Published in Nature on June 15, 2000
ATI Evidence-based Guide Investigating Clinical Services (AEGIS) | NCT02285868
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Finding the missing heritability of complex diseases. Nature (2009) 67.95
Human non-synonymous SNPs: server and survey. Nucleic Acids Res (2002) 50.45
Why most published research findings are false. PLoS Med (2005) 41.68
Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet (2001) 22.46
Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet (2001) 22.07
Atherosclerosis. Nature (2000) 15.95
Methods for high-density admixture mapping of disease genes. Am J Hum Genet (2004) 12.02
Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms. Am J Hum Genet (2001) 10.48
Multiple common variants for celiac disease influencing immune gene expression. Nat Genet (2010) 6.90
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet (2011) 6.36
Highly multiplexed molecular inversion probe genotyping: over 10,000 targeted SNPs genotyped in a single tube assay. Genome Res (2005) 6.32
Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered (2008) 5.89
How malaria has affected the human genome and what human genetics can teach us about malaria. Am J Hum Genet (2005) 5.79
A method for fine mapping quantitative trait loci in outbred animal stocks. Proc Natl Acad Sci U S A (2000) 5.46
The future of association studies: gene-based analysis and replication. Am J Hum Genet (2004) 5.44
Coalescent-based association mapping and fine mapping of complex trait loci. Genetics (2004) 5.26
A genome-wide linkage and association scan reveals novel loci for autism. Nature (2009) 4.76
Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology. Int J Epidemiol (2008) 4.53
Powerful multilocus tests of genetic association in the presence of gene-gene and gene-environment interactions. Am J Hum Genet (2006) 4.40
Association mapping of kernel size and milling quality in wheat (Triticum aestivum L.) cultivars. Genetics (2005) 4.19
Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies. Am J Hum Genet (2004) 4.15
Evaluation of candidate genes in case-control studies: a statistical method to account for related subjects. Am J Hum Genet (2001) 4.09
Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am J Hum Genet (2002) 4.03
Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations. Am J Hum Genet (2004) 3.91
Inference on haplotype effects in case-control studies using unphased genotype data. Am J Hum Genet (2003) 3.74
Genomewide scans of complex human diseases: true linkage is hard to find. Am J Hum Genet (2001) 3.70
Confounding from cryptic relatedness in case-control association studies. PLoS Genet (2005) 3.61
Candidate gene studies of ADHD: a meta-analytic review. Hum Genet (2009) 3.56
SNP frequency, haplotype structure and linkage disequilibrium in elite maize inbred lines. BMC Genet (2002) 3.23
Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes. Cold Spring Harb Symp Quant Biol (2005) 3.19
Matching strategies for genetic association studies in structured populations. Am J Hum Genet (2004) 3.13
Markers for mapping by admixture linkage disequilibrium in African American and Hispanic populations. Am J Hum Genet (2001) 3.04
PupaSuite: finding functional single nucleotide polymorphisms for large-scale genotyping purposes. Nucleic Acids Res (2006) 3.04
A unified association analysis approach for family and unrelated samples correcting for stratification. Am J Hum Genet (2008) 3.00
POCUS: mining genomic sequence annotation to predict disease genes. Genome Biol (2003) 2.93
A fast method for computing high-significance disease association in large population-based studies. Am J Hum Genet (2006) 2.84
Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility. Cancer Res (2010) 2.82
Detecting rare variants for complex traits using family and unrelated data. Genet Epidemiol (2010) 2.80
Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH): design and rationale of a prospective multicenter registry. Circ Cardiovasc Qual Outcomes (2011) 2.77
Efficient study designs for test of genetic association using sibship data and unrelated cases and controls. Am J Hum Genet (2006) 2.72
Power calculations for a general class of family-based association tests: dichotomous traits. Am J Hum Genet (2002) 2.55
Familial aggregation in lone atrial fibrillation. Hum Genet (2005) 2.55
Integration of text- and data-mining using ontologies successfully selects disease gene candidates. Nucleic Acids Res (2005) 2.46
Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene. Hum Mol Genet (2008) 2.42
Precision and error of three-dimensional phenotypic measures acquired from 3dMD photogrammetric images. Am J Med Genet A (2005) 2.39
Judging a plethora of p-values: how to contend with the problem of multiple testing--part 10 of a series on evaluation of scientific publications. Dtsch Arztebl Int (2010) 2.36
Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nat Genet (2010) 2.35
Computational identification of gene-social environment interaction at the human IL6 locus. Proc Natl Acad Sci U S A (2010) 2.31
Association between common variation in 120 candidate genes and breast cancer risk. PLoS Genet (2007) 2.27
Testing for population subdivision and association in four case-control studies. Am J Hum Genet (2002) 2.26
