Published in Cell Signal on January 25, 2010
Distinct p53 genomic binding patterns in normal and cancer-derived human cells. Cell Cycle (2011) 2.01
LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. Mol Cell (2014) 1.79
TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. Clin Cancer Res (2011) 1.71
Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells. Am J Physiol Cell Physiol (2010) 1.47
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Runx1 directly promotes proliferation of hair follicle stem cells and epithelial tumor formation in mouse skin. Mol Cell Biol (2010) 1.23
Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum. Ann N Y Acad Sci (2012) 1.22
Inhibition of autophagy and tumor growth in colon cancer by miR-502. Oncogene (2012) 1.15
Killing the second messenger: targeting loss of cell cycle control in endocrine-resistant breast cancer. Endocr Relat Cancer (2011) 1.12
Serum-nutrient starvation induces cell death mediated by Bax and Puma that is counteracted by p21 and unmasked by Bcl-x(L) inhibition. PLoS One (2011) 1.07
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Regulation of p21/CIP1/WAF-1 mediated cell-cycle arrest by RNase L and tristetraprolin, and involvement of AU-rich elements. Nucleic Acids Res (2012) 1.04
Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation. Mol Cell Biol (2011) 1.03
The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability. Nucleic Acids Res (2010) 1.03
Regulation of autophagy by nucleoporin Tpr. Sci Rep (2012) 1.02
Computational analysis of target hub gene repression regulated by multiple and cooperative miRNAs. Nucleic Acids Res (2012) 1.00
p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes. Oncogene (2013) 0.98
Human rpL3 induces G₁/S arrest or apoptosis by modulating p21 (waf1/cip1) levels in a p53-independent manner. Cell Cycle (2012) 0.98
Glioma-specific cation conductance regulates migration and cell cycle progression. J Biol Chem (2011) 0.96
The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNP. Genes Dev (2013) 0.96
Role of the translationally controlled tumor protein in DNA damage sensing and repair. Proc Natl Acad Sci U S A (2012) 0.95
Growth inhibition by miR-519 via multiple p21-inducing pathways. Mol Cell Biol (2012) 0.95
Defining a role for sphingosine kinase 1 in p53-dependent tumors. Oncogene (2011) 0.94
Pirh2 RING-finger E3 ubiquitin ligase: its role in tumorigenesis and cancer therapy. FEBS Lett (2012) 0.92
5-aza-2'-deoxycytidine-mediated c-myc Down-regulation triggers telomere-dependent senescence by regulating human telomerase reverse transcriptase in chronic myeloid leukemia. Neoplasia (2014) 0.91
Potential biofluid markers and treatment targets for renal cell carcinoma. Nat Rev Urol (2013) 0.91
Lenalidomide inhibits the proliferation of CLL cells via a cereblon/p21(WAF1/Cip1)-dependent mechanism independent of functional p53. Blood (2014) 0.90
Requirement for MLL3 in p53 regulation of hepatic expression of small heterodimer partner and bile acid homeostasis. Mol Endocrinol (2011) 0.89
The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21WAF1/CIP1. Cell Death Dis (2013) 0.89
Stabilization of p21 (Cip1/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage response. Cell Death Differ (2012) 0.89
Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence. Cell Cycle (2010) 0.89
Effects of hypoxia-inducible factor-1α silencing on the proliferation of CBRH-7919 hepatoma cells. World J Gastroenterol (2013) 0.89
Gamma rays induce a p53-independent mitochondrial biogenesis that is counter-regulated by HIF1α. Cell Death Dis (2013) 0.89
Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. J Biol Chem (2013) 0.88
Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment. EMBO J (2012) 0.88
Regulatory role of rpL3 in cell response to nucleolar stress induced by Act D in tumor cells lacking functional p53. Cell Cycle (2016) 0.87
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Effects of atmospheric pressure plasmas on isolated and cellular DNA-a review. Int J Mol Sci (2015) 0.86
Epimorphic regeneration in mice is p53-independent. Cell Cycle (2010) 0.86
Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer. Sci Rep (2016) 0.86
Specific inhibition of the nuclear exporter exportin-1 attenuates kidney cancer growth. PLoS One (2014) 0.85
p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase. Mol Cancer Res (2010) 0.85
Embryonic senescence and laminopathies in a progeroid zebrafish model. PLoS One (2011) 0.84
Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors. Cell Cycle (2012) 0.83
