Published in EMBO J on April 02, 2001
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. Proc Natl Acad Sci U S A (2002) 10.28
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat Neurosci (2011) 6.01
A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes Dev (2007) 5.83
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Hum Mol Genet (2010) 5.75
Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay. Genes Dev (2007) 4.75
Crossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1. Mol Cell (2007) 3.22
Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression. Genes Dev (2006) 3.18
The multiple lives of NMD factors: balancing roles in gene and genome regulation. Nat Rev Genet (2008) 3.00
TDP-43 regulates its mRNA levels through a negative feedback loop. EMBO J (2010) 2.90
hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay. Mol Cell Biol (2006) 2.69
Discovery and analysis of evolutionarily conserved intronic splicing regulatory elements. PLoS Genet (2007) 2.60
A combinatorial code for splicing silencing: UAGG and GGGG motifs. PLoS Biol (2005) 2.48
An unappreciated role for RNA surveillance. Genome Biol (2004) 2.28
Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay. Mol Cell Biol (2008) 2.25
Context-dependent control of alternative splicing by RNA-binding proteins. Nat Rev Genet (2014) 2.17
Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation. Genome Res (2010) 1.80
SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control. Nat Struct Mol Biol (2010) 1.78
Nonsense-mediated mRNA decay affects nonsense transcript levels and governs response of cystic fibrosis patients to gentamicin. J Clin Invest (2007) 1.73
How cells get the message: dynamic assembly and function of mRNA-protein complexes. Nat Rev Genet (2013) 1.67
Role of BMPR2 alternative splicing in heritable pulmonary arterial hypertension penetrance. Circulation (2012) 1.64
Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes. Nat Rev Mol Cell Biol (2015) 1.61
Regulation of nonsense-mediated mRNA decay: implications for physiology and disease. Biochim Biophys Acta (2013) 1.59
Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife. Genome Biol (2004) 1.59
A splicing-independent function of SF2/ASF in microRNA processing. Mol Cell (2010) 1.55
The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway. Nucleic Acids Res (2007) 1.53
Alternative splicing and nonsense-mediated mRNA decay regulate mammalian ribosomal gene expression. Nucleic Acids Res (2005) 1.48
Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies. J Cell Biol (2007) 1.47
Nutritional control of mRNA isoform expression during developmental arrest and recovery in C. elegans. Genome Res (2012) 1.46
Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. PLoS Genet (2009) 1.46
Reciprocal regulation of glycine-rich RNA-binding proteins via an interlocked feedback loop coupling alternative splicing to nonsense-mediated decay in Arabidopsis. Nucleic Acids Res (2008) 1.43
Misregulated RNA processing in amyotrophic lateral sclerosis. Brain Res (2012) 1.42
The function of introns. Front Genet (2012) 1.42
Ectopic expression of atRSZ33 reveals its function in splicing and causes pleiotropic changes in development. Mol Biol Cell (2003) 1.37
High resolution transcriptome maps for wild-type and nonsense-mediated decay-defective Caenorhabditis elegans. Genome Biol (2009) 1.36
Autoregulation of Fox protein expression to produce dominant negative splicing factors. RNA (2009) 1.34
SFmap: a web server for motif analysis and prediction of splicing factor binding sites. Nucleic Acids Res (2010) 1.33
A conserved Drosophila transportin-serine/arginine-rich (SR) protein permits nuclear import of Drosophila SR protein splicing factors and their antagonist repressor splicing factor 1. Mol Biol Cell (2002) 1.30
Antagonistic factors control the unproductive splicing of SC35 terminal intron. Nucleic Acids Res (2009) 1.28
NeuN/Rbfox3 nuclear and cytoplasmic isoforms differentially regulate alternative splicing and nonsense-mediated decay of Rbfox2. PLoS One (2011) 1.27
Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin. EMBO J (2010) 1.23
Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2. Crit Rev Biochem Mol Biol (2012) 1.20
Extended base pair complementarity between U1 snRNA and the 5' splice site does not inhibit splicing in higher eukaryotes, but rather increases 5' splice site recognition. Nucleic Acids Res (2005) 1.17
Deciphering the role of RNA-binding proteins in the post-transcriptional control of gene expression. Brief Funct Genomics (2010) 1.14
Identification of hundreds of novel UPF1 target transcripts by direct determination of whole transcriptome stability. RNA Biol (2012) 1.13
Rescue of nonsense mutations by amlexanox in human cells. Orphanet J Rare Dis (2012) 1.13
Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay. BMC Biol (2009) 1.11
Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay. BMC Genomics (2010) 1.07
An apparent pseudo-exon acts both as an alternative exon that leads to nonsense-mediated decay and as a zero-length exon. Mol Cell Biol (2006) 1.07
The origins, evolution, and functional potential of alternative splicing in vertebrates. Mol Biol Evol (2011) 1.05
The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD). Nucleic Acids Res (2006) 1.03
Exon identity crisis: disease-causing mutations that disrupt the splicing code. Genome Biol (2014) 1.02
Aberrant alternative splicing is another hallmark of cancer. Int J Cell Biol (2013) 1.02
