HMG-1 as a mediator of acute lung inflammation.

Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci U S A (2003) 7.14

HMGB1 is a therapeutic target for sterile inflammation and infection. Annu Rev Immunol (2011) 6.23

CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science (2009) 5.00

HMGB1: endogenous danger signaling. Mol Med (2008) 4.02

Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A (2002) 3.68

The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells. J Cell Biol (2001) 3.43

DAMPening inflammation by modulating TLR signalling. Mediators Inflamm (2010) 3.29

Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones. PLoS One (2012) 3.13

New EMBO members' review: the double life of HMGB1 chromatin protein: architectural factor and extracellular signal. EMBO J (2001) 3.04

Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J Immunol (2010) 2.88

Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation. J Cell Biol (2004) 2.75

ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury. Hepatology (2013) 2.45

NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways. J Immunol (2009) 2.39

Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med (2003) 2.30

High-mobility group box 1, oxidative stress, and disease. Antioxid Redox Signal (2011) 2.19

Alarmins: awaiting a clinical response. J Clin Invest (2012) 2.19

Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1. J Leukoc Biol (2006) 2.17

Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2008) 2.15

Targeting HMGB1 in inflammation. Biochim Biophys Acta (2009) 2.11

Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice. Hepatology (2011) 1.94

HMGB1 contributes to kidney ischemia reperfusion injury. J Am Soc Nephrol (2010) 1.89

HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin. Am J Physiol Cell Physiol (2010) 1.75

Angiogenetic signaling through hypoxia: HMGB1: an angiogenetic switch molecule. Am J Pathol (2005) 1.75

The receptor for advanced glycation end products (RAGE) and the lung. J Biomed Biotechnol (2010) 1.68

HMGB1 in health and disease. Mol Aspects Med (2014) 1.67

HMGB1 is markedly elevated within 6 hours of mechanical trauma in humans. Shock (2009) 1.64

Potential role of high-mobility group box 1 in cystic fibrosis airway disease. Am J Respir Crit Care Med (2008) 1.62

Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma. Cancer Res (2012) 1.61

A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol (2007) 1.60

Receptor for advanced glycation end products (RAGE) on iNKT cells mediates lung ischemia-reperfusion injury. Am J Transplant (2013) 1.59

Red blood cells induce necroptosis of lung endothelial cells and increase susceptibility to lung inflammation. Am J Respir Crit Care Med (2014) 1.52

Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Mol Cell Biol (2009) 1.49

Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and release. J Immunol (2007) 1.48

High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine. J Immunol (2008) 1.45

Blockade of high mobility group box-1 protein attenuates experimental severe acute pancreatitis. World J Gastroenterol (2006) 1.44

Initial delay in the immune response to Francisella tularensis is followed by hypercytokinemia characteristic of severe sepsis and correlating with upregulation and release of damage-associated molecular patterns. Infect Immun (2008) 1.41

CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns. Trends Immunol (2009) 1.39

The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis. J Nutr (2006) 1.38

Trauma: the role of the innate immune system. World J Emerg Surg (2006) 1.37

Immunosuppression following surgical and traumatic injury. Surg Today (2010) 1.36

NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice. J Immunol (2012) 1.34

Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis. Crit Care (2008) 1.34

Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function. Am J Respir Cell Mol Biol (2009) 1.32

A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1. PLoS One (2007) 1.30

Therapeutic potential of HMGB1-targeting agents in sepsis. Expert Rev Mol Med (2008) 1.30

Anti-high-mobility group box chromosomal protein 1 antibodies improve survival of rats with sepsis. World J Surg (2006) 1.30

Novel HMGB1-inhibiting therapeutic agents for experimental sepsis. Shock (2009) 1.29

Role of HMGB1 in cardiovascular diseases. Curr Opin Pharmacol (2006) 1.26

Inhibition of high-mobility group box 1 protein (HMGB1) enhances bacterial clearance and protects against Pseudomonas Aeruginosa pneumonia in cystic fibrosis. Mol Med (2012) 1.26

Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells. J Immunol (2011) 1.25

Novel insights for systemic inflammation in sepsis and hemorrhage. Mediators Inflamm (2010) 1.24

Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitation. J Cell Mol Med (2008) 1.22

Receptor for advanced glycation end products and its involvement in inflammatory diseases. Int J Inflam (2013) 1.22

Acute lung injury induced by lipopolysaccharide is independent of complement activation. J Immunol (2008) 1.22

Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting. Nat Rev Drug Discov (2009) 1.21

Damage associated molecular pattern molecules. Clin Immunol (2007) 1.19

Extracellular high mobility group box-1 (HMGB1) inhibits enterocyte migration via activation of Toll-like receptor-4 and increased cell-matrix adhesiveness. J Biol Chem (2009) 1.16

Hyperoxia-induced signal transduction pathways in pulmonary epithelial cells. Free Radic Biol Med (2007) 1.16

Scientific and clinical challenges in sepsis. Curr Pharm Des (2009) 1.14

Bench-to-bedside review: High-mobility group box 1 and critical illness. Crit Care (2007) 1.14

Role of ERK map kinase and CRM1 in IL-1beta-stimulated release of HMGB1 from cortical astrocytes. Glia (2010) 1.09

Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine? Intensive Care Med (2010) 1.07

HMGB1 in renal ischemic injury. Am J Physiol Renal Physiol (2012) 1.07

Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock. J Immunol (2009) 1.07

Intranasal delivery of HMGB1 siRNA confers target gene knockdown and robust neuroprotection in the postischemic brain. Mol Ther (2012) 1.05

Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels. J Immunol (2008) 1.05

Pathogenic anti-DNA antibodies modulate gene expression in mesangial cells: involvement of HMGB1 in anti-DNA antibody-induced renal injury. Immunol Lett (2008) 1.04

High Mobility Group Box-1 mediates hyperoxia-induced impairment of Pseudomonas aeruginosa clearance and inflammatory lung injury in mice. Am J Respir Cell Mol Biol (2012) 1.04

HMGB1 cytoplasmic translocation in patients with acute liver failure. BMC Gastroenterol (2011) 1.04

Elevated plasma level of HMGB1 is associated with disease activity and combined alterations with IFN-α and TNF-α in systemic lupus erythematosus. Rheumatol Int (2010) 1.03

Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation. Am J Respir Crit Care Med (2009) 1.03

HMGB1 increases permeability of the endothelial cell monolayer via RAGE and Src family tyrosine kinase pathways. Inflammation (2012) 1.02

Immunomodulatory drugs regulate HMGB1 release from activated human monocytes. Mol Med (2010) 1.02

High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy. Lab Invest (2010) 1.01

Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination. Front Cell Infect Microbiol (2013) 1.01

TLR3-mediated NF-{kappa}B signaling in human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol (2009) 0.99

Targeting HMGB1 in the treatment of sepsis. Expert Opin Ther Targets (2014) 0.99

HMGB1 release by inflammasomes. Virulence (2011) 0.99

Bench-to-bedside review: Damage-associated molecular patterns in the onset of ventilator-induced lung injury. Crit Care (2011) 0.99

Potential role of high mobility group box 1 in viral infectious diseases. Viral Immunol (2006) 0.98

Delayed ethyl pyruvate therapy attenuates experimental severe acute pancreatitis via reduced serum high mobility group box 1 levels in rats. World J Gastroenterol (2008) 0.98

Toll-like receptor 4 mediates acute lung injury induced by high mobility group box-1. PLoS One (2013) 0.97

The C-terminal acidic tail is responsible for the inhibitory effects of HMGB1 on efferocytosis. J Leukoc Biol (2010) 0.97

Role of Apoptosis in Amplifying Inflammatory Responses in Lung Diseases. J Cell Death (2010) 0.97

Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis. Arthritis Res Ther (2007) 0.96

Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on focal cerebral ischemia/reperfusion-induced inflammation, oxidative stress, and apoptosis in rats. PLoS One (2014) 0.96

Anti-inflammatory role of fetuin-A in injury and infection. Curr Mol Med (2012) 0.96

Toll-like receptor 3 signaling enables human esophageal epithelial cells to sense endogenous danger signals released by necrotic cells. Am J Physiol Gastrointest Liver Physiol (2011) 0.95

