Published in Genes Dev on March 01, 1993
Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes Dev (1998) 5.79
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The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities. EMBO J (1995) 4.66
SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex. Mol Cell Biol (1994) 4.25
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The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element. Mol Cell Biol (1993) 3.48
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Identification of a new class of exonic splicing enhancers by in vivo selection. Mol Cell Biol (1997) 3.36
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A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer. Mol Cell Biol (1995) 3.18
Polypurine sequences within a downstream exon function as a splicing enhancer. Mol Cell Biol (1994) 3.15
Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Mol Cell Biol (2000) 3.01
Phosphorylated RNA polymerase II stimulates pre-mRNA splicing. Genes Dev (1999) 3.00
Multiple splicing defects in an intronic false exon. Mol Cell Biol (2000) 2.97
Golgi vesiculation and lysosome dispersion in cells lacking cytoplasmic dynein. J Cell Biol (1998) 2.87
A novel bipartite splicing enhancer modulates the differential processing of the human fibronectin EDA exon. Nucleic Acids Res (1994) 2.80
Multiple distinct splicing enhancers in the protein-coding sequences of a constitutively spliced pre-mRNA. Mol Cell Biol (1999) 2.72
Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene. Genes Dev (1999) 2.69
A complex intronic splicing enhancer from the c-src pre-mRNA activates inclusion of a heterologous exon. Mol Cell Biol (1997) 2.66
A nonsense mutation in the fibrillin-1 gene of a Marfan syndrome patient induces NMD and disrupts an exonic splicing enhancer. Genes Dev (2002) 2.61
Presence of exon splicing silencers within human immunodeficiency virus type 1 tat exon 2 and tat-rev exon 3: evidence for inhibition mediated by cellular factors. Mol Cell Biol (1995) 2.51
Pre-mRNA splicing of IgM exons M1 and M2 is directed by a juxtaposed splicing enhancer and inhibitor. Genes Dev (1999) 2.42
Sequence information for the splicing of human pre-mRNA identified by support vector machine classification. Genome Res (2003) 2.42
Presence of negative and positive cis-acting RNA splicing elements within and flanking the first tat coding exon of human immunodeficiency virus type 1. Mol Cell Biol (1994) 2.35
Exon and intron sequences, respectively, repress and activate splicing of a fibroblast growth factor receptor 2 alternative exon. Mol Cell Biol (1995) 2.34
Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer. Proc Natl Acad Sci U S A (1997) 2.34
Selection of novel exon recognition elements from a pool of random sequences. Mol Cell Biol (1995) 2.27
Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements. Proc Natl Acad Sci U S A (1999) 2.26
The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites. Proc Natl Acad Sci U S A (1994) 2.14
Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17. Proc Natl Acad Sci U S A (1998) 2.13
Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping. Mol Cell Biol (1994) 2.13
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A 32-nucleotide exon-splicing enhancer regulates usage of competing 5' splice sites in a differential internal exon. Mol Cell Biol (1995) 1.92
Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon. EMBO J (1994) 1.91
The tat/rev intron of human immunodeficiency virus type 1 is inefficiently spliced because of suboptimal signals in the 3' splice site. J Virol (1994) 1.87
Order of intron removal during splicing of endogenous adenine phosphoribosyltransferase and dihydrofolate reductase pre-mRNA. Mol Cell Biol (1993) 1.85
The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the beta-tropomyosin alternative exon 6A. EMBO J (1997) 1.84
Molecular biology of borna disease virus: prototype of a new group of animal viruses. J Virol (1994) 1.83
Multiple interdependent sequence elements control splicing of a fibroblast growth factor receptor 2 alternative exon. Mol Cell Biol (1997) 1.83
Natural trans-splicing in carnitine octanoyltransferase pre-mRNAs in rat liver. Proc Natl Acad Sci U S A (1998) 1.83
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Control of calcitonin/calcitonin gene-related peptide pre-mRNA processing by constitutive intron and exon elements. Mol Cell Biol (1993) 1.76
The role of U2AF35 and U2AF65 in enhancer-dependent splicing. RNA (2001) 1.76
Conserved intron elements repress splicing of a neuron-specific c-src exon in vitro. Mol Cell Biol (1995) 1.75
An intronic splicing enhancer binds U1 snRNPs to enhance splicing and select 5' splice sites. Mol Cell Biol (2000) 1.75
Human genomic sequences that inhibit splicing. Mol Cell Biol (2000) 1.73
The hnRNP A1 protein regulates HIV-1 tat splicing via a novel intron silencer element. EMBO J (2001) 1.70
An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing. Mol Cell Biol (1998) 1.64
Two different sequence elements within exon 4 are necessary for calcitonin-specific splicing of the human calcitonin/calcitonin gene-related peptide I pre-mRNA. Mol Cell Biol (1994) 1.64
