Published in Proc Natl Acad Sci U S A on November 13, 2001
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
Mammalian glycosylation in immunity. Nat Rev Immunol (2008) 2.74
Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways. Proc Natl Acad Sci U S A (2003) 2.69
Roles of Pofut1 and O-fucose in mammalian Notch signaling. J Biol Chem (2008) 1.71
Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol Biol Cell (2004) 1.71
Regulation of Notch signaling by glycosylation. Curr Opin Struct Biol (2007) 1.68
The diversity of O-linked glycans expressed during Drosophila melanogaster development reflects stage- and tissue-specific requirements for cell signaling. J Biol Chem (2008) 1.47
Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Science (2015) 1.41
Notch-dependent control of myelopoiesis is regulated by fucosylation. Blood (2008) 1.40
Highly conserved O-fucose sites have distinct effects on Notch1 function. J Biol Chem (2005) 1.35
Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype. Am J Hum Genet (2005) 1.31
Fringe benefits: functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors. Curr Opin Struct Biol (2011) 1.29
Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling. BMC Biol (2008) 1.26
Identification of a potential ovarian cancer stem cell gene expression profile from advanced stage papillary serous ovarian cancer. PLoS One (2012) 1.18
Role of glycosylation of Notch in development. Semin Cell Dev Biol (2010) 1.10
Significance of glycosylation in Notch signaling. Biochem Biophys Res Commun (2014) 1.09
Role of unusual O-glycans in intercellular signaling. Int J Biochem Cell Biol (2008) 1.08
Canonical Notch signaling is dispensable for early cell fate specifications in mammals. Mol Cell Biol (2005) 1.08
Notch in the kidney: development and disease. J Pathol (2011) 1.08
Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands. Proc Natl Acad Sci U S A (2014) 1.06
Competition between Delta and the Abruptex domain of Notch. BMC Dev Biol (2008) 0.99
Golgi glycosylation and human inherited diseases. Cold Spring Harb Perspect Biol (2011) 0.99
Role of glycans and glycosyltransferases in the regulation of Notch signaling. Glycobiology (2010) 0.97
Wnt10b activates the Wnt, notch, and NFκB pathways in U2OS osteosarcoma cells. J Cell Biochem (2011) 0.96
Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells. J Biol Chem (2010) 0.95
O-fucosylation of DLL3 is required for its function during somitogenesis. PLoS One (2015) 0.93
Role of a single amino acid in the evolution of glycans of invertebrates and vertebrates. J Mol Biol (2006) 0.93
Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila. Proc Natl Acad Sci U S A (2003) 0.92
Glycosylation of the receptor guanylate cyclase C: role in ligand binding and catalytic activity. Biochem J (2004) 0.92
Galactose differentially modulates lunatic and manic fringe effects on Delta1-induced NOTCH signaling. J Biol Chem (2011) 0.91
Functional roles for beta1,4-N-acetlygalactosaminyltransferase-A in Drosophila larval neurons and muscles. Genetics (2006) 0.89
Insect galectins: roles in immunity and development. Glycoconj J (2004) 0.89
Antibodies that detect O-linked β-D-N-acetylglucosamine on the extracellular domain of cell surface glycoproteins. J Biol Chem (2014) 0.88
Novel roles for O-linked glycans in protein folding. Glycoconj J (2014) 0.86
Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands. Dev Cell (2016) 0.85
Effects of varying Notch1 signal strength on embryogenesis and vasculogenesis in compound mutant heterozygotes. BMC Dev Biol (2010) 0.82
Structural and mechanistic insights into lunatic fringe from a kinetic analysis of enzyme mutants. J Biol Chem (2008) 0.80
Protein O-fucosyltransferase 1 expression impacts myogenic C2C12 cell commitment via the Notch signaling pathway. Mol Cell Biol (2014) 0.78
Rapid assays for lectin toxicity and binding changes that reflect altered glycosylation in mammalian cells. Curr Protoc Chem Biol (2014) 0.77
The multiple roles of epidermal growth factor repeat O-glycans in animal development. Glycobiology (2015) 0.77
Reduced Notch signalling leads to postnatal skeletal muscle hypertrophy in Pofut1cax/cax mice. Open Biol (2016) 0.75
