Published in EMBO J on March 08, 2007
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06
Autophagy and the integrated stress response. Mol Cell (2010) 11.21
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol (2011) 7.40
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
Selective autophagy mediated by autophagic adapter proteins. Autophagy (2011) 6.88
Pancreatic cancers require autophagy for tumor growth. Genes Dev (2011) 6.17
Autophagy, immunity, and microbial adaptations. Cell Host Microbe (2009) 5.84
Signal transduction by reactive oxygen species. J Cell Biol (2011) 5.21
Physiological roles of mitochondrial reactive oxygen species. Mol Cell (2012) 5.05
Endogenous HMGB1 regulates autophagy. J Cell Biol (2010) 4.71
Toll-like receptors control autophagy. EMBO J (2008) 4.50
Autophagy in infection, inflammation and immunity. Nat Rev Immunol (2013) 4.16
Activation of antibacterial autophagy by NADPH oxidases. Proc Natl Acad Sci U S A (2009) 3.87
LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. EMBO J (2010) 3.68
Quality control of mitochondria: protection against neurodegeneration and ageing. EMBO J (2008) 3.39
Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J (2012) 3.37
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. J Cell Biol (2008) 3.36
Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J Biol Chem (2010) 2.93
Orchestrating redox signaling networks through regulatory cysteine switches. ACS Chem Biol (2010) 2.87
IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans. Proc Natl Acad Sci U S A (2014) 2.86
Neutrophil extracellular trap cell death requires both autophagy and superoxide generation. Cell Res (2010) 2.82
Cellular stress responses: cell survival and cell death. Int J Cell Biol (2010) 2.74
The regulation of autophagy - unanswered questions. J Cell Sci (2011) 2.73
Mechanisms of age-related macular degeneration. Neuron (2012) 2.62
Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality. Cell Death Differ (2011) 2.60
Autophagy in immunity and cell-autonomous defense against intracellular microbes. Immunol Rev (2011) 2.58
Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation. PLoS One (2010) 2.45
Mitochondria and mitophagy: the yin and yang of cell death control. Circ Res (2012) 2.38
Complex inhibitory effects of nitric oxide on autophagy. Mol Cell (2011) 2.36
Autophagy negatively regulates cell death by controlling NPR1-dependent salicylic acid signaling during senescence and the innate immune response in Arabidopsis. Plant Cell (2009) 2.32
Modulation of intracellular ROS levels by TIGAR controls autophagy. EMBO J (2009) 2.31
The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J (2009) 2.25
Autophagy in ischemic heart disease. Circ Res (2009) 2.20
High-mobility group box 1, oxidative stress, and disease. Antioxid Redox Signal (2011) 2.19
The emerging role of autophagy in the pathophysiology of diabetes mellitus. Autophagy (2011) 2.18
Activation of autophagy protects against acetaminophen-induced hepatotoxicity. Hepatology (2011) 2.15
Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy. Mol Biol Cell (2008) 2.14
Ubiquitination and selective autophagy. Cell Death Differ (2012) 2.12
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A (2010) 2.10
Atg8: an autophagy-related ubiquitin-like protein family. Genome Biol (2011) 2.04
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
microRNA-101 is a potent inhibitor of autophagy. EMBO J (2011) 2.00
LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection. Am J Physiol Heart Circ Physiol (2008) 1.97
Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice. Gastroenterology (2011) 1.96
A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nat Cell Biol (2013) 1.96
Mitophagy: mechanisms, pathophysiological roles, and analysis. Biol Chem (2012) 1.95
Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. J Cell Sci (2009) 1.92
Mitochondria-ros crosstalk in the control of cell death and aging. J Signal Transduct (2011) 1.89
Autophagy during cardiac stress: joys and frustrations of autophagy. Annu Rev Physiol (2010) 1.87
Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling. PLoS Pathog (2010) 1.79
Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: implications for neurodegeneration and cell death. Autophagy (2007) 1.79
Mammalian macroautophagy at a glance. J Cell Sci (2009) 1.78
