WW6: an embryonic stem cell line with an inert genetic marker that can be traced in chimeras.

PubWeight™: 1.56‹?› | Rank: Top 4%

🔗 View Article (PMC 41338)

Published in Proc Natl Acad Sci U S A on August 01, 1995

Authors

E Ioffe1, Y Liu, M Bhaumik, F Poirier, S M Factor, P Stanley

Author Affiliations

1: Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Articles citing this

Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways. Proc Natl Acad Sci U S A (2003) 2.69

H1 linker histones are essential for mouse development and affect nucleosome spacing in vivo. Mol Cell Biol (2003) 2.29

Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration. J Exp Med (1999) 2.21

Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae. Mol Cell Biol (2002) 1.93

Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PLoS Genet (2006) 1.86

Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol Cell Biol (2006) 1.82

Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation. Proc Natl Acad Sci U S A (2002) 1.77

Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss. Proc Natl Acad Sci U S A (2005) 1.48

Essential role for Max in early embryonic growth and development. Genes Dev (2000) 1.46

The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development. Proc Natl Acad Sci U S A (2008) 1.46

Mek2 is dispensable for mouse growth and development. Mol Cell Biol (2003) 1.44

Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis. Proc Natl Acad Sci U S A (1999) 1.41

Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Proc Natl Acad Sci U S A (2000) 1.29

Normal spermatogenesis in mice lacking the testis-specific linker histone H1t. Mol Cell Biol (2000) 1.20

Galectin-7 in the control of epidermal homeostasis after injury. Mol Biol Cell (2008) 1.11

An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. Gastroenterology (2009) 1.11

Canonical Notch signaling is dispensable for early cell fate specifications in mammals. Mol Cell Biol (2005) 1.08

Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus. J Immunol (2012) 0.97

Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region. Proc Natl Acad Sci U S A (2000) 0.93

APLP2, a member of the Alzheimer precursor protein family, is required for correct genomic segregation in dividing mouse cells. EMBO J (1998) 0.90

In vivo consequences of deleting EGF repeats 8-12 including the ligand binding domain of mouse Notch1. BMC Dev Biol (2008) 0.89

A strategy to study tyrosinase transgenes in mouse melanocytes. BMC Cell Biol (2005) 0.88

Identification of Mom12 and Mom13, two novel modifier loci of Apc (Min) -mediated intestinal tumorigenesis. Cell Cycle (2011) 0.85

Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor body. PLoS Genet (2014) 0.85

Lens complementation system for the genetic analysis of growth, differentiation, and apoptosis in vivo. Proc Natl Acad Sci U S A (1996) 0.83

Disruption of the Cockayne syndrome B gene impairs spontaneous tumorigenesis in cancer-predisposed Ink4a/ARF knockout mice. Mol Cell Biol (2001) 0.83

Essential role for complex N-glycans in forming an organized layer of bronchial epithelium. Proc Natl Acad Sci U S A (1996) 0.81

Embryonic stem cells overexpressing Pitx2c engraft in infarcted myocardium and improve cardiac function. Int Heart J (2009) 0.80

Complex cytogenetic analysis of early lethality mouse embryos. Chromosome Res (2011) 0.77

Phagocytosis reveals a reversible differentiated state early in the development of the mouse embryo. EMBO J (2000) 0.77

Mosaic variegated aneuploidy in mouse BubR1 deficient embryos and pregnancy loss in human. Chromosome Res (2014) 0.77

Mouse chimeras and their application to circadian biology. Methods Enzymol (2005) 0.76

Lessons from mouse chimaera experiments with a reiterated transgene marker: revised marker criteria and a review of chimaera markers. Transgenic Res (2015) 0.76

Articles cited by this

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science (1994) 13.47

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev (1991) 13.28

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature (1992) 8.16

Embryonic stem cells alone are able to support fetal development in the mouse. Development (1990) 6.37

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci U S A (1994) 5.71

Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences. Proc Natl Acad Sci U S A (1977) 5.28

Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs. Proc Natl Acad Sci U S A (1992) 4.50

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proc Natl Acad Sci U S A (1993) 3.65

Developmental regulation of a cloned adult beta-globin gene in transgenic mice. Nature (1985) 3.63

c-jun is essential for normal mouse development and hepatogenesis. Nature (1993) 3.43

Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates. Proc Natl Acad Sci U S A (1994) 2.21

Embryonic stem cell-derived cystic embryoid bodies form vascular channels: an in vitro model of blood vessel development. Development (1992) 1.77

Localization of low abundance DNA sequences in tissue sections by in situ hybridization. J Cell Sci (1986) 1.39

Using embryonic stem cells to introduce mutations into the mouse germ line. Biol Reprod (1991) 1.39

Transforming growth factor-beta in the early mouse embryo: implications for the regulation of muscle formation and implantation. Dev Genet (1993) 1.15