Glycosylated Notch and Cancer. Front Oncol (2016) 0.75
O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals. Elife (2017) 0.75
Glycan Engineering for Cell and Developmental Biology. Cell Chem Biol (2016) 0.75
Notch signaling: from the outside in. Dev Biol (2000) 6.06
Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09
Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature (2000) 3.51
Jagged: a mammalian ligand that activates Notch1. Cell (1995) 3.51
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2. Nat Cell Biol (2000) 2.83
Fringe modulates Notch-ligand interactions. Nature (1997) 2.44
Defects in somite formation in lunatic fringe-deficient mice. Nature (1998) 2.37
Specific changes in the oligosaccharide moieties of VSV grown in different lectin-resistnat CHO cells. Cell (1978) 2.30
Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules. J Biol Chem (2000) 2.18
lunatic fringe is an essential mediator of somite segmentation and patterning. Nature (1998) 2.09
A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development (1997) 1.74
Structure of the altered oligosaccharide present in glycoproteins from a clone of Chinese hamster ovary cells deficient in N-acetylglucosaminyltransferase activity. J Biol Chem (1978) 1.55
Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. Mol Cell Biol (2000) 1.54
Growth retardation and early death of beta-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells. EMBO J (1997) 1.50
Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc. Development (1997) 1.47
Fringe, Notch, and making developmental boundaries. Curr Opin Genet Dev (1999) 1.38
Cloning and expression of a proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I. A seventh member of the human beta4-galactosyltransferase gene family. J Biol Chem (1999) 1.37
The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD. Curr Biol (2000) 1.36
Mutants of the CMP-sialic acid transporter causing the Lec2 phenotype. J Biol Chem (1998) 1.28
fringe and Notch specify polar cell fate during Drosophila oogenesis. Development (2001) 1.28
Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro. J Biol Chem (1998) 1.27
Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation. J Biol Chem (2001) 1.23
A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3. J Biol Chem (1997) 1.22
Point mutations identified in Lec8 Chinese hamster ovary glycosylation mutants that inactivate both the UDP-galactose and CMP-sialic acid transporters. J Biol Chem (2001) 1.20
The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Glycobiology (1998) 1.17
Targeted mutation in beta1,4-galactosyltransferase leads to pituitary insufficiency and neonatal lethality. Dev Biol (1997) 1.14
Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells. J Biol Chem (1998) 1.12
Lec1A Chinese hamster ovary cell mutants appear to arise from a structural alteration in N-acetylglucosaminyltransferase I. J Biol Chem (1986) 1.08
Galectins structure and function--a synopsis. Results Probl Cell Differ (2001) 1.02
Chinese hamster ovary (CHO) cells may express six beta 4-galactosyltransferases (beta 4GalTs). Consequences of the loss of functional beta 4GalT-1, beta 4GalT-6, or both in CHO glycosylation mutants. J Biol Chem (2001) 1.00
The effect of O-fucosylation on the first EGF-like domain from human blood coagulation factor VII. Biochemistry (1999) 0.81
Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09
Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study. J Clin Oncol (1999) 3.08
Selection and characterization of eight phenotypically distinct lines of lectin-resistant Chinese hamster ovary cell. Cell (1975) 2.72
Specific changes in the oligosaccharide moieties of VSV grown in different lectin-resistnat CHO cells. Cell (1978) 2.30
High-frequency transfection of CHO cells using polybrene. Somat Cell Mol Genet (1986) 2.29
Survival and prognostic factors following radiation therapy and chemotherapy for ependymomas in children: a report of the Children's Cancer Group. J Neurosurg (1998) 2.22
Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates. Proc Natl Acad Sci U S A (1994) 2.21
