PubRank

S Narumiya

Author PubWeight™ 357.80‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 1997 14.91
2 Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol 2001 9.73
3 Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 1999 7.12
4 Cooperation between mDia1 and ROCK in Rho-induced actin reorganization. Nat Cell Biol 1999 5.84
5 Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature 1989 5.21
6 International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 1994 5.11
7 The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J 1996 5.09
8 p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J 1997 5.03
9 Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol 2000 4.80
10 p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett 1997 4.31
11 An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat Med 1999 3.76
12 Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J Cell Biol 1994 3.65
13 Role of citron kinase as a target of the small GTPase Rho in cytokinesis. Nature 1998 3.55
14 Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase. J Biol Chem 1989 3.47
15 ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett 1996 3.46
16 Prostaglandin D2 as a mediator of allergic asthma. Science 2000 3.19
17 Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature 1997 3.07
18 Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science 1996 2.99
19 Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem 2000 2.99
20 Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice. Nat Med 2001 2.98
21 Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. J Biol Chem 1996 2.92
22 Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. Nature 1993 2.91
23 Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature 1998 2.88
24 Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J Cell Biol 1998 2.81
25 A rho-like protein is involved in the organisation of the contractile ring in dividing sand dollar eggs. Zygote 1993 2.71
26 A novel partner for the GTP-bound forms of rho and rac. FEBS Lett 1995 2.52
27 Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas. Br J Cancer 1998 2.48
28 Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol 1997 2.44
29 Transformation mediated by RhoA requires activity of ROCK kinases. Curr Biol 1999 2.39
30 Failure of parturition in mice lacking the prostaglandin F receptor. Science 1997 2.27
31 Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1. Nat Cell Biol 2001 2.27
32 Cloning and expression of cDNA for a human thromboxane A2 receptor. Nature 1991 2.26
33 Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho. J Cell Biol 1993 2.26
34 ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. J Biol Chem 1993 2.20
35 Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2). Proc Natl Acad Sci U S A 1999 2.15
36 Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor. Nature 1995 2.09
37 Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo. Nat Genet 1996 2.09
38 Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow. Oncogene 2000 2.08
39 The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology 2000 2.08
40 Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice. Biochem Biophys Res Commun 1998 2.04
41 Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation. J Biol Chem 2000 2.04
42 Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility. Invest Ophthalmol Vis Sci 2001 1.88
43 Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation. Mol Biol Cell 2001 1.88
44 Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia. Gastroenterology 2001 1.79
45 A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons. Neuron 2000 1.76
46 Cloning and expression of a cDNA for mouse prostaglandin E receptor EP3 subtype. J Biol Chem 1992 1.75
47 Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor. J Biol Chem 1993 1.72
48 A rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation. J Biol Chem 1992 1.67
49 Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis. Cancer Res 1999 1.65
50 Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype. J Biol Chem 1993 1.61
51 Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists. Biochem Pharmacol 2001 1.56
52 Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase. J Biol Chem 1996 1.55
