Limb and skin abnormalities in mice lacking IKKalpha.

PubWeight™: 3.85‹?› | Rank: Top 1%

🔗 View Article (PMID 10195895)

Published in Science on April 09, 1999

Authors

K Takeda1, O Takeuchi, T Tsujimura, S Itami, O Adachi, T Kawai, H Sanjo, K Yoshikawa, N Terada, S Akira

Author Affiliations

1: Department of Biochemistry and Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation, Department of Pathology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.

Articles citing this

(truncated to the top 100)

p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev (2004) 6.40

NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev (2012) 5.77

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice. Genes Dev (2000) 4.51

NF-κB in the liver--linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol (2011) 3.28

NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase. Mol Cell Biol (2000) 2.71

The IKK complex, a central regulator of NF-kappaB activation. Cold Spring Harb Perspect Biol (2010) 2.64

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J (2000) 2.48

Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol (2002) 2.45

Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex. Mol Cell Biol (1999) 2.39

Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. Mol Cell Biol (2001) 2.36

p63 induces key target genes required for epidermal morphogenesis. Proc Natl Acad Sci U S A (2007) 2.31

Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest (2005) 2.20

Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I. J Exp Med (2001) 2.07

NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions. Clin Microbiol Rev (2002) 1.97

Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation. Genes Dev (2000) 1.96

Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation. Proc Natl Acad Sci U S A (2003) 1.96

IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program. J Biol Chem (2002) 1.94

NF-kappaB signaling: multiple angles to target OA. Curr Drug Targets (2010) 1.89

SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. EMBO J (2007) 1.87

IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf. Mol Biol Cell (2003) 1.86

NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK. Genes Dev (2004) 1.85

PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex. Mol Cell Biol (2000) 1.82

IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis. J Cell Biol (2008) 1.76

IkappaB kinase alpha is essential for mature B cell development and function. J Exp Med (2001) 1.76

A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity. Br J Pharmacol (2005) 1.73

LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia. Blood (2005) 1.70

New insights into the role of nuclear factor-kappaB in cell growth regulation. Am J Pathol (2001) 1.69

IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation. Proc Natl Acad Sci U S A (2008) 1.66

Transcriptional control of epidermal specification and differentiation. Curr Opin Genet Dev (2004) 1.63

The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol (2002) 1.61

Upregulation of Twist-1 by NF-kappaB blocks cytotoxicity induced by chemotherapeutic drugs. Mol Cell Biol (2007) 1.54

CIKS, a connection to Ikappa B kinase and stress-activated protein kinase. Proc Natl Acad Sci U S A (2000) 1.47

Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions. Mol Cell Biol (2000) 1.46

Signal processing by its coil zipper domain activates IKK gamma. Proc Natl Acad Sci U S A (2008) 1.46

Role of NF-κB in the skeleton. Cell Res (2010) 1.45

Efficient replication by herpes simplex virus type 1 involves activation of the IkappaB kinase-IkappaB-p65 pathway. J Virol (2004) 1.42

Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcription. J Cell Biol (2006) 1.42

NOD mice are defective in proteasome production and activation of NF-kappaB. Mol Cell Biol (1999) 1.41

Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signaling. Mol Cell Biol (2003) 1.41

Nuclear factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium. Mol Biol Cell (2001) 1.40

The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms. Mol Cell Biol (2004) 1.39

A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. Proc Natl Acad Sci U S A (2006) 1.37

Raf induces NF-kappaB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation. Proc Natl Acad Sci U S A (2000) 1.36

Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor kappaB activation in mouse colonocytes. Gastroenterology (1999) 1.35

The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation. Mol Cell Biol (2002) 1.33

NF-kappaB activation by protein kinase C isoforms and B-cell function. EMBO Rep (2003) 1.30

Activation of the NF-kappaB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoter. J Virol (2004) 1.30

Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis [corrected]. J Immunol (2010) 1.27

It's got you covered. NF-kappaB in the epidermis. J Cell Biol (2000) 1.27

IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer. EMBO J (2008) 1.24

IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism. J Cell Biol (2012) 1.23

IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway. PLoS One (2010) 1.22

Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice. Am J Pathol (2005) 1.21

Role of the IkappaB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells. Mol Cell Biol (2000) 1.21

IkappaB kinases: kinsmen with different crafts. Science (1999) 1.19

Novel functions for NFκB: inhibition of bone formation. Nat Rev Rheumatol (2010) 1.19

Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. J Clin Invest (2013) 1.17

IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung. Am J Respir Cell Mol Biol (2008) 1.17

Covering the limb--formation of the integument. J Anat (2003) 1.16

NF-kappaB determines localization and features of cell death in epidermis. J Clin Invest (2000) 1.15

Inhibitory kappa B Kinases as targets for pharmacological regulation. Br J Pharmacol (2012) 1.14

Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming. EMBO J (2014) 1.12

Mutations in RIPK4 cause the autosomal-recessive form of popliteal pterygium syndrome. Am J Hum Genet (2011) 1.11

NIK is involved in nucleosomal regulation by enhancing histone H3 phosphorylation by IKKalpha. J Biol Chem (2006) 1.08

Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers. J Cell Mol Med (2008) 1.08

Receptor-interacting protein (RIP) kinase family. Cell Mol Immunol (2010) 1.07

Activation of NF-kappaB by double-stranded RNA (dsRNA) in the absence of protein kinase R and RNase L demonstrates the existence of two separate dsRNA-triggered antiviral programs. Mol Cell Biol (2001) 1.07

Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation. PLoS One (2010) 1.06

poky/chuk/ikk1 is required for differentiation of the zebrafish embryonic epidermis. Dev Biol (2010) 1.04

Dendritic cells for active anti-cancer immunotherapy: targeting activation pathways through genetic modification. Endocr Metab Immune Disord Drug Targets (2009) 1.01

Interferon regulatory factor 6 is necessary, but not sufficient, for keratinocyte differentiation. J Invest Dermatol (2011) 1.01

Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locus. Am J Hum Genet (2011) 1.00

IKKβ regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways. Nat Commun (2011) 0.99

IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity. Mol Cell Biol (2000) 0.98

IKKα represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin. Cell Death Differ (2011) 0.96

Helicobacter pylori induces IkappaB kinase alpha nuclear translocation and chemokine production in gastric epithelial cells. Infect Immun (2006) 0.96

NIK prevents the development of hypereosinophilic syndrome-like disease in mice independent of IKKα activation. J Immunol (2012) 0.96

The role of nuclear factor-kappaB essential modulator (NEMO) in B cell development and survival. Proc Natl Acad Sci U S A (2003) 0.95

Gene expression profiling in conjunction with physiological rescues of IKKalpha-null cells with wild type or mutant IKKalpha reveals distinct classes of IKKalpha/NF-kappaB-dependent genes. J Biol Chem (2005) 0.95

Poxvirus MC160 protein utilizes multiple mechanisms to inhibit NF-kappaB activation mediated via components of the tumor necrosis factor receptor 1 signal transduction pathway. J Virol (2009) 0.95

The c-Rel subunit of NF-κB regulates epidermal homeostasis and promotes skin fibrosis in mice. Am J Pathol (2013) 0.94

IKK1 control of epidermal differentiation is modulated by notch signaling. Am J Pathol (2011) 0.93

Beyond NF-κB activation: nuclear functions of IκB kinase α. J Biomed Sci (2013) 0.93

FAF1, a gene that is disrupted in cleft palate and has conserved function in zebrafish. Am J Hum Genet (2011) 0.92

Transcriptional induction of ADAMTS5 protein by nuclear factor-κB (NF-κB) family member RelA/p65 in chondrocytes during osteoarthritis development. J Biol Chem (2013) 0.92

Periderm prevents pathological epithelial adhesions during embryogenesis. J Clin Invest (2014) 0.91

Non-Canonical NF-κB Signaling Initiated by BAFF Influences B Cell Biology at Multiple Junctures. Front Immunol (2014) 0.91

Tumor necrosis factor alpha induction of NF-kappaB requires the novel coactivator SIMPL. Mol Cell Biol (2004) 0.90

Transcriptional regulation of cytokine function in airway smooth muscle cells. Pulm Pharmacol Ther (2009) 0.90

IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling. Mol Cell Biol (2012) 0.89

Phosphorylation and stabilization of TAp63gamma by IkappaB kinase-beta. J Biol Chem (2008) 0.89

Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription. Mol Cell Biol (2004) 0.88

Recent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies. J Cell Mol Med (2009) 0.88

Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice. Blood Cancer J (2013) 0.88

Tumor necrosis factor-alpha promotes survival of opossum kidney cells via Cdc42-induced phospholipase C-gamma1 activation and actin filament redistribution. Mol Biol Cell (2003) 0.87

