Published in Proc Natl Acad Sci U S A on December 01, 1992
Sorting out the complexity of SR protein functions. RNA (2000) 9.25
Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Res (1993) 6.15
Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes Dev (1998) 5.79
The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities. EMBO J (1995) 4.66
A nuclear localization domain in the hnRNP A1 protein. J Cell Biol (1995) 4.51
SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex. Mol Cell Biol (1994) 4.25
Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. RNA (1998) 4.05
General and specific functions of exonic splicing silencers in splicing control. Mol Cell (2006) 3.76
Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. EMBO J (1995) 3.56
Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains. EMBO J (1993) 3.51
Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. J Cell Biol (1997) 3.36
Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. EMBO J (1994) 3.35
A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer. Mol Cell Biol (1995) 3.18
Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Mol Cell Biol (1993) 3.16
Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism. EMBO J (1994) 3.11
Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF. EMBO J (1993) 3.11
Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA. Genes Dev (1999) 3.08
hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells. Mol Cell Biol (1999) 3.06
Association of nuclear matrix antigens with exon-containing splicing complexes. J Cell Biol (1994) 3.01
The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo. Proc Natl Acad Sci U S A (1994) 2.92
Functional domains of the human splicing factor ASF/SF2. EMBO J (1993) 2.83
SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. J Cell Biol (1998) 2.69
The splicing factors 9G8 and SRp20 transactivate splicing through different and specific enhancers. RNA (1999) 2.66
Sequences homologous to 5' splice sites are required for the inhibitory activity of papillomavirus late 3' untranslated regions. Mol Cell Biol (1994) 2.49
A combinatorial code for splicing silencing: UAGG and GGGG motifs. PLoS Biol (2005) 2.48
The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation. EMBO J (1997) 2.43
Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2. EMBO J (1998) 2.37
Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer. Proc Natl Acad Sci U S A (1997) 2.34
Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors. Proc Natl Acad Sci U S A (1994) 2.34
Transportin-SR, a nuclear import receptor for SR proteins. J Cell Biol (1999) 2.31
The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes. J Cell Biol (2000) 2.26
The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences. EMBO J (1995) 2.25
Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family. EMBO J (1994) 2.23
Selection of alternative 5' splice sites: role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1. Mol Cell Biol (2000) 2.22
The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites. Proc Natl Acad Sci U S A (1994) 2.14
Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors. J Cell Biol (1994) 2.12
An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein. Mol Cell Biol (2000) 2.08
Human SR proteins and isolation of a cDNA encoding SRp75. Mol Cell Biol (1993) 2.04
Global analysis of positive and negative pre-mRNA splicing regulators in Drosophila. Genes Dev (2005) 2.03
The SR protein B52/SRp55 is essential for Drosophila development. Mol Cell Biol (1994) 2.02
A 32-nucleotide exon-splicing enhancer regulates usage of competing 5' splice sites in a differential internal exon. Mol Cell Biol (1995) 1.92
Functional properties of p54, a novel SR protein active in constitutive and alternative splicing. Mol Cell Biol (1996) 1.90
Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins. Genes Dev (2002) 1.89
Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J (2004) 1.88
Genetic analysis of the SR protein ASF/SF2: interchangeability of RS domains and negative control of splicing. Genes Dev (1998) 1.85
Control of calcitonin/calcitonin gene-related peptide pre-mRNA processing by constitutive intron and exon elements. Mol Cell Biol (1993) 1.76
Tracking COL1A1 RNA in osteogenesis imperfecta. splice-defective transcripts initiate transport from the gene but are retained within the SC35 domain. J Cell Biol (2000) 1.74
RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins. Proc Natl Acad Sci U S A (1997) 1.72
The hnRNP A1 protein regulates HIV-1 tat splicing via a novel intron silencer element. EMBO J (2001) 1.70
An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing. Mol Cell Biol (1998) 1.64
Hepatitis C virus core protein interacts with cellular putative RNA helicase. J Virol (1999) 1.63
The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation. EMBO J (1999) 1.63
The SRm160/300 splicing coactivator is required for exon-enhancer function. Proc Natl Acad Sci U S A (1999) 1.62
The concentration of B52, an essential splicing factor and regulator of splice site choice in vitro, is critical for Drosophila development. Mol Cell Biol (1994) 1.62
Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. Nucleic Acids Res (1993) 1.57
Human papillomavirus type 31b late gene expression is regulated through protein kinase C-mediated changes in RNA processing. J Virol (1995) 1.57
