Published in RNA on September 01, 2000
ESEfinder: A web resource to identify exonic splicing enhancers. Nucleic Acids Res (2003) 12.81
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol (2009) 7.11
Splicing regulation: from a parts list of regulatory elements to an integrated splicing code. RNA (2008) 6.29
Tissue-dependent isoforms of mammalian Fox-1 homologs are associated with tissue-specific splicing activities. Nucleic Acids Res (2005) 4.06
Deep sequencing of subcellular RNA fractions shows splicing to be predominantly co-transcriptional in the human genome but inefficient for lncRNAs. Genome Res (2012) 3.83
RESCUE-ESE identifies candidate exonic splicing enhancers in vertebrate exons. Nucleic Acids Res (2004) 3.70
Identification of alternative splicing regulators by RNA interference in Drosophila. Proc Natl Acad Sci U S A (2004) 3.58
SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs. EMBO J (2001) 3.55
Variation in sequence and organization of splicing regulatory elements in vertebrate genes. Proc Natl Acad Sci U S A (2004) 3.34
Testing gene function early in the B cell lineage in mb1-cre mice. Proc Natl Acad Sci U S A (2006) 3.32
Crossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1. Mol Cell (2007) 3.22
Splicing in action: assessing disease causing sequence changes. J Med Genet (2005) 3.07
A novel role for shuttling SR proteins in mRNA translation. Genes Dev (2004) 3.02
Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution. Nature (2009) 2.82
Single nucleotide polymorphism-based validation of exonic splicing enhancers. PLoS Biol (2004) 2.77
SR proteins in vertical integration of gene expression from transcription to RNA processing to translation. Mol Cell (2009) 2.73
SRm160 splicing coactivator promotes transcript 3'-end cleavage. Mol Cell Biol (2002) 2.73
Bifunctional antisense oligonucleotides provide a trans-acting splicing enhancer that stimulates SMN2 gene expression in patient fibroblasts. Proc Natl Acad Sci U S A (2003) 2.65
A nonsense mutation in the fibrillin-1 gene of a Marfan syndrome patient induces NMD and disrupts an exonic splicing enhancer. Genes Dev (2002) 2.61
Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition. Genes Dev (2005) 2.52
Medical sequencing of candidate genes for nonsyndromic cleft lip and palate. PLoS Genet (2005) 2.52
A molecular link between SR protein dephosphorylation and mRNA export. Proc Natl Acad Sci U S A (2004) 2.49
Genome analysis: RNA recognition motif (RRM) and K homology (KH) domain RNA-binding proteins from the flowering plant Arabidopsis thaliana. Nucleic Acids Res (2002) 2.44
Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron. Mol Cell Biol (2006) 2.41
Intronic CA-repeat and CA-rich elements: a new class of regulators of mammalian alternative splicing. EMBO J (2005) 2.30
A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Mol Cell (2008) 2.29
RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humans. Genes Dev (2006) 2.25
Proteomic analysis of interchromatin granule clusters. Mol Biol Cell (2004) 2.12
Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression. J Biomed Sci (2004) 2.11
Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation. Mol Cell (2009) 2.10
The SR protein family. Genome Biol (2009) 2.09
Polypyrimidine tract binding protein blocks the 5' splice site-dependent assembly of U2AF and the prespliceosomal E complex. Mol Cell (2005) 2.05
SR proteins and hnRNP H regulate the splicing of the HIV-1 tev-specific exon 6D. EMBO J (2002) 2.04
Nuclear export and retention signals in the RS domain of SR proteins. Mol Cell Biol (2002) 2.04
Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis. Mol Cell Biol (2007) 2.04
Global analysis of alternative splicing differences between humans and chimpanzees. Genes Dev (2007) 2.00
Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB). RNA (2001) 1.98
Defective splicing, disease and therapy: searching for master checkpoints in exon definition. Nucleic Acids Res (2006) 1.89
Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins. Genes Dev (2002) 1.89
Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J (2004) 1.88
Modulating role of RNA structure in alternative splicing of a critical exon in the spinal muscular atrophy genes. Nucleic Acids Res (2006) 1.84
Serine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers. Proc Natl Acad Sci U S A (2005) 1.83
Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping. Structure (2011) 1.82
ICP27 interacts with SRPK1 to mediate HSV splicing inhibition by altering SR protein phosphorylation. EMBO J (2003) 1.79
An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries. EMBO J (2006) 1.79
The role of U2AF35 and U2AF65 in enhancer-dependent splicing. RNA (2001) 1.76
Processive phosphorylation of alternative splicing factor/splicing factor 2. Proc Natl Acad Sci U S A (2003) 1.75
