A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction.

PubWeight™: 2.00‹?› | Rank: Top 2%

🔗 View Article (PMC 359498)

Published in Mol Cell Biol on March 01, 1993

Authors

Y Nishio1, H Isshiki, T Kishimoto, S Akira

Author Affiliations

1: Institute for Molecular and Cellular Biology, Osaka University, Japan.

Articles citing this

A compilation of composite regulatory elements affecting gene transcription in vertebrates. Nucleic Acids Res (1995) 4.93

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci U S A (1993) 4.23

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc Natl Acad Sci U S A (1994) 2.99

Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol Cell Biol (1995) 2.71

CRP2 (C/EBP beta) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity. EMBO J (1995) 2.28

Regulation of serum amyloid A protein expression during the acute-phase response. Biochem J (1998) 1.83

C/EBP proteins activate transcription from the human immunodeficiency virus type 1 long terminal repeat in macrophages/monocytes. J Virol (1995) 1.64

Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex. EMBO J (2003) 1.48

C/EBP beta regulation of the tumor necrosis factor alpha gene. J Clin Invest (1994) 1.45

The lipopolysaccharide-binding protein is a secretory class 1 acute-phase protein whose gene is transcriptionally activated by APRF/STAT/3 and other cytokine-inducible nuclear proteins. Mol Cell Biol (1996) 1.38

CCAAT/enhancer-binding protein beta: its role in breast cancer and associations with receptor tyrosine kinases. Expert Rev Mol Med (2009) 1.38

Functional cooperation between CCAAT/enhancer-binding proteins and the vitamin D receptor in regulation of 25-hydroxyvitamin D3 24-hydroxylase. Mol Cell Biol (2005) 1.28

Serum amyloid A gene expression under acute-phase conditions involves participation of inducible C/EBP-beta and C/EBP-delta and their activation by phosphorylation. Mol Cell Biol (1994) 1.25

Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor. Mol Cell Biol (1997) 1.22

A novel C/EBP beta-YY1 complex controls the cell-type-specific activity of the human papillomavirus type 18 upstream regulatory region. J Virol (1996) 1.20

Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosus-prone B6.Sle1.Yaa animals. Blood (2009) 1.17

Transcriptional inhibition of the interleukin-8 gene by interferon is mediated by the NF-kappa B site. Mol Cell Biol (1994) 1.16

Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase I gene. Mol Cell Biol (1998) 1.15

Promoter selective transcriptional synergy mediated by sterol regulatory element binding protein and Sp1: a critical role for the Btd domain of Sp1. Mol Cell Biol (1997) 1.14

Interaction of C/EBPbeta and v-Myb is required for synergistic activation of the mim-1 gene. Mol Cell Biol (1996) 1.13

Transcriptional regulation of human dual specificity protein phosphatase 1 (DUSP1) gene by glucocorticoids. PLoS One (2010) 1.12

NF-IL6-mediated transcriptional activation of the long terminal repeat of the human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1993) 1.11

CCAAT/enhancer binding proteins in normal mammary development and breast cancer. Breast Cancer Res (2002) 1.11

Multiple forms of C/EBP beta bind the EFII enhancer sequence in the Rous sarcoma virus long terminal repeat. Mol Cell Biol (1994) 1.10

Recruitment of octamer transcription factors to DNA by glucocorticoid receptor. Mol Cell Biol (1998) 1.06

AIDS-related Kaposi's sarcoma: evidence for direct stimulatory effect of glucocorticoid on cell proliferation. Am J Pathol (1995) 1.06

Induction of the mouse serum amyloid A3 gene by cytokines requires both C/EBP family proteins and a novel constitutive nuclear factor. Mol Cell Biol (1994) 1.05

C/EBP-related protein 2 confers lipopolysaccharide-inducible expression of interleukin 6 and monocyte chemoattractant protein 1 to a lymphoblastic cell line. Proc Natl Acad Sci U S A (1994) 1.04

The nuclear factor interleukin-6 (NF-IL6) and signal transducer and activator of transcription-3 (STAT-3) signalling pathways co-operate to mediate the activation of the hsp90beta gene by interleukin-6 but have opposite effects on its inducibility by heat shock. Biochem J (1998) 1.04

