Published in J Cell Biol on May 01, 1996
Identification of different roles for RanGDP and RanGTP in nuclear protein import. EMBO J (1996) 5.53
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. EMBO J (1997) 5.08
A novel class of RanGTP binding proteins. J Cell Biol (1997) 4.36
Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. J Cell Biol (1997) 3.36
NTF2 mediates nuclear import of Ran. EMBO J (1998) 2.79
Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure. EMBO J (1998) 2.71
In vivo nuclear transport kinetics in Saccharomyces cerevisiae: a role for heat shock protein 70 during targeting and translocation. J Cell Biol (1996) 2.33
A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. J Cell Biol (1999) 2.27
The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins. EMBO J (2001) 2.14
The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import. J Cell Biol (2002) 2.13
Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor. EMBO J (1998) 2.01
Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities. EMBO J (1996) 2.01
Nuclear import of U snRNPs requires importin beta. EMBO J (1997) 2.00
Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT In vitro. J Cell Biol (1998) 1.83
A centriole- and RanGTP-independent spindle assembly pathway in meiosis I of vertebrate oocytes. J Cell Biol (2007) 1.58
Characterization of HIV-1 vpr nuclear import: analysis of signals and pathways. J Cell Biol (1998) 1.50
Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta. Proc Natl Acad Sci U S A (1999) 1.39
Two distinct classes of Ran-binding sites on the nucleoporin Nup-358. Proc Natl Acad Sci U S A (1999) 1.37
Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport. Mol Cell (2008) 1.33
Nucleocytoplasmic shuttling: a novel in vivo property of antisense phosphorothioate oligodeoxynucleotides. Nucleic Acids Res (2000) 1.25
Importin alpha can migrate into the nucleus in an importin beta- and Ran-independent manner. EMBO J (2002) 1.24
Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly. Mol Biol Cell (2009) 1.20
HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic intervention. Retrovirology (2011) 1.17
A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing. Mol Cell Biol (1999) 1.15
Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-β1. PLoS One (2011) 1.11
The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export. RNA (2001) 1.03
An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins. J Cell Biol (2000) 1.02
The dynamics and mechanisms of interleukin-1alpha and beta nuclear import. Traffic (2008) 0.92
In vitro analysis of nuclear mRNA export using molecular beacons for target detection. Nucleic Acids Res (2003) 0.90
The ins and outs of nuclear trafficking: unusual aspects in apicomplexan parasites. DNA Cell Biol (2009) 0.89
A T42A Ran mutation: differential interactions with effectors and regulators, and defect in nuclear protein import. Mol Biol Cell (1997) 0.88
Importin beta-depending nuclear import pathways: role of the adapter proteins in the docking and releasing steps. Mol Biol Cell (2003) 0.88
Characterization of the human herpesvirus 6 U69 gene product and identification of its nuclear localization signal. J Virol (2007) 0.80
Probing of the nuclear import and export signals and subcellular transport mechanism of varicella-zoster virus tegument protein open reading frame 10. Med Microbiol Immunol (2011) 0.76
Probing the nuclear import signal and nuclear transport molecular determinants of PRV ICP22. Cell Biosci (2016) 0.75
Structural analysis of the role of TPX2 in branching microtubule nucleation. J Cell Biol (2017) 0.75
Cloning and expression of the gene for bacteriophage T7 RNA polymerase. Proc Natl Acad Sci U S A (1984) 13.68
Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J Cell Biol (1990) 8.75
Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis. EMBO J (1994) 8.02
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature (1993) 7.80
Nuclear protein migration involves two steps: rapid binding at the nuclear envelope followed by slower translocation through nuclear pores. Cell (1988) 7.23
Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol Cell Biol (1988) 7.06
Isolation of a protein that is essential for the first step of nuclear protein import. Cell (1994) 6.63
Nuclear import can be separated into distinct steps in vitro: nuclear pore binding and translocation. Cell (1988) 6.60
Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor. J Cell Biol (1993) 6.47
Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. Nature (1991) 5.39
Biological and biochemical properties of human rasH genes mutated at codon 61. Cell (1986) 5.05
Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Proc Natl Acad Sci U S A (1995) 5.04
Nuclear segregation of U2 snRNA requires binding of specific snRNP proteins. Cell (1985) 4.98
