Published in Proc Natl Acad Sci U S A on October 24, 2008
Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing. Blood (2013) 1.84
p53-based cancer therapy. Cold Spring Harb Perspect Biol (2010) 1.62
A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation. BMC Cancer (2011) 1.15
The CRM1 nuclear export protein in normal development and disease. Int J Biochem Mol Biol (2012) 1.14
p53 N-terminal phosphorylation: a defining layer of complex regulation. Carcinogenesis (2012) 1.06
Decision Making by p53: Life versus Death. Mol Cell Pharmacol (2010) 1.01
Chemotherapeutic sensitization of leptomycin B resistant lung cancer cells by pretreatment with doxorubicin. PLoS One (2012) 0.85
PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress. Antioxid Redox Signal (2013) 0.84
Evidence for activation of mutated p53 by apigenin in human pancreatic cancer. Biochim Biophys Acta (2011) 0.83
HIPK1 drives p53 activation to limit colorectal cancer cell growth. Cell Cycle (2013) 0.82
Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. Mol Cell (2013) 0.79
Real-time and simultaneous monitoring of the phosphorylation and enhanced interaction of p53 and XPC acidic domains with the TFIIH p62 subunit. Oncogenesis (2015) 0.77
p53 regulation upon genotoxic stress: intricacies and complexities. Mol Cell Oncol (2014) 0.76
X-linked Dystonia-Parkinsonism patient cells exhibit altered signaling via nuclear factor-kappa B. Neurobiol Dis (2016) 0.75
Bioinformatics study of cancer-related mutations within p53 phosphorylation site motifs. Int J Mol Sci (2014) 0.75
Determination of Total Apigenin in Herbs by Micellar Electrokinetic Chromatography with UV Detection. J Anal Methods Chem (2016) 0.75
Apigenin enhances the cisplatin cytotoxic effect through p53-modulated apoptosis. Oncol Lett (2016) 0.75
OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKCδ/p53. Front Pharmacol (2016) 0.75
Epigallocatechin-3-gallate augments the therapeutic effects of benzo[a]pyrene-mediated lung carcinogenesis. Biofactors (2017) 0.75
Surfing the p53 network. Nature (2000) 35.36
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science (2004) 24.42
Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer (2004) 6.67
Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp Cell Res (1998) 6.11
Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem (2001) 5.43
Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23
A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J (1999) 4.68
Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol Cell Biol (1998) 3.99
A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation. Science (2001) 3.35
Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc Natl Acad Sci U S A (1992) 3.27
The MDM2 RING-finger domain is required to promote p53 nuclear export. Nat Cell Biol (2000) 3.25
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Nat Cell Biol (2000) 3.07
Parc: a cytoplasmic anchor for p53. Cell (2003) 3.06
Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53. Proc Natl Acad Sci U S A (1999) 2.89
Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc Natl Acad Sci U S A (1995) 2.56
The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein. Mol Cell Biol (1991) 2.30
p53: good cop/bad cop. Cell (2002) 2.11
Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med (2004) 2.07
Promoter-selective transcriptional defect in cell cycle mutant ts13 rescued by hTAFII250. Science (1994) 2.02
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53. Nat Cell Biol (2007) 1.94
Mechanistic insights into maintenance of high p53 acetylation by PTEN. Mol Cell (2006) 1.68
Regulation of histone deacetylase 2 by protein kinase CK2. J Biol Chem (2002) 1.63
Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage. Mol Cell Biol (1996) 1.61
Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination. Mol Cell Biol (2003) 1.59
Regulation of p53 localization. Eur J Biochem (2001) 1.57
Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression. Mol Cell (2004) 1.44
Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A. Mol Cell Biol (2007) 1.37
Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma. Mol Cancer Ther (2005) 1.17
The carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities. Oncogene (1994) 1.15
