Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2.

PubWeight™: 3.23‹?› | Rank: Top 1%

🔗 View Article (PMC 2193345)

Published in J Exp Med on January 15, 2001

Authors

H Hirai1, K Tanaka, O Yoshie, K Ogawa, K Kenmotsu, Y Takamori, M Ichimasa, K Sugamura, M Nakamura, S Takano, K Nagata

Author Affiliations

1: R&D Center, BML, Saitama 350-1101, Japan.

Articles citing this

(truncated to the top 100)

Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol (2011) 4.67

Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Invest (2001) 2.86

Genetic and pharmacological analysis of prostanoid receptor function. J Clin Invest (2001) 2.19

Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med (2013) 2.01

Role of the parasite-derived prostaglandin D2 in the inhibition of epidermal Langerhans cell migration during schistosomiasis infection. J Exp Med (2001) 1.79

Biology of the eosinophil. Adv Immunol (2009) 1.74

Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis. Chem Rev (2011) 1.67

The diverse roles of mast cells. J Exp Med (2001) 1.61

T cell homing to epithelial barriers in allergic disease. Nat Med (2012) 1.58

Novel cannabinoid receptors. Br J Pharmacol (2007) 1.55

Protective and pathological roles of mast cells and basophils. Nat Rev Immunol (2013) 1.54

Endothelium-mediated control of vascular tone: COX-1 and COX-2 products. Br J Pharmacol (2011) 1.51

Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. EMBO J (2005) 1.49

Targeting eosinophils in allergy, inflammation and beyond. Nat Rev Drug Discov (2013) 1.47

NF-κB hyperactivation in tumor tissues allows tumor-selective reprogramming of the chemokine microenvironment to enhance the recruitment of cytolytic T effector cells. Cancer Res (2012) 1.46

Platelets in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol (2015) 1.46

Eosinophils: multifaceted biological properties and roles in health and disease. Immunol Rev (2011) 1.45

Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci U S A (2006) 1.44

Involvement of cyclooxygenase-2 and prostaglandins in the molecular pathogenesis of inflammatory lung diseases. Am J Physiol Lung Cell Mol Physiol (2006) 1.40

Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development. Gut (2004) 1.39

Mechanisms of eosinophilia in the pathogenesis of hypereosinophilic disorders. Immunol Allergy Clin North Am (2007) 1.37

A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q. BMC Genet (2006) 1.33

Prostanoid receptor antagonists: development strategies and therapeutic applications. Br J Pharmacol (2009) 1.31

The basophil activation test by flow cytometry: recent developments in clinical studies, standardization and emerging perspectives. Clin Mol Allergy (2005) 1.28

Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. J Biol Chem (2008) 1.25

Omega-3 Fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment. PLoS Biol (2009) 1.22

The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses. Br J Pharmacol (2007) 1.21

TSG-6 protein is crucial for the development of pulmonary hyaluronan deposition, eosinophilia, and airway hyperresponsiveness in a murine model of asthma. J Biol Chem (2012) 1.18

GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist. Br J Pharmacol (2006) 1.17

Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation. Respir Res (2007) 1.15

Identification and characterization of an endogenous chemotactic ligand specific for FPRL2. J Exp Med (2004) 1.14

Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. Proc Natl Acad Sci U S A (2001) 1.14

Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers. Inflammation (2010) 1.13

Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol (2002) 1.13

Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine. J Exp Med (2003) 1.12

High-quality crystals of human haematopoietic prostaglandin D synthase with novel inhibitors. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 1.11

Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis. J Allergy Clin Immunol (2013) 1.11

Augmentation of allergic inflammation in prostanoid IP receptor deficient mice. Br J Pharmacol (2002) 1.09

Mast cell function: a new vision of an old cell. J Histochem Cytochem (2014) 1.08

Mast cell chemotaxis - chemoattractants and signaling pathways. Front Immunol (2012) 1.07

Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis. J Immunol (2011) 1.03

Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement. Proc Natl Acad Sci U S A (2013) 1.03

Prostaglandin D₂: a dominant mediator of aspirin-exacerbated respiratory disease. J Allergy Clin Immunol (2014) 1.02