53 ADP-ribosylation of the rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle. Oncogene 1993 1.55
54 cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla. J Biol Chem 1994 1.53
55 Multiple receptors for modified low density lipoproteins in mouse peritoneal macrophages: different uptake mechanisms for acetylated and oxidized low density lipoproteins. Biochem Biophys Res Commun 1989 1.52
56 Roles of prostaglandin I(2) and thromboxane A(2) in cardiac ischemia-reperfusion injury: a study using mice lacking their respective receptors. Circulation 2001 1.51
57 Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice. J Biol Chem 2000 1.51
58 Rho-dependent transfer of Citron-kinase to the cleavage furrow of dividing cells. J Cell Sci 2001 1.50
59 p160ROCK mediates RhoA activation of Na-H exchange. EMBO J 1998 1.45
60 Sevoflurane inhibits human platelet aggregation and thromboxane A2 formation, possibly by suppression of cyclooxygenase activity. Anesthesiology 1996 1.45
61 Prostaglandin D2 in rat brain, spinal cord and pituitary: basal level and regional distribution. Life Sci 1982 1.44
62 International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol Rev 2011 1.43
63 LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505. Biochem J 2001 1.40
64 Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development. Gut 2004 1.39
65 ADP-ribosylation of the rho/rac proteins induces growth inhibition, neurite outgrowth and acetylcholine esterase in cultured PC-12 cells. Biochem Biophys Res Commun 1990 1.38
66 Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells. J Biol Chem 1997 1.38
67 Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide. Proc Natl Acad Sci U S A 1982 1.37
68 Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins. J Biol Chem 1993 1.37
69 Different responsiveness of prostaglandin D2-sensitive systems to prostaglandin D2 and its analogues. Br J Pharmacol 1985 1.36
70 PGE(2) -EP(2) signalling in endothelium is activated by haemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κB. Br J Pharmacol 2011 1.34
71 Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase. Eur J Biochem 1993 1.33
72 Localization of a mammalian homolog of diaphanous, mDia1, to the mitotic spindle in HeLa cells. J Cell Sci 2001 1.33
73 In situ hybridization studies of prostacyclin receptor mRNA expression in various mouse organs. Br J Pharmacol 1995 1.33
74 Lysophosphatidic acid induces tyrosine phosphorylation and activation of MAP-kinase and focal adhesion kinase in cultured Swiss 3T3 cells. FEBS Lett 1993 1.31
75 Distribution and function of prostanoid receptors: studies from knockout mice. Prog Lipid Res 2000 1.31
76 Activation of the osmo-sensitive chloride conductance involves P21rho and is accompanied by a transient reorganization of the F-actin cytoskeleton. Mol Biol Cell 1996 1.30
77 Cell motility mediated by rho and Rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma. Hepatology 1999 1.27
78 Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. Proc Natl Acad Sci U S A 1994 1.27
79 Binding of a radioiodinated 13-azapinane thromboxane antagonist to platelets: correlation with antiaggregatory activity in different species. Br J Pharmacol 1986 1.25
80 Arachidonic acid 15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes. Partial purification and properties. J Biol Chem 1981 1.25
81 Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb Vasc Biol 2000 1.24
82 Adhesion of immature thymocytes to thymic stromal cells through fibronectin molecules and its significance for the induction of thymocyte differentiation. Proc Natl Acad Sci U S A 1991 1.24
83 Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder. J Clin Invest 1994 1.23
84 Occurrence of 9-deoxy-delta 9,delta 12-13,14-dihydroprostaglandin D2 in human urine. J Biol Chem 1988 1.23
85 Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules. J Biol Chem 1998 1.21
86 Clostridium botulinum C3 ADP-ribosyltransferase gene. Cloning, sequencing, and expression of a functional protein in Escherichia coli. J Biol Chem 1991 1.20
87 Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. J Cell Sci 2000 1.19
88 Distribution of the messenger RNA for the prostaglandin E receptor subtype EP3 in the mouse nervous system. Neuroscience 1994 1.19