CCAAT/enhancer-binding protein beta and delta binding to CIITA promoters is associated with the inhibition of CIITA expression in response to Mycobacterium tuberculosis 19-kDa lipoprotein. J Immunol (2007) 1.03

Tumor necrosis factor alpha gene regulation: enhancement of C/EBPbeta-induced activation by c-Jun. Mol Cell Biol (1998) 1.02

The promoter of IL-18 binding protein: activation by an IFN-gamma -induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein beta. Proc Natl Acad Sci U S A (2002) 1.01

NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1. Mol Cell Biol (1994) 1.01

Identification and characterization of a nucleolar phosphoprotein, Nopp140, as a transcription factor. Mol Cell Biol (1997) 1.01

Drosophila immunity. A sequence homologous to mammalian interferon consensus response element enhances the activity of the diptericin promoter. Nucleic Acids Res (1995) 0.99

Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression. Mol Cell Biol (1998) 0.97

Cross-talk between glucocorticoid and retinoic acid signals involving glucocorticoid receptor interaction with the homoeodomain protein Pbx1. Biochem J (2003) 0.93

C/EBPbeta is a negative regulator of human papillomavirus type 11 in keratinocytes. J Virol (1996) 0.91

Genetic analysis of cis regulatory elements within the 5' region of the human papillomavirus type 31 upstream regulatory region during different stages of the viral life cycle. J Virol (2002) 0.90

Overexpression of C/EBPbeta represses human papillomavirus type 18 upstream regulatory region activity in HeLa cells by interfering with the binding of TATA-binding protein. J Virol (1998) 0.90

Glucocorticoid-stimulated CCAAT/enhancer-binding protein alpha expression is required for steroid-induced G1 cell cycle arrest of minimal-deviation rat hepatoma cells. Mol Cell Biol (1996) 0.88

Innate immune responses and chronic obstructive pulmonary disease: "Terminator" or "Terminator 2"? Proc Am Thorac Soc (2005) 0.87

Transcriptional induction of the alpha-1 acid glycoprotein (AGP) gene by synergistic interaction of two alternative activator forms of AGP/enhancer-binding protein (C/EBP beta) and NF-kappaB or Nopp140. Mol Cell Biol (1996) 0.86

Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein δ. Kidney Int (2015) 0.86

Paradoxical early glucocorticoid induction of stem cell factor (SCF) expression in inflammatory conditions. Br J Pharmacol (2003) 0.85

Transcriptional repression of human hepatitis B virus genes by a bZIP family member, E4BP4. J Virol (1999) 0.85

Mechanism of negative regulation of rat glutathione S-transferase A2 by the cytokine interleukin 6. Biochem J (2002) 0.84

Delineation of the insulin-responsive sequence in the rat cytosolic aspartate aminotransferase gene: binding sites for hepatocyte nuclear factor-3 and nuclear factor I. Biochem J (1999) 0.78

Dexamethasone-induced up-regulation of the human norepinephrine transporter involves the glucocorticoid receptor and increased binding of C/EBP-β to the proximal promoter of norepinephrine transporter. J Neurochem (2011) 0.78

Inhibition of corticosteroid-binding globulin gene expression by glucocorticoids involves C/EBPβ. PLoS One (2014) 0.78

C/EBPbeta (NF-M) is essential for activation of the p20K lipocalin gene in growth-arrested chicken embryo fibroblasts. Mol Cell Biol (1999) 0.77

USF2 inhibits C/EBP-mediated transcriptional regulation of the RIIbeta subunit of cAMP-dependent protein kinase. BMC Mol Biol (2002) 0.77

Analysis of chromatin structure of rat alpha1-acid glycoprotein gene; changes in DNase I hypersensitive sites after thyroid hormone, glucocorticoid hormone and turpentine oil treatment. Nucleic Acids Res (1997) 0.76

Connections between ETV6-modulated genes: identification of shared features. Cancer Inform (2008) 0.76

The human topoisomerase I gene promoter is regulated by NF-IL6. Mol Cell Biol (1995) 0.75

Glucocorticoid receptor is involved in the breed-dependent transcriptional regulation of 3β-hydroxysteroid dehydrogenase in the liver of preweaning piglets. BMC Vet Res (2015) 0.75