Cellular protein modulates effects of human immunodeficiency virus type 1 Rev. J Virol (1994) 1.56
A splicing-independent function of SF2/ASF in microRNA processing. Mol Cell (2010) 1.55
Identification of a bidirectional splicing enhancer: differential involvement of SR proteins in 5' or 3' splice site activation. Mol Cell Biol (1999) 1.52
SR protein splicing factors interact with the Rous sarcoma virus negative regulator of splicing element. J Virol (1996) 1.49
Enhancer-dependent interaction between 5' and 3' splice sites in trans. Proc Natl Acad Sci U S A (1995) 1.46
The SRm160/300 splicing coactivator subunits. RNA (2000) 1.43
Identification of a plant serine-arginine-rich protein similar to the mammalian splicing factor SF2/ASF. Proc Natl Acad Sci U S A (1995) 1.43
Genetic enhancement of RNA-processing defects by a dominant mutation in B52, the Drosophila gene for an SR protein splicing factor. Mol Cell Biol (1995) 1.41
Characterization of a novel arginine/serine-rich splicing factor in Arabidopsis. Plant Cell (1996) 1.33
Interactions among SR proteins, an exonic splicing enhancer, and a lentivirus Rev protein regulate alternative splicing. Mol Cell Biol (1996) 1.29
Altered levels of the Drosophila HRB87F/hrp36 hnRNP protein have limited effects on alternative splicing in vivo. Mol Biol Cell (1996) 1.26
Pre-mRNA splicing in plants: characterization of Ser/Arg splicing factors. Proc Natl Acad Sci U S A (1996) 1.26
The choice of alternative 5' splice sites in influenza virus M1 mRNA is regulated by the viral polymerase complex. Proc Natl Acad Sci U S A (1995) 1.23
Regulated expression and RNA processing of transcripts from the Srp20 splicing factor gene during the cell cycle. Mol Cell Biol (1997) 1.22
Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1. Mol Cell Biol (2003) 1.19
Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch. EMBO J (2002) 1.19
Distinct functions of the closely related tandem RNA-recognition motifs of hnRNP A1. RNA (1998) 1.18
Functional conservation of the transportin nuclear import pathway in divergent organisms. Mol Cell Biol (1998) 1.16
In vitro generation of a circular exon from a linear pre-mRNA transcript. Nucleic Acids Res (1996) 1.10
FF domains of CA150 bind transcription and splicing factors through multiple weak interactions. Mol Cell Biol (2004) 1.09
Biased exon/intron distribution of cryptic and de novo 3' splice sites. Nucleic Acids Res (2005) 1.08
Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene. Nucleic Acids Res (1997) 1.08
Exon skipping by overexpression of a Drosophila heterogeneous nuclear ribonucleoprotein in vivo. Proc Natl Acad Sci U S A (1995) 1.05
Exonic splicing enhancers contribute to the use of both 3' and 5' splice site usage of rat beta-tropomyosin pre-mRNA. RNA (1999) 1.04
Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. Mol Cell Biol (2000) 1.04
Exonization of AluYa5 in the human ACE gene requires mutations in both 3' and 5' splice sites and is facilitated by a conserved splicing enhancer. Nucleic Acids Res (2005) 1.02
Phosphorylated Ser/Arg-rich proteins: limiting factors in the assembly of 200S large nuclear ribonucleoprotein particles. Proc Natl Acad Sci U S A (1996) 1.02
Several mRNAs with variable 3' untranslated regions and different stability encode the human PR264/SC35 splicing factor. Proc Natl Acad Sci U S A (1994) 1.02
Characterization of SRp46, a novel human SR splicing factor encoded by a PR264/SC35 retropseudogene. Mol Cell Biol (1998) 1.01
Specific combinations of SR proteins associate with single pre-messenger RNAs in vivo and contribute different functions. J Cell Biol (2009) 1.01
Association of the mammalian helicase MAH with the pre-mRNA splicing complex. Proc Natl Acad Sci U S A (1997) 0.99
Caffeine regulates alternative splicing in a subset of cancer-associated genes: a role for SC35. Mol Cell Biol (2007) 0.99
Association of phosphorylated serine/arginine (SR) splicing factors with the U1-small ribonucleoprotein (snRNP) autoantigen complex accompanies apoptotic cell death. J Exp Med (1998) 0.95
SR proteins control a complex network of RNA-processing events. RNA (2014) 0.93
Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1. Nucleic Acids Res (2002) 0.93
SR proteins are required for nematode trans-splicing in vitro. RNA (1999) 0.92
Distribution of B52 within a chromosomal locus depends on the level of transcription. Mol Biol Cell (1994) 0.92
Inverse splicing of a discontinuous pre-mRNA intron generates a circular exon in a HeLa cell nuclear extract. Nucleic Acids Res (1996) 0.89
The intronic splicing code: multiple factors involved in ATM pseudoexon definition. EMBO J (2010) 0.89
Deep intron elements mediate nested splicing events at consecutive AG dinucleotides to regulate alternative 3' splice site choice in vertebrate 4.1 genes. Mol Cell Biol (2012) 0.87
Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function. Biochem J (2015) 0.85
PSKH1, a novel splice factor compartment-associated serine kinase. Nucleic Acids Res (2002) 0.84
SR proteins and galectins: what's in a name? Glycobiology (2010) 0.83
Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell (1984) 12.30
RNA recognition: towards identifying determinants of specificity. Trends Biochem Sci (1991) 9.03
Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature (1990) 8.79
