Published in J Biol Chem on September 20, 1996
RhoE binds to ROCK I and inhibits downstream signaling. Mol Cell Biol (2003) 2.46
PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation. Biochem J (2005) 2.19
Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J Cell Biol (1999) 2.17
Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. Cell Metab (2012) 1.66
Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy. EMBO Rep (2012) 1.66
RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42Hs. Mol Biol Cell (1998) 1.66
Rho kinase in the regulation of cell death and survival. Arch Immunol Ther Exp (Warsz) (2007) 1.60
Dynamics of the Rho-family small GTPases in actin regulation and motility. Cell Adh Migr (2011) 1.60
Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family. Mol Biol Cell (2000) 1.58
ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinases. Neuroscientist (2007) 1.38
CCL2/CCR2 chemokine signaling coordinates survival and motility of breast cancer cells through Smad3 protein- and p42/44 mitogen-activated protein kinase (MAPK)-dependent mechanisms. J Biol Chem (2012) 1.28
Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil. J Cardiovasc Pharmacol (2013) 1.24
Activation of the ROCK1 branch of the transforming growth factor-beta pathway contributes to RAGE-dependent acceleration of atherosclerosis in diabetic ApoE-null mice. Circ Res (2010) 1.22
Activation of rho through a cross-link with polyamines catalyzed by Bordetella dermonecrotizing toxin. EMBO J (2000) 1.22
Rho GTPase and Shroom direct planar polarized actomyosin contractility during convergent extension. J Cell Biol (2014) 1.16
Tumour suppressor microRNA-584 directly targets oncogene Rock-1 and decreases invasion ability in human clear cell renal cell carcinoma. Br J Cancer (2010) 1.13
Induction of cell retraction by the combined actions of Abl-CrkII and Rho-ROCK1 signaling. J Cell Biol (2008) 1.13
Dual requirement for rho and protein kinase C in direct activation of phospholipase D1 through G protein-coupled receptor signaling. Mol Biol Cell (2000) 1.10
Regulation of RhoA-dependent ROCKII activation by Shp2. J Cell Biol (2008) 1.08
A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination. Development (2011) 1.07
Arachidonic acid stimulates cell adhesion through a novel p38 MAPK-RhoA signaling pathway that involves heat shock protein 27. J Biol Chem (2009) 1.06
Integrin-dependent translocation of p160ROCK to cytoskeletal complex in thrombin-stimulated human platelets. Biochem J (1997) 1.04
Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization. Endocrinology (2012) 1.03
The small GTP-binding protein Rho potentiates AP-1 transcription in T cells. Mol Cell Biol (1998) 1.02
Embryonic morphogenesis in Caenorhabditis elegans integrates the activity of LET-502 Rho-binding kinase, MEL-11 myosin phosphatase, DAF-2 insulin receptor and FEM-2 PP2c phosphatase. Genetics (2000) 1.01
c-Jun N-terminal kinase (JNK) cooperates with Gsk3beta to regulate Dishevelled-mediated microtubule stability. BMC Cell Biol (2007) 0.96
The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells. J Cell Sci (2010) 0.95
Regulation of adherens junction dynamics by phosphorylation switches. J Signal Transduct (2012) 0.92
Negative control of keratinocyte differentiation by Rho/CRIK signaling coupled with up-regulation of KyoT1/2 (FHL1) expression. Proc Natl Acad Sci U S A (2005) 0.91
Rho-kinase in development and heart failure: insights from genetic models. Pediatr Cardiol (2011) 0.91
A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway. J Biol Chem (2010) 0.91
A role for myosin IXb, a motor-RhoGAP chimera, in epithelial wound healing and tight junction regulation. Mol Biol Cell (2012) 0.85
Determination of interaction sites of phospholipase D1 for RhoA. Biochem J (2001) 0.85
A molecular ruler regulates cytoskeletal remodelling by the Rho kinases. Nat Commun (2015) 0.84
RhoA/Rho kinase (ROCK) alters fetuin-A uptake and regulates calcification in bovine vascular smooth muscle cells (BVSMC). Am J Physiol Renal Physiol (2010) 0.83
Nir2, a novel regulator of cell morphogenesis. Mol Cell Biol (2002) 0.81
RhoA Kinase (Rock) and p90 Ribosomal S6 Kinase (p90Rsk) phosphorylation of the sodium hydrogen exchanger (NHE1) is required for lysophosphatidic acid-induced transport, cytoskeletal organization and migration. Cell Signal (2015) 0.81
Structure of a highly conserved domain of Rock1 required for Shroom-mediated regulation of cell morphology. PLoS One (2013) 0.81
ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice. Am J Physiol Lung Cell Mol Physiol (2015) 0.79
Selective glucocorticoid control of Rho kinase isoforms regulate cell-cell interactions. Biochem Biophys Res Commun (2007) 0.79
Ser1333 phosphorylation indicates ROCKI activation. J Biomed Sci (2013) 0.79
Drug repositioning for orphan genetic diseases through Conserved Anticoexpressed Gene Clusters (CAGCs). BMC Bioinformatics (2013) 0.77
Novel Insights into the Roles of Rho Kinase in Cancer. Arch Immunol Ther Exp (Warsz) (2016) 0.76
The effect of antenatal depression and selective serotonin reuptake inhibitor treatment on nerve growth factor signaling in human placenta. PLoS One (2015) 0.76
Little ROCK is a ROCK1 pseudogene expressed in human smooth muscle cells. BMC Genet (2010) 0.75
Made to measure - keeping Rho kinase at a distance. Small GTPases (2016) 0.75
Immunohistochemical evaluation of ROCK activation in invasive breast cancer. BMC Cancer (2015) 0.75
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature (1997) 14.91
Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol (2001) 9.73
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science (1999) 7.12
Cooperation between mDia1 and ROCK in Rho-induced actin reorganization. Nat Cell Biol (1999) 5.84
Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature (1989) 5.21
International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev (1994) 5.11
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J (1996) 5.09
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J (1997) 5.03
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol (2000) 4.80
Magnetic-field-induced shape recovery by reverse phase transformation. Nature (2006) 4.43