Immunochemical demonstration of the clonal organization of chimaeric mouse epidermis. Development (1987) 1.13

Tracking of mouse cell lineage using microinjected DNA sequences: analyses using genomic Southern blotting and tissue-section in situ hybridizations. Differentiation (1987) 1.10

Identification of embryonic cell lineages in histological sections of M. musculus in-equilibrium M. caroli chimaeras. J Embryol Exp Morphol (1983) 0.99

Cell lineage analysis of cerebellar Purkinje cells in mouse chimeras. Dev Biol (1981) 0.95

Organization of chromosomes in the mouse nucleus: analysis by in situ hybridization. J Cell Sci (1988) 0.95

Heterochromatic features of an 11-megabase transgene in brain cells. Proc Natl Acad Sci U S A (1991) 0.89

Somatic and germline mosaicism in interspecific chimaeras between Mus musculus and Mus caroli. J Embryol Exp Morphol (1983) 0.86

The development potential of parthenogenetically derived cells in chimeric mouse embryos: implications for action of imprinted genes. Development (1988) 0.85

Newly acquired peri-telomeric heterochromatin in a transgenic mouse lineage. Cytogenet Cell Genet (1993) 0.80

Articles by these authors

(truncated to the top 100)

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity (2000) 16.03

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science (1997) 13.61

Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base. Pharmacogenomics J (2001) 5.94

Myocarditis. A histopathologic definition and classification. Am J Cardiovasc Pathol (1987) 5.33

Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes. Biophys J (2001) 5.28

HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol (2000) 4.96

The urea reduction ratio and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis. N Engl J Med (1993) 4.88

A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature (1990) 4.69

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A (2001) 4.58

Diffusion of the Interspecies Electron Carriers H(2) and Formate in Methanogenic Ecosystems and Its Implications in the Measurement of K(m) for H(2) or Formate Uptake. Appl Environ Microbiol (1989) 4.53

The cpr5 mutant of Arabidopsis expresses both NPR1-dependent and NPR1-independent resistance. Plant Cell (1997) 4.47

Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity (2000) 4.44

Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol (2001) 4.39

Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques (1994) 4.24

Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09

Junction adhesion molecule is a receptor for reovirus. Cell (2001) 4.00

Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex. Genes Dev (1998) 3.84

Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. J Biol Chem (2000) 3.75

Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol (1985) (1999) 3.65

Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury. J Biol Chem (1996) 3.65

Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol (2001) 3.63

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates. Proc Natl Acad Sci U S A (1997) 3.59

Response regulator output in bacterial chemotaxis. EMBO J (1998) 3.40

Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY. Cell (1997) 3.32

Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors. Mol Ther (2000) 3.32

Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. Nature (2000) 3.26

Proto-oncogene PML controls genes devoted to MHC class I antigen presentation. Nature (1998) 3.22

Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study. J Clin Oncol (1999) 3.08

Subsequent pulmonary embolism: risk after a negative helical CT pulmonary angiogram--prospective comparison with scintigraphy. Radiology (2000) 3.06

IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J (1998) 2.99

Activation of a mitogen-activated protein kinase pathway is involved in disease resistance in tobacco. Proc Natl Acad Sci U S A (2001) 2.98

Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest (1997) 2.93

Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions. EMBO J (1993) 2.92

Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles. J Virol (1997) 2.91

Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export. EMBO J (1998) 2.90

Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem (2000) 2.89

Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene (2012) 2.82

Structure of the adenylyl cyclase catalytic core. Nature (1997) 2.81

Interlocked feedback loops contribute to the robustness of the Neurospora circadian clock. Proc Natl Acad Sci U S A (2001) 2.77

Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol (2001) 2.73

Selection and characterization of eight phenotypically distinct lines of lectin-resistant Chinese hamster ovary cell. Cell (1975) 2.72

Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J Neurochem (2000) 2.71

The regulation of reactive oxygen species production during programmed cell death. J Cell Biol (1998) 2.62

The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci (1998) 2.58

The C termini of Arabidopsis cryptochromes mediate a constitutive light response. Cell (2000) 2.53

Nitric oxide and cutaneous active vasodilation during heat stress in humans. J Appl Physiol (1985) (1998) 2.53

The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J (1998) 2.50

Uncoupling PR gene expression from NPR1 and bacterial resistance: characterization of the dominant Arabidopsis cpr6-1 mutant. Plant Cell (1998) 2.48

On the use of thiol-modifying agents to determine channel topology. Neuropharmacology (1996) 2.47

Increased thermal stability of proteins in the presence of naturally occurring osmolytes. Biochemistry (1992) 2.47

Zinc inhibition of mitochondrial aconitase and its importance in citrate metabolism of prostate epithelial cells. J Biol Chem (1997) 2.47