89 Two isoforms of prostaglandin E receptor EP3 subtype. Different COOH-terminal domains determine sensitivity to agonist-induced desensitization. J Biol Chem 1993 1.19
90 Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125FAK and paxillin induced by bombesin and endothelin. FEBS Lett 1994 1.17
91 The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and northern blot analysis. FEBS Lett 1995 1.16
92 Prostacyclin receptor-dependent modulation of pulmonary vascular remodeling. Am J Respir Crit Care Med 2001 1.16
93 Cloning and expression of a cDNA for mouse prostaglandin F receptor. J Biol Chem 1994 1.15
94 Inhibition of Rho is required for cAMP-induced melanoma cell differentiation. Mol Biol Cell 1998 1.15
95 Cellular localization of mRNAs for prostaglandin E receptor subtypes in mouse gastrointestinal tract. Am J Physiol 1997 1.14
96 Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. Proc Natl Acad Sci U S A 2001 1.14
97 Prostaglandin D2: a biochemical perspective. Prostaglandins Leukot Essent Fatty Acids 1989 1.14
98 Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. J Clin Invest 1996 1.13
99 Citron, a Rho target that affects contractility during cytokinesis. Microsc Res Tech 2000 1.13
100 Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. J Biol Chem 2001 1.13
101 Prostaglandin E2 protects cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity. Brain Res 1994 1.12
102 Site and mechanism of growth inhibition by prostaglandins. III. Distribution and binding of prostaglandin A2 and delta 12-prostaglandin J2 in nuclei. J Pharmacol Exp Ther 1987 1.12
103 Regional distribution of prostaglandins D2, E2, and F2 alpha and related enzymes in postmortem human brain. J Neurochem 1984 1.12
104 Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice. Br J Pharmacol 2001 1.11
105 Site and mechanism of growth inhibition by prostaglandins. II. Temperature-dependent transfer of a cyclopentenone prostaglandin to nuclei. J Pharmacol Exp Ther 1986 1.11
106 Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis. Biochem Biophys Res Commun 1992 1.11
107 The small GTP-binding protein, rho p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts. J Cell Sci 1995 1.10
108 Involvement of rho p21 in cyclic strain-induced tyrosine phosphorylation of focal adhesion kinase (pp125FAK), morphological changes and migration of endothelial cells. Biochem Biophys Res Commun 1996 1.10
109 Activation of extracellular signal-regulated kinases and CREB/ATF-1 mediate the expression of CCAAT/enhancer binding proteins beta and -delta in preadipocytes. Mol Endocrinol 2001 1.10
110 9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma. Proc Natl Acad Sci U S A 1984 1.10
111 Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions. Mol Pharmacol 1995 1.09
112 Stimulated arachidonate metabolism during foam cell transformation of mouse peritoneal macrophages with oxidized low density lipoprotein. J Clin Invest 1988 1.09
113 Characterization of the interaction between RhoA and the amino-terminal region of PKN. FEBS Lett 1996 1.09
114 Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus. J Neurosci 1999 1.08
115 ADP-ribosylation of a Mr 21,000 membrane protein by type D botulinum toxin. J Biol Chem 1987 1.08
116 Characterization and chromosomal mapping of the human thromboxane A2 receptor gene. J Biol Chem 1993 1.07
117 Thromboxane A2 receptor is highly expressed in mouse immature thymocytes and mediates DNA fragmentation and apoptosis. J Exp Med 1993 1.07
118 Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells. J Neurosci 1999 1.06
119 Agonist-induced regulation of myosin phosphatase activity in human platelets through activation of Rho-kinase. Blood 1999 1.05
120 Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney. Am J Physiol 1994 1.04
121 Effect of ultraviolet irradiation on mast cell-deficient W/Wv mice. J Invest Dermatol 1985 1.04
122 Molecular evolution of receptors for eicosanoids. FEBS Lett 1995 1.04
123 Guanosine 5'-3-O-(thio)triphosphate stimulates tyrosine phosphorylation of p125FAK and paxillin in permeabilized Swiss 3T3 cells. Role of p21rho. J Biol Chem 1995 1.04
124 Identification of prostaglandin E receptor 'EP2' cloned from mastocytoma cells EP4 subtype. FEBS Lett 1995 1.04