Translocation across Golgi vesicle membranes: a CHO glycosylation mutant deficient in CMP-sialic acid transport. Cell (1984) 2.15
Glycosylation mutants of animal cells. Annu Rev Genet (1984) 2.12
The polypeptides of influenza virus. V. Localization of polypeptides in the virion by iodination techniques. Virology (1971) 2.00
Complementation between mutants of CHO cells resistant to a variety of plant lectins. Somatic Cell Genet (1977) 1.98
Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation. Proc Natl Acad Sci U S A (1990) 1.81
Chinese hamster ovary cells selected for resistance to the cytotoxicity of phytohemagglutinin are deficient in a UDP-N-acetylglucosamine--glycoprotein N-acetylglucosaminyltransferase activity. Proc Natl Acad Sci U S A (1975) 1.79
Communicating bronchopulmonary foregut malformations: classification and embryogenesis. J Pediatr Surg (1992) 1.68
A mouse model for mucopolysaccharidosis type III A (Sanfilippo syndrome). Glycobiology (1999) 1.67
Efficacy of a saccharin test for screening to detect abnormal mucociliary clearance. Br J Dis Chest (1984) 1.63
Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase. J Biol Chem (2001) 1.58
WW6: an embryonic stem cell line with an inert genetic marker that can be traced in chimeras. Proc Natl Acad Sci U S A (1995) 1.56
Altered vitamin-D metabolism in pregnancy. Lancet (1977) 1.55
Value of x ray examinations of the cervical spine. Br Med J (Clin Res Ed) (1983) 1.52
Inhibition of influenza viral glycoprotein synthesis by sugars. Microbios (1972) 1.46
Low-stage medulloblastoma: final analysis of trial comparing standard-dose with reduced-dose neuraxis irradiation. J Clin Oncol (2000) 1.44
Microbial bioburden in endoscope reprocessing and an in-use evaluation of the high-level disinfection capabilities of Cidex PA. Gastroenterol Nurs (2000) 1.43
Hepatobiliary rhabdomyosarcoma in children: diagnostic radiology. Pediatr Radiol (1998) 1.42
The success of rectus and gracilis muscle flaps in the treatment of chronic pelvic sepsis and persistent perineal sinus: a systematic review. Colorectal Dis (2014) 1.41
Effects of medulloblastoma resections on outcome in children: a report from the Children's Cancer Group. Neurosurgery (1996) 1.40
Postoperative evaluation after end-to-end subclavian-left coronary artery anastomosis in anomalous left coronary artery. J Thorac Cardiovasc Surg (1990) 1.39
Maintaining long-term central venous access by repetitive hepatic vein cannulation. J Pediatr Surg (1994) 1.39
Pulmonary banding complicated by low origin of right pulmonary artery. Tex Heart Inst J (1993) 1.38
"Abnormal" illness behaviour in chronic fatigue syndrome and multiple sclerosis. BMJ (1995) 1.37
Transaortic occlusion of collateral arteries to the lung by detachable valved balloons in a patient with tetralogy of Fallot. Circulation (1982) 1.34
Control of carbohydrate processing: the lec1A CHO mutation results in partial loss of N-acetylglucosaminyltransferase I activity. Mol Cell Biol (1985) 1.34
Control of glycoprotein synthesis. Lectin-resistant mutant containing only one of two distinct N-acetylglucosaminyltransferase activities present in wild type Chinese hamster ovary cells. J Biol Chem (1977) 1.31
Differential involvement of cell surface sialic acid residues in wheat germ agglutinin binding to parental and wheat germ agglutinin-resistant Chinese hamster ovary cells. J Cell Biol (1980) 1.28
Selection of lectin-resistant mutants of animal cells. Methods Enzymol (1983) 1.28
Selective loss of wheat germ agglutinin binding to agglutinin-resistant mutants of Chinese hamster ovary cells. Proc Natl Acad Sci U S A (1977) 1.23
The regulation of integrin function by Ca(2+). Biochim Biophys Acta (2000) 1.21
Survival and prognostic factors following radiation and/or chemotherapy for primitive neuroectodermal tumors of the pineal region in infants and children: a report of the Childrens Cancer Group. J Clin Oncol (1995) 1.20
Membrane mutants of animal cells: rapid identification of those with a primary defect in glycosylation. Mol Cell Biol (1985) 1.20
