Published in Am J Hum Genet on May 15, 2001
A fast, powerful method for detecting identity by descent. Am J Hum Genet (2011) 4.26
Case-control association testing with related individuals: a more powerful quasi-likelihood score test. Am J Hum Genet (2007) 3.74
Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus. Am J Hum Genet (2003) 3.62
Confounding from cryptic relatedness in case-control association studies. PLoS Genet (2005) 3.61
ROADTRIPS: case-control association testing with partially or completely unknown population and pedigree structure. Am J Hum Genet (2010) 2.92
Case-control association testing in the presence of unknown relationships. Genet Epidemiol (2009) 2.63
STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. PLoS Med (2009) 2.39
Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J Invest Dermatol (2008) 2.20
Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information. Am J Hum Genet (2004) 2.19
PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size. BMC Bioinformatics (2006) 2.06
Mutations in CHEK2 associated with prostate cancer risk. Am J Hum Genet (2003) 1.96
Estimating kinship in admixed populations. Am J Hum Genet (2012) 1.95
Accounting for linkage in family-based tests of association with missing parental genotypes. Am J Hum Genet (2003) 1.92
STrengthening the REporting of Genetic Association studies (STREGA)--an extension of the STROBE statement. Eur J Clin Invest (2009) 1.82
Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL. Blood (2010) 1.79
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity. Proc Natl Acad Sci U S A (2010) 1.60
Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT. Am J Hum Genet (2005) 1.56
A kinship-based modification of the armitage trend test to address hidden population structure and small differential genotyping errors. PLoS One (2009) 1.50
Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement. Hum Genet (2009) 1.47
Comparing strategies for association mapping in samples with related individuals. BMC Genet (2005) 1.41
Analysis of the RNASEL gene in familial and sporadic prostate cancer. Am J Hum Genet (2002) 1.41
Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement. Eur J Epidemiol (2009) 1.25
Linkage analysis without defined pedigrees. Genet Epidemiol (2011) 1.20
Testing for genetic association taking into account phenotypic information of relatives. BMC Proc (2009) 1.16
Overview of techniques to account for confounding due to population stratification and cryptic relatedness in genomic data association analyses. Heredity (Edinb) (2010) 1.11
The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura. BMC Med (2004) 1.10
An Incomplete-Data Quasi-likelihood Approach to Haplotype-Based Genetic Association Studies on Related Individuals. J Am Stat Assoc (2009) 1.07
A comparison of strategies for analyzing dichotomous outcomes in genome-wide association studies with general pedigrees. Genet Epidemiol (2011) 1.04
Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study. J Natl Cancer Inst (2010) 1.04
Shrinkage estimation for robust and efficient screening of single-SNP association from case-control genome-wide association studies. Genet Epidemiol (2009) 1.00
Estimating gene penetrance from family data. Genet Epidemiol (2010) 0.99
Robust trend tests for genetic association in case-control studies using family data. BMC Genet (2005) 0.99
Effective sample size: Quick estimation of the effect of related samples in genetic case-control association analyses. Comput Biol Chem (2011) 0.98
Disentangling genetic vs. environmental causes of sex determination in the common frog, Rana temporaria. BMC Genet (2008) 0.94
On combining family-based and population-based case-control data in association studies. Biometrics (2010) 0.93
XM: association testing on the X-chromosome in case-control samples with related individuals. Genet Epidemiol (2012) 0.93
High degree of sex chromosome differentiation in stickleback fishes. BMC Genomics (2011) 0.90
BLUP genotype imputation for case-control association testing with related individuals and missing data. J Comput Biol (2012) 0.89
Association of MTHFR C677T and A1298C gene polymorphisms with hypertension. Int J Health Sci (Qassim) (2012) 0.89
Case-control association analysis of rheumatoid arthritis with candidate genes using related cases. BMC Proc (2007) 0.87
Parente2: a fast and accurate method for detecting identity by descent. Genome Res (2014) 0.87
Pedigree association: assigning individual weights to pedigree members for genetic association analysis. BMC Proc (2009) 0.86
Testing for association based on excess allele sharing in a sample of related cases and controls. Hum Genet (2007) 0.85