125 Integrin-dependent translocation of p160ROCK to cytoskeletal complex in thrombin-stimulated human platelets. Biochem J 1997 1.04
126 Preparation of native and recombinant Clostridium botulinum C3 ADP-ribosyltransferase and identification of Rho proteins by ADP-ribosylation. Methods Enzymol 1995 1.04
127 Characterization of prostanoid receptors mediating contraction of the gastric fundus and ileum: studies using mice deficient in prostanoid receptors. Br J Pharmacol 2000 1.04
128 Distribution of prostaglandin E receptors in the rat gastrointestinal tract. Prostaglandins 1997 1.03
129 Protection from anti-TCR/CD3-induced apoptosis in immature thymocytes by a signal through thymic shared antigen-1/stem cell antigen-2. J Exp Med 1996 1.03
130 Molecular biology of prostanoid receptors; an overview. J Lipid Mediat Cell Signal 1995 1.03
131 Purification and properties of the cytosolic substrate for botulinum ADP-ribosyltransferase. Identification as an Mr 22,000 guanine nucleotide-binding protein. J Biol Chem 1988 1.02
132 Purification of the thromboxane A2/prostaglandin H2 receptor from human blood platelets. J Biol Chem 1989 1.01
133 Crucial involvement of the EP4 subtype of prostaglandin E receptor in osteoclast formation by proinflammatory cytokines and lipopolysaccharide. J Bone Miner Res 2000 0.99
134 Impaired bone resorption by lipopolysaccharide in vivo in mice deficient in the prostaglandin E receptor EP4 subtype. Infect Immun 2000 0.99
135 Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxillin and p130Cas mediated by Ret kinase. Oncogene 1999 0.99
136 Site and mechanism of growth inhibition by prostaglandins. I. Active transport and intracellular accumulation of cyclopentenone prostaglandins, a reaction leading to growth inhibition. J Pharmacol Exp Ther 1986 0.98
137 Purification of GTPase-activating protein specific for the rho gene products. J Biol Chem 1991 0.98
138 Synergistic activation of rat brain phospholipase D by ADP-ribosylation factor and rhoA p21, and its inhibition by Clostridium botulinum C3 exoenzyme. J Biol Chem 1995 0.97
139 Induction of 68,000-dalton heat shock proteins by cyclopentenone prostaglandins. Its association with prostaglandin-induced G1 block in cell cycle progression. J Biol Chem 1988 0.97
140 Diabetes enhances lectin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: possible role of LOX-1 ligand and AGE. Biochem Biophys Res Commun 2001 0.97
141 Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). Genomics 1997 0.97
142 Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein. Mol Cell Biol 1998 0.96
143 Characterization of the biosynthetic pathway of prostaglandin D2 in human platelet-rich plasma. J Biol Chem 1982 0.96
144 Impaired duodenal bicarbonate secretion and mucosal integrity in mice lacking prostaglandin E-receptor subtype EP(3). Gastroenterology 1999 0.96
145 Inhibitory effect of a prostaglandin E receptor subtype EP(1) selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice. Cancer Lett 2000 0.95
146 Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding. Biochem J 2001 0.95
147 Increased bleeding tendency and decreased susceptibility to thromboembolism in mice lacking the prostaglandin E receptor subtype EP(3). Circulation 2001 0.95
148 Rho and Rho-associated kinase modulate the tyrosine kinase PYK2 in T-cells through regulation of the activity of the integrin LFA-1. J Biol Chem 2001 0.95
149 Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system. Circulation 1994 0.94
150 Rhophilin, a small GTPase Rho-binding protein, is abundantly expressed in the mouse testis and localized in the principal piece of the sperm tail. FEBS Lett 1999 0.94
151 Prostanoid and leukotriene receptors: a progress report from the IUPHAR working parties on classification and nomenclature. Adv Prostaglandin Thromboxane Leukot Res 1995 0.94
152 Requirements of basic amino acid residues within the lectin-like domain of LOX-1 for the binding of oxidized low-density lipoprotein. FEBS Lett 2001 0.94
153 Prostaglandin E receptor subtypes in mouse osteoblastic cell line. Endocrinology 1996 0.94
154 A rho gene product in human blood platelets. I. Identification of the platelet substrate for botulinum C3 ADP-ribosyltransferase as rhoA protein. J Biol Chem 1992 0.93
