PubRank

S Akira

Author PubWeight™ 459.12‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A Toll-like receptor recognizes bacterial DNA. Nature 2000 26.34
2 Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 1998 18.12
3 Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999 17.40
4 Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 1999 16.86
5 The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001 14.24
6 Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 1999 11.64
7 TLR signaling. Cell Death Differ 2006 9.24
8 Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 1999 7.90
9 Toll-like receptors control activation of adaptive immune responses. Nat Immunol 2001 7.54
10 Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A 1997 7.08
11 Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol 2000 6.61
12 Essential role of Stat6 in IL-4 signalling. Nature 1996 6.56
13 Structure and function of a new STAT-induced STAT inhibitor. Nature 1997 6.02
14 Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol 2001 5.36
15 Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol 2001 5.27
16 Biological and clinical aspects of interleukin 6. Immunol Today 1990 5.17
17 Cytokine signal transduction. Cell 1994 5.14
18 Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci U S A 2001 5.02
19 Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J Immunol 1998 4.74
20 Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 1998 4.70
21 Interleukin-6 family of cytokines and gp130. Blood 1995 4.52
22 Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene. EMBO J 1997 4.51
23 Induction of direct antimicrobial activity through mammalian toll-like receptors. Science 2001 4.46
24 Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 1995 4.34
25 Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci U S A 1993 4.23
26 Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol 2000 4.10
27 IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc Natl Acad Sci U S A 1989 4.03
28 Limb and skin abnormalities in mice lacking IKKalpha. Science 1999 3.85
29 Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci U S A 1993 3.59
30 IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. J Immunol 1998 3.56
31 Interleukin-6 and its receptor: a paradigm for cytokines. Science 1992 3.51
32 Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci U S A 2001 3.49
33 Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol 2001 3.26
34 Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J 1999 3.19
35 Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway. J Immunol 2000 3.15
36 CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med 2001 3.05
37 Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev 1999 2.91
38 IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol 1999 2.84
39 Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation. Immunity 2000 2.81
40 STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc Natl Acad Sci U S A 1996 2.64
41 Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6. Blood 1992 2.62
42 Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite. J Immunol 2001 2.60
43 TLR6: A novel member of an expanding toll-like receptor family. Gene 1999 2.55
44 A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc Natl Acad Sci U S A 1992 2.55
45 Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Lett 1996 2.53
46 Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J Immunol 2000 2.41
47 Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene. Mol Cell Biol 1990 2.41
48 Toll-like receptors; their physiological role and signal transduction system. Int Immunopharmacol 2001 2.36
49 TLR engagement prevents transplantation tolerance. Am J Transplant 2006 2.36
50 IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. Proc Natl Acad Sci U S A 1999 2.35
51 The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function. J Exp Med 1999 2.32
52 Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice. Trends Immunol 2001 2.29
53 Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J Exp Med 2000 2.16
54 NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A. J Virol 1992 2.10
55 Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptors. Infect Immun 2000 2.10
56 Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I. J Exp Med 2001 2.07
57 Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes Cells 2000 2.05
58 Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int Immunol 2000 2.05
59 STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev 2000 2.02