Reversible phosphorylation differentially affects nuclear and cytoplasmic functions of splicing factor 2/alternative splicing factor. Proc Natl Acad Sci U S A (2005) 1.74
A nucleo-cytoplasmic SR protein functions in viral IRES-mediated translation initiation. EMBO J (2006) 1.71
The hnRNP A1 protein regulates HIV-1 tat splicing via a novel intron silencer element. EMBO J (2001) 1.70
Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes. Nucleic Acids Res (2005) 1.70
The PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicing. EMBO J (2003) 1.68
The retrovirus RNA trafficking granule: from birth to maturity. Retrovirology (2006) 1.63
In vivo selection reveals combinatorial controls that define a critical exon in the spinal muscular atrophy genes. RNA (2004) 1.60
Functional specificity of shuttling hnRNPs revealed by genome-wide analysis of their RNA binding profiles. RNA (2005) 1.58
A purine-rich intronic element enhances alternative splicing of thyroid hormone receptor mRNA. RNA (2001) 1.55
An intronic element contributes to splicing repression in spinal muscular atrophy. Proc Natl Acad Sci U S A (2007) 1.55
The Arabidopsis cyclophilin gene family. Plant Physiol (2004) 1.53
Identification of novel mutations in RBM20 in patients with dilated cardiomyopathy. Clin Transl Sci (2010) 1.52
A novel splicing regulator shares a nuclear import pathway with SR proteins. EMBO J (2003) 1.51
The search for alternative splicing regulators: new approaches offer a path to a splicing code. Genes Dev (2008) 1.50
Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA. EMBO J (2004) 1.50
Depolarization and CaM kinase IV modulate NMDA receptor splicing through two essential RNA elements. PLoS Biol (2007) 1.49
Antagonistic regulation of alpha-actinin alternative splicing by CELF proteins and polypyrimidine tract binding protein. RNA (2003) 1.47
Evolutionary conservation and regulation of particular alternative splicing events in plant SR proteins. Nucleic Acids Res (2006) 1.47
Determinants of the Usage of Splice-Associated cis-Motifs Predict the Distribution of Human Pathogenic SNPs. Mol Biol Evol (2015) 1.46
Selective modification of alternative splicing by indole derivatives that target serine-arginine-rich protein splicing factors. Proc Natl Acad Sci U S A (2005) 1.45
Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation. Mol Cell Biol (2003) 1.44
A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation. Genome Res (2008) 1.44
A general role for splicing enhancers in exon definition. RNA (2002) 1.43
Dichotomous splicing signals in exon flanks. Genome Res (2005) 1.42
Regulated cellular partitioning of SR protein-specific kinases in mammalian cells. Mol Biol Cell (2005) 1.42
Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway. RNA (2001) 1.42
Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo. Mol Cell Biol (2004) 1.39
Misregulation of pre-mRNA alternative splicing in cancer. Cancer Discov (2013) 1.39
Serine/arginine-rich splicing factors belong to a class of intrinsically disordered proteins. Nucleic Acids Res (2006) 1.39
Tau exon 10 alternative splicing and tauopathies. Mol Neurodegener (2008) 1.38
Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. Mol Cell Biol (2002) 1.38
Ectopic expression of atRSZ33 reveals its function in splicing and causes pleiotropic changes in development. Mol Biol Cell (2003) 1.37
Evolution of SR protein and hnRNP splicing regulatory factors. Wiley Interdiscip Rev RNA (2011) 1.37
The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins. EMBO J (2001) 1.36
A novel approach to describe a U1 snRNA binding site. Nucleic Acids Res (2003) 1.35
A bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates human immunodeficiency virus type 1 rev, env, vpu, and nef gene expression. J Virol (2004) 1.35
A regulator of Dscam mutually exclusive splicing fidelity. Nat Struct Mol Biol (2007) 1.35
Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a natural BRCA1 exon 18 mutant. Mol Cell Biol (2008) 1.35
ASAP, a novel protein complex involved in RNA processing and apoptosis. Mol Cell Biol (2003) 1.34
Regulation of plant developmental processes by a novel splicing factor. PLoS One (2007) 1.34
Computational comparative analyses of alternative splicing regulation using full-length cDNA of various eukaryotes. RNA (2004) 1.33
In vivo requirement of the small subunit of U2AF for recognition of a weak 3' splice site. Mol Cell Biol (2006) 1.33
Hypophosphorylated SR splicing factors transiently localize around active nucleolar organizing regions in telophase daughter nuclei. J Cell Biol (2004) 1.32
Detained introns are a novel, widespread class of post-transcriptionally spliced introns. Genes Dev (2015) 1.31
The serine/arginine-rich protein family in rice plays important roles in constitutive and alternative splicing of pre-mRNA. Plant Cell (2005) 1.30
