Published in Hypertension on July 01, 2001
Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol (2009) 3.05
Rho kinase (ROCK) inhibitors. J Cardiovasc Pharmacol (2007) 1.89
Magnesium lithospermate B, an active extract of Salvia miltiorrhiza, mediates sGC/cGMP/PKG translocation in experimental vasospasm. Biomed Res Int (2014) 1.40
Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension. Br J Pharmacol (2008) 1.35
ROCKs as therapeutic targets in cardiovascular diseases. Expert Rev Cardiovasc Ther (2005) 1.25
Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases. Drug Discov Today (2010) 1.24
Rho kinase as a therapeutic target in cardiovascular disease. Future Cardiol (2011) 1.18
Rho kinase: an important mediator of atherosclerosis and vascular disease. Curr Pharm Des (2009) 1.04
Nuclear factor-kappaB as a hormonal intracellular signaling molecule: focus on angiotensin II-induced cardiovascular and renal injury. Curr Opin Nephrol Hypertens (2008) 0.99
ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion. Cardiovasc Diabetol (2012) 0.99
Fasudil, a Rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice. Int J Mol Sci (2012) 0.98
Rho/Rho-associated coiled-coil forming kinase pathway as therapeutic targets for statins in atherosclerosis. Antioxid Redox Signal (2013) 0.96
Angiotensin II increases GABAB receptor expression in nucleus tractus solitarii of rats. Am J Physiol Heart Circ Physiol (2008) 0.91
Increased leukocyte ROCK activity in patients after acute ischemic stroke. Brain Res (2008) 0.90
Inflammation and hypertension: new understandings and potential therapeutic targets. Curr Hypertens Rep (2015) 0.89
Angiotensin II participates in hepatic inflammation and fibrosis through MCP-1 expression. Dig Dis Sci (2005) 0.87
Elevated rho-kinase activity as a marker indicating atherosclerosis and inflammation burden in polyvascular disease patients with concomitant coronary and peripheral arterial disease. Clin Cardiol (2013) 0.84
Cardiovascular effects of losartan and its relevant clinical application. Curr Med Chem (2009) 0.84
Monocyte chemoattractant protein-1: a key mediator of angiotensin II-induced target organ damage in hypertensive heart disease? J Hypertens (2004) 0.84
Caffeic acid phenethyl amide ameliorates ischemia/reperfusion injury and cardiac dysfunction in streptozotocin-induced diabetic rats. Cardiovasc Diabetol (2014) 0.81
Potential pathophysiological role for the vitamin D deficiency in essential hypertension. World J Cardiol (2014) 0.80
Calycosin-7-O-β-D-glucoside promotes oxidative stress-induced cytoskeleton reorganization through integrin-linked kinase signaling pathway in vascular endothelial cells. BMC Complement Altern Med (2015) 0.78
Angiotensin II induces apoptosis of human pulmonary microvascular endothelial cells in acute aortic dissection complicated with lung injury patients through modulating the expression of monocyte chemoattractant protein-1. Am J Transl Res (2016) 0.78
Does it matter whether or not a lipid-lowering agent inhibits Rho kinase? Curr Atheroscler Rep (2007) 0.76
Elevated plasma interleukin-37 playing an important role in acute coronary syndrome through suppression of ROCK activation. Oncotarget (2017) 0.75
Bindarit reduces the incidence of acute aortic dissection complicated lung injury via modulating NF-κB pathway. Exp Ther Med (2017) 0.75
AT1 receptor signaling pathways in the cardiovascular system. Pharmacol Res (2017) 0.75
A Toll-like receptor recognizes bacterial DNA. Nature (2000) 26.34
Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol (2001) 18.80
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity (1999) 17.40
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol (1999) 16.86
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem (1982) 16.71
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) Science (1996) 15.88
Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity (1999) 11.64
Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem (1996) 10.51
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J (1998) 9.36
Toll-like receptors control activation of adaptive immune responses. Nat Immunol (2001) 7.54
Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med (1997) 7.12
Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. J Exp Med (1988) 7.12
Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science (1997) 5.80
Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL 1). J Immunol (1987) 5.64
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature (1997) 5.55
Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol (2001) 5.36
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep (2001) 5.32
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood (2001) 5.17
Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association. J Cell Biol (1998) 5.15
Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J (1996) 5.14
Evidence of impaired endothelium-dependent coronary vasodilatation in patients with angina pectoris and normal coronary angiograms. N Engl J Med (1993) 5.04
Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries. BMJ (2005) 4.91
Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. Proc Natl Acad Sci U S A (1991) 4.56
GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction. Cell (1987) 4.50
The 15-Country Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry: estimates of radiation-related cancer risks. Radiat Res (2007) 4.41
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J Biol Chem (1999) 4.38