The role of surfactant protein A in bleomycin-induced acute lung injury. Am J Respir Crit Care Med (2010) 0.94

Burn-induced acute lung injury requires a functional Toll-like receptor 4. Shock (2011) 0.94

Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury. Redox Biol (2014) 0.93

Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice. Crit Care (2015) 0.92

ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia-reperfusion injury. Neurol Sci (2012) 0.92

High mobility group box 1 protein as a potential drug target for infection- and injury-elicited inflammation. Inflamm Allergy Drug Targets (2010) 0.92

Native versus recombinant high-mobility group B1 proteins: functional activity in vitro. Inflammation (2004) 0.92

Oxidation of HMGB1 causes attenuation of its pro-inflammatory activity and occurs during liver ischemia and reperfusion. PLoS One (2012) 0.92

Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model. Respir Res (2009) 0.92

Preconditioning with high mobility group box 1 (HMGB1) induces lipopolysaccharide (LPS) tolerance. J Leukoc Biol (2008) 0.92

Involvement of high mobility group box 1 and the therapeutic effect of recombinant thrombomodulin in a mouse model of severe acute respiratory distress syndrome. Clin Exp Immunol (2013) 0.91

Experimental models and emerging hypotheses for acute lung injury. Crit Care Clin (2011) 0.91

HMG-1 as a late mediator of endotoxin lethality in mice. Science (1999) 17.72

Shock and tissue injury induced by recombinant human cachectin. Science (1986) 16.24

LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell (2001) 11.99

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature (2000) 11.49

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med (2000) 7.38

Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest (2001) 7.20

Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol (1997) 6.61

Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med (1999) 6.27

Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein. Science (1997) 6.10

Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci U S A (1996) 6.00

MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia. Nature (1993) 5.60

Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell (1996) 5.45

Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia. J Exp Med (1989) 4.66

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc Natl Acad Sci U S A (2001) 4.62

Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science (1999) 4.61

Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog. Surg Gynecol Obstet (1987) 4.18

Evolutionary analyses of the human genome. Nature (2001) 4.13

Gene expression profiles during the initial phase of salt stress in rice. Plant Cell (2001) 4.11

Quantum ground state and single-phonon control of a mechanical resonator. Nature (2010) 3.71

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med (1999) 3.57

Cytokine appearance in human endotoxemia and primate bacteremia. Surg Gynecol Obstet (1988) 3.30

Requirement for math5 in the development of retinal ganglion cells. Genes Dev (2001) 3.26

Alternative gene form discovery and candidate gene selection from gene indexing projects. Genome Res (1998) 3.26

A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature (1997) 3.26

Hyperexpression of mitogen-activated protein kinase in human breast cancer. J Clin Invest (1997) 3.26

Deletion of the K(V)1.1 potassium channel causes epilepsy in mice. Neuron (1998) 3.18

An association between renal cell carcinoma and lymphoid malignancies. A case series of eight patients. Cancer (1996) 3.12

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest (1991) 3.00

Extracellular role of HMGB1 in inflammation and sepsis. J Intern Med (2004) 2.94

HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene (2010) 2.91

A floral transmitting tissue-specific glycoprotein attracts pollen tubes and stimulates their growth. Cell (1995) 2.85

Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol (2001) 2.85

Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. Intern Med J (2012) 2.81

HMGB1 as a late mediator of lethal systemic inflammation. Am J Respir Crit Care Med (2001) 2.80

Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity. J Virol (2001) 2.79

MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene (2007) 2.79

Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat Immunol (2000) 2.78

Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution. Acta Crystallogr D Biol Crystallogr (1999) 2.77

Ecology. Giant pandas in a changing landscape. Science (2001) 2.73

Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J Neurochem (2000) 2.71

Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions. Br J Anaesth (2013) 2.70

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene (2007) 2.68

Effect of peer led programme for asthma education in adolescents: cluster randomised controlled trial. BMJ (2001) 2.67

Macrophage inflammatory protein 1 modulates macrophage function. J Immunol (1992) 2.66

Adhesion formation after previous caesarean section-a meta-analysis and systematic review. BJOG (2010) 2.66