60 A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction. Mol Cell Biol 1993 2.00
61 CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression. J Immunol 2001 1.95
62 ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Mol Cell Biol 1998 1.88
63 Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J Exp Med 1998 1.88
64 A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages. J Immunol 1999 1.86
65 Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human. J Immunol 1988 1.86
66 Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice. Infect Immun 1999 1.85
67 Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism. J Immunol 2001 1.82
68 Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr Biol 2000 1.81
69 Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action. J Biol Chem 1999 1.77
70 IkappaB kinase alpha is essential for mature B cell development and function. J Exp Med 2001 1.76
71 The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol. Eur J Immunol 2001 1.71
72 Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture. Infect Immun 2001 1.71
73 MyD88 as a bottle neck in Toll/IL-1 signaling. Curr Top Microbiol Immunol 2002 1.71
74 Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: possible involvement of NF-IL6 in acute phase protein gene expression. New Biol 1991 1.70
75 Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J Immunol 1999 1.69
76 Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice. Immunity 1999 1.67
77 DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J Biol Chem 1998 1.65
78 STAT6 deficiency in a mouse model of allergen-induced airways inflammation abolishes eosinophilia but induces infiltration of CD8+ T cells. Clin Exp Allergy 1999 1.64
79 Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infection. J Immunol 2000 1.63
80 Critical roles of Toll-like receptors in host defense. Crit Rev Immunol 2000 1.63
81 Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta. J Immunol 2001 1.62
82 Expression of toll-like receptor 2 on gamma delta T cells bearing invariant V gamma 6/V delta 1 induced by Escherichia coli infection in mice. J Immunol 2000 1.59
83 Roles of Toll-like receptors in innate immune responses. Genes Cells 2001 1.56
84 Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. J Immunol 1996 1.56
85 Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function. J Immunol 2000 1.52
86 Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres. Genes Cells 1998 1.50
87 IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor. J Immunol 1999 1.48
88 The role of NF-kappa B and NF-IL6 transactivating factors in the synergistic activation of human serum amyloid A gene expression by interleukin-1 and interleukin-6. J Biol Chem 1993 1.46
89 Novel engagement of CD14 and multiple toll-like receptors by group B streptococci. J Immunol 2001 1.46
90 Age-associated increase in interleukin 6 in MRL/lpr mice. Int Immunol 1991 1.45
91 Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model. Br J Pharmacol 2009 1.43
92 Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia. Neuroscience 2010 1.43
93 A pre-B cell nuclear protein that specifically interacts with the immunoglobulin V-J recombination sequences. Cell 1987 1.42
94 Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice. Scand J Gastroenterol 2003 1.41
95 Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases. Mol Cell Biol 2001 1.39
96 Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation. J Exp Med 2001 1.35
97 Introduction of human gamma 1 immunoglobulin genes into fertilized mouse eggs. J Biochem 1984 1.35
98 Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells 1999 1.35
99 The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3. Adv Exp Med Biol 2000 1.34
100 Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease. Gastroenterology 2001 1.33
101 Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes. Int Immunol 1998 1.32
102 Functional V region formation during in vitro culture of a murine immature B precursor cell line. Nature 1983 1.30
103 SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility. EMBO J 2000 1.29
104 Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis. Gut 2009 1.28
105 Video-assisted neck surgery: endoscopic resection of thyroid tumors with a very minimal neck wound. J Am Coll Surg 1999 1.28
106 Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity. Oncogene 1999 1.27
107 Toll-like receptors and chondrocytes: the lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7. Arthritis Rheum 2007 1.23