Two alternatively spliced isoforms of the Arabidopsis SR45 protein have distinct roles during normal plant development. Plant Physiol (2009) 1.30
A conserved Drosophila transportin-serine/arginine-rich (SR) protein permits nuclear import of Drosophila SR protein splicing factors and their antagonist repressor splicing factor 1. Mol Biol Cell (2002) 1.30
Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms. RNA (2012) 1.28
Highly variable mRNA expression and splicing of L-type voltage-dependent calcium channel alpha subunit 1C in human heart tissues. Pharmacogenet Genomics (2006) 1.27
Roles for SR proteins and hnRNP A1 in the regulation of c-src exon N1. Mol Cell Biol (2003) 1.27
Compensatory relationship between splice sites and exonic splicing signals depending on the length of vertebrate introns. BMC Genomics (2006) 1.26
Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases. Trends Biochem Sci (2000) 10.77
Exon recognition in vertebrate splicing. J Biol Chem (1995) 10.08
Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature (1990) 8.79
SR proteins: a conserved family of pre-mRNA splicing factors. Genes Dev (1992) 8.60
Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell (1993) 8.07
The superfamily of arginine/serine-rich splicing factors. RNA (1995) 7.96
A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein. Cell (1989) 7.42
Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science (1994) 7.09
Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors. Nature (1994) 6.97
Cloning and domain structure of the mammalian splicing factor U2AF. Nature (1992) 6.55
Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators. Cell (1991) 6.50
A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly. Cell (1988) 6.16
A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro. Cell (1990) 5.92
Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes Dev (1998) 5.79
Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators. Cell (1991) 5.72
The essential pre-mRNA splicing factor SF2 influences 5' splice site selection by activating proximal sites. Cell (1990) 5.67
Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells. Genes Dev (1990) 5.36
Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor. Proc Natl Acad Sci U S A (1989) 5.11
A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding. Genes Dev (1993) 5.10
A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature (1994) 5.01
The dynamics of a pre-mRNA splicing factor in living cells. Nature (1997) 4.97
A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell (1993) 4.82
A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription. J Cell Biol (1991) 4.80
Distinct functions of SR proteins in alternative pre-mRNA splicing. Science (1993) 4.79
Specific commitment of different pre-mRNAs to splicing by single SR proteins. Nature (1993) 4.74
The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities. EMBO J (1995) 4.66
The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J (1996) 4.65
General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes Dev (1993) 4.40
A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. Genes Dev (1998) 4.19
Scanning from an independently specified branch point defines the 3' splice site of mammalian introns. Nature (1989) 4.18
Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides. Cell (1989) 4.15
An ATP-independent complex commits pre-mRNA to the mammalian spliceosome assembly pathway. Genes Dev (1991) 3.99
General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proc Natl Acad Sci U S A (1992) 3.97
Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes Dev (1997) 3.87
Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene. Cell (1987) 3.86
Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Cell (1997) 3.85
Functional recognition of the 3' splice site AG by the splicing factor U2AF35. Nature (1999) 3.72
Initial splice-site recognition and pairing during pre-mRNA splicing. Curr Opin Genet Dev (1996) 3.68
The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. Genes Dev (1996) 3.63
Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. EMBO J (1995) 3.56
Isolation of a complementary DNA that encodes the mammalian splicing factor SC35. Science (1992) 3.52
Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains. EMBO J (1993) 3.51
An exonic enhancer is required for inclusion of an essential exon in the SMA-determining gene SMN. Hum Mol Genet (2000) 3.41
Selection and characterization of pre-mRNA splicing enhancers: identification of novel SR protein-specific enhancer sequences. Mol Cell Biol (1999) 3.36
Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell (1996) 3.30
The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2. Cell (1994) 3.18