Casein kinase II is a selective target of HIV-1 transcriptional inhibitors. Proc Natl Acad Sci U S A (1997) 1.12
Functional analysis of the human TAFII250 N-terminal kinase domain. Mol Cell (1998) 1.00
Apoptosis is induced in BHK cells by the tsBN462/13 mutation in the CCG1/TAFII250 subunit of the TFIID basal transcription factor. Exp Cell Res (1995) 0.93
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell (2003) 5.13
Vorapaxar in the secondary prevention of atherothrombotic events. N Engl J Med (2012) 4.10
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
Comparative transcriptional profiling of two contrasting rice genotypes under salinity stress during the vegetative growth stage. Plant Physiol (2005) 2.28
Endoscopic Functional Fourier Domain Common Path Optical Coherence Tomography for Microsurgery. IEEE J Sel Top Quantum Electron (2010) 1.88
Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. Sci Transl Med (2012) 1.71
Mechanistic insights into maintenance of high p53 acetylation by PTEN. Mol Cell (2006) 1.68
Miniature fiber-optic force sensor based on low-coherence Fabry-Pérot interferometry for vitreoretinal microsurgery. Biomed Opt Express (2012) 1.63
Experimental results from a preclinical X-ray phase-contrast CT scanner. Proc Natl Acad Sci U S A (2012) 1.63
Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage. Proc Natl Acad Sci U S A (2010) 1.60
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. EMBO J (2007) 1.58
p53 acetylation is crucial for its transcription-independent proapoptotic functions. J Biol Chem (2009) 1.48
An acetylation switch in p53 mediates holo-TFIID recruitment. Mol Cell (2007) 1.48
Oxytocin is an anabolic bone hormone. Proc Natl Acad Sci U S A (2009) 1.44
Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression. Mol Cell (2004) 1.44
Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A. Mol Cell Biol (2007) 1.37
Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β-catenin signal pathway. PLoS One (2013) 1.34
ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy. Mol Ther (2011) 1.32
AAV-mediated cone rescue in a naturally occurring mouse model of CNGA3-achromatopsia. PLoS One (2012) 1.28
Short-term effect of cocoa product consumption on lipid profile: a meta-analysis of randomized controlled trials. Am J Clin Nutr (2010) 1.28
ACTH protects against glucocorticoid-induced osteonecrosis of bone. Proc Natl Acad Sci U S A (2010) 1.26
Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90. J Cell Physiol (2012) 1.25
Real-time 3D and 4D Fourier domain Doppler optical coherence tomography based on dual graphics processing units. Biomed Opt Express (2012) 1.25
Large-scale expression profiling and physiological characterization of jasmonic acid-mediated adaptation of barley to salinity stress. Plant Cell Environ (2007) 1.22
Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases. J Biol Chem (2003) 1.22
Development of a prototype gantry system for preclinical x-ray phase-contrast computed tomography. Med Phys (2011) 1.16
Safety, biodistribution, and dosimetry of 99mTc-HYNIC-annexin V, a novel human recombinant annexin V for human application. J Nucl Med (2003) 1.14
Motion-compensated hand-held common-path Fourier-domain optical coherence tomography probe for image-guided intervention. Biomed Opt Express (2012) 1.14
Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity. Mol Endocrinol (2002) 1.12
Gene therapy for retinitis pigmentosa caused by MFRP mutations: human phenotype and preliminary proof of concept. Hum Gene Ther (2012) 1.12
Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo. Food Chem Toxicol (2009) 1.10
Phytochemical analysis of traditional Chinese medicine using liquid chromatography coupled with mass spectrometry. J Chromatogr A (2008) 1.10
Signal-to-noise ratio analysis of all-fiber common-path optical coherence tomography. Appl Opt (2008) 1.09
Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4alpha (HNF4alpha) gene. Biochem J (2006) 1.09
Transcriptomic signatures in cartilage ageing. Arthritis Res Ther (2013) 1.07
Optical coherence tomography scanning with a handheld vitreoretinal micromanipulator. Conf Proc IEEE Eng Med Biol Soc (2012) 1.07