Modulation of 5' splice site choice in pre-messenger RNA by two distinct steps. Proc Natl Acad Sci U S A (1995) 1.58
Pre-mRNA splicing in the absence of an SR protein RS domain. Genes Dev (2000) 1.58
Identification of a bidirectional splicing enhancer: differential involvement of SR proteins in 5' or 3' splice site activation. Mol Cell Biol (1999) 1.52
A sequence compilation and comparison of exons that are alternatively spliced in neurons. Nucleic Acids Res (1994) 1.50
Enhancer-dependent interaction between 5' and 3' splice sites in trans. Proc Natl Acad Sci U S A (1995) 1.46
Loss of exon identity is a common mechanism of human inherited disease. Genome Res (2011) 1.44
Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation. Mol Cell Biol (2003) 1.44
Control of BEK and K-SAM splice sites in alternative splicing of the fibroblast growth factor receptor 2 pre-mRNA. Mol Cell Biol (1993) 1.41
A single-base-pair deletion in the beta-glucuronidase gene accounts for the phenotype of murine mucopolysaccharidosis type VII. Proc Natl Acad Sci U S A (1993) 1.40
Selection of the bovine papillomavirus type 1 nucleotide 3225 3' splice site is regulated through an exonic splicing enhancer and its juxtaposed exonic splicing suppressor. J Virol (1996) 1.39
Molecular genetic dissection of mouse unconventional myosin-VA: tail region mutations. Genetics (1998) 1.38
A pyrimidine-rich exonic splicing suppressor binds multiple RNA splicing factors and inhibits spliceosome assembly. Proc Natl Acad Sci U S A (1998) 1.37
Evidence for substrate-specific requirement of the splicing factor U2AF(35) and for its function after polypyrimidine tract recognition by U2AF(65). Mol Cell Biol (1999) 1.35
A bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates human immunodeficiency virus type 1 rev, env, vpu, and nef gene expression. J Virol (2004) 1.35
MutPred Splice: machine learning-based prediction of exonic variants that disrupt splicing. Genome Biol (2014) 1.32
Antagonism between RSF1 and SR proteins for both splice-site recognition in vitro and Drosophila development. Genes Dev (1999) 1.31
A naturally arising mutation of a potential silencer of exon splicing in human immunodeficiency virus type 1 induces dominant aberrant splicing and arrests virus production. J Virol (1997) 1.31
Interactions among SR proteins, an exonic splicing enhancer, and a lentivirus Rev protein regulate alternative splicing. Mol Cell Biol (1996) 1.29
Characterization of RNA binding specificity of the Drosophila sex-lethal protein by in vitro ligand selection. Nucleic Acids Res (1994) 1.28
Disruption of the splicing enhancer sequence within exon 27 of the dystrophin gene by a nonsense mutation induces partial skipping of the exon and is responsible for Becker muscular dystrophy. J Clin Invest (1997) 1.27
The impact of multiple splice sites in human L1 elements. Gene (2008) 1.26
Accumulation of a novel spliceosomal complex on pre-mRNAs containing branch site mutations. Mol Cell Biol (1995) 1.24
Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing. Proc Natl Acad Sci U S A (1999) 1.23
Caspase-2 pre-mRNA alternative splicing: Identification of an intronic element containing a decoy 3' acceptor site. Proc Natl Acad Sci U S A (2001) 1.22
Dual function for U2AF(35) in AG-dependent pre-mRNA splicing. Mol Cell Biol (2001) 1.21
Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch. EMBO J (2002) 1.19
Specific SR protein-dependent splicing substrates identified through genomic SELEX. Nucleic Acids Res (2003) 1.18
Comparison of intron-containing and intron-lacking human genes elucidates putative exonic splicing enhancers. Nucleic Acids Res (2001) 1.18
Trans-acting factors regulate the expression of CD44 splice variants. EMBO J (1996) 1.15
A single polypyrimidine tract binding protein (PTB) binding site mediates splicing inhibition at mouse IgM exons M1 and M2. RNA (2004) 1.14
B-cell and plasma-cell splicing differences: a potential role in regulated immunoglobulin RNA processing. RNA (2003) 1.12
Exon size affects competition between splicing and cleavage-polyadenylation in the immunoglobulin mu gene. Mol Cell Biol (1994) 1.11
SR proteins are sufficient for exon bridging across an intron. Proc Natl Acad Sci U S A (1998) 1.10
Structural, functional, and protein binding analyses of bovine papillomavirus type 1 exonic splicing enhancers. J Virol (1997) 1.09
Congenital end-plate acetylcholinesterase deficiency caused by a nonsense mutation and an A-->G splice-donor-site mutation at position +3 of the collagenlike-tail-subunit gene (COLQ): how does G at position +3 result in aberrant splicing? Am J Hum Genet (1999) 1.08
Identification and characterization by antisense oligonucleotides of exon and intron sequences required for splicing. Mol Cell Biol (1994) 1.08
A short sequence within two purine-rich enhancers determines 5' splice site specificity. Mol Cell Biol (1998) 1.08
Intronic and exonic sequences modulate 5' splice site selection in plant nuclei. Nucleic Acids Res (1997) 1.07
The conserved RNA recognition motif 3 of U2 snRNA auxiliary factor (U2AF 65) is essential in vivo but dispensable for activity in vitro. RNA (2004) 1.06
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