RanGAP1 induces GTPase activity of nuclear Ras-related Ran. Proc Natl Acad Sci U S A (1994) 4.58
Purification of a Ran-interacting protein that is required for protein import into the nucleus. Proc Natl Acad Sci U S A (1994) 4.49
Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. Curr Biol (1995) 4.46
Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope. J Cell Biol (1994) 4.25
Distinct functions for the two importin subunits in nuclear protein import. Nature (1995) 4.16
The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors. Cell (1992) 4.05
Sequence and characterization of cytoplasmic nuclear protein import factor p97. J Cell Biol (1995) 3.85
Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. Science (1995) 3.79
Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. Proc Natl Acad Sci U S A (1995) 3.73
Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62. J Cell Biol (1995) 3.73
Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide. Proc Natl Acad Sci U S A (1991) 3.70
Assembly in vitro of nuclei active in nuclear protein transport: ATP is required for nucleoplasmin accumulation. EMBO J (1986) 3.60
Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes. Proc Natl Acad Sci U S A (1995) 3.52
Mammalian nuclei contain foci which are highly enriched in components of the pre-mRNA splicing machinery. EMBO J (1991) 3.49
Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. Mol Cell Biol (1990) 3.31
The trimethylguanosine cap structure of U1 snRNA is a component of a bipartite nuclear targeting signal. Cell (1990) 3.24
Cloning and characterization of SRP1, a suppressor of temperature-sensitive RNA polymerase I mutations, in Saccharomyces cerevisiae. Mol Cell Biol (1992) 3.05
RNA export. Cell (1995) 3.03
Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily. EMBO J (1993) 3.00
Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. Proc Natl Acad Sci U S A (1995) 3.00
An essential signaling role for the m3G cap in the transport of U1 snRNP to the nucleus. Science (1990) 2.98
Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1. Biochemistry (1995) 2.91
Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. Proc Natl Acad Sci U S A (1994) 2.86
In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import. EMBO J (1995) 2.74
RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. Proc Natl Acad Sci U S A (1994) 2.58
Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes. J Biol Chem (1995) 2.56
Nucleo-cytoplasmic transport of U snRNPs: definition of a nuclear location signal in the Sm core domain that binds a transport receptor independently of the m3G cap. EMBO J (1993) 2.55
The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm. Proc Natl Acad Sci U S A (1995) 2.48
Diversity in the signals required for nuclear accumulation of U snRNPs and variety in the pathways of nuclear transport. J Cell Biol (1991) 2.45
Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import. J Cell Biol (1995) 2.43
RCC1 in the cell cycle: the regulator of chromosome condensation takes on new roles. Trends Biochem Sci (1993) 2.26
Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression. J Cell Biol (1994) 2.17
A karyophilic protein forms a stable complex with cytoplasmic components prior to nuclear pore binding. J Biol Chem (1995) 2.12
Cytosolic factors in nuclear transport: what's importin? Cell (1994) 1.92
Microinjected U snRNAs are imported to oocyte nuclei via the nuclear pore complex by three distinguishable targeting pathways. J Cell Biol (1992) 1.76
Multiple pathways in nuclear transport: the import of U2 snRNP occurs by a novel kinetic pathway. J Cell Biol (1991) 1.71
Pendulin, a Drosophila protein with cell cycle-dependent nuclear localization, is required for normal cell proliferation. J Cell Biol (1995) 1.67
Targeting bacteriophage T7 RNA polymerase to the mammalian cell nucleus. Gene (1988) 1.67
Loss of RCC1 leads to suppression of nuclear protein import in living cells. J Biol Chem (1994) 1.62
The overgrown hematopoietic organs-31 tumor suppressor gene of Drosophila encodes an Importin-like protein accumulating in the nucleus at the onset of mitosis. J Cell Biol (1995) 1.57
Purification of small nuclear ribonucleoprotein particles with antibodies against modified nucleosides of small nuclear RNAs. Methods Enzymol (1990) 1.53
Stereochemistry of the elongation factor Tu X GTP complex. Eur J Biochem (1983) 1.19
A spectroscopic study of the binding of N-7-substituted cap analogues to human protein synthesis initiation factor 4E. Biochemistry (1990) 1.13
Taking from the cytoplasm and giving to the pore: soluble transport factors in nuclear protein import. Trends Cell Biol (1995) 1.06
Most nuclear proteins are imported by a single pathway. Exp Cell Res (1993) 0.97
A cytoplasmically anchored nuclear protein interferes specifically with the import of nuclear proteins but not U1 snRNA. J Cell Biol (1993) 0.91