Resolution of inflammation in asthma. Clin Chest Med (2012) 1.02

Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44. J Invest Dermatol (2012) 1.01

Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy. Front Oncol (2013) 0.99

Non-steroid anti-inflammatory drugs, prostaglandins, and cancer. Cell Biosci (2013) 0.99

Prostaglandin D₂ and T(H)2 inflammation in the pathogenesis of bronchial asthma. Korean J Intern Med (2011) 0.98

A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. Int Immunol (2008) 0.98

PPAR and immune system--what do we know? Int Immunopharmacol (2002) 0.97

Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2. Arthritis Rheum (2008) 0.95

Eosinophils in human oral squamous carcinoma; role of prostaglandin D2. J Inflamm (Lond) (2013) 0.94

Dendritic cells express hematopoietic prostaglandin D synthase and function as a source of prostaglandin D2 in the skin. Am J Pathol (2009) 0.94

Unraveling the genetic basis of aspirin hypersensitivity in asthma beyond arachidonate pathways. Allergy Asthma Immunol Res (2013) 0.93

Group 2 innate lymphoid cells: new players in human allergic diseases. J Investig Allergol Clin Immunol (2015) 0.92

CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation. Am J Physiol Lung Cell Mol Physiol (2008) 0.92

Human basophils express amphiregulin in response to T cell-derived IL-3. J Allergy Clin Immunol (2010) 0.92

Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy. Biochem J (2010) 0.92

A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants. Immunology (2006) 0.92

Lipocalin-prostaglandin D synthase is a critical beneficial factor in transient and permanent focal cerebral ischemia. Neuroscience (2009) 0.91

Prostanoid signaling: dual role for prostaglandin E2 in neurotoxicity. Neurotoxicology (2011) 0.91

The prostaglandin D2 receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung. Mucosal Immunol (2015) 0.91

Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease. J Biol Chem (2010) 0.91

Eosinophils as a novel cell source of prostaglandin D2: autocrine role in allergic inflammation. J Immunol (2011) 0.91

Putative role of prostaglandin receptor in intracerebral hemorrhage. Front Neurol (2012) 0.90

CRTH2 expression on T cells in asthma. Clin Exp Immunol (2010) 0.90

Prostaglandin D2 DP1 receptor is beneficial in ischemic stroke and in acute exicitotoxicity in young and old mice. Age (Dordr) (2010) 0.89

Chitin particles induce size-dependent but carbohydrate-independent innate eosinophilia. J Leukoc Biol (2011) 0.89

Physiology and pathophysiology of prostanoid receptors. Proc Jpn Acad Ser B Phys Biol Sci (2007) 0.89

IgE-dependent enhancement of Th2 cell-mediated allergic inflammation in the airways. Clin Exp Immunol (2004) 0.88

Polyunsaturated Fatty Acid-derived lipid mediators and T cell function. Front Immunol (2014) 0.88

Pathogenesis of aspirin-exacerbated respiratory disease and reactions. Immunol Allergy Clin North Am (2012) 0.88

A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D2. Infect Immun (2003) 0.88

At the bench: understanding group 2 innate lymphoid cells in disease. J Leukoc Biol (2014) 0.87

Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells. Clin Exp Immunol (2009) 0.87

Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. PLoS One (2013) 0.87

The prostaglandin D₂ receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge. J Allergy Clin Immunol (2010) 0.87

FcεRI, but not FcγR, signals induce prostaglandin D2 and E2 production from basophils. Am J Pathol (2011) 0.87

Proinflammatory and immunoregulatory roles of eicosanoids in T cells. Front Immunol (2013) 0.87

The role of prostaglandins in allergic lung inflammation and asthma. Expert Rev Respir Med (2014) 0.87

The contribution of the genomes of a termite and a locust to our understanding of insect neuropeptides and neurohormones. Front Physiol (2014) 0.87

Leukotriene E4 activates human Th2 cells for exaggerated proinflammatory cytokine production in response to prostaglandin D2. J Immunol (2011) 0.86

Inhibition of prostaglandin D synthase suppresses muscular necrosis. Am J Pathol (2009) 0.86