Strongly enhanced current densities in superconducting coated conductors of YBa2Cu3O7-x + BaZrO3. Nat Mater (2004) 2.61

Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol (2000) 2.58

Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. Cancer Res (2001) 2.53

Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature (2000) 2.51

Integrin activation by R-ras. Cell (1996) 2.50

High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Arthritis Rheum (2002) 2.45

Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes. Surgery (1999) 2.44

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci U S A (1999) 2.42

A theoretical solution for the frictionless rolling contact of cylindrical biphasic articular cartilage layers. J Biomech (1995) 2.42

On sample size calculation in bioequivalence trials. J Pharmacokinet Pharmacodyn (2001) 2.40

GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development (1997) 2.38

Fire and flood management of coastal swamp enabled first rice paddy cultivation in east China. Nature (2007) 2.36

Discovering molecular pathways from protein interaction and gene expression data. Bioinformatics (2003) 2.32

Phylogeny of the Simbu serogroup of the genus Bunyavirus. J Gen Virol (2001) 2.30

A PhoP-regulated outer membrane protease of Salmonella enterica serovar typhimurium promotes resistance to alpha-helical antimicrobial peptides. J Bacteriol (2000) 2.26

Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity. Arthritis Rheum (2003) 2.26

Mechanisms of DNA double strand break repair and chromosome aberration formation. Cytogenet Genome Res (2004) 2.26

Single-molecule recognition imaging microscopy. Proc Natl Acad Sci U S A (2004) 2.25

Pinhole collimation for ultra-high-resolution, small-field-of-view SPECT. Phys Med Biol (1994) 2.19

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP. Nature (1999) 2.18

Quality of life for children with fecal incontinence after surgically corrected anorectal malformation. J Pediatr Surg (2000) 2.17

Energy transduction in ATP synthase. Nature (1998) 2.15

Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J Biol Chem (1998) 2.15

Ossifying fibromas of the jaw bone: 20 cases. Dentomaxillofac Radiol (2010) 2.15

TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. J Dent Res (2010) 2.14

A pollen tube growth stimulatory glycoprotein is deglycosylated by pollen tubes and displays a glycosylation gradient in the flower. Cell (1995) 2.14

Materials science challenges for high-temperature superconducting wire. Nat Mater (2007) 2.13

Cholinergic control of inflammation. J Intern Med (2009) 2.12

The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action. Diabetologia (2009) 2.11

The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway and implications for therapy. J Intern Med (2011) 2.08

Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation. Auton Neurosci (2000) 2.06

CORG: a database for COmparative Regulatory Genomics. Nucleic Acids Res (2003) 2.06

Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism. Mol Cell Biol (1997) 2.04

Synthesizing arbitrary quantum states in a superconducting resonator. Nature (2009) 2.03

Regional hippocampal atrophy in multiple sclerosis. Brain (2008) 2.02

In vitro Arabidopsis pollen germination and characterization of the inward potassium currents in Arabidopsis pollen grain protoplasts. J Exp Bot (2001) 2.01

High mobility group 1 B-box mediates activation of human endothelium. J Intern Med (2003) 2.00

Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice. J Clin Invest (1997) 2.00

Expression of ethylene biosynthetic pathway transcripts in senescing carnation flowers. Plant Physiol (1992) 1.99

Cachectin/TNF or IL-1 alpha induces cachexia with redistribution of body proteins. Am J Physiol (1989) 1.99

Identification of two factors required for transcription of the ovalbumin gene. Mol Cell Biol (1986) 1.96

Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II). Cell (1987) 1.95

Violation of Bell's inequality in Josephson phase qubits. Nature (2009) 1.92

Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat. Pain (1997) 1.90

Building a root: the control of patterning and morphogenesis during root development. Plant Cell (1997) 1.89

The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70. J Biol Chem (1997) 1.87

Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis. Hum Mol Genet (2000) 1.87

Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity. Kidney Int (2008) 1.86

Raf-1 kinase and exoenzyme S interact with 14-3-3zeta through a common site involving lysine 49. J Biol Chem (1997) 1.83

Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120. Brain Res (2000) 1.83

Polymer-assisted deposition of metal-oxide films. Nat Mater (2004) 1.83