Profiling serine hydrolase activities in complex proteomes. Biochemistry (2001) 2.46

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Oncogene (2012) 2.41

A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis. Neurology (2011) 2.39

Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37

GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes. Nat Med (1997) 2.37

Establishment, maintenance and description of cell lines from the tick Ixodes scapularis. J Parasitol (1994) 2.36

Design of allele-specific inhibitors to probe protein kinase signaling. Curr Biol (1998) 2.36

Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron (1997) 2.34

Specific changes in the oligosaccharide moieties of VSV grown in different lectin-resistnat CHO cells. Cell (1978) 2.30

High-frequency transfection of CHO cells using polybrene. Somat Cell Mol Genet (1986) 2.29

The transcriptome of the arbuscular mycorrhizal fungus Glomus intraradices (DAOM 197198) reveals functional tradeoffs in an obligate symbiont. New Phytol (2011) 2.29

The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev (1997) 2.26

Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat Genet (2000) 2.24

Acute motor axonal neuropathy: a frequent cause of acute flaccid paralysis in China. Ann Neurol (1993) 2.23

Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. J Cell Biol (2001) 2.23

Hippocampal sclerosis: a common pathological feature of dementia in very old (> or = 80 years of age) humans. Acta Neuropathol (1994) 2.23

Odd-parity superconductivity in Sr2RuO4. Science (2004) 2.22

Survival and prognostic factors following radiation therapy and chemotherapy for ependymomas in children: a report of the Children's Cancer Group. J Neurosurg (1998) 2.22

Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates. Proc Natl Acad Sci U S A (1994) 2.21

Systemic gene expression after intravenous DNA delivery into adult mice. Science (1993) 2.21

Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A (2001) 2.21

Coiled-coil domain-mediated FRQ-FRQ interaction is essential for its circadian clock function in Neurospora. EMBO J (2001) 2.19

Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity (1999) 2.18

Human albumin therapy of acute ischemic stroke: marked neuroprotective efficacy at moderate doses and with a broad therapeutic window. Stroke (2001) 2.16

Translocation across Golgi vesicle membranes: a CHO glycosylation mutant deficient in CMP-sialic acid transport. Cell (1984) 2.15

Glycosylation mutants of animal cells. Annu Rev Genet (1984) 2.12

Characterization of apelin, the ligand for the APJ receptor. J Neurochem (2000) 2.11

Dissecting glycoprotein quality control in the secretory pathway. Trends Biochem Sci (2001) 2.08

Method for obtaining structure and interactions from oriented lipid bilayers. Phys Rev E Stat Nonlin Soft Matter Phys (2000) 2.08

Covalent catalysis in nucleotidyl transfer reactions: essential motifs in Saccharomyces cerevisiae RNA capping enzyme are conserved in Schizosaccharomyces pombe and viral capping enzymes and among polynucleotide ligases. Proc Natl Acad Sci U S A (1994) 2.07

PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. J Cell Biol (2000) 2.07

Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease. J Intern Med (2014) 2.06

Identification of a global repressor gene, rsmA, of Erwinia carotovora subsp. carotovora that controls extracellular enzymes, N-(3-oxohexanoyl)-L-homoserine lactone, and pathogenicity in soft-rotting Erwinia spp. J Bacteriol (1995) 2.06

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. Mol Cell Biol (2000) 2.06

A comparison of the pathological spectrum of hypertensive, diabetic, and hypertensive-diabetic heart disease. Circulation (1990) 2.05

Preconditioning protects ischemic rabbit heart by protein kinase C activation. Am J Physiol (1994) 2.04

Discovery of a receptor related to the galanin receptors. FEBS Lett (1999) 2.01

The polypeptides of influenza virus. V. Localization of polypeptides in the virion by iodination techniques. Virology (1971) 2.00

Cloning and functional expression of two families of beta-subunits of the large conductance calcium-activated K+ channel. J Biol Chem (2000) 1.99

A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice. Carcinogenesis (2001) 1.99

Unnatural ligands for engineered proteins: new tools for chemical genetics. Annu Rev Biophys Biomol Struct (2000) 1.99

Complementation between mutants of CHO cells resistant to a variety of plant lectins. Somatic Cell Genet (1977) 1.98

Investigating the hows and whys of DNA endoreduplication. J Exp Bot (2001) 1.97

Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element. Genes Dev (1997) 1.97

Human hair follicle bulge cells are biochemically distinct and possess an epithelial stem cell phenotype. J Investig Dermatol Symp Proc (1999) 1.96

Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects. Proc Natl Acad Sci U S A (1999) 1.95

Programmed myocyte cell death affects the viable myocardium after infarction in rats. Exp Cell Res (1996) 1.95

Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy. J Clin Invest (1999) 1.95