Protein components specifically associated with prespliceosome and spliceosome complexes. Genes Dev (1992) 3.16
RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo. Mol Cell (1999) 3.10
Positive control of pre-mRNA splicing in vitro. Science (1992) 3.05
A coactivator of pre-mRNA splicing. Genes Dev (1998) 3.04
The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3' splice site. Proc Natl Acad Sci U S A (1992) 3.04
Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Mol Cell Biol (2000) 3.01
Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability. Genes Dev (1996) 2.99
Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer. Genes Dev (1996) 2.90
Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3' splice site AG. Nature (1999) 2.87
Functional domains of the human splicing factor ASF/SF2. EMBO J (1993) 2.83
Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit. Proc Natl Acad Sci U S A (1992) 2.82
Determinants of SR protein specificity. Curr Opin Cell Biol (1999) 2.72
Multiple distinct splicing enhancers in the protein-coding sequences of a constitutively spliced pre-mRNA. Mol Cell Biol (1999) 2.72
A systematic analysis of the factors that determine the strength of pre-mRNA splicing enhancers. EMBO J (1998) 2.71
Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing. Cell (1991) 2.69
SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. J Cell Biol (1998) 2.69
The splicing factors 9G8 and SRp20 transactivate splicing through different and specific enhancers. RNA (1999) 2.66
Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing. Proc Natl Acad Sci U S A (1992) 2.66
Both subunits of U2AF recognize the 3' splice site in Caenorhabditis elegans. Nature (1999) 2.65
Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways. RNA (1995) 2.60
Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. J Cell Biol (1998) 2.60
SR proteins can compensate for the loss of U1 snRNP functions in vitro. Genes Dev (1994) 2.55
Arginine/serine-rich domains of SR proteins can function as activators of pre-mRNA splicing. Mol Cell (1998) 2.54
The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein. Cell (1988) 2.47
A splicing enhancer exhibits both constitutive and regulated activities. Genes Dev (1994) 2.46
Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I. Nature (1996) 2.45
Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity. RNA (1995) 2.44
Pre-mRNA splicing of IgM exons M1 and M2 is directed by a juxtaposed splicing enhancer and inhibitor. Genes Dev (1999) 2.42
The cellular organization of gene expression. Curr Opin Cell Biol (1998) 2.41
Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2. EMBO J (1998) 2.37
Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer. Proc Natl Acad Sci U S A (1997) 2.34
Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors. Proc Natl Acad Sci U S A (1994) 2.34
Complementation by SR proteins of pre-mRNA splicing reactions depleted of U1 snRNP. Science (1994) 2.33
Regulation of adenovirus alternative RNA splicing by dephosphorylation of SR proteins. Nature (1998) 2.26
Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Cell (1998) 2.25
Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family. EMBO J (1994) 2.23
The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites. Proc Natl Acad Sci U S A (1994) 2.14
The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing. Mol Cell Biol (1999) 2.09
Functional characterization of SR and SR-related genes in Caenorhabditis elegans. EMBO J (2000) 2.05
Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements. Mol Cell Biol (1999) 2.05
Human SR proteins and isolation of a cDNA encoding SRp75. Mol Cell Biol (1993) 2.04
SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome. RNA (1995) 2.02
The SR protein B52/SRp55 is essential for Drosophila development. Mol Cell Biol (1994) 2.02
Characterization of a Drosophila protein associated with boundaries of transcriptionally active chromatin. Genes Dev (1991) 1.95
Common themes in the function of transcription and splicing enhancers. Curr Opin Cell Biol (1997) 1.92
Functional properties of p54, a novel SR protein active in constitutive and alternative splicing. Mol Cell Biol (1996) 1.90
A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs. Nucleic Acids Res (1991) 1.86
A two-step mechanism for 5' and 3' splice-site pairing. Nature (1995) 1.85
Genetic analysis of the SR protein ASF/SF2: interchangeability of RS domains and negative control of splicing. Genes Dev (1998) 1.85
Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22. Mol Cell Biol (1994) 1.78
U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements. Nucleic Acids Res (1995) 1.77
RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins. Proc Natl Acad Sci U S A (1997) 1.72
Bimolecular exon ligation by the human spliceosome. Science (1997) 1.72