155 Cholesteryl ester accumulation in macrophages incubated with low density lipoprotein pretreated with cigarette smoke extract. Proc Natl Acad Sci U S A 1988 0.93
156 Activation-dependent surface expression of LOX-1 in human platelets. Biochem Biophys Res Commun 2001 0.93
157 Cloning and expression of a cDNA for the human prostacyclin receptor. FEBS Lett 1994 0.93
158 Expression of messenger RNA for the prostaglandin D receptor in the leptomeninges of the mouse brain. FEBS Lett 1997 0.93
159 Intrinsic prostacyclin contributes to exudation induced by bradykinin or carrageenin: a study on the paw edema induced in IP-receptor-deficient mice. Life Sci 2000 0.93
160 Stimulation of cholesteryl ester synthesis in mouse peritoneal macrophages by cholesterol-rich very low density lipoproteins from the Watanabe heritable hyperlipidemic rabbit, an animal model of familial hypercholesterolemia. J Clin Invest 1986 0.92
161 Do structural changes of T cell receptor complex occur in tumor-bearing state? Jpn J Cancer Res 1995 0.92
162 9-deoxy-delta 9-prostaglandin D2, a prostaglandin D2 derivative with potent antineoplastic and weak smooth muscle-contracting activities. Biochem Biophys Res Commun 1982 0.92
163 Activation-induced expression of thymic shared antigen-1 on T lymphocytes and its inhibitory role for TCR-mediated IL-2 production. Int Immunol 1994 0.92
164 Adaptive cytoprotection mediated by prostaglandin I(2) is attributable to sensitization of CRGP-containing sensory nerves. Gastroenterology 2001 0.91
165 Galpha11 induces caspase-mediated proteolytic activation of Rho-associated kinase, ROCK-I, in HeLa cells. J Biol Chem 2001 0.91
166 NAD+ binding site of Clostridium botulinum C3 ADP-ribosyltransferase. Identification of peptide in the adenine ring binding domain using 2-azido NAD. J Biol Chem 1992 0.89
167 Functional reconstitution of platelet thromboxane A2 receptors with Gq and Gi2 in phospholipid vesicles. Mol Pharmacol 1994 0.89
168 Prostaglandin A and J: antitumor and antiviral prostaglandins. Adv Prostaglandin Thromboxane Leukot Res 1989 0.89
169 Crystalline hemoprotein from Pseudomonas that catalyzes oxidation of side chain of tryptophan and other indole derivatives. J Biol Chem 1977 0.88
170 Multiple signal transduction pathways through two prostaglandin E receptor EP3 subtype isoforms expressed in human uterus. J Clin Endocrinol Metab 2000 0.88
171 Metabolic dehydration of prostaglandin E2 and cellular uptake of the dehydration product: correlation with prostaglandin E2-induced growth inhibition. Biochem Biophys Res Commun 1986 0.88
172 Activation of interleukin-2 receptor gene by forskolin and cyclic AMP analogues. Biochem Biophys Res Commun 1987 0.88
173 Roles of prostanoids revealed from studies using mice lacking specific prostanoid receptors. Jpn J Pharmacol 2000 0.87
174 rho GAP of 28 kDa (GAP2), but not of 190 kDa (p190), requires Asp65 and Asp67 of rho GTPase for its activation. J Biol Chem 1993 0.87
175 Signal transductions of three isoforms of mouse prostaglandin E receptor EP3 subtype. Adv Prostaglandin Thromboxane Leukot Res 1995 0.87
176 Prostate-specific amplification of expanded polyglutamine expression: a novel approach for cancer gene therapy. Cancer Res 1998 0.86
177 Neuroprotective properties of prostaglandin I2 IP receptor in focal cerebral ischemia. Neuroscience 2010 0.86
178 Ear swelling in response to UVB irradiation. Arch Dermatol Res 1986 0.86
179 Alteration of a single amino acid residue in retinoic acid receptor causes dominant-negative phenotype. J Biol Chem 1994 0.86
180 Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression. J Biol Chem 1998 0.86
181 Hemorrhagic thrombocytopathy with platelet thromboxane A2 receptor abnormality: defective signal transduction with normal binding activity. Thromb Haemost 1987 0.86
182 Prostaglandin D2, a potential antineoplastic agent. Biochem Biophys Res Commun 1982 0.86
183 Prostaglandin D2 and prostaglandin D synthetase in mast cell deficient mice. Prostaglandins 1984 0.86
184 Roles of insulin, guanosine 5'-[gamma-thio]triphosphate and phorbol 12-myristate 13-acetate in signalling pathways of GLUT4 translocation. Biochem J 1996 0.86
185 Retardation of skeletal development and cervical abnormalities in transgenic mice expressing a dominant-negative retinoic acid receptor in chondrogenic cells. Proc Natl Acad Sci U S A 1998 0.86
