Published in Am J Hum Genet on February 02, 2004
Family-based association tests for genomewide association scans. Am J Hum Genet (2007) 10.67
Handling marker-marker linkage disequilibrium: pedigree analysis with clustered markers. Am J Hum Genet (2005) 6.12
Efficient study designs for test of genetic association using sibship data and unrelated cases and controls. Am J Hum Genet (2006) 2.72
A powerful strategy to account for multiple testing in the context of haplotype analysis. Am J Hum Genet (2004) 2.07
Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26. Am J Hum Genet (2005) 1.76
Systematic association mapping identifies NELL1 as a novel IBD disease gene. PLoS One (2007) 1.57
High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. Mol Psychiatry (2009) 1.45
Comparing strategies for association mapping in samples with related individuals. BMC Genet (2005) 1.41
Mapping quantitative trait loci for canine hip dysplasia in German Shepherd dogs. Mamm Genome (2007) 1.04
Family-based samples can play an important role in genetic association studies. Cancer Epidemiol Biomarkers Prev (2008) 0.95
Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate. PLoS Genet (2014) 0.92
Genome-wide investigation of gene-environment interactions in colorectal cancer. Hum Genet (2012) 0.89
Increased efficiency of case-control association analysis by using allele-sharing and covariate information. Hum Hered (2007) 0.89
Fine mapping of a region on chromosome 21q21.11-q22.3 showing linkage to type 1 diabetes. J Med Genet (2005) 0.88
Sampling strategies for rare variant tests in case-control studies. Eur J Hum Genet (2012) 0.87
Three ways of combining genotyping and resequencing in case-control association studies. PLoS One (2010) 0.86
A quantitative linkage score for an association study following a linkage analysis. BMC Genet (2006) 0.85
Selecting cases from nuclear families for case-control association analysis. BMC Genet (2005) 0.80
NYD-SP18 is associated with obesity in the NHLBI Family Heart Study. Int J Obes (Lond) (2008) 0.79
Two-stage study designs for analyzing disease-associated covariates: linkage thresholds and case-selection strategies. BMC Proc (2007) 0.78
Validity and power of association testing in family-based sampling designs: evidence for and against the common wisdom. Genet Epidemiol (2011) 0.77
Robust and Powerful Affected Sibpair Test for Rare Variant Association. Genet Epidemiol (2015) 0.76
Comparisons of case-selection approaches based on allele sharing and/or disease severity index: application to the GAW14 simulated data. BMC Genet (2005) 0.75
Visualization of haplotype sharing patterns in pedigree samples. Hum Hered (2014) 0.75
Identification of susceptibility loci for complex diseases in a case-control association study using the Genetic Analysis Workshop 14 dataset. BMC Genet (2005) 0.75
Selection of the most informative individuals from families with multiple siblings for association studies. Genet Epidemiol (2009) 0.75
Merlin--rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet (2001) 53.16
The structure of haplotype blocks in the human genome. Science (2002) 50.88
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature (2001) 42.18
Searching for genetic determinants in the new millennium. Nature (2000) 17.50
A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. Am J Hum Genet (1998) 15.76
Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science (2001) 15.54
Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet (1997) 13.93
A class of tests for linkage using affected pedigree members. Biometrics (1994) 10.40
Association study designs for complex diseases. Nat Rev Genet (2001) 8.91
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet (2000) 8.33
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature (2002) 8.28
A test for linkage and association in general pedigrees: the pedigree disequilibrium test. Am J Hum Genet (2000) 7.70
A first-generation linkage disequilibrium map of human chromosome 22. Nature (2002) 7.03
Genetic association mapping based on discordant sib pairs: the discordant-alleles test. Am J Hum Genet (1998) 7.02
BeadArray technology: enabling an accurate, cost-effective approach to high-throughput genotyping. Biotechniques (2002) 5.98
Pedigree tests of transmission disequilibrium. Eur J Hum Genet (2000) 5.93
Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans. Nat Genet (2003) 5.30
Powerful regression-based quantitative-trait linkage analysis of general pedigrees. Am J Hum Genet (2002) 5.20
The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases I. DNA pooling. Genome Res (1998) 5.11
Accessing genetic variation: genotyping single nucleotide polymorphisms. Nat Rev Genet (2001) 5.00
Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science (2003) 4.48
Evaluation of candidate genes in case-control studies: a statistical method to account for related subjects. Am J Hum Genet (2001) 4.09
Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Diabetes Care (1998) 3.99
Closing in on a breast cancer gene on chromosome 17q. Am J Hum Genet (1992) 3.89
Extent and distribution of linkage disequilibrium in three genomic regions. Am J Hum Genet (2000) 3.68
High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools. Proc Natl Acad Sci U S A (2002) 2.32
Genetic epidemiology of breast cancer and associated cancers in high-risk families. I. Segregation analysis. J Natl Cancer Inst (1983) 2.21
Use of pooled DNA samples to detect linkage disequilibrium of polymorphic restriction fragments and human disease: studies of the HLA class II loci. Proc Natl Acad Sci U S A (1985) 2.19
Association mapping of disease loci, by use of a pooled DNA genomic screen. Am J Hum Genet (1997) 2.07
A genetic epidemiologic investigation of breast cancer in families with bilateral breast cancer. I. Segregation analysis. J Natl Cancer Inst (1987) 1.70
Optimal allele-sharing statistics for genetic mapping using affected relatives. Genet Epidemiol (1999) 1.54
High-throughput genotyping of single nucleotide polymorphisms using new biplex invader technology. Nucleic Acids Res (2002) 1.51
A survey of affected-sibship statistics for nonparametric linkage analysis. Am J Hum Genet (2001) 1.30
High-throughput SNP detection by using DNA pooling and denaturing high performance liquid chromatography (DHPLC). Hum Genet (2000) 1.27
Nonparametric linkage regression. II: Identification of influential pedigrees in tests for linkage. Genet Epidemiol (2001) 0.92
A new nonparametric linkage statistic for mapping both qualitative and quantitative trait loci. Genet Epidemiol (2001) 0.87
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Finding the missing heritability of complex diseases. Nature (2009) 67.95
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol (2010) 26.41
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
A genome-wide association study of global gene expression. Nat Genet (2007) 22.98
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics (2010) 21.21
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Rare-variant association testing for sequencing data with the sequence kernel association test. Am J Hum Genet (2011) 18.88
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet (2006) 17.36
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Replicating genotype-phenotype associations. Nature (2007) 16.11
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43
LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics (2010) 13.54
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
A global reference for human genetic variation. Nature (2015) 12.85
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature (2003) 12.10
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet (2012) 11.29
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet (2006) 8.19
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
In silico method for inferring genotypes in pedigrees. Nat Genet (2006) 7.08
A first-generation linkage disequilibrium map of human chromosome 22. Nature (2002) 7.03
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests. Am J Hum Genet (2007) 6.26
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15
Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med (2014) 6.12
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Low-coverage sequencing: implications for design of complex trait association studies. Genome Res (2011) 5.34
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A (2008) 5.27
Powerful regression-based quantitative-trait linkage analysis of general pedigrees. Am J Hum Genet (2002) 5.20
PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data. Bioinformatics (2005) 5.14
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet (2008) 4.84
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. Nat Genet (2010) 4.69
Genome-wide association studies in diverse populations. Nat Rev Genet (2010) 4.68
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Using haplotype blocks to map human complex trait loci. Trends Genet (2003) 4.61
CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. Nat Genet (2006) 4.51
Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A (2010) 4.30
Optimal designs for two-stage genome-wide association studies. Genet Epidemiol (2007) 4.22
Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet (2006) 4.22
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet (2009) 4.10
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Sequence features in regions of weak and strong linkage disequilibrium. Genome Res (2005) 3.74
Genome-wide association study of PR interval. Nat Genet (2010) 3.73
GENOME: a rapid coalescent-based whole genome simulator. Bioinformatics (2007) 3.65
Joint modeling of linkage and association: identifying SNPs responsible for a linkage signal. Am J Hum Genet (2005) 3.62
Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet (2011) 3.56