Fgf8 signalling from the AER is essential for normal limb development.

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Published in Nat Genet on December 01, 2000

Authors

M Lewandoski1, X Sun, G R Martin

Author Affiliations

1: Department of Anatomy and Program in Developmental Biology, School of Medicine, San Francisco, California, USA.

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Biological activities of laminin. J Cell Biochem (1985) 2.03

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