Gene therapy targeting nuclear factor-kappaB: towards clinical application in inflammatory diseases and cancer. Curr Gene Ther (2009) 0.86

A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity. J Biol Chem (2011) 0.86

Caspase inhibition sensitizes inhibitor of NF-kappaB kinase beta-deficient fibroblasts to caspase-independent cell death via the generation of reactive oxygen species. J Biol Chem (2007) 0.85

Genetic heterogeneity of skin microvasculature. Dev Biol (2010) 0.85

Inhibition of human immunodeficiency virus type 1 replication in latently infected cells by a novel IkappaB kinase inhibitor. Antimicrob Agents Chemother (2006) 0.85

Articles by these authors

A Toll-like receptor recognizes bacterial DNA. Nature (2000) 26.34

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity (1999) 17.40

Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol (1999) 16.86

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature (2001) 14.24

Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity (1999) 11.64

TLR signaling. Cell Death Differ (2006) 9.24

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity (1999) 7.90

Toll-like receptors control activation of adaptive immune responses. Nat Immunol (2001) 7.54

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A (1997) 7.08

Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol (2000) 6.61

Essential role of Stat6 in IL-4 signalling. Nature (1996) 6.56

Structure and function of a new STAT-induced STAT inhibitor. Nature (1997) 6.02

Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol (2001) 5.36

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol (2001) 5.27

Biological and clinical aspects of interleukin 6. Immunol Today (1990) 5.17

Cytokine signal transduction. Cell (1994) 5.14

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci U S A (2001) 5.02

Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J Immunol (1998) 4.74

Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity (1998) 4.70

Interleukin-6 family of cytokines and gp130. Blood (1995) 4.52

Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene. EMBO J (1997) 4.51

Induction of direct antimicrobial activity through mammalian toll-like receptors. Science (2001) 4.46

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J (2001) 4.40

Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell (1995) 4.34

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci U S A (1993) 4.23

Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol (2000) 4.10

IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc Natl Acad Sci U S A (1989) 4.03

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci U S A (1993) 3.59

Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest (1993) 3.57

IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. J Immunol (1998) 3.56

Interleukin-6 and its receptor: a paradigm for cytokines. Science (1992) 3.51

Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci U S A (2001) 3.49

Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation: in vivo and in vitro analyses. Am J Transplant (2006) 3.34

Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol (2001) 3.26

Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J (1999) 3.19

Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway. J Immunol (2000) 3.15

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci U S A (2001) 3.11

CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med (2001) 3.05

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev (1999) 2.91

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol (1999) 2.84

Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation. Immunity (2000) 2.81

STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc Natl Acad Sci U S A (1996) 2.64

Univalent reduction of molecular oxygen by spinach chloroplasts on illumination. J Biol Chem (1974) 2.63

Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6. Blood (1992) 2.62

Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand. Nat Med (2000) 2.61

Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite. J Immunol (2001) 2.60

TLR6: A novel member of an expanding toll-like receptor family. Gene (1999) 2.55

A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc Natl Acad Sci U S A (1992) 2.55

Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Lett (1996) 2.53

Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J Immunol (2000) 2.41

Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene. Mol Cell Biol (1990) 2.41

Production of human alpha-interferon in silkworm using a baculovirus vector. Nature (1985) 2.37

TLR engagement prevents transplantation tolerance. Am J Transplant (2006) 2.36

Toll-like receptors; their physiological role and signal transduction system. Int Immunopharmacol (2001) 2.36

IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. Proc Natl Acad Sci U S A (1999) 2.35

The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function. J Exp Med (1999) 2.32

Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice. Trends Immunol (2001) 2.29

Crystallization of a poly(ethylene-co-octene): I. A precursor structure and two competing mechanisms. Eur Phys J E Soft Matter (2005) 2.17

Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J Exp Med (2000) 2.16

Superoxide dismutases from a blue-green alga, Plectonema boryanum. J Biol Chem (1975) 2.11

Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling. EMBO J (1993) 2.11

NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A. J Virol (1992) 2.10

Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptors. Infect Immun (2000) 2.10

Coudability hairs: a revisited sign of alopecia areata assessed by trichoscopy. Clin Exp Dermatol (2009) 2.08

Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation. J Biol Chem (1999) 2.08

Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I. J Exp Med (2001) 2.07

Native portal vein embolization for persistent hyperoxaluria following kidney and auxiliary partial liver transplantation. Am J Transplant (2013) 2.05

Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes Cells (2000) 2.05