186 Site and mechanism of growth inhibition by prostaglandins. IV. Effect of cyclopentenone prostaglandins on cell cycle progression of G1-enriched HeLa S3 cells. J Pharmacol Exp Ther 1988 0.85
187 delta 12-Prostaglandin J2, an ultimate metabolite of prostaglandin D2 exerting cell growth inhibition. Biochem Biophys Res Commun 1985 0.85
188 Structural organization and chromosomal assignment of the human prostacyclin receptor gene. Genomics 1995 0.85
189 Expression of prostacyclin receptor in human megakaryocytes. Blood 1997 0.85
190 Prostaglandin E receptor subtypes involved in stimulation of gastroduodenal bicarbonate secretion in rats and mice. J Physiol Pharmacol 1999 0.85
191 Prostacyclin receptor deletion aggravates hippocampal neuronal loss after bilateral common carotid artery occlusion in mouse. Neuroscience 2008 0.84
192 Cloning and expression of a cDNA for rat prostacyclin receptor. Biochim Biophys Acta 1994 0.84
193 NADP-linked 15-hydroxyprostaglandin dehydrogenase for prostaglandin D in human blood platelets. Arch Biochem Biophys 1982 0.84
194 Prostaglandin E(2) (PGE(2)) induces the c-fos and c-jun expressions via the EP(1) subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells. Calcif Tissue Int 2000 0.84
195 Gq-coupled receptors transmit the signal for GLUT4 translocation via an insulin-independent pathway. J Biol Chem 1996 0.84
196 Molecular cloning and expression of rat prostaglandin E receptor EP2 subtype. Biochem Biophys Res Commun 1994 0.84
197 Expression of thromboxane A2 receptor in cultured human erythroleukemia cells and its induction by 12-O-tetradecanoylphorbol-13-acetate. Biochem Biophys Res Commun 1989 0.84
198 Lysophosphatidic acid-induced activation of protein Ser/Thr kinases in cultured rat 3Y1 fibroblasts. Possible involvement in rho p21-mediated signalling. FEBS Lett 1995 0.84
199 The regional distribution and cellular localization of mRNA encoding rat prostacyclin synthase. Eur J Cell Biol 1997 0.84
200 Functional interaction of prostaglandin E receptor EP3 subtype with guanine nucleotide-binding proteins, showing low-affinity ligand binding. Biochim Biophys Acta 1993 0.83
201 Prevention of atherosclerotic progression in Watanabe rabbits by probucol. Am J Cardiol 1988 0.83
202 Cloning, functional expression and tissue distribution of rabbit alpha 1d-adrenoceptor. Biochim Biophys Acta 1997 0.83
203 Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester. J Mol Med (Berl) 1996 0.83
204 Copresence of prostaglandin EP2 and EP3 receptors on gastric enterochromaffin-like cell carcinoid in African rodents. Gastroenterology 1995 0.83
205 Prostaglandin E2 (PGE2) autoamplifies its production through EP1 subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells. Calcif Tissue Int 1998 0.83
206 A CAG/CTG expansion in the normal population. Nat Genet 1997 0.83
207 Endogenous prostaglandin I2 regulates the neural emergency system through release of calcitonin gene related peptide. Gut 2003 0.83
208 Aprosencephaly with rhombencephalosynapsis and hamartomatous midbrain dysplasia. Neuropathol Appl Neurobiol 2009 0.82
209 Hormone-induced apoptosis by Fas-nuclear receptor fusion proteins: novel biological tools for controlling apoptosis in vivo. Cancer Res 1996 0.82
210 Roles of prostaglandin E receptors in mesangial cells under high-glucose conditions. Kidney Int 1999 0.82
211 Lysophosphatidic acid-induced association of SHP-2 with SHPS-1: roles of RHO, FAK, and a SRC family kinase. Oncogene 1998 0.82
212 Major roles of prostanoid receptors IP and EP(3) in endotoxin-induced enhancement of pain perception. Biochem Pharmacol 2001 0.82
213 Osmotic swelling-induced activation of the extracellular-signal-regulated protein kinases Erk-1 and Erk-2 in intestine 407 cells involves the Ras/Raf-signalling pathway. Biochem J 1998 0.81
214 Identification of domains conferring ligand binding specificity to the prostanoid receptor. Studies on chimeric prostacyclin/prostaglandin D receptors. J Biol Chem 1997 0.81
215 A new metabolic pathway of tryptophan initiated by tryptophan side chain oxidase. J Biol Chem 1979 0.81
216 cDNA cloning of Gb, the substrate for botulinum ADP-ribosyltransferase from bovine adrenal gland and its identification as a rho gene product. Biochem Biophys Res Commun 1989 0.81