Point mutations identified in Lec8 Chinese hamster ovary glycosylation mutants that inactivate both the UDP-galactose and CMP-sialic acid transporters. J Biol Chem (2001) 1.20
Survival of infants with primitive neuroectodermal tumors or malignant ependymomas of the CNS treated with eight drugs in 1 day: a report from the Childrens Cancer Group. J Clin Oncol (1994) 1.19
Neurological complications associated with parenteral treatment: central pontine myelinolysis and Wernicke's encephalopathy. Br Med J (Clin Res Ed) (1986) 1.18
Stable alterations at the cell membrane of Chinese hamster ovary cells resistant to the cytotoxicity of phytohemagglutinin. Somatic Cell Genet (1975) 1.17
Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. Proc Natl Acad Sci U S A (1998) 1.17
A dominant mutation to ricin resistance in Chinese hamster ovary cells induces UDP-GlcNAc:glycopeptide beta-4-N-acetylglucosaminyltransferase III activity. J Biol Chem (1984) 1.16
Characterization of cell surface carbohydrate receptors for Entamoeba histolytica adherence lectin. Infect Immun (1989) 1.14
Pilot study of high-dose thiotepa and etoposide with autologous bone marrow rescue in children and young adults with recurrent CNS tumors. The Children's Cancer Group. J Clin Oncol (1996) 1.13
Lectin-resistant CHO cells: selection of new mutant phenotypes. Somatic Cell Genet (1983) 1.13
Microheterogeneity among carbohydrate structures at the cell surface may be important in recognition phenomena. Cell (1981) 1.12
The I domain of integrin leukocyte function-associated antigen-1 is involved in a conformational change leading to high affinity binding to ligand intercellular adhesion molecule 1 (ICAM-1). J Biol Chem (1998) 1.12
Induction for senior house officers. Part I: The hospital programme. Postgrad Med J (1999) 1.11
Altered cell surface glycoproteins in phytohemagglutinin-resistant mutants of Chinese hamster ovary cells. Biochim Biophys Acta (1975) 1.11
Molecular study of the T cell repertoire in family contacts and patients with leprosy. J Immunol (1989) 1.10
Lec1A Chinese hamster ovary cell mutants appear to arise from a structural alteration in N-acetylglucosaminyltransferase I. J Biol Chem (1986) 1.08
The Lec4A CHO glycosylation mutant arises from miscompartmentalization of a Golgi glycosyltransferase. J Cell Biol (1989) 1.08
Reconsideration of the anatomy of sling left pulmonary artery: the association of one form with bridging bronchus and imperforate anus. Anatomic and diagnostic aspects. J Pediatr Surg (1988) 1.08
Craniopharyngioma in children. J Pediatr (1973) 1.06
Echocardiographic manifestations of persistence of the right sinus venosus valve. Am J Cardiol (1979) 1.06
Two Chinese hamster ovary glycosylation mutants affected in the conversion of GDP-mannose to GDP-fucose. Arch Biochem Biophys (1986) 1.05
Partial splenic embolization. An effective alternative to splenectomy for hypersplenism. Am Surg (1990) 1.03
Percutaneous drainage of abdominal fluid collections in children. AJR Am J Roentgenol (1984) 1.02
A novel missense mutation in lysosomal sulfamidase is the basis of MPS III A in a spontaneous mouse mutant. Glycobiology (2001) 1.02
The GDP-fucose:N-acetylglucosaminide 3-alpha-L-fucosyltransferases of LEC11 and LEC12 Chinese hamster ovary mutants exhibit novel specificities for glycolipid substrates. J Biol Chem (1987) 1.02
Transfection of a human gene that corrects the Lec1 glycosylation defect: evidence for transfer of the structural gene for N-acetylglucosaminyltransferase I. Mol Cell Biol (1989) 1.01
Aseptic necrosis after renal transplantation in children. Am J Dis Child (1978) 1.01
A novel glycosylation phenotype expressed by Lec23, a Chinese hamster ovary mutant deficient in alpha-glucosidase I. J Biol Chem (1991) 1.01
Chinese hamster ovary (CHO) cells may express six beta 4-galactosyltransferases (beta 4GalTs). Consequences of the loss of functional beta 4GalT-1, beta 4GalT-6, or both in CHO glycosylation mutants. J Biol Chem (2001) 1.00
Melanoma sentinel node biopsy and prediction models for relapse and overall survival. Br J Cancer (2010) 0.99
Binding of [125I] wheat germ agglutinin to Chinese hamster ovary cells under conditions which affect the mobility of membrane components. J Cell Biol (1978) 0.99