A genome-wide association study for late-onset Alzheimer's disease using DNA pooling. BMC Med Genomics (2008) 2.20
Geography is a better determinant of human genetic differentiation than ethnicity. Hum Genet (2005) 2.20
Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information. Am J Hum Genet (2004) 2.19
Current status of genome-wide association studies in cancer. Hum Genet (2011) 2.14
Valid consent for genomic epidemiology in developing countries. PLoS Med (2007) 2.14
SNP genotyping on pooled DNAs: comparison of genotyping technologies and a semi automated method for data storage and analysis. Nucleic Acids Res (2002) 2.12
Overlapping pools for high-throughput targeted resequencing. Genome Res (2009) 2.11
The genome Assembly Archive: a new public resource. PLoS Biol (2004) 2.09
Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays. Genes Brain Behav (2008) 2.08
The genetic epidemiology of neurodegenerative disease. J Clin Invest (2005) 2.08
Hierarchical modeling of linkage disequilibrium: genetic structure and spatial relations. Am J Hum Genet (2003) 2.05
A random forest approach to the detection of epistatic interactions in case-control studies. BMC Bioinformatics (2009) 2.03
Widespread purifying selection at polymorphic sites in human protein-coding loci. Proc Natl Acad Sci U S A (2003) 2.01
Pooled DNA genotyping on Affymetrix SNP genotyping arrays. BMC Genomics (2006) 1.96
Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes. Nucleic Acids Res (2006) 1.95
Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles. Hum Hered (2008) 1.92
A general population-genetic model for the production by population structure of spurious genotype-phenotype associations in discrete, admixed or spatially distributed populations. Genetics (2006) 1.92
Molecular engineering of DNA: molecular beacons. Angew Chem Int Ed Engl (2009) 1.84
Breast cancer susceptibility: current knowledge and implications for genetic counselling. Eur J Hum Genet (2008) 1.82
Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region. Hum Genet (2008) 1.81
A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus. Am J Hum Genet (2001) 1.80
An integrated approach to inferring gene-disease associations in humans. Proteins (2008) 1.80
Genetic demography of Antioquia (Colombia) and the Central Valley of Costa Rica. Hum Genet (2003) 1.76
A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samples. Behav Genet (2009) 1.75
A comparison of linkage disequilibrium patterns and estimated population recombination rates across multiple populations. Am J Hum Genet (2005) 1.75
PupaSNP Finder: a web tool for finding SNPs with putative effect at transcriptional level. Nucleic Acids Res (2004) 1.74
The use of racial, ethnic, and ancestral categories in human genetics research. Am J Hum Genet (2005) 1.73
Prospects for association mapping in classical inbred mouse strains. Genetics (2007) 1.71
High-resolution multipoint linkage-disequilibrium mapping in the context of a human genome sequence. Am J Hum Genet (2001) 1.69
Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs. BMC Genomics (2005) 1.68
Genetic dissection of ethanol tolerance in the budding yeast Saccharomyces cerevisiae. Genetics (2006) 1.67
Incorporating genotyping uncertainty in haplotype inference for single-nucleotide polymorphisms. Am J Hum Genet (2004) 1.66
Two-stage designs in case-control association analysis. Genetics (2006) 1.65
The power to detect linkage disequilibrium with quantitative traits in selected samples. Am J Hum Genet (2001) 1.64
Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolate. Am J Hum Genet (2002) 1.62
Orofacial pain prospective evaluation and risk assessment study--the OPPERA study. J Pain (2011) 1.62
Nucleotide polymorphism and phenotypic associations within and around the phytochrome B2 Locus in European aspen (Populus tremula, Salicaceae). Genetics (2008) 1.61
Analysis of genetically complex epilepsies. Epilepsia (2005) 1.58
The genetics of congenital amusia (tone deafness): a family-aggregation study. Am J Hum Genet (2007) 1.54
Experimental designs for reliable detection of linkage disequilibrium in unstructured random population association studies. Genetics (2005) 1.54
Experiences with community engagement and informed consent in a genetic cohort study of severe childhood diseases in Kenya. BMC Med Ethics (2010) 1.54
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. PLoS Genet (2012) 1.52
Backward genotype-trait association (BGTA)-based dissection of complex traits in case-control designs. Hum Hered (2006) 1.52
Leveraging hierarchical population structure in discrete association studies. PLoS One (2007) 1.48
Modifier genes for hypertrophic cardiomyopathy. Curr Opin Cardiol (2002) 1.47
Comparison of family history and SNPs for predicting risk of complex disease. PLoS Genet (2012) 1.47
Genome-wide association studies: progress and potential for drug discovery and development. Nat Rev Drug Discov (2008) 1.45
AVPR1a and SLC6A4 gene polymorphisms are associated with creative dance performance. PLoS Genet (2005) 1.45
Association of the DTNBP1 locus with schizophrenia in a U.S. population. Am J Hum Genet (2004) 1.45
Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci. Arch Neurol (2008) 1.44