Negative feedback regulation among SR splicing factors encoded by Rbp1 and Rbp1-like in Drosophila. EMBO J (2005) 1.01
Regulation of alternative splicing by SRrp86 and its interacting proteins. Mol Cell Biol (2003) 1.01
Nonsense-mediated mRNA decay in humans at a glance. J Cell Sci (2016) 1.01
Global analysis of alternative splicing uncovers developmental regulation of nonsense-mediated decay in C. elegans. RNA (2009) 0.97
SRSF1 regulates the assembly of pre-mRNA processing factors in nuclear speckles. Mol Biol Cell (2012) 0.97
Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways. Mol Cell Biol (2007) 0.96
Alternative RNA splicing and cancer. Wiley Interdiscip Rev RNA (2013) 0.96
Gene expression networks: competing mRNA decay pathways in mammalian cells. Biochem Soc Trans (2009) 0.96
A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay. Mol Cell (2015) 0.95
Transcriptome-wide modulation of splicing by the exon junction complex. Genome Biol (2014) 0.94
A minor alternative transcript of the fumarylacetoacetate hydrolase gene produces a protein despite being likely subjected to nonsense-mediated mRNA decay. BMC Mol Biol (2005) 0.94
The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatids. Nucleic Acids Res (2012) 0.94
Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synuclein. Nucleic Acids Res (2013) 0.93
Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay. RNA Biol (2013) 0.92
SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing. Mol Cell Biol (2015) 0.89
Regulation of splicing factors by alternative splicing and NMD is conserved between kingdoms yet evolutionarily flexible. Mol Biol Evol (2015) 0.89
A plant 5S ribosomal RNA mimic regulates alternative splicing of transcription factor IIIA pre-mRNAs. Nat Struct Mol Biol (2009) 0.89
A nonsense exon in the Tpm1 gene is silenced by hnRNP H and F. RNA (2008) 0.88
Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation. RNA Biol (2013) 0.88
An integrated regulatory network reveals pervasive cross-regulation among transcription and splicing factors. PLoS Comput Biol (2012) 0.88
Expression of two novel alternatively spliced COL2A1 isoforms during chondrocyte differentiation. Matrix Biol (2007) 0.88
PTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells. Sci Rep (2015) 0.87
SRSF2 promotes splicing and transcription of exon 11 included isoform in Ron proto-oncogene. Biochim Biophys Acta (2014) 0.86
Nonsense-mediated messenger RNA decay of survival motor neuron 1 causes spinal muscular atrophy. Hum Genet (2008) 0.86
Delineation of the mechanisms of aberrant splicing caused by two unusual intronic mutations in the RSK2 gene involved in Coffin-Lowry syndrome. Nucleic Acids Res (2004) 0.86
The structure and selectivity of the SR protein SRSF2 RRM domain with RNA. Nucleic Acids Res (2011) 0.86
Predominance of spliceosomal complex formation over polyadenylation site selection in TDP-43 autoregulation. Nucleic Acids Res (2013) 0.85
The SERRATE protein is involved in alternative splicing in Arabidopsis thaliana. Nucleic Acids Res (2013) 0.85
Functionally antagonistic sequences are required for normal autoregulation of Drosophila tra-2 pre-mRNA splicing. Nucleic Acids Res (2001) 0.84
XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265. Nucleic Acids Res (2006) 0.83
Human Papillomavirus 16 Oncoprotein Expression Is Controlled by the Cellular Splicing Factor SRSF2 (SC35). J Virol (2015) 0.83
Caspases shutdown nonsense-mediated mRNA decay during apoptosis. Cell Death Differ (2015) 0.82
A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineages. Blood (2016) 0.82
The unfolded protein response affects readthrough of premature termination codons. EMBO Mol Med (2014) 0.82
Origins and impacts of new mammalian exons. Cell Rep (2015) 0.81
Alternative splicing and nonsense-mediated decay regulate telomerase reverse transcriptase (TERT) expression during virus-induced lymphomagenesis in vivo. BMC Cancer (2010) 0.81
CWC22-dependent pre-mRNA splicing and eIF4A3 binding enables global deposition of exon junction complexes. Nucleic Acids Res (2015) 0.81
Proteasome-mediated proteolysis of SRSF5 splicing factor intriguingly co-occurs with SRSF5 mRNA upregulation during late erythroid differentiation. PLoS One (2013) 0.81
Identification of new branch points and unconventional introns in Saccharomyces cerevisiae. RNA (2016) 0.80
RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns. Nucleic Acids Res (2016) 0.80
Physiological and pathophysiological role of nonsense-mediated mRNA decay. Pflugers Arch (2016) 0.80
Exon Junction Complexes Show a Distributional Bias toward Alternatively Spliced mRNAs and against mRNAs Coding for Ribosomal Proteins. Cell Rep (2016) 0.79
Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4. ACS Med Chem Lett (2014) 0.79
Splicing-factor alterations in cancers. RNA (2016) 0.78
Alternative splicing mechanisms orchestrating post-transcriptional gene expression: intron retention and the intron-rich genome of apicomplexan parasites. Curr Genet (2015) 0.77
Multiple transcripts from a 3'-UTR reporter vary in sensitivity to nonsense-mediated mRNA decay in Saccharomyces cerevisiae. PLoS One (2013) 0.77
Evolutionarily conserved autoregulation of alternative pre-mRNA splicing by ribosomal protein L10a. Nucleic Acids Res (2016) 0.77
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Sorting out the complexity of SR protein functions. RNA (2000) 9.25
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