p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proc Natl Acad Sci U S A (2010) 1.77
Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Antioxid Redox Signal (2011) 1.76
Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nat Cell Biol (2010) 1.76
The cell biology of autophagy in metazoans: a developing story. Development (2008) 1.76
Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation. J Biol Chem (2011) 1.74
Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes. Hepatology (2008) 1.73
Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins. Nat Cell Biol (2015) 1.73
Autophagy in health and disease. 5. Mitophagy as a way of life. Am J Physiol Cell Physiol (2010) 1.72
Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy. Mol Cancer Ther (2009) 1.69
Signal transduction by mitochondrial oxidants. J Biol Chem (2011) 1.65
The ATG12-conjugating enzyme ATG10 Is essential for autophagic vesicle formation in Arabidopsis thaliana. Genetics (2008) 1.63
The multiple roles of autophagy in cancer. Carcinogenesis (2011) 1.63
All-you-can-eat: autophagy in neurodegeneration and neuroprotection. Mol Neurodegener (2009) 1.60
Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy (2010) 1.58
Mitohormesis. Cell Metab (2014) 1.57
Signaling pathways in mitochondrial dysfunction and aging. Mech Ageing Dev (2010) 1.54
Multiple regulatory and effector roles of autophagy in immunity. Curr Opin Immunol (2009) 1.54
Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities. Circ Res (2012) 1.53
Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines. Neuro Oncol (2009) 1.51
Regulation of macroautophagy in Saccharomyces cerevisiae. Semin Cell Dev Biol (2010) 1.51
Autophagy and pattern recognition receptors in innate immunity. Immunol Rev (2009) 1.51
Mitochondrial electron transport chain complex III is required for antimycin A to inhibit autophagy. Chem Biol (2011) 1.50
Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes. J Pharmacol Exp Ther (2011) 1.49
Autophagy and innate immunity: triggering, targeting and tuning. Semin Cell Dev Biol (2010) 1.49
In vivo reconstitution of autophagy in Saccharomyces cerevisiae. J Cell Biol (2008) 1.48
Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer. Oxid Med Cell Longev (2010) 1.48
Genetic variants in MicroRNA biosynthesis pathways and binding sites modify ovarian cancer risk, survival, and treatment response. Cancer Res (2010) 1.48
Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. EMBO J (2013) 1.47
Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. Autophagy (2008) 1.46
Cellular metabolic and autophagic pathways: traffic control by redox signaling. Free Radic Biol Med (2013) 1.46
Mitochondria regulate autophagy by conserved signalling pathways. EMBO J (2011) 1.45
Cell death pathways in photodynamic therapy of cancer. Cancers (Basel) (2011) 1.45
Autophagy, a guardian against neurodegeneration. Semin Cell Dev Biol (2010) 1.45
Increased levels of reduced cytochrome b and mitophagy components are required to trigger nonspecific autophagy following induced mitochondrial dysfunction. J Cell Sci (2012) 1.45
Heme oxygenase-1 inhibits renal tubular macroautophagy in acute kidney injury. J Am Soc Nephrol (2010) 1.45
Autophagy in idiopathic pulmonary fibrosis. PLoS One (2012) 1.45
Autophagy promotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-β1. J Biol Chem (2012) 1.45
The role of surface functionality on acute cytotoxicity, ROS generation and DNA damage by cationic gold nanoparticles. Small (2010) 1.43
Current concepts on the role of inflammation in COPD and lung cancer. Curr Opin Pharmacol (2009) 1.42
Globular Adiponectin Causes Tolerance to LPS-Induced TNF-α Expression via Autophagy Induction in RAW 264.7 Macrophages: Involvement of SIRT1/FoxO3A Axis. PLoS One (2015) 1.42
Cysteine/cystine redox signaling in cardiovascular disease. Free Radic Biol Med (2010) 1.42
Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers. J Hematol Oncol (2013) 1.42
A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease. Hum Mol Genet (2010) 1.41
Sphingolipids: regulators of crosstalk between apoptosis and autophagy. J Lipid Res (2012) 1.40
Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway. Cardiovasc Res (2009) 1.40
Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation. Trends Cell Biol (2012) 1.39
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J (2000) 41.48
