology. Giant pandas in a changing landscape. Science (2001) 2.73
Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J Neurochem (2000) 2.71
Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions. Br J Anaesth (2013) 2.70
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene (2007) 2.68
Effect of peer led programme for asthma education in adolescents: cluster randomised controlled trial. BMJ (2001) 2.67
Adhesion formation after previous caesarean section-a meta-analysis and systematic review. BJOG (2010) 2.66
Strongly enhanced current densities in superconducting coated conductors of YBa2Cu3O7-x + BaZrO3. Nat Mater (2004) 2.61
Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. Cancer Res (2001) 2.53
Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature (2000) 2.51
Integrin activation by R-ras. Cell (1996) 2.50
High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Arthritis Rheum (2002) 2.45
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci U S A (1999) 2.42
A theoretical solution for the frictionless rolling contact of cylindrical biphasic articular cartilage layers. J Biomech (1995) 2.42
On sample size calculation in bioequivalence trials. J Pharmacokinet Pharmacodyn (2001) 2.40
Comparison of droplet digital PCR to real-time PCR for quantitative detection of cytomegalovirus. J Clin Microbiol (2012) 2.39
GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development (1997) 2.38
Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replication. J Virol (1994) 2.37
Fire and flood management of coastal swamp enabled first rice paddy cultivation in east China. Nature (2007) 2.36
In vivo nuclear transport kinetics in Saccharomyces cerevisiae: a role for heat shock protein 70 during targeting and translocation. J Cell Biol (1996) 2.33
Discovering molecular pathways from protein interaction and gene expression data. Bioinformatics (2003) 2.32
Phylogeny of the Simbu serogroup of the genus Bunyavirus. J Gen Virol (2001) 2.30
Comparison of deoxyoligonucleotide and tRNA(Lys-3) as primers in an endogenous human immunodeficiency virus-1 in vitro reverse transcription/template-switching reaction. J Biol Chem (1994) 2.28
Mechanisms of DNA double strand break repair and chromosome aberration formation. Cytogenet Genome Res (2004) 2.26
A PhoP-regulated outer membrane protease of Salmonella enterica serovar typhimurium promotes resistance to alpha-helical antimicrobial peptides. J Bacteriol (2000) 2.26
Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function. J Biol Chem (2000) 2.26
Single-molecule recognition imaging microscopy. Proc Natl Acad Sci U S A (2004) 2.25
Overlapping genomic sequences: a treasure trove of single-nucleotide polymorphisms. Genome Res (1998) 2.24
Pinhole collimation for ultra-high-resolution, small-field-of-view SPECT. Phys Med Biol (1994) 2.19
NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP. Nature (1999) 2.18
Quality of life for children with fecal incontinence after surgically corrected anorectal malformation. J Pediatr Surg (2000) 2.17
Energy transduction in ATP synthase. Nature (1998) 2.15
Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J Biol Chem (1998) 2.15
Ossifying fibromas of the jaw bone: 20 cases. Dentomaxillofac Radiol (2010) 2.15
PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats. J Control Release (2001) 2.15
TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. J Dent Res (2010) 2.14
A pollen tube growth stimulatory glycoprotein is deglycosylated by pollen tubes and displays a glycosylation gradient in the flower. Cell (1995) 2.14
Materials science challenges for high-temperature superconducting wire. Nat Mater (2007) 2.13
The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action. Diabetologia (2009) 2.11
CORG: a database for COmparative Regulatory Genomics. Nucleic Acids Res (2003) 2.06
Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism. Mol Cell Biol (1997) 2.04
Synthesizing arbitrary quantum states in a superconducting resonator. Nature (2009) 2.03
Regional hippocampal atrophy in multiple sclerosis. Brain (2008) 2.02
In vitro Arabidopsis pollen germination and characterization of the inward potassium currents in Arabidopsis pollen grain protoplasts. J Exp Bot (2001) 2.01
Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice. J Clin Invest (1997) 2.00
Expression of ethylene biosynthetic pathway transcripts in senescing carnation flowers. Plant Physiol (1992) 1.99
Identification of two factors required for transcription of the ovalbumin gene. Mol Cell Biol (1986) 1.96
Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II). Cell (1987) 1.95
Violation of Bell's inequality in Josephson phase qubits. Nature (2009) 1.92
Building a root: the control of patterning and morphogenesis during root development. Plant Cell (1997) 1.89
The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70. J Biol Chem (1997) 1.87
Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis. Hum Mol Genet (2000) 1.87
Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity. Kidney Int (2008) 1.86
Generation of drug-resistant variants of human immunodeficiency virus type 1 by in vitro passage in increasing concentrations of 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine. Antimicrob Agents Chemother (1993) 1.86
Raf-1 kinase and exoenzyme S interact with 14-3-3zeta through a common site involving lysine 49. J Biol Chem (1997) 1.83
Polymer-assisted deposition of metal-oxide films. Nat Mater (2004) 1.83
Effects of the renin-angiotensin system on the current I(to) in epicardial and endocardial ventricular myocytes from the canine heart. Circ Res (2000) 1.81
Generation of three-qubit entangled states using superconducting phase qubits. Nature (2010) 1.81
Protein kinase CK2 signal in neoplasia. Histol Histopathol (2001) 1.79
MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation. Circ Res (2001) 1.78
Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2. Nat Med (1998) 1.76
Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent. Diabetologia (2007) 1.73
Increased serum concentrations of high-mobility-group protein 1 in haemorrhagic shock. Lancet (1999) 1.71
Reverse engineering a protein: the mechanochemistry of ATP synthase. Biochim Biophys Acta (2000) 1.71
Genetic variation in the 3' non-coding region of dengue viruses. Virology (2001) 1.71