108 IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells. J Immunol 2000 1.22
109 Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by Toll-like receptor 2: role of N-terminal hydrophobic portion in its multiple functions. J Immunol 2001 1.20
110 Video-assisted neck surgery: endoscopic resection of benign thyroid tumor aiming at scarless surgery on the neck. J Surg Oncol 1998 1.19
111 Functional expression of a microinjected Ed alpha gene in C57BL/6 transgenic mice. Nature 1985 1.18
112 IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells. J Immunol 2000 1.17
113 IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock. Int Immunol 1999 1.16
114 Interleukin (IL)-18 promotes the development of chronic gastrointestinal helminth infection by downregulating IL-13. J Exp Med 2001 1.16
115 TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy. J Autoimmun 2010 1.16
116 Effect of B cell differentiation factor (BCDF) on biosynthesis and secretion of immunoglobulin molecules in human B cell lines. J Immunol 1985 1.15
117 Potentiality of interleukin-18 as a useful reagent for treatment and prevention of Leishmania major infection. Infect Immun 2000 1.13
118 NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation. Genes Cells 2000 1.13
119 The genomic structure and chromosomal localization of the mouse STAT3 gene. Int Immunol 1996 1.11
120 Lipocalin 2 is required for BCR-ABL-induced tumorigenesis. Oncogene 2008 1.11
121 Augmentation of haptoglobin production in Hep3B cell line by a nuclear factor NF-IL6. FEBS Lett 1991 1.10
122 A novel lipopolysaccharide inducible C-C chemokine receptor related gene in murine macrophages. FEBS Lett 1998 1.08
123 Signal transducer and activator of transcription 6 is essential in the induction of contact hypersensitivity. J Exp Med 2000 1.07
124 Impairment of natural killer cytotoxic activity and interferon gamma production in CCAAT/enhancer binding protein gamma-deficient mice. J Exp Med 1999 1.07
125 Toll-like receptors and their signaling mechanism in innate immunity. Acta Odontol Scand 2001 1.07
126 Suppression of allergic reaction by lambda-carrageenan: toll-like receptor 4/MyD88-dependent and -independent modulation of immunity. Clin Exp Allergy 2003 1.07
127 Modulation of endocytosis in nuclear factor IL-6(-/-) macrophages is responsible for a high susceptibility to intracellular bacterial infection. J Immunol 1999 1.05
128 Relationship between the rearrangement of immunoglobulin genes, the appearance of a B lymphocyte antigen, and immunoglobulin synthesis in murine pre-B cell lines. J Immunol 1982 1.05
129 STAT6: its role in interleukin 4-mediated biological functions. J Mol Med (Berl) 1997 1.05
130 Kupffer cells from Schistosoma mansoni-infected mice participate in the prompt type 2 differentiation of hepatic T cells in response to worm antigens. J Immunol 1999 1.05
131 The nuclear factor interleukin-6 (NF-IL6) and signal transducer and activator of transcription-3 (STAT-3) signalling pathways co-operate to mediate the activation of the hsp90beta gene by interleukin-6 but have opposite effects on its inducibility by heat shock. Biochem J 1998 1.04
132 MyD88-dependent pathways mediate resistance to Cryptosporidium parvum infection in mice. Infect Immun 2006 1.04
133 IL-6/BSF2 in normal and abnormal regulation of immune responses. Ann N Y Acad Sci 1989 1.03
134 Enhanced gamma interferon production through activation of Valpha14(+) natural killer T cells by alpha-galactosylceramide in interleukin-18-deficient mice with systemic cryptococcosis. Infect Immun 2001 1.03
135 Isotype switching in murine pre-B cell lines. Cell 1983 1.02
136 Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-kappa B and NF-IL6 in cardiac myocytes. Cardiovasc Res 1999 1.02
137 Chlamydia trachomatis mouse pneumonitis lung infection in IL-18 and IL-12 knockout mice: IL-12 is dominant over IL-18 for protective immunity. Mol Med 2000 1.02
138 Involvement of MyD88 in host defense and the down-regulation of anti-heat shock protein 70 autoantibody formation by MyD88 in Toxoplasma gondii-infected mice. J Parasitol 2002 1.02
139 Expressions of CCAAT/Enhancer-binding proteins beta and delta and their activities are intensified by cAMP signaling as well as Ca2+/calmodulin kinases activation in hippocampal neurons. J Biol Chem 1998 1.01
140 Normal development of the gut-associated lymphoid tissue except Peyer's patch in MyD88-deficient mice. Scand J Immunol 2003 1.00
141 Reduced host resistance and Th1 response to Cryptococcus neoformans in interleukin-18 deficient mice. FEMS Microbiol Lett 2000 0.99