The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression. Cell Cycle (2013) 0.83
A novel role for the anti-senescence factor TBX2 in DNA repair and cisplatin resistance. Cell Death Dis (2013) 0.83
Stress- and Rho-activated ZO-1-associated nucleic acid binding protein binding to p21 mRNA mediates stabilization, translation, and cell survival. Proc Natl Acad Sci U S A (2012) 0.83
TATA-binding protein (TBP)-like protein is required for p53-dependent transcriptional activation of upstream promoter of p21Waf1/Cip1 gene. J Biol Chem (2012) 0.82
Involvement of insulin-like growth factor-binding protein-3 in the effects of histone deacetylase inhibitor MS-275 in hepatoma cells. J Biol Chem (2011) 0.82
Association of p21 SNPs and risk of cervical cancer among Chinese women. BMC Cancer (2012) 0.82
The effects of fucodian on senescence are controlled by the p16INK4a-pRb and p14Arf-p53 pathways in hepatocellular carcinoma and hepatic cell lines. Int J Oncol (2014) 0.82
15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARγ-mediated activation of p21WAF1/Cip1. Oncogene (2013) 0.82
Clinical impact of circulating miR-26a, miR-191, and miR-208b in plasma of patients with acute myocardial infarction. Eur J Med Res (2015) 0.82
Tissue microarray analysis of cyclin-dependent kinase inhibitors p21 and p16 in Fuchs dystrophy. Cornea (2013) 0.81
Tumor suppressor genes promote rhabdomyosarcoma progression in p53 heterozygous, HER-2/neu transgenic mice. Oncotarget (2014) 0.81
Identification of herpesvirus proteins that contribute to G1/S arrest. J Virol (2014) 0.81
Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism. Cancer Res (2016) 0.81
Epigenetic changes in p21 expression in renal cells after exposure to bromate. Toxicol Sci (2014) 0.81
A systems' biology approach to study microRNA-mediated gene regulatory networks. Biomed Res Int (2013) 0.81
Late onset neuropathy with spontaneous clinical remission in mice lacking the POZ domain of the transcription factor Myc-interacting zinc finger protein 1 (Miz1) in Schwann cells. J Biol Chem (2014) 0.81
The role of p21 in regulating mammalian regeneration. Stem Cell Res Ther (2011) 0.81
Genetic prevention of lymphoma in p53 knockout mice allows the early development of p53-related sarcomas. Oncotarget (2014) 0.80
Actin polymerization negatively regulates p53 function by impairing its nuclear import in response to DNA damage. PLoS One (2013) 0.80
LRH-1 controls proliferation in breast tumor cells by regulating CDKN1A gene expression. Oncogene (2014) 0.80
The Role of Sulforaphane in Epigenetic Mechanisms, Including Interdependence between Histone Modification and DNA Methylation. Int J Mol Sci (2015) 0.80
Serine 123 phosphorylation modulates p21 protein stability and activity by suppressing ubiquitin-independent proteasomal degradation. J Biol Chem (2012) 0.80
Identification of TSG101 functional domains and p21 loci required for TSG101-mediated p21 gene regulation. PLoS One (2013) 0.79
Lymphocytes of patients with Alzheimer's disease display different DNA damage repair kinetics and expression profiles of DNA repair and stress response genes. Int J Mol Sci (2013) 0.79
Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers. Nat Commun (2016) 0.79
Interaction between transactivation domain of p53 and middle part of TBP-like protein (TLP) is involved in TLP-stimulated and p53-activated transcription from the p21 upstream promoter. PLoS One (2014) 0.79
Changed genome heterochromatinization upon prolonged activation of the Raf/ERK signaling pathway. PLoS One (2010) 0.79
Cell cycle delay in murine pre-osteoblasts is more pronounced after exposure to high-LET compared to low-LET radiation. Radiat Environ Biophys (2013) 0.79
The effect of 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) on cell viability under hypoxia. Mol Vis (2013) 0.79
MAPK signaling pathway regulates p27 phosphorylation at threonin 187 as part of the mechanism triggered by early-weaning to induce cell proliferation in rat gastric mucosa. PLoS One (2013) 0.78
LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner. Nucleic Acids Res (2015) 0.78
Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition. Oncotarget (2015) 0.78
C/EBPα regulates CRL4(Cdt2)-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint. Cell Cycle (2014) 0.78
miR-30e controls DNA damage-induced stress responses by modulating expression of the CDK inhibitor p21WAF1/CIP1 and caspase-3. Oncotarget (2016) 0.77