RNA-binding proteins as developmental regulators. Genes Dev (1989) 8.78
SR proteins: a conserved family of pre-mRNA splicing factors. Genes Dev (1992) 8.60
Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell (1992) 7.90
Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell (1985) 6.85
Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators. Cell (1991) 6.50
A role for exon sequences and splice-site proximity in splice-site selection. Cell (1986) 6.41
A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro. Cell (1990) 5.92
Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators. Cell (1991) 5.72
The essential pre-mRNA splicing factor SF2 influences 5' splice site selection by activating proximal sites. Cell (1990) 5.67
Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells. Genes Dev (1990) 5.36
A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription. J Cell Biol (1991) 4.80
RNA binding specificity of hnRNP proteins: a subset bind to the 3' end of introns. EMBO J (1988) 4.26
Isolation of a complementary DNA that encodes the mammalian splicing factor SC35. Science (1992) 3.52
A monoclonal antibody that recognizes a phosphorylated epitope stains lampbrush chromosome loops and small granules in the amphibian germinal vesicle. J Cell Biol (1990) 3.15
The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3' splice site. Proc Natl Acad Sci U S A (1992) 3.04
Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing. Proc Natl Acad Sci U S A (1992) 2.66
A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon. Proc Natl Acad Sci U S A (1992) 2.05
A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs. Nucleic Acids Res (1991) 1.86
Crosslinking of hnRNP proteins to pre-mRNA requires U1 and U2 snRNPs. Nucleic Acids Res (1990) 1.68
Ribonucleoproteins package 700 nucleotides of pre-mRNA into a repeating array of regular particles. Mol Cell Biol (1988) 1.53
A novel protein factor is required for use of distal alternative 5' splice sites in vitro. Mol Cell Biol (1991) 1.43
Multiple activities of the human splicing factor ASF. Gene Expr (1992) 1.27
RNA processing. Curr Opin Cell Biol (1992) 1.11
Beta-globin transcripts carrying a single intron with three adjacent nucleotides of 5' exon are efficiently spliced in vitro irrespective of intron position or surrounding exon sequences. Nucleic Acids Res (1990) 1.04
Will the real splicing sites please light up? Curr Biol (1992) 1.02
Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing. Mol Cell Biol (1989) 0.94
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res (1984) 86.56
Nucleotide sequence of the rightward operator of phage lambda. Proc Natl Acad Sci U S A (1975) 56.75
The isolation of structural genes from libraries of eucaryotic DNA. Cell (1978) 37.13
The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA. Cell (1978) 22.88
Chain length determination of small double- and single-stranded DNA molecules by polyacrylamide gel electrophoresis. Biochemistry (1975) 22.00
The structure and evolution of the human beta-globin gene family. Cell (1980) 21.24
Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell (1979) 21.15
Identification of two distinct regulatory regions adjacent to the human beta-interferon gene. Cell (1983) 17.60
Regulation of inducible and tissue-specific gene expression. Science (1987) 15.04
Amplification and characterization of a beta-globin gene synthesized in vitro. Cell (1976) 14.99
Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell (1984) 12.30
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell (1994) 11.62
The primary structure of rabbit beta-globin mRNA as determined from cloned DNA. Cell (1977) 11.05
Detection and localization of single base changes by denaturing gradient gel electrophoresis. Methods Enzymol (1987) 10.90
Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system. Cell (1981) 9.81
Human beta-globin pre-mRNA synthesized in vitro is accurately spliced in Xenopus oocyte nuclei. Cell (1983) 9.77
Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro. Cell (1984) 9.13
The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions. Cell (1980) 9.13
Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature (1990) 8.79
Transcriptional activation: a complex puzzle with few easy pieces. Cell (1994) 8.63
The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing. Nature (1987) 8.28
The nucleotide sequence of the human beta-globin gene. Cell (1980) 8.11
Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell (1993) 8.07
Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell (1992) 7.90
Molecular cloning and characterization of the human beta-like globin gene cluster. Cell (1980) 7.77
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes Dev (1995) 7.36
NF-kappa B: a lesson in family values. Cell (1995) 7.33
Transcriptional activation of cloned human beta-globin genes by viral immediate-early gene products. Cell (1983) 7.22
Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell (1995) 7.17
Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science (1994) 7.09
Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol Cell (1998) 7.01
Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell (1985) 6.85
Structure of the lambda operators. Nature (1973) 6.66
Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis. Nucleic Acids Res (1985) 6.52
Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators. Cell (1991) 6.50
Specific transcription and RNA splicing defects in five cloned beta-thalassaemia genes. Nature (1983) 6.48
A role for exon sequences and splice-site proximity in splice-site selection. Cell (1986) 6.41
Fine structure genetic analysis of a beta-globin promoter. Science (1986) 6.36
Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA duplexes. Science (1985) 6.35
Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter. Cell (2000) 6.32
Sequence of a repressor-binding site in the DNA of bacteriophage lamda. Nature (1974) 6.22
Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Res (1993) 6.15
Detection of single base substitutions in total genomic DNA. Nature (1985) 5.99
Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. Cell (1996) 5.91
The high mobility group protein HMG I(Y) is required for NF-kappa B-dependent virus induction of the human IFN-beta gene. Cell (1992) 5.85
Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes Dev (1998) 5.79
The human beta-interferon gene enhancer is under negative control. Cell (1986) 5.61
Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J (1995) 5.59
The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Cell (1989) 5.50
Enzymatic in vitro synthesis of globin genes. Cell (1976) 5.31
Intron sequences involved in lariat formation during pre-mRNA splicing. Cell (1985) 5.30
Multiple repressor binding at the operators in bacteriophage lambda. Proc Natl Acad Sci U S A (1973) 5.15
Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell (1984) 5.12
A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes. Nat Genet (2001) 5.02
AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes. Mol Cell Biol (1999) 4.87
A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell (1993) 4.82
NF-kappaB signaling pathways in mammalian and insect innate immunity. Genes Dev (2001) 4.70
Bovine papillomavirus vector that propagates as a plasmid in both mouse and bacterial cells. Proc Natl Acad Sci U S A (1982) 4.69
Human beta-interferon gene expression is regulated by an inducible enhancer element. Cell (1985) 4.68
The molecular genetics of human hemoglobins. Annu Rev Genet (1980) 4.67
Structure and in vitro transcription of human globin genes. Science (1980) 4.65
Pre-mRNA splicing in the new millennium. Curr Opin Cell Biol (2001) 4.64
cis and trans activation of globin gene transcription in transient assays. Proc Natl Acad Sci U S A (1983) 4.41
General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes Dev (1993) 4.40
Associations between distinct pre-mRNA splicing components and the cell nucleus. EMBO J (1991) 4.38
Activation of the human beta-interferon gene requires an interferon-inducible factor. Mol Cell Biol (1986) 4.38
Recognition sequences of repressor and polymerase in the operators of bacteriophage lambda. Cell (1975) 4.28
A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell (1999) 4.25
Tuberculosis as a manifestation of the acquired immunodeficiency syndrome (AIDS). JAMA (1986) 4.25
Control elements in the DNA of bacteriophage lambda. Cold Spring Harb Symp Quant Biol (1974) 4.23
A single-base change at a splice site in a beta 0-thalassemic gene causes abnormal RNA splicing. Cell (1982) 4.22
A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. Genes Dev (1998) 4.19
Characterisation of deletions which affect the expression of fetal globin genes in man. Nature (1979) 4.18
Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. Proc Natl Acad Sci U S A (1995) 4.16
The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication. Cell (1980) 4.15
The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene. Cell (1982) 4.13
Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. RNA (1998) 4.05
Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell (1993) 4.01
Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. J Cell Biol (1997) 3.95
A general method for saturation mutagenesis of cloned DNA fragments. Science (1985) 3.94
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. Cell (1997) 3.91
Full length and discrete partial reverse transcripts of globin and chorion mRNAs. Cell (1975) 3.83
Correct developmental expression of a cloned alcohol dehydrogenase gene transduced into the Drosophila germ line. Cell (1983) 3.83
GAL4 activates transcription in Drosophila. Nature (1988) 3.73
The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. Genes Dev (1996) 3.63
Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. EMBO J (1995) 3.56
Overlapping positive and negative regulatory domains of the human beta-interferon gene. Proc Natl Acad Sci U S A (1988) 3.54
Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. Proc Natl Acad Sci U S A (1979) 3.53
Isolation of a complementary DNA that encodes the mammalian splicing factor SC35. Science (1992) 3.52
Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains. EMBO J (1993) 3.51
Selection and characterization of pre-mRNA splicing enhancers: identification of novel SR protein-specific enhancer sequences. Mol Cell Biol (1999) 3.36
Detection of factors that interact with the human beta-interferon regulatory region in vivo by DNAase I footprinting. Cell (1986) 3.35
Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. EMBO J (1994) 3.35
The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. J Cell Biol (2000) 3.34