Articles cited by this

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol (1982) 116.75

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev (1991) 11.10

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J (1990) 9.17

Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell (1990) 6.84

Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science (1990) 6.72

Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell (1990) 6.56

The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite. Science (1989) 6.46

The phenomenon of the acute phase response. Ann N Y Acad Sci (1982) 6.14

Transcriptional repression of eukaryotic promoters. Cell (1989) 5.60

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell (1990) 5.59

Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB J (1990) 5.16

LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev (1990) 4.98

IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell (1990) 4.58

A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev (1991) 4.50

Synergistic activation by the glutamine-rich domains of human transcription factor Sp1. Cell (1989) 4.49

An Escherichia coli vector to express and purify foreign proteins by fusion to and separation from maltose-binding protein. Gene (1988) 3.97

Vectors that facilitate the expression and purification of foreign peptides in Escherichia coli by fusion to maltose-binding protein. Gene (1988) 3.92

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor. Cell (1987) 3.62

Functional antagonism between c-Jun and MyoD proteins: a direct physical association. Cell (1992) 3.55

Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement. Nature (1987) 3.42

The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor. Proc Natl Acad Sci U S A (1992) 2.93

Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family. Mol Cell Biol (1990) 2.78

Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta. Science (1992) 2.61

Direct cloning of leucine zipper proteins: Jun binds cooperatively to the CRE with CRE-BP1. Oncogene (1990) 2.51

Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene. Mol Cell Biol (1990) 2.41

Dexamethasone regulation of alpha 1-acid glycoprotein and other acute phase reactants in rat liver and hepatoma cells. J Biol Chem (1983) 2.26

Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities. Genes Dev (1989) 2.15

Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6. EMBO J (1989) 1.98

Induction of rat acute-phase proteins by interleukin 6 in vivo. Eur J Immunol (1988) 1.95

A family of constitutive C/EBP-like DNA binding proteins attenuate the IL-1 alpha induced, NF kappa B mediated trans-activation of the angiotensinogen gene acute-phase response element. EMBO J (1990) 1.92

Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes. Proc Natl Acad Sci U S A (1989) 1.89

Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation. Mol Biol Med (1990) 1.88

Action of recombinant human interleukin 6, interleukin 1 beta and tumor necrosis factor alpha on the mRNA induction of acute-phase proteins. Eur J Immunol (1988) 1.76

Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: possible involvement of NF-IL6 in acute phase protein gene expression. New Biol (1991) 1.70

Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the rat alpha 2-macroglobulin gene. Proc Natl Acad Sci U S A (1990) 1.66

Synergistic action of interleukin-6 and glucocorticoids is mediated by the interleukin-6 response element of the rat alpha 2 macroglobulin gene. Mol Cell Biol (1992) 1.46

Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation. New Biol (1991) 1.44

Localization of DNA sequences involved in dexamethasone-dependent expression of the rat alpha 1-acid glycoprotein gene. Mol Cell Biol (1986) 1.40

The cytokine response element of the rat alpha 1-acid glycoprotein gene is a complex of several interacting regulatory sequences. Mol Cell Biol (1990) 1.22

Sequences downstream of the glucocorticoid regulatory element mediate cycloheximide inhibition of steroid induced expression from the rat alpha 1-acid glycoprotein promoter: evidence for a labile transcription factor. Mol Endocrinol (1988) 1.13

Interaction of cytokine- and glucocorticoid-response elements of acute-phase plasma protein genes. Importance of glucocorticoid receptor level and cell type for regulation of the elements from rat alpha 1-acid glycoprotein and beta-fibrinogen genes. J Biol Chem (1990) 1.12

Augmentation of haptoglobin production in Hep3B cell line by a nuclear factor NF-IL6. FEBS Lett (1991) 1.10

Multiple elements within the glucocorticoid regulatory unit of the rat alpha 1-acid glycoprotein gene are recognition sites for C/EBP. J Biol Chem (1992) 1.01

AGP/EBP(LAP) expressed in rat hepatoma cells interacts with multiple promoter sites and is necessary for maximal glucocorticoid induction of the rat alpha-1 acid glycoprotein gene. Mol Cell Biol (1991) 0.94

Interleukin 6 response factor binds co-operatively at two adjacent sites in the promoter upstream region of the rat alpha 2-macroglobulin gene. Mol Biol Med (1991) 0.86