The polypeptides of influenza virus. VII. Synthesis of the hemagglutinin. Virology (1973) 0.99
[Heart tumors in children. Report of 3 cases with favorable spontaneous courses]. Arch Mal Coeur Vaiss (1975) 0.99
A new surgical approach for correction of partial anomalous pulmonary venous drainage into the superior vena cava. J Thorac Cardiovasc Surg (1976) 0.97
Acquired aortic stenosis in a twelve-year-old girl with xanthomatosis: successful surgical correction. N Engl J Med (1965) 0.96
Induction for senior house officers. Part II: The departmental programme. Postgrad Med J (1999) 0.96
Simple d-transposition of the great arteries. Results of early balloon septotomy followed by two-stage surgical correction. J Thorac Cardiovasc Surg (1977) 0.95
Interaction of Escherichia coli hemolysin with biological membranes. A study using cysteine scanning mutagenesis. Eur J Biochem (2001) 0.95
Hepatic chemoembolization: safety with portal vein thrombosis. J Vasc Interv Radiol (1993) 0.95
Cloning and expression of the murine gene and chromosomal location of the human gene encoding N-acetylglucosaminyltransferase I. Glycobiology (1992) 0.95
Kasabach-Merritt syndrome treated by therapeutic embolization with polyvinyl alcohol. Am J Pediatr Hematol Oncol (1986) 0.93
Actinomycosis infection of the finger. Hand Surg (2005) 0.93
Real-time imaging of gene promoter activity using an adenoviral reporter construct demonstrates transcriptional dynamics in normal anterior pituitary cells. J Endocrinol (2003) 0.93
1H NMR spectroscopy of carbohydrates from the G glycoprotein of vesicular stomatitis virus grown in parental and Lec4 Chinese hamster ovary cells. Arch Biochem Biophys (1984) 0.92
Carbohydrate heterogeneity of vesicular stomatitis virus G glycoprotein allows localization of the defect in a glycosylation mutant of CHO cells. Arch Biochem Biophys (1982) 0.92
Ependymal cells of the choroid plexus express tumour necrosis factor-alpha. Neuropathol Appl Neurobiol (1993) 0.92
Prognostic factors and treatment results for supratentorial primitive neuroectodermal tumors in children using radiation and chemotherapy: a Childrens Cancer Group randomized trial. J Clin Oncol (1995) 0.92
The Chinese hamster ovary glycosylation mutants LEC11 and LEC12 express two novel GDP-fucose:N-acetylglucosaminide 3-alpha-L-fucosyltransferase enzymes. J Biol Chem (1984) 0.92
Intraspinal seeding from intracranial tumors in children. AJR Am J Roentgenol (1985) 0.92
Results of a prospective randomized trial comparing standard dose neuraxis irradiation (3,600 cGy/20) with reduced neuraxis irradiation (2,340 cGy/13) in patients with low-stage medulloblastoma. A Combined Children's Cancer Group-Pediatric Oncology Group Study. Pediatr Neurosurg (1996) 0.91
Coarctation of the aorta in infancy. Postoperative follow-up. J Thorac Cardiovasc Surg (1969) 0.91
Lectin receptors and lectin resistance in chinese hamster ovary cells. Adv Exp Med Biol (1977) 0.91
Mesenchymal hamartomas of the liver in childhood: sonographic and CT findings. AJR Am J Roentgenol (1986) 0.91
Multicentric giant cell tumor: report of five new cases. Skeletal Radiol (1994) 0.90
Serial section-reconstruction of anomalous tracheobronchial branching patterns from CT scan images: bridging bronchus associated with sling left pulmonary artery. Pediatr Radiol (1990) 0.90
A comparison of the fine saccharide-binding specificity of Dioclea grandiflora lectin and concanavalin A. Eur J Biochem (1996) 0.90
E. coli hemolysin interactions with prokaryotic and eukaryotic cell membranes. Bioessays (1992) 0.90
Cytotoxicity of plant lectins for mouse embryonal carcinoma cells. Somat Cell Mol Genet (1984) 0.90
Chronic spinal epidural hematoma in hemophilia A in a child. Pediatr Radiol (1983) 0.89
Selection and characterization of Chinese hamster ovary cells resistant to the cytotoxicity of lectins. In Vitro (1976) 0.89
The material tensile strength of convex-faced aspirin tablets. J Pharm Pharmacol (1989) 0.89
The gain-of-function Chinese hamster ovary mutant LEC11B expresses one of two Chinese hamster FUT6 genes due to the loss of a negative regulatory factor. J Biol Chem (1999) 0.89