Catalytic antibody route to the naturally occurring epothilones: total synthesis of epothilones A-F.

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Published in Chemistry on April 17, 2001

Authors

S C Sinha1, J Sun, G P Miller, M Wartmann, R A Lerner

Author Affiliations

1: Department of Molecular Biology and the Skaggs Institute for Chemical Biology, the Scripps Research Institute, La Jolla, California 92037, USA. subhash@scripps.edu

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The sequence of the human genome. Science (2001) 101.55

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The structure of an antigenic determinant in a protein. Cell (1984) 10.85

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature (1996) 8.99

Immunogenic structure of the influenza virus hemagglutinin. Cell (1982) 8.93

Mitotic misregulation and human aging. Science (2000) 8.47

Radioiodination of proteins in single polyacrylamide gel slices. Tryptic peptide analysis of all the major members of complex multicomponent systems using microgram quantities of total protein. J Biol Chem (1977) 8.03

The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J Exp Med (1967) 6.81

Biochemical evidence that MCF murine leukemia viruses are envelope (env) gene recombinants. Proc Natl Acad Sci U S A (1977) 6.80

cPLA2 is phosphorylated and activated by MAP kinase. Cell (1993) 6.61

A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals. Proc Natl Acad Sci U S A (1991) 6.13

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Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition. Proc Natl Acad Sci U S A (1983) 4.56

Chemical synthesis of a polypeptide predicted from nucleotide sequence allows detection of a new retroviral gene product. Nature (1980) 4.35

Polymorphism of the major envelope glycoprotein (gp70) of murine C-type viruses: virion associated and differentiation antigens encoded by a multi-gene family. Nature (1977) 4.31

Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles. Proc Natl Acad Sci U S A (1981) 4.26

The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein. Nature (1984) 4.05

Shwartzman reaction after human renal homotransplantation. N Engl J Med (1968) 4.05

Encoded combinatorial chemistry. Proc Natl Acad Sci U S A (1992) 4.00

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Endogenous oncornaviral gene expression in adult and fetal mice: quantitative, histologic, and physiologic studies of the major viral glycorprotein, gp70. J Exp Med (1976) 3.51

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Immunopathogenicity and oncogenicity of murine leukemia viruses. I. Induction of immunologic disease and lymphoma in (BALB-c times NZB)F1 mice by Scripps leukemia virus. J Exp Med (1974) 2.12

Gene expression in synchronized lymphocytes: studies on the control of synthesis of immunoglobulin polypeptides. J Cell Physiol (1971) 2.11

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Identifier sequences are transcribed specifically in brain. Nature (1984) 1.95

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Properties of an oncornavirus glycoprotein: evidence for its presence on the surface of virions and infected cells. Virology (1973) 1.71

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High-dose/activation-associated tolerance: a mechanism for allograft tolerance. Transplantation (1997) 1.65

Karyotypic, virologic, and immunologic analyses of two continuous lymphocyte lines established from New Zealand black mice: possible relationship of chromosomal mosaicism to autoimmunity. Proc Natl Acad Sci U S A (1972) 1.65

Antibodies to peptides detect new hepatitis B antigen: serological correlation with hepatocellular carcinoma. Science (1985) 1.63

Production of macrophage migration inhibition factor by continuous cell lines. J Exp Med (1972) 1.62

Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection. J Immunol (1997) 1.62

A short course of methylprednisolone immunosuppression inhibits both rejection and spontaneous acceptance of rat liver allografts. Transplantation (2001) 1.61

Prevalence of naturally occurring surface gene variants of hepatitis B virus in nonimmunized surface antigen-negative Chinese carriers. Hepatology (2001) 1.61

The Bacillus subtilis DinR binding site: redefinition of the consensus sequence. J Bacteriol (1998) 1.61

Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway. Mol Cell Biol (1998) 1.59

Endometrial progesterone receptors and markers of uterine receptivity in the window of implantation. Fertil Steril (1996) 1.58