142 Microsomal prostaglandin E synthase-1 contributes to ischaemic excitotoxicity through prostaglandin E2 EP3 receptors. Br J Pharmacol 2010 0.99
143 Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia. Cell Death Differ 2011 0.98
144 Macrophage migration inhibitory factor contributes to the development of acute dextran sulphate sodium-induced colitis in Toll-like receptor 4 knockout mice. Clin Exp Immunol 2005 0.98
145 Targeted disruption of the aromatase P450 gene (Cyp19) in mice and their ovarian and uterine responses to 17beta-oestradiol. J Endocrinol 2001 0.98
146 The myeloid differentiation factor 88 is dispensable for the development of a delayed host response to Pseudomonas aeruginosa lung infection in mice. Clin Exp Immunol 2006 0.98
147 Soluble CD14 enriched in colostrum and milk induces B cell growth and differentiation. Proc Natl Acad Sci U S A 2001 0.98
148 IL-18 gene therapy develops Th1-type immune responses in Leishmania major-infected BALB/c mice: is the effect mediated by the CpG signaling TLR9? Gene Ther 2004 0.97
149 Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice. Biochem Biophys Res Commun 2008 0.97
150 IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation. Cell Death Differ 2009 0.97
151 IL-6 receptor and mechanism of signal transduction. Int J Immunopharmacol 1992 0.96
152 Interleukin 6 activates heat-shock protein 90 beta gene expression. Biochem J 1997 0.96
153 Differential utilization of Janus kinase-signal transducer activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-alpha. J Immunol 1996 0.96
154 Intussusception caused by a carcinoma of the cecum during pregnancy: report of a case and review of the literature. Surg Today 1993 0.96
155 Disruption of nuclear factor-interleukin-6, a transcription factor, results in severe mycobacterial infection. Am J Pathol 2001 0.96
156 Genetically resistant mice lacking IL-18 gene develop Th1 response and control cutaneous Leishmania major infection. J Immunol 2000 0.95
157 Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis. Oncogene 2011 0.95
158 Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells. Biol Reprod 2003 0.95
159 Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus. Proc Natl Acad Sci U S A 2001 0.95
160 Toll receptor families: structure and function. Semin Immunol 2004 0.94
161 STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF-kappaB p65. J Immunol 2001 0.94
162 Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy. Mol Cell Biol 2000 0.94
163 Inducible expression of nuclear factor IL-6 increases endogenous gene expression of macrophage inflammatory protein-1 alpha, osteopontin and CD14 in a monocytic leukemia cell line. Int Immunol 1998 0.94
164 Oestrogen at the neonatal stage is critical for the reproductive ability of male mice as revealed by supplementation with 17beta-oestradiol to aromatase gene (Cyp19) knockout mice. J Endocrinol 2001 0.92
165 Class-switching from mu to gamma 3 or gamma 2b production at pre-B cell stage. J Immunol 1986 0.92
166 IL-5 induces IgG1 isotype switch recombination in mouse CD38-activated sIgD-positive B lymphocytes. J Immunol 1999 0.90
167 NF-IL6 represses early gene expression of human papillomavirus type 16 through binding to the noncoding region. J Virol 1993 0.89
168 Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor. J Steroid Biochem Mol Biol 1997 0.89
169 Multi-functional roles of Stat3 revealed by conditional gene targeting. Arch Immunol Ther Exp (Warsz) 2001 0.88
170 Regulation of transcription factor C/ATF by the cAMP signal activation in hippocampal neurons, and molecular interaction of C/ATF with signal integrator CBP/p300. Brain Res Mol Brain Res 1999 0.88
171 Regulation of innate immune responses by Toll-like receptors. Jpn J Infect Dis 2001 0.87
172 IL-18 deficiency selectively enhances allergen-induced eosinophilia in mice. J Allergy Clin Immunol 2000 0.86
173 Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains. Gene 1999 0.86
174 Monocytic cell activation by Nonendotoxic glycoprotein from Prevotella intermedia ATCC 25611 is mediated by toll-like receptor 2. Infect Immun 2001 0.85
175 The amino acid residues immediately carboxyl-terminal to the tyrosine phosphorylation site contribute to interleukin 6-specific activation of signal transducer and activator of transcription 3. J Biol Chem 1997 0.85
176 Mycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+ CD11c+ cells. Eur Respir J 2011 0.85