217 Opposite coupling of prostaglandin E receptor EP3C with Gs and G(o). Stimulation of Gs and inhibition of G(o). J Biol Chem 1993 0.81
218 ADP-ribosylation by type C1 and D botulinum neurotoxins: stimulation by guanine nucleotides and inhibition by guanidino-containing compounds. Biochem Biophys Res Commun 1987 0.81
219 Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors. Identification by site-directed mutagenesis. J Biol Chem 2000 0.80
220 Identification of Glu173 as the critical amino acid residue for the ADP-ribosyltransferase activity of Clostridium botulinum C3 exoenzyme. FEBS Lett 1995 0.80
221 Female reproduction in mice lacking the prostaglandin F receptor. Roles of prostaglandin and oxytocin receptors in parturition. Adv Exp Med Biol 1998 0.80
222 Purification and properties of prostaglandin H-E isomerase from the cytosol of human brain: identification as anionic forms of glutathione S-transferase. J Neurochem 1987 0.80
223 Evidence for involvement of prostaglandin I2 as a major nociceptive mediator in acetic acid-induced writhing reaction: a study using IP-receptor disrupted mice. Adv Exp Med Biol 1999 0.80
224 The expression of thromboxane A2 synthase and thromboxane A2 receptor gene in human uterus. Biol Reprod 1992 0.79
225 Recruited bone marrow cells expressing the EP3 prostaglandin E receptor subtype enhance angiogenesis during chronic inflammation. Biomed Pharmacother 2009 0.79
226 Expression of platelet-derived growth factor B-chain and beta-receptor in hypoxic/ischemic encephalopathy of neonatal rats. Neuroscience 1999 0.79
227 Analysis of the defective signal transduction mechanism through the platelet thromboxane A2 receptor in a patient with polycythemia vera. Thromb Haemost 1992 0.79
228 The effect of inhaled anesthetics on the platelet aggregation and the ligand-binding affinity of the platelet thromboxane A2 receptor. Anesth Analg 1995 0.79
229 Specific bindings of prostaglandin D2, E2 and F2 alpha in postmortem human brain. Brain Res 1985 0.79
230 Immunochemical identification of the ADP-ribosyltransferase in botulinum C1 neurotoxin as C3 exoenzyme-like molecule. J Biochem 1990 0.79
231 Decreased arachidonate metabolism in mouse peritoneal macrophages after foam cell transformation with oxidized low-density lipoproteins. J Biochem 1992 0.78
232 Membrane depolarization by activation of prostaglandin E receptor EP3 subtype of putative serotonergic neurons in the dorsal raphe nucleus of the rat. Naunyn Schmiedebergs Arch Pharmacol 1996 0.78
233 Expression of prostaglandin E receptor EP4 subtype in rat adrenal zona glomerulosa: involvement in aldosterone release. Endocr J 2000 0.78
234 Arachidonate metabolism during foam cell transformation of macrophages. Adv Prostaglandin Thromboxane Leukot Res 1987 0.77
235 Lipopolysaccharide induces proinflammatory cytokines and chemokines in experimental otitis media through the prostaglandin D2 receptor (DP)-dependent pathway. Clin Exp Immunol 2010 0.77
236 Effect of glutathione content on cellular uptake and growth inhibitory activity of prostaglandin A2 in L-1210 cells. Eicosanoids 1992 0.77
237 Arachidonic acid-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes. Methods Enzymol 1982 0.77
238 Characterization of the prostaglandin E receptor expressed on a cultured mast cell line, BNu-2cl3. Biochem Pharmacol 1993 0.77
239 Presence of prostaglandin D2, E2 and F2 alpha in rat pancreatic islets. Prostaglandins Leukot Med 1984 0.76
240 [Thromboxane A2 receptor; structure, function and tissue distribution]. Nihon Rinsho 1993 0.76
241 Pharmacological properties of nicotinic acetylcholine receptors on adrenal chromaffin cells and their modification by hypoxic exposure. Yakubutsu Seishin Kodo 1993 0.76
242 Modulation of ocular inflammatory responses by EP1 receptors in mice. Exp Eye Res 2006 0.76
243 Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors. Genomics 1996 0.75
244 Subunit composition of the pre-T-cell receptor complex analysed by monoclonal antibody against the pre-T-cell receptor alpha chain. Immunology 1997 0.75
245 Tryptophan side chain oxidase from Pseudomonas. Oxidation of skatole to indole-3-carboxaldehyde via indole-3-methanol. J Biol Chem 1978 0.75