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol (2001) 13.98
Autophagy in health and disease: a double-edged sword. Science (2004) 13.69
WWW-query: an on-line retrieval system for biological sequence banks. Biochimie (1996) 11.59
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science (2004) 10.77
A ubiquitin-like system mediates protein lipidation. Nature (2000) 10.61
Formation process of autophagosome is traced with Apg8/Aut7p in yeast. J Cell Biol (1999) 9.33
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci (2004) 9.20
A unified nomenclature for yeast autophagy-related genes. Dev Cell (2003) 9.18
The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J (2001) 8.84
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem (2000) 8.68
Molecular dissection of autophagy: two ubiquitin-like systems. Nat Rev Mol Cell Biol (2001) 8.62
The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J Cell Biol (2000) 7.48
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci (2003) 6.50
LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol (2004) 6.34
Autophagy: in sickness and in health. Trends Cell Biol (2004) 5.49
Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ (2005) 5.40
Autophagic programmed cell death by selective catalase degradation. Proc Natl Acad Sci U S A (2006) 4.81
Aut2p and Aut7p, two novel microtubule-associated proteins are essential for delivery of autophagic vesicles to the vacuole. EMBO J (1998) 4.38
A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Mol Cell (2006) 3.98
Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. J Biol Chem (1994) 3.89
GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. Nature (1999) 3.88
GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28. EMBO J (2000) 3.39
Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay. Anal Biochem (1983) 2.85
Oxidative stress and autophagy. Antioxid Redox Signal (2006) 2.79
HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. J Biol Chem (2004) 2.58
Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes. J Biol Chem (2006) 2.51
Class III phosphoinositide 3-kinase--Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes. Biochem J (2003) 2.45
Reactive oxygen intermediates as mediators of programmed cell death in plants and animals. Biochem Pharmacol (1999) 2.32
A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L. J Biol Chem (2003) 2.22
Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling. J Biol Chem (2001) 2.16
Influence of induced reactive oxygen species in p53-mediated cell fate decisions. Mol Cell Biol (2003) 2.16
Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. J Biol Chem (2002) 2.15
Autophagy in yeast: a review of the molecular machinery. Cell Struct Funct (2002) 2.09
Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion. J Mol Cell Cardiol (1997) 1.90
Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy. J Biol Chem (2005) 1.70
Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver. J Biol Chem (1998) 1.59
Metal and redox modulation of cysteine protein function. Chem Biol (2003) 1.52
The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A. J Biol Chem (2002) 1.40
Stress, protein (mis)folding, and signaling: the redox connection. Sci STKE (2004) 1.35
The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers. J Mol Biol (2005) 1.34
Lipid oxidation and autophagy in yeast. Free Radic Biol Med (2006) 1.31
Scavenging of extracellular H2O2 by catalase inhibits the proliferation of HER-2/Neu-transformed rat-1 fibroblasts through the induction of a stress response. J Biol Chem (2000) 1.25
Effects of inhibitors of the vacuolar proton pump on hepatic heterophagy and autophagy. Biochim Biophys Acta (2001) 1.24
Oxidative stress-induced apoptosis is mediated by ERK1/2 phosphorylation. Exp Cell Res (2003) 1.22
Autophagy and aging--when "all you can eat" is yourself. Sci Aging Knowledge Environ (2003) 1.07
Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1. Mol Pharmacol (1998) 1.00
Oxidant-mediated AA release from astrocytes involves cPLA(2) and iPLA(2). Free Radic Biol Med (2003) 0.98
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell (2009) 6.88
ROS, mitochondria and the regulation of autophagy. Trends Cell Biol (2007) 3.73
LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. EMBO J (2010) 3.68
Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy (2008) 3.47
Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci (2010) 3.32
Biogenesis and cargo selectivity of autophagosomes. Annu Rev Biochem (2011) 3.15
Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes. J Biol Chem (2006) 2.51
Utilizing flow cytometry to monitor autophagy in living mammalian cells. Autophagy (2008) 2.16
Mechanisms of autophagosome biogenesis. Curr Biol (2012) 2.13
Atg8: an autophagy-related ubiquitin-like protein family. Genome Biol (2011) 2.04
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00
LC3 and GATE-16 N termini mediate membrane fusion processes required for autophagosome biogenesis. Dev Cell (2011) 1.84
p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proc Natl Acad Sci U S A (2010) 1.77
Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy. EMBO Rep (2006) 1.72
Erythropoietin enhances immune responses in mice. Eur J Immunol (2007) 1.68
The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes. J Cell Sci (2008) 1.67
Altered autophagy in human adipose tissues in obesity. J Clin Endocrinol Metab (2010) 1.47
The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A. J Biol Chem (2002) 1.40
Flow cytometric analysis of autophagy in living mammalian cells. Methods Enzymol (2009) 1.28
The autophagy-associated Atg8 gene family operates both under favourable growth conditions and under starvation stresses in Arabidopsis plants. J Exp Bot (2005) 1.27
Deletion of cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae. Nat Commun (2013) 1.24
Oxidation as a post-translational modification that regulates autophagy. Autophagy (2007) 1.23
Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion. J Cell Biol (2002) 1.20
TBK1 mediates crosstalk between the innate immune response and autophagy. Sci Signal (2011) 1.18
Autophagy-independent incorporation of GFP-LC3 into protein aggregates is dependent on its interaction with p62/SQSTM1. Autophagy (2008) 1.07
The Atg8 family: multifunctional ubiquitin-like key regulators of autophagy. Essays Biochem (2013) 1.04
GABARAP is not essential for GABA receptor targeting to the synapse. Eur J Neurosci (2005) 1.04
Importin beta regulates the seeding of chromatin with initiation sites for nuclear pore assembly. Mol Biol Cell (2009) 1.00
Mutation in TECPR2 reveals a role for autophagy in hereditary spastic paraparesis. Am J Hum Genet (2012) 0.99
Lipophagy: selective catabolism designed for lipids. Dev Cell (2009) 0.98
Intra-Golgi protein transport depends on a cholesterol balance in the lipid membrane. J Biol Chem (2003) 0.97
Dissecting the involvement of LC3B and GATE-16 in p62 recruitment into autophagosomes. Autophagy (2011) 0.97
Development. Inheriting maternal mtDNA. Science (2011) 0.91
Endocytosis and autophagy: exploitation or cooperation? Cold Spring Harb Perspect Biol (2014) 0.91
Involvement of LMA1 and GATE-16 family members in intracellular membrane dynamics. Biochim Biophys Acta (2003) 0.90
Foot-and-mouth disease virus induces autophagosomes during cell entry via a class III phosphatidylinositol 3-kinase-independent pathway. J Virol (2012) 0.89
Identification of essential residues for the C-terminal cleavage of the mammalian LC3: a lesson from yeast Atg8. Autophagy (2007) 0.88
Modulation of N-ethylmaleimide-sensitive factor activity upon amino acid deprivation. J Biol Chem (2005) 0.87
Nuclear import of an intact preassembled proteasome particle. Mol Biol Cell (2011) 0.83
The prodomain of a secreted hydrophobic mini-protein facilitates its export from the endoplasmic reticulum by hitchhiking on sorting receptors. J Biol Chem (2003) 0.83
A new autophagy-related checkpoint in the degradation of an ERAD-M target. J Biol Chem (2011) 0.82
Mammalian Atg8s: one is simply not enough. Autophagy (2010) 0.82
Geldanamycin-associated inhibition of intracellular trafficking is attributed to a co-purified activity. J Biol Chem (2003) 0.82
Ubiquitin-like proteins and autophagy at a glance. J Cell Sci (2012) 0.82
Monitoring starvation-induced reactive oxygen species formation. Methods Enzymol (2009) 0.79
Autophagic factors cut to the bone. Dev Cell (2011) 0.78
Shedding light on mammalian microautophagy. Dev Cell (2011) 0.77
TECPR2: a new autophagy link for neurodegeneration. Autophagy (2013) 0.77
Essential role for the mammalian ATG8 isoform LC3C in xenophagy. Mol Cell (2012) 0.76