ATRIUM: testing untyped SNPs in case-control association studies with related individuals. Am J Hum Genet (2009) 0.85
Application of a new method for GWAS in a related case/control sample with known pedigree structure: identification of new loci for nephrolithiasis. PLoS Genet (2011) 0.84
Selection of single-nucleotide polymorphisms in disease association data. BMC Genet (2005) 0.84
Selecting cases from nuclear families for case-control association analysis. BMC Genet (2005) 0.80
A cautionary note on the appropriateness of using a linkage resource for an association study. BMC Genet (2003) 0.79
Correcting for cryptic relatedness in population-based association studies of continuous traits. Hum Hered (2009) 0.78
Validity and power of association testing in family-based sampling designs: evidence for and against the common wisdom. Genet Epidemiol (2011) 0.77
Case-control studies with affected sibships. BMC Proc (2007) 0.75
Generalizing Terwilliger's likelihood approach: a new score statistic to test for genetic association. BMC Genet (2007) 0.75
Comparing strategies for evaluation of candidate genes in case-control studies using family data. BMC Proc (2007) 0.75
A comparison of founder-only and all-pedigree-members genotype-expression association by regression analysis. BMC Proc (2007) 0.75
Genotype-Based Score Test for Association Testing in Families. Stat Biosci (2015) 0.75
LEVERAGING LOCAL IDENTITY-BY-DESCENT INCREASES THE POWER OF CASE/CONTROL GWAS WITH RELATED INDIVIDUALS. Ann Appl Stat (2014) 0.75
Haplotype estimation from fuzzy genotypes using penalized likelihood. PLoS One (2011) 0.75
Genomic control for association studies. Biometrics (1999) 64.39
Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet (1996) 39.80
Searching for genetic determinants in the new millennium. Nature (2000) 17.50
From genotypes to genes: doubling the sample size. Biometrics (1997) 11.46
The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases I. DNA pooling. Genome Res (1998) 5.11
The power of genomic control. Am J Hum Genet (2000) 4.99
Population stratification in epidemiologic studies of common genetic variants and cancer: quantification of bias. J Natl Cancer Inst (2000) 4.51
Asymptotic bias and efficiency in case-control studies of candidate genes and gene-environment interactions: basic family designs. Am J Epidemiol (1999) 3.31
Tests and estimates of allelic association in complex inheritance. Proc Natl Acad Sci U S A (1998) 2.78
The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. II. Individual genotyping. Genome Res (1999) 2.04
The future of genetic studies of complex human diseases: an epidemiologic perspective. Epidemiology (1998) 1.27
Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer. N Engl J Med (1999) 7.81
Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous. Hum Hered (2003) 5.06
Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals. JAMA (1995) 3.84
Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers. J Natl Cancer Inst (1999) 3.46
Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers. J Natl Cancer Inst (2001) 3.37
Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1. Cancer Res (1998) 3.36
Incidence of reading disability in a population-based birth cohort, 1976-1982, Rochester, Minn. Mayo Clin Proc (2001) 3.18
The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas. Am J Hum Genet (2001) 2.68
Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis. J Exp Med (2001) 2.41
Smoking, alcohol, and coffee consumption preceding Parkinson's disease: a case-control study. Neurology (2000) 2.31
Anxiety disorders and depressive disorders preceding Parkinson's disease: a case-control study. Mov Disord (2000) 2.20
Potential influence of migration bias in birth cohort studies. Mayo Clin Proc (1998) 2.19
Case-control studies of genetic markers: power and sample size approximations for Armitage's test for trend. Hum Hered (2001) 2.14
Increased risk for cancer in patients with the Peutz-Jeghers syndrome. Ann Intern Med (1998) 1.96
Controlled trial of megestrol acetate for the treatment of cancer anorexia and cachexia. J Natl Cancer Inst (1990) 1.92
Sequence analysis of the fragile X trinucleotide repeat: implications for the origin of the fragile X mutation. Hum Mol Genet (1994) 1.90
Apolipoprotein E: risk factor for Alzheimer disease. Am J Hum Genet (1994) 1.83
Identification of an association between HLA class II alleles and low antibody levels after measles immunization. Vaccine (2001) 1.77
Evidence for a prostate cancer-susceptibility locus on chromosome 20. Am J Hum Genet (2000) 1.69