Investigation into the antioxidant activity and chemical composition of alcoholic extracts from defatted marigold (Tagetes erecta L.) residue. Fitoterapia (2011) 1.06
Genome-wide detection of copy number variations using high-density SNP genotyping platforms in Holsteins. BMC Genomics (2013) 1.06
Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth. J Cell Sci (2006) 1.06
Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Mol Cell Proteomics (2007) 1.05
COX-2 contributes to P-glycoprotein-mediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer. Carcinogenesis (2011) 1.05
De novo assembly and characterization of Camelina sativa transcriptome by paired-end sequencing. BMC Genomics (2013) 1.04
A comparison of strategies for analyzing dichotomous outcomes in genome-wide association studies with general pedigrees. Genet Epidemiol (2011) 1.04
Anti-tumor activity and apoptosis-regulation mechanisms of bufalin in various cancers: new hope for cancer patients. Asian Pac J Cancer Prev (2012) 1.04
AAV-mediated gene therapy in the guanylate cyclase (RetGC1/RetGC2) double knockout mouse model of Leber congenital amaurosis. Hum Gene Ther (2013) 1.03
Preservation of parotid function with uncomplicated conformal radiotherapy. Radiother Oncol (2002) 1.03
Microtubule-binding natural products for cancer therapy. Planta Med (2010) 1.01
Preparation of curcumin-loaded liposomes and evaluation of their skin permeation and pharmacodynamics. Molecules (2012) 1.00
TSP-1 secreted by bone marrow stromal cells contributes to retinal ganglion cell neurite outgrowth and survival. PLoS One (2008) 0.99
Multiple gene mutations, not the type of mutation, are the modifier of left ventricle hypertrophy in patients with hypertrophic cardiomyopathy. Mol Biol Rep (2013) 0.99
Cardio-protection of salvianolic acid B through inhibition of apoptosis network. PLoS One (2011) 0.97
An exotic species is the favorite prey of a native enemy. PLoS One (2011) 0.96
Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases. Biochemistry (2003) 0.95
Zuo Jin Wan, a Traditional Chinese Herbal Formula, Reverses P-gp-Mediated MDR In Vitro and In Vivo. Evid Based Complement Alternat Med (2013) 0.95
Ruggedness and robustness of conversion factors in method of simultaneous determination of multi-components with single reference standard. J Chromatogr A (2011) 0.94
From a single whole exome read to notions of clinical screening: primary ciliary dyskinesia and RSPH9 p.Lys268del in the Arabian Peninsula. Ann Hum Genet (2012) 0.94
Bufalin-loaded mPEG-PLGA-PLL-cRGD nanoparticles: preparation, cellular uptake, tissue distribution, and anticancer activity. Int J Nanomedicine (2012) 0.94
Spatial Latent Class Analysis Model for Spatially Distributed Multivariate Binary Data. Comput Stat Data Anal (2009) 0.94
Human papillomavirus type 16 E6 and E7 oncoproteins upregulate c-IAP2 gene expression and confer resistance to apoptosis. Oncogene (2005) 0.93
Matrix metalloproteinase-9 induces cardiac fibroblast migration, collagen and cytokine secretion: inhibition by salvianolic acid B from Salvia miltiorrhiza. Phytomedicine (2011) 0.92
Mutations in NEXN, a Z-disc gene, are associated with hypertrophic cardiomyopathy. Am J Hum Genet (2010) 0.92
Identification of DNA-binding proteins by combining auto-cross covariance transformation and ensemble learning. IEEE Trans Nanobioscience (2016) 0.92
Antigen-specific T cell functions are suppressed over the estrogen-dendritic cell-indoleamine 2,3-dioxygenase axis. Steroids (2004) 0.92
Population size and time since island isolation determine genetic diversity loss in insular frog populations. Mol Ecol (2014) 0.91
Selective tropism of the recombinant adeno-associated virus 9 serotype for rat cardiac tissue. J Gene Med (2010) 0.90
Cardioprotection and matrix metalloproteinase-9 regulation of salvianolic acids on myocardial infarction in rats. Planta Med (2009) 0.90
The role of p53 deacetylation in p21Waf1 regulation by laminar flow. J Biol Chem (2003) 0.90
Therapeutic potential of IFN-gamma-modified dendritic cells in acute and chronic experimental allergic encephalomyelitis. Int Immunol (2004) 0.90
Common-Path Optical Coherence Tomography for Biomedical Imaging and Sensing. J Opt Soc Korea (2010) 0.90