Articles by these authors

A Toll-like receptor recognizes bacterial DNA. Nature (2000) 26.34

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell (1997) 18.91

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity (1999) 17.40

Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol (1999) 16.86

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature (2001) 14.24

Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity (1999) 11.64

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature (1996) 10.67

TLR signaling. Cell Death Differ (2006) 9.24

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J (1990) 9.17

Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature (1994) 8.85

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity (1999) 7.90

Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci U S A (1998) 7.69

Toll-like receptors control activation of adaptive immune responses. Nat Immunol (2001) 7.54

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature (1998) 7.38

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A (1997) 7.08

Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med (2000) 6.68

Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol (2000) 6.61

Essential role of Stat6 in IL-4 signalling. Nature (1996) 6.56

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell (1994) 6.45

The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity (1994) 6.18

Structure and function of a new STAT-induced STAT inhibitor. Nature (1997) 6.02

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell (1989) 5.72

Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B-cell activation antigen CD23. Proc Natl Acad Sci U S A (1987) 5.68

Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol (1997) 5.38

Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol (2001) 5.36

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol (2001) 5.27

Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum (2006) 5.20

Biological and clinical aspects of interleukin 6. Immunol Today (1990) 5.17

Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB J (1990) 5.16

Cytokine signal transduction. Cell (1994) 5.14

Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell (1990) 5.06

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci U S A (2001) 5.02

Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. Science (1988) 4.93

Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J Immunol (1998) 4.74

Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity (1998) 4.70

Interleukin-6 family of cytokines and gp130. Blood (1995) 4.52

Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene. EMBO J (1997) 4.51

Induction of direct antimicrobial activity through mammalian toll-like receptors. Science (2001) 4.46

Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell (1995) 4.34

The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J Exp Med (1988) 4.31

Molecular cloning and structure of a pre-B-cell growth-stimulating factor. Proc Natl Acad Sci U S A (1994) 4.25

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci U S A (1993) 4.23

Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol (2000) 4.10

Interleukin-6 in biology and medicine. Adv Immunol (1993) 4.06

IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc Natl Acad Sci U S A (1989) 4.03

Infection with HIV is associated with elevated IL-6 levels and production. J Immunol (1990) 3.89

Limb and skin abnormalities in mice lacking IKKalpha. Science (1999) 3.85

Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene. EMBO J (1987) 3.64

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci U S A (1993) 3.59

IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. J Immunol (1998) 3.56

Interleukin-6 and its receptor: a paradigm for cytokines. Science (1992) 3.51

Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci U S A (2001) 3.49

Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proc Natl Acad Sci U S A (1985) 3.46

Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev Dyn (1999) 3.33

Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family. Proc Natl Acad Sci U S A (1991) 3.31

Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells. J Exp Med (1989) 3.28

Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol (2001) 3.26

Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J (1999) 3.19

Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway. J Immunol (2000) 3.15

IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science (1993) 3.13

IL-6 is required for the development of Th1 cell-mediated murine colitis. J Immunol (2000) 3.08

CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med (2001) 3.05

Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J Immunol (1989) 3.01

LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science (1993) 2.93

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev (1999) 2.91

B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes. J Exp Med (1988) 2.88

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res (1996) 2.86

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol (1999) 2.84

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell (1992) 2.83

Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation. Immunity (2000) 2.81

IL-6 and NF-IL6 in acute-phase response and viral infection. Immunol Rev (1992) 2.80

AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6. Proc Natl Acad Sci U S A (1990) 2.79

Factors affecting B-cell growth and differentiation. Annu Rev Immunol (1985) 2.78

Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum (2002) 2.75

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci U S A (1996) 2.70

Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF. EMBO J (1991) 2.68

Rheumatoid factor secretion from human Leu-1+ B cells. Science (1987) 2.65

STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc Natl Acad Sci U S A (1996) 2.64

Severely reduced production of klotho in human chronic renal failure kidney. Biochem Biophys Res Commun (2001) 2.63

Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6. Blood (1992) 2.62

Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite. J Immunol (2001) 2.60

TLR6: A novel member of an expanding toll-like receptor family. Gene (1999) 2.55

A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc Natl Acad Sci U S A (1992) 2.55