Familial aneurysmal subarachnoid hemorrhage: a community-based study. J Neurosurg (1995) 1.68
Germ-line origins of mutation in families with hemophilia B: the sex ratio varies with the type of mutation. Am J Hum Genet (1993) 1.66
Validation of a telephone questionnaire for Parkinson's disease. J Clin Epidemiol (1998) 1.65
Efficacy of contralateral prophylactic mastectomy in women with a personal and family history of breast cancer. J Clin Oncol (2001) 1.63
The location of the Philadelphia chromosomal breakpoint site and prognosis in chronic granulocytic leukemia. Leukemia (1990) 1.49
Familial aggregation of gastroesophageal reflux in patients with Barrett's esophagus and esophageal adenocarcinoma. Gastroenterology (1997) 1.46
Hereditary motor and sensory neuropathy type 2C is genetically distinct from types 2B and 2D. Arch Neurol (2000) 1.45
Validity of family history data on PD: evidence for a family information bias. Neurology (2003) 1.41
Long-term satisfaction and psychological and social function following bilateral prophylactic mastectomy. JAMA (2000) 1.40
Radiation therapy for squamous cell carcinoma of the tonsil. Mayo Clin Proc (1994) 1.39
Candidate-gene association studies with pedigree data: controlling for environmental covariates. Genet Epidemiol (2003) 1.36
Hysterectomy, menopause, and estrogen use preceding Parkinson's disease: an exploratory case-control study. Mov Disord (2001) 1.35
SLC6A4 variation and citalopram response. Am J Med Genet B Neuropsychiatr Genet (2009) 1.32
The genomic organization of human dystrobrevin. Neurogenetics (1997) 1.29
Allelic imbalance and microsatellite instability in prostatic adenocarcinoma. Cancer Res (1996) 1.28
Hereditary motor and sensory neuropathy with diaphragm and vocal cord paresis. Ann Neurol (1994) 1.26
Role of HPC2/ELAC2 in hereditary prostate cancer. Cancer Res (2001) 1.24
The gene for HMSN2C maps to 12q23-24: a region of neuromuscular disorders. Neurology (2003) 1.22
Genetic heterogeneity in Peutz-Jeghers syndrome. Hum Mutat (2000) 1.22
Microsatellite instability in Muir-Torre syndrome. Cancer Res (1994) 1.19
Potential misinterpretation of the case-only study to assess gene-environment interaction. Am J Epidemiol (1999) 1.19
Factor VIII gene inversions causing severe hemophilia A originate almost exclusively in male germ cells. Hum Mol Genet (1994) 1.19
Complete responses and long-term survivals after systemic chemotherapy for patients with advanced malignant melanoma. Cancer (1989) 1.18
Choosing a pediatric recipient for orthotopic liver transplantation. J Pediatr (1987) 1.14
Combination hormonal therapy with tamoxifen plus fluoxymesterone versus tamoxifen alone in postmenopausal women with metastatic breast cancer. An updated analysis. Cancer (1991) 1.13
Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas. J Clin Invest (1991) 1.11
Expression of p53 and 17p allelic loss in colorectal carcinoma. Cancer Res (1992) 1.11
Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q. Am J Hum Genet (2003) 1.10
Familial predisposition for colorectal cancer in chronic ulcerative colitis: a case-control study. Gastroenterology (1998) 1.10
Reduced COX-2 protein in colorectal cancer with defective mismatch repair. Cancer Res (1998) 1.09
Body-composition changes in patients who gain weight while receiving megestrol acetate. J Clin Oncol (1993) 1.07
Linkage analyses at the chromosome 1 loci 1q24-25 (HPC1), 1q42.2-43 (PCAP), and 1p36 (CAPB) in families with hereditary prostate cancer. Am J Hum Genet (2000) 1.04
Progression of familial and non-familial dilated cardiomyopathy: long term follow up. Heart (2003) 1.03
Association of Peutz-Jeghers-like mucocutaneous pigmentation with breast and gynecologic carcinomas in women. Medicine (Baltimore) (2000) 1.01
Current status of adjuvant chemotherapy for colorectal cancer. Can molecular markers play a role in predicting prognosis? Cancer (1992) 1.00
Autosomal dominant supravalvular aortic stenosis: localization to chromosome 7. Hum Mol Genet (1993) 0.97
A controlled trial of cyproheptadine in cancer patients with anorexia and/or cachexia. Cancer (1990) 0.97
Genetic diversity and function in the human cytosolic sulfotransferases. Pharmacogenomics J (2006) 0.97
Fluorescence in situ hybridization: a sensitive method for trisomy 8 detection in bone marrow specimens. Blood (1992) 0.96
Novel pattern of P53 mutation in breast cancers from Austrian women. J Clin Invest (1995) 0.95
Base of tongue carcinoma: patterns of failure and predictors of recurrence after surgery alone. Head Neck (1993) 0.94
Tumor necrosis factor-alpha allelic frequency and chromosome 6 allelic imbalance in patients with colorectal cancer. Cancer Res (1996) 0.94