Piglet saphenous vein contains multiple relaxatory prostanoid receptors: evidence for EP4, EP2, DP and IP receptor subtypes. Br J Pharmacol (2005) 0.86

Growth, phenotype, and function of human intestinal mast cells are tightly regulated by transforming growth factor beta1. Gut (2005) 0.86

Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms. Int Immunol (2008) 0.86

CRTH2 is a critical regulator of neutrophil migration and resistance to polymicrobial sepsis. J Immunol (2012) 0.86

Biochemical, functional, and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase. J Biol Chem (2009) 0.85

Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2. Am J Pathol (2011) 0.85

Prostaglandins and rheumatoid arthritis. Arthritis (2012) 0.85

Seeing the future of bioactive lipid drug targets. Nat Chem Biol (2010) 0.84

Prostaglandin D2 and leukotriene E4 synergize to stimulate diverse TH2 functions and TH2 cell/neutrophil crosstalk. J Allergy Clin Immunol (2014) 0.84

A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes. Immunology (2007) 0.83

Cyclooxygenase-2 in newborn hyperoxic lung injury. Free Radic Biol Med (2013) 0.83

Lipid mediator metabolic profiling demonstrates differences in eicosanoid patterns in two phenotypically distinct mast cell populations. J Lipid Res (2012) 0.83

Cerebral arachidonate cascade in dementia: Alzheimer's disease and vascular dementia. Curr Neuropharmacol (2006) 0.83

Evidence for asthma susceptibility genes on chromosome 11 in an African-American population. Hum Genet (2003) 0.82

Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage. Arthritis Res Ther (2008) 0.82

Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol (2015) 0.81

PGD2-CRTH2 pathway promotes tubulointerstitial fibrosis. J Am Soc Nephrol (2012) 0.81

Articles cited by this

Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell (1994) 27.85

Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med (1992) 11.90

Prostanoid receptors: structures, properties, and functions. Physiol Rev (1999) 8.60

The molecular biology of leukocyte chemoattractant receptors. Annu Rev Immunol (1994) 6.82

Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol Today (1998) 4.21

Prostaglandin D2 as a mediator of allergic asthma. Science (2000) 3.19

Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int Immunol (1999) 2.96

Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE. J Immunol (1982) 2.69

Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. J Exp Med (1994) 2.38

A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med (2000) 2.30

Selective expression of a novel surface molecule by human Th2 cells in vivo. J Immunol (1999) 2.07

CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease. Eur J Immunol (2000) 1.96

Molecular cloning and characterization of the human prostanoid DP receptor. J Biol Chem (1995) 1.61

CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett (1999) 1.57

Mediators of inflammation. Annu Rev Immunol (1983) 1.43

The biology and pharmacology of PGD2. Prostaglandins (1988) 1.42

Different responsiveness of prostaglandin D2-sensitive systems to prostaglandin D2 and its analogues. Br J Pharmacol (1985) 1.36

Cutaneous late-phase response to allergen. Mediator release and inflammatory cell infiltration. J Clin Invest (1989) 1.23

Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol (1998) 1.08

Specific binding of prostaglandin D2 to rat brain synaptic membrane. Occurrence, properties, and distribution. J Biol Chem (1982) 1.07

Prostaglandin D2 causes accumulation of eosinophils in the lumen of the dog trachea. J Appl Physiol (1985) (1989) 0.99

Effects of a selective DP receptor agonist (BW 245C) and antagonist (BW A868C) on the canine colonic epithelium: an argument for a different DP receptor? J Pharmacol Exp Ther (1995) 0.95

Biological activity of metabolites of PGD2 on canine proximal colon. Am J Physiol (1993) 0.94

Studies on the ocular pharmacology of prostaglandin D2. Invest Ophthalmol Vis Sci (1990) 0.91

Prostaglandin D2 modulates human neutrophil intracellular calcium flux and inhibits superoxide release via its ring carbonyl. Life Sci (1990) 0.87

Vasodilation in multistep paradigm of leucocyte extravasation. Lancet (1994) 0.86

Articles by these authors

(truncated to the top 100)

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79

Antisense transcription in the mammalian transcriptome. Science (2005) 15.69

Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci U S A (1981) 11.92

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. Antimicrob Agents Chemother (1990) 11.71

Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem (1996) 10.70

Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature (1981) 9.25

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet (2000) 7.83

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature (1998) 7.30

Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor. Nature (1979) 6.56

T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature (2000) 6.49

Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli. Antimicrob Agents Chemother (1991) 6.19

SLAM (CDw150) is a cellular receptor for measles virus. Nature (2000) 6.07

A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhIR (VsmR) to expression of the stationary-phase sigma factor RpoS. Mol Microbiol (1996) 6.07

Specific binding of a cellular DNA replication protein to the origin of replication of adenovirus DNA. Proc Natl Acad Sci U S A (1983) 5.21

High-frequency transformation method and library transducing vectors for cloning mammalian cDNAs by trans-complementation of Schizosaccharomyces pombe. Nucleic Acids Res (1990) 5.00

The role of exon sequences in splice site selection. Genes Dev (1993) 4.86

Adenovirus DNA replication in vitro: identification of a host factor that stimulates synthesis of the preterminal protein-dCMP complex. Proc Natl Acad Sci U S A (1982) 4.72

Cloning of the gamma chain of the human IL-2 receptor. Science (1992) 4.50

Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination. Nature (1992) 4.43

Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science (1993) 4.39

Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. Infect Immun (1995) 4.28

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J Biol Chem (2001) 4.22

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. J Cell Biol (1998) 3.72

gyrA and gyrB mutations in quinolone-resistant strains of Escherichia coli. Antimicrob Agents Chemother (1989) 3.67

Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis. Brain (2007) 3.64

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell (1990) 3.56

Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials. Spinal Cord (2006) 3.55

On the process of cellular division in Escherichia coli: nucleotide sequence of the gene for penicillin-binding protein 3. Mol Gen Genet (1983) 3.43

Rho1p, a yeast protein at the interface between cell polarization and morphogenesis. Science (1996) 3.42

Rifampicin resistance and mutation of the rpoB gene in Mycobacterium tuberculosis. FEMS Microbiol Lett (1996) 3.40

Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway. Cancer Res (1996) 3.37

Report on 640 victims of the Tokyo subway sarin attack. Ann Emerg Med (1996) 3.34

Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer. Nat Genet (1997) 3.34

The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol (1997) 3.33

Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology (1996) 3.30

Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat Cell Biol (2001) 3.26

RNA polymerase of influenza virus: role of NP in RNA chain elongation. J Biochem (1988) 3.23

A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae. EMBO J (1995) 3.20

The fission yeast gamma-tubulin is essential for mitosis and is localized at microtubule organizing centers. J Cell Sci (1991) 3.20

Depletion of CD4(+) T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon gamma and nitric oxide synthase 2. J Exp Med (2000) 3.20

CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein. EMBO Rep (2001) 3.19

Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation. J Biol Chem (2000) 3.15

Light-dependent translocation of a phytochrome B-GFP fusion protein to the nucleus in transgenic Arabidopsis. J Cell Biol (1999) 3.14

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem (2000) 2.99

Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol (1999) 2.99

Diet-dependent shifts in the bacterial population of the rumen revealed with real-time PCR. Appl Environ Microbiol (2001) 2.98

Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses. Genes Dev (2001) 2.96

A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation. EMBO Rep (2001) 2.96

Antigen-induced T cell-replacing factor (TRF). III. Establishment of T cell hybrid clone continuously producing TRF and functional analysis of released TRF. J Immunol (1980) 2.95

Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. EMBO J (1994) 2.94

NEDD8 recruits E2-ubiquitin to SCF E3 ligase. EMBO J (2001) 2.94

Columns for visual features of objects in monkey inferotemporal cortex. Nature (1992) 2.93

A class-wide phylogenetic assessment of Dothideomycetes. Stud Mycol (2009) 2.91

Neuronal selectivities to complex object features in the ventral visual pathway of the macaque cerebral cortex. J Neurophysiol (1994) 2.87

Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J (1996) 2.87

A new NEDD8-ligating system for cullin-4A. Genes Dev (1998) 2.82

Bni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae. EMBO J (1997) 2.80

Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes. Science (1994) 2.78

Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J (1996) 2.76

Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1+ B-cell subset. Science (1987) 2.75

Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae. J Cell Biol (1994) 2.74

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci U S A (1996) 2.70

Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature (1996) 2.70

Covalent modification of all members of human cullin family proteins by NEDD8. Oncogene (1999) 2.67

Portal vein anomaly associated with deviation of the ligamentum teres to the right and malposition of the gallbladder. Radiology (1998) 2.62

Impact of graft size mismatching on graft prognosis in liver transplantation from living donors. Transplantation (1999) 2.61

Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res (1994) 2.61

Rapid focus reduction neutralization test of influenza A and B viruses in microtiter system. J Clin Microbiol (1990) 2.60

Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteins. Mol Gen Genet (1973) 2.59

Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran. Science (1999) 2.59

Adenovirus DNA replication in vitro: synthesis of full-length DNA with purified proteins. Proc Natl Acad Sci U S A (1983) 2.58

Microsatellite instability in acute myelocytic leukaemia developed from A-bomb survivors. Int J Radiat Biol (2001) 2.54

Rho as a regulator of the cytoskeleton. Trends Biochem Sci (1995) 2.52

Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain. Stroke (2001) 2.51

Molecular analysis of the Escherichia coli hns gene encoding a DNA-binding protein, which preferentially recognizes curved DNA sequences. Mol Gen Genet (1991) 2.50

The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu Rev Immunol (1996) 2.50

Mechanism of action of quinolones against Escherichia coli DNA gyrase. Antimicrob Agents Chemother (1993) 2.48

High-titer human immunodeficiency virus type 1-based vector systems for gene delivery into nondividing cells. J Virol (1998) 2.47

Expression of H-2Dd and H-2Ld mouse major histocompatibility antigen genes in L cells after DNA-mediated gene transfer. J Immunol (1983) 2.45

Nucleotide sequence of the asnA gene coding for asparagine synthetase of E. coli K-12. Nucleic Acids Res (1981) 2.42

Location of functional regions of acetylcholine receptor alpha-subunit by site-directed mutagenesis. Nature (1985) 2.40

Ampulla cardiomyopathy ('Takotusbo' cardiomyopathy)--reversible left ventricular dysfunction: with ST segment elevation. Jpn Circ J (2000) 2.39

Size and position invariance of neuronal responses in monkey inferotemporal cortex. J Neurophysiol (1995) 2.39

Human ocular dominance columns as revealed by high-field functional magnetic resonance imaging. Neuron (2001) 2.38

Structure of the 5' upstream region and the regulation of the rpoS gene of Escherichia coli. Mol Gen Genet (1994) 2.38

CDC33 encodes mRNA cap-binding protein eIF-4E of Saccharomyces cerevisiae. Mol Cell Biol (1988) 2.33

Cellular splicing factor RAF-2p48/NPI-5/BAT1/UAP56 interacts with the influenza virus nucleoprotein and enhances viral RNA synthesis. J Virol (2001) 2.33

The fission yeast cut1+ gene regulates spindle pole body duplication and has homology to the budding yeast ESP1 gene. Cell (1990) 2.32

Reproducible establishment of hemopoietic supportive stromal cell lines from murine bone marrow. Exp Hematol (1989) 2.31

Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome. J Biol Chem (1999) 2.30

Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures. Spinal Cord (2006) 2.28

Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung. Nature (1991) 2.28

Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme. J Biol Chem (1985) 2.27

Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast. EMBO J (2000) 2.27

Isolation and characterization of a novel actin filament-binding protein from Saccharomyces cerevisiae. Oncogene (1998) 2.27

The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice. J Cell Biol (2001) 2.26

Embryonic lethality of molecular chaperone hsp47 knockout mice is associated with defects in collagen biosynthesis. J Cell Biol (2000) 2.24

The Saccharomyces cerevisiae genes (CMP1 and CMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B. Mol Gen Genet (1991) 2.23

Reversal of oncogenesis by the expression of a major histocompatibility complex class I gene. Science (1985) 2.22

Host range of human T-cell leukemia virus type I analyzed by a cell fusion-dependent reporter gene activation assay. Virology (1999) 2.21