CRM1 is an export receptor for leucine-rich nuclear export signals. Cell (1997) 18.60
Exportin 1 (Crm1p) is an essential nuclear export factor. Cell (1997) 10.32
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell (1995) 9.98
Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell (1991) 9.96
Nucleocytoplasmic transport. Science (1996) 8.76
Nuclear protein migration involves two steps: rapid binding at the nuclear envelope followed by slower translocation through nuclear pores. Cell (1988) 7.23
Protein import into the cell nucleus. Annu Rev Cell Biol (1986) 7.04
A polypeptide domain that specifies migration of nucleoplasmin into the nucleus. Cell (1982) 6.39
Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding. Cell (1986) 5.59
Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity. Cell (2001) 5.33
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. EMBO J (1997) 5.08
Nuclear export of different classes of RNA is mediated by specific factors. J Cell Biol (1994) 4.99
Nuclear segregation of U2 snRNA requires binding of specific snRNP proteins. Cell (1985) 4.98
Monomethylated cap structures facilitate RNA export from the nucleus. Cell (1990) 4.72
Identification of the RNA binding segment of human U1 A protein and definition of its binding site on U1 snRNA. EMBO J (1989) 4.69
Major determinants of the specificity of interaction between small nuclear ribonucleoproteins U1A and U2B'' and their cognate RNAs. Nature (1990) 4.67
RanGAP1 induces GTPase activity of nuclear Ras-related Ran. Proc Natl Acad Sci U S A (1994) 4.58
A nuclear cap binding protein complex involved in pre-mRNA splicing. Cell (1994) 4.56
HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region. Cell (1990) 4.50
Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. Curr Biol (1995) 4.46
Importin beta is a mitotic target of the small GTPase Ran in spindle assembly. Cell (2001) 4.23
Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex. EMBO J (1997) 4.06
Structure of importin-beta bound to the IBB domain of importin-alpha. Nature (1999) 4.05
A cap-binding protein complex mediating U snRNA export. Nature (1995) 3.89
Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation. Nature (1999) 3.84
An enhancer-like sequence within the Xenopus U2 gene promoter facilitates the formation of stable transcription complexes. Nature (1985) 3.80
Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. Science (1995) 3.79
Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci (1999) 3.77
Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Nat Cell Biol (2001) 3.67
High sequence specificity of micrococcal nuclease. Nucleic Acids Res (1981) 3.66
Fungal small nuclear ribonucleoproteins share properties with plant and vertebrate U-snRNPs. EMBO J (1987) 3.50
Identification of a nuclear export receptor for tRNA. Curr Biol (1998) 3.49
U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase. Mol Cell (1998) 3.39
The trimethylguanosine cap structure of U1 snRNA is a component of a bipartite nuclear targeting signal. Cell (1990) 3.24
In vitro assembly of U1 snRNPs. EMBO J (1987) 3.18
RNA export. Cell (1995) 3.03
Nucleocytoplasmic transport: the last 200 nanometers. Cell (1998) 3.00
Nucleoplasmin cDNA sequence reveals polyglutamic acid tracts and a cluster of sequences homologous to putative nuclear localization signals. EMBO J (1987) 2.91
PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation. Cell (2000) 2.88
A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export. J Cell Biol (1996) 2.84
Xenopus laevis U2 snRNA genes: tandemly repeated transcription units sharing 5' and 3' flanking homology with other RNA polymerase II transcribed genes. EMBO J (1983) 2.81
A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. J Cell Biol (1997) 2.74
Importin provides a link between nuclear protein import and U snRNA export. Cell (1996) 2.65
The human U1 snRNP-specific U1A protein inhibits polyadenylation of its own pre-mRNA. Cell (1993) 2.58
The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein. Nat Struct Biol (2000) 2.53
Nucleocytoplasmic transport: Ran, beta and beyond. Trends Cell Biol (2001) 2.50
A nuclear cap-binding complex facilitates association of U1 snRNP with the cap-proximal 5' splice site. Genes Dev (1996) 2.50
A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes. Nature (1987) 2.48
Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif. Cell (1994) 2.45
Diversity in the signals required for nuclear accumulation of U snRNPs and variety in the pathways of nuclear transport. J Cell Biol (1991) 2.45
High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region. J Mol Biol (1993) 2.44
The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller. Nature (1998) 2.42
The role of exportin-t in selective nuclear export of mature tRNAs. EMBO J (1998) 2.40
RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase. Mol Cell Biol (1999) 2.37
Participation of the nuclear cap binding complex in pre-mRNA 3' processing. Proc Natl Acad Sci U S A (1997) 2.31
The carboxyl terminus of vertebrate poly(A) polymerase interacts with U2AF 65 to couple 3'-end processing and splicing. Genes Dev (2000) 2.27
Molecular characterization of a karyophilic, histone-binding protein: cDNA cloning, amino acid sequence and expression of nuclear protein N1/N2 of Xenopus laevis. EMBO J (1986) 2.25
Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1. Mol Cell Biol (2000) 2.24
Functional analysis of mutant Xenopus U2 snRNAs. Cell (1989) 2.23
GTP hydrolysis by Ran is required for nuclear envelope assembly. Mol Cell (2000) 2.22
A cap binding protein that may mediate nuclear export of RNA polymerase II-transcribed RNAs. J Cell Biol (1992) 2.20
Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway. EMBO J (2001) 2.17
The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins. EMBO J (2001) 2.14
The U2B'' RNP motif as a site of protein-protein interaction. EMBO J (1990) 2.12
Structure and sequence of the promoter area and of a 5' upstream demethylation site of the estrogen-regulated chicken vitellogenin ii gene. J Biol Chem (1983) 2.11
Xenopus laevis U1 snRNA genes: characterisation of transcriptionally active genes reveals major and minor repeated gene families. EMBO J (1984) 2.08
Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis. Curr Biol (1999) 2.08
Importin-beta-like nuclear transport receptors. Genome Biol (2001) 2.03
Involvement of the carboxyl terminus of vertebrate poly(A) polymerase in U1A autoregulation and in the coupling of splicing and polyadenylation. Genes Dev (1997) 2.03
Intracellular distribution of the U1A protein depends on active transport and nuclear binding to U1 snRNA. J Cell Biol (1992) 2.01
Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities. EMBO J (1996) 2.01
Nuclear import of U snRNPs requires importin beta. EMBO J (1997) 2.00
The direction of transport through the nuclear pore can be inverted. Proc Natl Acad Sci U S A (1999) 1.99
TFIID is required for in vitro transcription of the human U6 gene by RNA polymerase III. EMBO J (1991) 1.97
Domains of U4 and U6 snRNAs required for snRNP assembly and splicing complementation in Xenopus oocytes. EMBO J (1990) 1.96
Monospecific antibodies reveal details of U2 snRNP structure and interaction between U1 and U2 snRNPs. EMBO J (1986) 1.96
Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly. Nat Cell Biol (2001) 1.95
An abundant U6 snRNP found in germ cells and embryos of Xenopus laevis. EMBO J (1989) 1.94
Comparative mutagenesis of nuclear localization signals reveals the importance of neutral and acidic amino acids. Curr Biol (1996) 1.92
Genetic transformation of HeLa cells by Agrobacterium. Proc Natl Acad Sci U S A (2001) 1.90
Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts. Curr Biol (2001) 1.78
Loop I of U1 small nuclear RNA is the only essential RNA sequence for binding of specific U1 small nuclear ribonucleoprotein particle proteins. Mol Cell Biol (1988) 1.77
Transport of RNA between nucleus and cytoplasm. Semin Cell Biol (1992) 1.77
RNA-protein interactions. Cell (1991) 1.71
The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation. Mol Cell (2000) 1.71
Immunodetection of poly(A) binding protein II in the cell nucleus. Exp Cell Res (1994) 1.67
The determinants for Sm protein binding to Xenopus U1 and U5 snRNAs are complex and non-identical. EMBO J (1993) 1.67
The crystal structure of nucleoplasmin-core: implications for histone binding and nucleosome assembly. Mol Cell (2001) 1.66
Nuclear shuttling: the default pathway for nuclear proteins? Cell (1993) 1.63
Estrogen induces a demethylation at the 5' end region of the chicken vitellogenin gene. Proc Natl Acad Sci U S A (1982) 1.63
Structure and expression of a Xenopus gene encoding an snRNP protein (U1 70K). EMBO J (1988) 1.62
Functional characterization of X. laevis U5 snRNA genes. EMBO J (1987) 1.62
A complex secondary structure in U1A pre-mRNA that binds two molecules of U1A protein is required for regulation of polyadenylation. EMBO J (1993) 1.62
Roles of U4 and U6 snRNAs in the assembly of splicing complexes. EMBO J (1992) 1.60
Multiple domains of U1 snRNA, including U1 specific protein binding sites, are required for splicing. EMBO J (1990) 1.60
Molecular analysis of the coiled body. J Cell Sci Suppl (1995) 1.59
Nuclear retention of RNA as a mechanism for localization. RNA (1995) 1.57
A yeast cap binding protein complex (yCBC) acts at an early step in pre-mRNA splicing. Nucleic Acids Res (1996) 1.57
Genetic and physical interactions involving the yeast nuclear cap-binding complex. Mol Cell Biol (1999) 1.56
Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. Eur J Biochem (2000) 1.56