Cytotoxic triterpenoids from Ganoderma lucidum. Phytochemistry (2010) 0.89
Reduced prefrontal activation during Tower of London in first-episode schizophrenia: a multi-channel near-infrared spectroscopy study. Neurosci Lett (2010) 0.89
Improved heterologous gene expression in Trichoderma reesei by cellobiohydrolase I gene (cbh1) promoter optimization. Acta Biochim Biophys Sin (Shanghai) (2008) 0.89
Association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants identified by UMOD gene region sequencing. PLoS One (2012) 0.89
Interaction of salvianolic acids and notoginsengnosides in inhibition of ADP-induced platelet aggregation. Am J Chin Med (2008) 0.89
A dynamic multiple reaction monitoring method for the multiple components quantification of complex traditional Chinese medicine preparations: Niuhuang Shangqing pill as an example. J Chromatogr A (2013) 0.88
Retrospective survey of museum specimens reveals historically widespread presence of Batrachochytrium dendrobatidis in China. Ecohealth (2014) 0.87
Norcantharidin inhibits tumor angiogenesis via blocking VEGFR2/MEK/ERK signaling pathways. Cancer Sci (2013) 0.87
Ligand-based neutral ruthenium(II) arene complex: selective anticancer action. Inorg Chem (2009) 0.87
Salvianolic acid A, a novel matrix metalloproteinase-9 inhibitor, prevents cardiac remodeling in spontaneously hypertensive rats. PLoS One (2013) 0.86
The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alpha. J Virol (2008) 0.86
Hemichorea associated with nonketotic hyperglycemia: clinical and neuroimaging features in 12 patients. Eur Neurol (2014) 0.86
Trends for nanotechnology development in China, Russia, and India. J Nanopart Res (2009) 0.86
Proteomic studies on protective effects of salvianolic acids, notoginsengnosides and combination of salvianolic acids and notoginsengnosides against cardiac ischemic-reperfusion injury. J Ethnopharmacol (2011) 0.86
[Expression of HIF-1 alpha and its relationship to apoptosis and proliferation in lung cancer]. Ai Zheng (2002) 0.85
Alcohol enhances HIV type 1 infection in normal human oral keratinocytes by up-regulating cell-surface CXCR4 coreceptor. AIDS Res Hum Retroviruses (2004) 0.85
CXCR4 down-regulation by small interfering RNA inhibits invasion and tubule formation of human retinal microvascular endothelial cells. Biochem Biophys Res Commun (2007) 0.85
Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells. FEBS J (2010) 0.85
B56γ tumor-associated mutations provide new mechanisms for B56γ-PP2A tumor suppressor activity. Mol Cancer Res (2013) 0.85
Interaction of Ganoderma triterpenes with doxorubicin and proteomic characterization of the possible molecular targets of Ganoderma triterpenes. Cancer Sci (2008) 0.85
Comparison of two officinal Chinese pharmacopoeia species of Ganoderma based on chemical research with multiple technologies and chemometrics analysis. J Chromatogr A (2011) 0.84
Tastin is required for bipolar spindle assembly and centrosome integrity during mitosis. FASEB J (2008) 0.84
Differential proteomic analysis of platelets suggested possible signal cascades network in platelets treated with salvianolic acid B. PLoS One (2011) 0.84
PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress. Antioxid Redox Signal (2013) 0.84
Tanshinone II--a inhibits angiogenesis through down regulation of COX-2 in human colorectal cancer. Asian Pac J Cancer Prev (2012) 0.84
Zuo Jin Wan reverses P-gp-mediated drug-resistance by inhibiting activation of the PI3K/Akt/NF-κB pathway. BMC Complement Altern Med (2014) 0.84
Insights into selective activation of p53 DNA binding by c-Abl. J Biol Chem (2005) 0.84
A single, multi-faceted, enhanced strategy to quantify the chromatographically diverse constituents in the roots of Euphorbia kansui. J Pharm Biomed Anal (2013) 0.83
Synthesis and structure-activity relationships study of cytotoxic bufalin 3-nitrogen-containing-ester derivatives. Steroids (2013) 0.83
Synthesis and preliminary biological evaluation of MMP inhibitor radiotracers [11C]methyl-halo-CGS 27023A analogs, new potential PET breast cancer imaging agents. Nucl Med Biol (2002) 0.83
Interaction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowth. J Biol Chem (2009) 0.83