Phase III evaluation of four doses of megestrol acetate as therapy for patients with cancer anorexia and/or cachexia. J Clin Oncol (1993) 0.93
Alpha-1-antitrypsin phenotypes among patients with intracranial aneurysms. J Neurosurg (1996) 0.92
Germline origins in the human F9 gene: frequent G:C-->A:T mosaicism and increased mutations with advanced maternal age. Hum Genet (1999) 0.91
On the inheritance of intracranial aneurysms. Stroke (1994) 0.91
Effect of megestrol acetate on the human pituitary-adrenal axis. Mayo Clin Proc (1992) 0.90
Spontaneous mutation in Big Blue transgenic mice: analysis of age, gender, and tissue type. Environ Mol Mutagen (1996) 0.90
Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees. Genet Epidemiol (2001) 0.90
Cisplatin-based chemotherapy for neoplasms arising from salivary glands and contiguous structures in the head and neck. Cancer (1988) 0.90
A randomized prospective assessment of recombinant leukocyte A human interferon with or without aspirin in advanced renal adenocarcinoma. J Clin Oncol (1991) 0.87
Mutation frequencies but not mutant frequencies in Big Blue mice fit a Poisson distribution. Environ Mol Mutagen (1996) 0.87
A novel mutation in KVLQT1 is the molecular basis of inherited long QT syndrome in a near-drowning patient's family. Pediatr Res (1998) 0.87
Microsatellite instability and hMLH1/hMSH2 expression in young endometrial carcinoma patients: associations with family history and histopathology. Int J Cancer (2000) 0.87
Correlations between measles, mumps, and rubella serum antibody levels in Olmsted County school children. Vaccine (2001) 0.87
Increased mutation frequency and altered spectrum in one of four thymic lymphomas derived from tumor prone p53/Big Blue double transgenic mice. Oncogene (1996) 0.87
Cervical nodal metastasis of squamous cell carcinoma of unknown origin: indications for withholding radiation therapy. Int J Radiat Oncol Biol Phys (1992) 0.87
Confirmation of linkage of supravalvular aortic stenosis to the elastin gene on chromosome 7q. Am J Cardiol (1994) 0.86
Familial occurrence of carcinoid tumors and association with other malignant neoplasms. Cancer Epidemiol Biomarkers Prev (1999) 0.86
Clinical options for women at high risk for breast cancer. Surg Clin North Am (1999) 0.85
Levamisole potentiation of fluorouracil antiproliferative activity mimicked by orthovanadate, an inhibitor of tyrosine phosphatase. J Natl Cancer Inst (1992) 0.85
Metastatic bronchioloalveolar carcinoma and metastatic adenocarcinoma of the lung: comparison of clinical manifestations, chemotherapeutic responses, and prognosis. Mayo Clin Proc (1992) 0.84
Relationship of HLA-DQA1 alleles and humoral antibody following measles vaccination. Int J Infect Dis (1998) 0.84
Familial medullary thyroid cancer and prominent corneal nerves: clinical and genetic analysis. J Clin Endocrinol Metab (1995) 0.83
Does histologic grade in soft tissue sarcoma influence response rate to systemic chemotherapy? Cancer (1991) 0.83
Randomized trial of doxorubicin alone or combined with vincristine and mitomycin C in women with metastatic breast cancer. Am J Clin Oncol (1989) 0.83
Genetic variation in the tumor necrosis factor alpha gene and the outcome of multiple sclerosis. Neurology (1997) 0.83
Analysis of the prostate cancer-susceptibility locus HPC20 in 172 families affected by prostate cancer. Am J Hum Genet (2001) 0.83
Expression of somatostatin receptors in childhood neuroblastoma. Am J Clin Pathol (1994) 0.83
Disseminated malignant melanoma and recombinant interferon: analysis of seven consecutive phase II investigations. J Invest Dermatol (1990) 0.82
Orientation of loci in the major histocompatibility complex of the rat and its comparison to man and the mouse. J Immunogenet (1982) 0.82
DNA ploidy and percent S-phase as prognostic factors in node-positive breast cancer: results from patients enrolled in two prospective randomized trials. J Clin Oncol (1993) 0.82
DNA ploidy and the percentage of cells in S-phase as prognostic factors for women with lymph node negative breast cancer. Cancer (1994) 0.82
Polymorphisms of the TAP2 gene may influence antibody response to live measles vaccine virus. Vaccine (1997) 0.81
The influence of the HLA-DRB1*13 allele on measles vaccine response. J Investig Med (1996) 0.81
Recombinant interferons in the management of advanced malignant melanoma. Updated review of five prospective clinical trials and long-term responders. Am J Clin Oncol (1988) 0.81
Anticipation in familial Parkinson's disease: a reanalysis of 13 United Kingdom kindreds. Neurology (1996) 0.81
Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease. Mov Disord (2000) 0.81