177 Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity. Br J Pharmacol 2010 0.84
178 Immunoglobulin gene expression and DNA methylation in murine pre-B cell lines. EMBO J 1984 0.84
179 Cytokine signal transduction through a homo- or heterodimer of gp130. Ann N Y Acad Sci 1995 0.83
180 CCAAT/enhancer-binding protein beta is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary-cultured hepatocytes. FEBS Lett 2001 0.82
181 Overexpression of a reversion-related protein in the revertant RR cells. Sci China C Life Sci 1996 0.82
182 Direct injection of plasmid DNA into the skin induces dermatitis by activation of monocytes through toll-like receptor 9. J Gene Med 2005 0.81
183 Involvement of endogenously synthesized interleukin (IL)-18 in the protective effects of IL-12 against pulmonary infection with Cryptococcus neoformans in mice. FEMS Immunol Med Microbiol 2000 0.81
184 In vitro-generated viral double-stranded RNA in contrast to polyinosinic:polycytidylic acid induces interferon-alpha in human plasmacytoid dendritic cells. Scand J Immunol 2006 0.81
185 Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting. Genomics 2000 0.81
186 Cytokine-inducing macromolecular glycolipids from Enterococcus hirae: improved method for separation and analysis of its effects on cellular activation. Biochem Biophys Res Commun 2000 0.80
187 Th2 cytokines, IgE and mast cells play a crucial role in the induction of para-phenylenediamine-induced contact hypersensitivity in mice. Clin Exp Immunol 2003 0.80
188 Identification of alternative splicing form of Stat2. FEBS Lett 1996 0.80
189 Alternations in hepatic expression of fatty-acid metabolizing enzymes in ArKO mice and their reversal by the treatment with 17beta-estradiol or a peroxisome proliferator. J Steroid Biochem Mol Biol 2001 0.80
190 Bug detectors. Nature 2001 0.79
191 Phenotypes of CCAAT/enhancer-binding protein beta deficiency: hyperdontia and elongated coronoid process. Oral Dis 2012 0.79
192 Molecular cloning of the cDNAs for interleukin-6/B cell stimulatory factor 2 and its receptor. Ann N Y Acad Sci 1989 0.78
193 Epicutaneously applied Der p 2 induces a strong TH 2-biased antibody response in C57BL/6 mice, independent of functional TLR4. Allergy 2014 0.78
194 Pregnancy can be established in superovulated adult rats treated with progesterone and an aromatase inhibitor. Life Sci 1993 0.78
195 In vivo transfection of a cis element 'decoy' against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late-phase reaction in an atopic dermatitis mouse model. Gene Ther 2004 0.78
196 Signal transducer and activator of transcription protein (STAT): its relation to Th1/Th2-mediated diseases. Nutrition 1998 0.77
197 Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice. Gut 2005 0.77
198 In vivo transfection of a cis element 'decoy' against signal transducers and activators of the transcription 6 (STAT6) binding site ameliorates the response of contact hypersensitivity. Gene Ther 2004 0.77
199 [Bacteria killing by macrophages via NF-IL6 gene dependent mechanism: the susceptibility to Mycobacterium leprae in NF-IL6 knockout mice]. Nihon Hansenbyo Gakkai Zasshi 1999 0.76
200 [Surgery for ischemic heart disease secondary to familial hyperlipidemia]. Kokyu To Junkan 1985 0.75
201 Preventive effect of monoclonal antibodies to intercellular adhesion molecule-1 and leukocyte function-associate antigen-1 on murine spontaneous fetal resorption. Am J Reprod Immunol 2000 0.75
202 Production of antisera to growth hormone-releasing factor: usefulness in radioimmunoassay and passive immunization. Endocrinol Jpn 1985 0.75
203 [Effect of testosterone on growth hormone (GH) secretory profiles in female rats]. Nihon Ika Daigaku Zasshi 1987 0.75
204 [Immunological mechanism in man against infection]. Nihon Naika Gakkai Zasshi 2001 0.75
205 [In vitro fertilization and embryo transfer. Present and future]. Nihon Ika Daigaku Zasshi 1999 0.75
206 Stimulatory effect of thymic factor(s) on steroidogenesis in cultured rat granulosa cells. Life Sci 1992 0.75
207 Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family. Eur J Biochem 1995 0.75
208 A radioimmunoassay for human pro-luteinizing hormone-releasing factor [pro-LRF(14-69)OH]. Endocrinol Jpn 1987 0.75
209 Effects of neonatal administration of monosodium glutamate on plasma growth hormone (GH) response to GH-releasing factor in adult male and female rats. Brain Res 1986 0.75
210 [Management of recurrent spontaneous abortion. The efficacy and the problem of immunotherapy]. Nihon Ika Daigaku Zasshi 1998 0.75