246 Isolation and reconstitution of two electron transfer components of tryptophan side chain oxidase. J Biol Chem 1979 0.75
247 [Platelet thromboxane A2 receptor]. Nihon Rinsho 1992 0.75
248 Gene expression of prostacyclin receptor in the hypertrophied heart of spontaneously hypertensive rats. Clin Exp Pharmacol Physiol Suppl 1995 0.75
249 Prostaglandin I receptor and prostaglandin D receptor. J Lipid Mediat Cell Signal 1995 0.75
250 [Two mechanisms of prostaglandin actions: prostaglandin receptor and transport]. Seikagaku 1986 0.75
251 [3H]S-145 and [125I]I-S-145-OH: new radioligands for platelet thromboxane A2 receptor with low nonspecific binding and high binding affinity for various receptor preparations. Eicosanoids 1989 0.75
252 [Molecular structure and function of the prostanoid receptors]. Seikagaku 1995 0.75
253 Prostaglandin anthrylmethyl ester: a membrane-permeant fluorescent analogue of prostaglandin with enhanced cell growth inhibitory activity. Adv Prostaglandin Thromboxane Leukot Res 1985 0.75
254 [Determination of ligand binding domains of the prostanoid receptors]. Nihon Yakurigaku Zasshi 1999 0.75
255 Inhibitory effects of botulinum toxin on 5-HT1C receptor-induced Cl- current in Xenopus oocytes. Eur J Pharmacol 1994 0.75
256 [Metabolism and action of prostaglandin D2 in blood platelets]. Rinsho Byori 1982 0.75
257 [A case of large colon cavernous hemangioma in childhood]. Nihon Shokakibyo Gakkai Zasshi 1990 0.75
258 [ras oncogene-related small molecular weight GTP-binding protein, rho gene product and botulinum C3 ADP-ribosyltransferase]. Nihon Yakurigaku Zasshi 1992 0.75
259 Mapping of the genes encoding mouse thromboxane A2 receptor and prostaglandin E receptor subtypes EP2 and EP3. Genomics 1994 0.75
260 [Introduction: cloned receptors and newly developed compounds]. Nihon Yakurigaku Zasshi 2001 0.75
261 [Analysis of the mice lacking the prostanoid receptor]. Tanpakushitsu Kakusan Koso 2000 0.75
262 Morphological effects of Clostridium botulinum C3 exoenzyme on cultured cells. Jpn J Med Sci Biol 1990 0.75
263 Cigarette smoke, LDL and cholesteryl ester accumulation in macrophages. Implications for atherosclerosis. Ann N Y Acad Sci 1993 0.75
264 [Eicosanoids; prostaglandins and other oxygenated arachidonate metabolites]. Tanpakushitsu Kakusan Koso 1984 0.75
265 Deficient elevation of the cytoplasmic calcium ion concentration by epinephrine in epinephrine-insensitive platelets of patients with myeloproliferative disorders. Am J Hematol 1990 0.75
266 [Structure and function of the prostanoid receptors in cardiovascular system]. Nihon Rinsho 1993 0.75
267 [Cell growth inhibition by prostaglandins and its action mechanism]. Seikagaku 1985 0.75
268 Enzymatic oxidation of acetyltryptophanamide- and tryptophan-containing peptides. Formation of dehydrotryptophan. J Biol Chem 1977 0.75
269 Lymphocyte aggregation assay and inhibition by Clostridium botulinum C3 ADP-ribosyltransferase. Methods Enzymol 1995 0.75
270 Intracellular Signal-transducing elements involved in transendothelial migration of lymphoma cells. Jpn J Cancer Res 1998 0.75
271 Prolonged gestation does not extend survival of uterine natural killer lymphocytes in mice deleted in the receptor for prostaglandin F2alpha. J Reprod Immunol 2000 0.75
272 Involvement of thromboxane A2-thromboxane A2 receptor system of the hepatic sinusoid in pathogenesis of cold preservation/reperfusion injury in the rat liver graft. Transplantation 1995 0.75
273 [Physiological and pharmacological action of prostaglandins and related substances on the nervous system]. Nihon Rinsho 1985 0.75
274 Molecular characterization of a dominantly inherited bleeding disorder with impaired platelet responses to thromboxane A2. Pol J Pharmacol 1997 0.75
275 Inhibition of brain prostaglandin D synthetase and prostaglandin D2 dehydrogenase by some saturated and unsaturated fatty acids. Biochim Biophys Acta 1983 0.75
276 Tryptophan side chain oxidase from Pseudomonas. pH-dependent formation of alpha,beta-didehydro, beta-hydroxy, and beta-keto derivatives of N-acetyltryptophanamide. J Biol Chem 1978 0.75
277 Purification and properties of arachidonate-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes. Adv Prostaglandin Thromboxane Leukot Res 1982 0.75