Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.

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Published in RNA on April 01, 1998

Authors

A Hanamura1, J F Cáceres, A Mayeda, B R Franza, A R Krainer

Author Affiliations

1: Cold Spring Harbor Laboratory, New York 11724-2208, USA.

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Stimulation of the human immunodeficiency virus type 1 enhancer by the human T-cell leukemia virus type I tax gene product involves the action of inducible cellular proteins. J Virol (1989) 1.49

A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs. RNA (1997) 1.43

An in vitro transcription analysis of early responses of the human immunodeficiency virus type 1 long terminal repeat to different transcriptional activators. Mol Cell Biol (1991) 1.42

Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway. RNA (2001) 1.42

RNA splicing at human immunodeficiency virus type 1 3' splice site A2 is regulated by binding of hnRNP A/B proteins to an exonic splicing silencer element. J Virol (2001) 1.41

The intracisternal A-particle proximal enhancer-binding protein activates transcription and is identical to the RNA- and DNA-binding protein p54nrb/NonO. Mol Cell Biol (1997) 1.41

Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs. Structure (1997) 1.40

Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription. Proc Natl Acad Sci U S A (1992) 1.40

Casein kinase II phosphorylates p34cdc2 kinase in G1 phase of the HeLa cell division cycle. J Biol Chem (1992) 1.38

A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor. Genes Dev (1997) 1.36

The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins. EMBO J (2001) 1.36

RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A. EMBO J (1995) 1.34

Molecular studies of HHV-6. J Virol Methods (1988) 1.32

Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 3, 5, 15, 16, 17, and 22. Am J Med Genet (1997) 1.30