Endovascular stent-graft placement for the treatment of acute aortic dissection. N Engl J Med (1999) 4.33
Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol (2000) 4.10
Detection of Mycobacterium tuberculosis in clinical specimens by polymerase chain reaction and Gen-Probe Amplified Mycobacterium Tuberculosis Direct Test. J Clin Microbiol (1993) 4.04
ASK1 is essential for JNK/SAPK activation by TRAF2. Mol Cell (1998) 3.98
Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation. J Biol Chem (1983) 3.69
IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. J Immunol (1998) 3.56
Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain. EMBO J (1989) 3.56
Pig cloning by microinjection of fetal fibroblast nuclei. Science (2000) 3.51
Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci U S A (2001) 3.49
Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. J Cell Biol (1999) 3.43
Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion. Science (1998) 3.39
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trends Pharmacol Sci (2001) 3.32
Human monocyte chemoattractant protein-1 (MCP-1). Immunol Today (1990) 3.31
Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation. Mol Biol Cell (1999) 3.27
Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. Am J Pathol (1990) 3.26
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J (1999) 3.19
Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem (1997) 3.12
Regulation and functions of Rho-associated kinase. Exp Cell Res (2000) 3.11
Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. J Immunol (2000) 3.10
Identification of a putative target for Rho as the serine-threonine kinase protein kinase N. Science (1996) 3.09
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med (2001) 3.05
Angina pectoris caused by coronary microvascular spasm. Lancet (1998) 3.01
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev (1999) 2.91
Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. J Biol Chem (1992) 2.90
Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice. J Clin Invest (2000) 2.89
Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins. Oncogene (1990) 2.89
IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol (1999) 2.84
Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation. Immunity (2000) 2.81
Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. J Pathol (2008) 2.79
CRMP-2 induces axons in cultured hippocampal neurons. Nat Neurosci (2001) 2.70
Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium. Circ Res (1999) 2.69
Rho-family GTPases in cadherin-mediated cell-cell adhesion. Nat Rev Mol Cell Biol (2001) 2.68
Endothelial dysfunction and vascular disease. Acta Physiol (Oxf) (2009) 2.67
STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc Natl Acad Sci U S A (1996) 2.64
Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins. J Biol Chem (1993) 2.62
Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction. Circ Res (2001) 2.62
TLR6: A novel member of an expanding toll-like receptor family. Gene (1999) 2.55
Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions. Proc Natl Acad Sci U S A (1988) 2.54
Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Lett (1996) 2.53
Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation. J Biol Chem (2000) 2.50
The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48
Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin. Mol Cell Biol (1993) 2.48
Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium. Circ Res (2000) 2.45
Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm. Circ Res (2000) 2.45
The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation. J Cardiovasc Pharmacol (1996) 2.43
Epidemiologic study on Yusho, a Poisoning Caused by Ingestion of Rice Oil Contaminated with a Commercial Brand of Polychlorinated Biphenyls. Environ Health Perspect (1972) 2.42
Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J Immunol (2000) 2.41
Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites. J Cell Sci (2001) 2.38
Cerivastatin, a hydroxymethylglutaryl coenzyme a reductase inhibitor, improves endothelial function in elderly diabetic patients within 3 days. Circulation (2001) 2.38
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis. J Exp Med (2001) 2.37
Non-A, non-B hepatitis specific antibodies directed at host-derived epitope: implication for an autoimmune process. Lancet (1990) 2.35
Nonmuscle myosin II-B is required for normal development of the mouse heart. Proc Natl Acad Sci U S A (1997) 2.35
Intraductal papillary mucinous tumors of the pancreas comprise 2 clinical subtypes: differences in clinical characteristics and surgical management. Arch Surg (1999) 2.33
The COOH terminus of Rho-kinase negatively regulates rho-kinase activity. J Biol Chem (1999) 2.32
The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function. J Exp Med (1999) 2.32
Role of nitric oxide in reactive hyperemia in human forearm vessels. Circulation (1994) 2.26
Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans. Hypertension (2001) 2.24
A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. Proc Natl Acad Sci U S A (1991) 2.22
Role for mitochondrial oxidants as regulators of cellular metabolism. Mol Cell Biol (2000) 2.22
Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1. J Biol Chem (1996) 2.22
Small GTP-binding proteins. Int Rev Cytol (1992) 2.19
Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J Cell Biol (1999) 2.17
Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Immunity (2001) 2.17
Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension. Circulation (2001) 2.14