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J (1994) 4.37
p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett (1997) 4.31
Trends in healthy life expectancy in the United States, 1970-1990: gender, racial, and educational differences. Soc Sci Med (2001) 4.30
An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat Med (1999) 3.76
Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide. J Clin Invest (1991) 3.70
Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J Cell Biol (1994) 3.65
Role of citron kinase as a target of the small GTPase Rho in cytokinesis. Nature (1998) 3.55
A new endoscopic mucosal resection procedure using an insulation-tipped electrosurgical knife for rectal flat lesions: report of two cases. Gastrointest Endosc (1999) 3.55
Routine coagulation of visible vessels may prevent delayed bleeding after endoscopic submucosal dissection--an analysis of risk factors. Endoscopy (2008) 3.50
Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase. J Biol Chem (1989) 3.47
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett (1996) 3.46
T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation (1999) 3.41
Prostaglandin D2 as a mediator of allergic asthma. Science (2000) 3.19
Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature (1997) 3.07
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science (1996) 2.99
Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem (2000) 2.99
Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice. Nat Med (2001) 2.98
Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. J Biol Chem (1996) 2.92
Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. Nature (1993) 2.91
Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature (1998) 2.88
Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J Cell Biol (1998) 2.81
A rho-like protein is involved in the organisation of the contractile ring in dividing sand dollar eggs. Zygote (1993) 2.71
Cardiac fibrosis in mice lacking brain natriuretic peptide. Proc Natl Acad Sci U S A (2000) 2.58
A novel partner for the GTP-bound forms of rho and rac. FEBS Lett (1995) 2.52
Structural and mechanistic insights into the interaction between Rho and mammalian Dia. Nature (2005) 2.52
Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J Clin Invest (1999) 2.50
Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas. Br J Cancer (1998) 2.48
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol (1997) 2.44
Transformation mediated by RhoA requires activity of ROCK kinases. Curr Biol (1999) 2.39
Superiority of brain natriuretic peptide as a hormonal marker of ventricular systolic and diastolic dysfunction and ventricular hypertrophy. Hypertension (1996) 2.37
Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene (2007) 2.34
Vectors carrying two separate T-DNAs for co-transformation of higher plants mediated by Agrobacterium tumefaciens and segregation of transformants free from selection markers. Plant J (1996) 2.32
Chromoscopy during colonoscopy. Endoscopy (2001) 2.30
Further evidence on recent trends in the prevalence and incidence of disability among older Americans from two sources: the LSOA and the NHIS. J Gerontol B Psychol Sci Soc Sci (1997) 2.28
Failure of parturition in mice lacking the prostaglandin F receptor. Science (1997) 2.27
Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1. Nat Cell Biol (2001) 2.27
Cloning and expression of cDNA for a human thromboxane A2 receptor. Nature (1991) 2.26
Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho. J Cell Biol (1993) 2.26
Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice. Kidney Int (2007) 2.21
ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. J Biol Chem (1993) 2.20
Rho effectors and reorganization of actin cytoskeleton. FEBS Lett (1997) 2.19
Use and properties of ROCK-specific inhibitor Y-27632. Methods Enzymol (2000) 2.19
Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics. Clin Pharmacol Ther (1992) 2.18
Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2). Proc Natl Acad Sci U S A (1999) 2.15
Endoscopic indications for endoscopic mucosal resection of laterally spreading tumours in the colorectum. Gut (2006) 2.14
Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor. Nature (1995) 2.09
Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo. Nat Genet (1996) 2.09
Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow. Oncogene (2000) 2.08
The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology (2000) 2.08
The addition of phenylephrine contributes to the development of transient neurologic symptoms after spinal anesthesia with 0.5% tetracaine. Anesthesiology (1997) 2.06
Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology (1992) 2.06
Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice. Biochem Biophys Res Commun (1998) 2.04
Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation. J Biol Chem (2000) 2.04
The relationships of proteinuria, serum creatinine, glomerular filtration rate with cardiovascular disease mortality in Japanese general population. Kidney Int (2006) 2.02
Pneumatic displacement of subretinal hemorrhage without tissue plasminogen activator. Arch Ophthalmol (1998) 2.01
Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine. J Biochem (1996) 2.00
Walking speed as a good predictor for the onset of functional dependence in a Japanese rural community population. Age Ageing (2000) 1.99
Dwarfism and early death in mice lacking C-type natriuretic peptide. Proc Natl Acad Sci U S A (2001) 1.99
Studies of prevalence of Japanese cedar pollinosis among the residents in a densely cultivated area. Ann Allergy (1987) 1.92
Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations. Pharmacogenetics (1997) 1.92
Causes of maternal mortality in Japan. JAMA (2000) 1.92
Nomenclature for human CYP2D6 alleles. Pharmacogenetics (1996) 1.91
Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension (1998) 1.88
Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility. Invest Ophthalmol Vis Sci (2001) 1.88
Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation. Mol Biol Cell (2001) 1.88
Hemodynamic, renal, and hormonal responses to brain natriuretic peptide infusion in patients with congestive heart failure. Circulation (1991) 1.87