Senescence evasion in melanoma progression: uncoupling of DNA-damage signaling from p53 activation and p21 expression. Pigment Cell Melanoma Res (2013) 0.77
Small-molecule inhibitors of p21 as novel therapeutics for chemotherapy-resistant kidney cancer. Future Med Chem (2013) 0.77
Transcriptome analysis of peripheral blood mononuclear cells in human subjects following a 36 h fast provides evidence of effects on genes regulating inflammation, apoptosis and energy metabolism. Genes Nutr (2014) 0.77
Novel mechanism of arenavirus-induced liver pathology. PLoS One (2015) 0.77
Immortalised breast epithelia survive prolonged DNA replication stress and return to cycle from a senescent-like state. Cell Death Dis (2014) 0.77
Methoxyacetic acid suppresses prostate cancer cell growth by inducing growth arrest and apoptosis. Am J Clin Exp Urol (2014) 0.77
Activity of the upstream TATA-less promoter of the p21(Waf1/Cip1) gene depends on transcription factor IIA (TFIIA) in addition to TFIIA-reactive TBP-like protein. FEBS J (2014) 0.77
EAPP modulates the activity of p21 and Chk2. Cell Cycle (2011) 0.77
The effects of two polymorphisms on p21cip1 function and their association with Alzheimer's disease in a population of European descent. PLoS One (2015) 0.76
Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYC. Leuk Res (2013) 0.76
PPM1D regulates p21 expression via dephoshporylation at serine 123. Cell Cycle (2015) 0.76
Sulforaphane Bioavailability and Chemopreventive Activity in Women Scheduled for Breast Biopsy. Cancer Prev Res (Phila) (2015) 0.76
Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress. PLoS Genet (2015) 0.76
Loss of protein targeting to glycogen sensitizes human hepatocellular carcinoma cells towards glucose deprivation mediated oxidative stress and cell death. Biosci Rep (2015) 0.75
ABCE1 is essential for S phase progression in human cells. Cell Cycle (2016) 0.75
RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway. J Biol Chem (2012) 0.75
Hypoxia induces an undifferentiated phenotype of oral keratinocytes in vitro. Cells Tissues Organs (2015) 0.75
Motif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulation. Cell Commun Signal (2015) 0.75
Brca2 deficiency leads to T cell loss and immune dysfunction. Mol Cells (2015) 0.75
How does ethanol induce apoptotic cell death of SK-N-SH neuroblastoma cells. Neural Regen Res (2013) 0.75
Association of p21 3' UTR gene polymorphism with cancer risk: Evidence from a meta-analysis. Sci Rep (2015) 0.75
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Mitochondrial uncoupling inhibits p53 mitochondrial translocation in TPA-challenged skin epidermal JB6 cells. PLoS One (2010) 0.98
Syntaxin 6, a regulator of the protein trafficking machinery and a target of the p53 family, is required for cell adhesion and survival. J Biol Chem (2008) 0.96
Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines. Cancer Chemother Pharmacol (2002) 0.96
Structural basis for gene activation by p53 family members. Cancer Biol Ther (2005) 0.96
Tumor suppression by p53: making cells senescent. Histol Histopathol (2010) 0.96
Establishment of a dog model for the p53 family pathway and identification of a novel isoform of p21 cyclin-dependent kinase inhibitor. Mol Cancer Res (2009) 0.96
Targeted repression of bone morphogenetic protein 7, a novel target of the p53 family, triggers proliferative defect in p53-deficient breast cancer cells. Cancer Res (2007) 0.96
Characterization of p73 functional domains necessary for transactivation and growth suppression. Oncogene (2003) 0.94
Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63. J Invest Dermatol (2012) 0.93
p73 can suppress the proliferation of cells that express mutant p53. Oncogene (2003) 0.93
Glycogen synthase kinase 3 promotes p53 mRNA translation via phosphorylation of RNPC1. Genes Dev (2013) 0.92
Pirh2 RING-finger E3 ubiquitin ligase: its role in tumorigenesis and cancer therapy. FEBS Lett (2012) 0.92
Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression. J Biol Chem (2011) 0.92
p53, a target of estrogen receptor (ER) α, modulates DNA damage-induced growth suppression in ER-positive breast cancer cells. J Biol Chem (2012) 0.92
Mammary epithelial cell polarity is regulated differentially by p73 isoforms via epithelial-to-mesenchymal transition. J Biol Chem (2012) 0.92
Definition of genetic events directing the development of distinct types of brain tumors from postnatal neural stem/progenitor cells. Cancer Res (2012) 0.90
RNPC1, an RNA-binding protein and a p53 target, regulates macrophage inhibitory cytokine-1 (MIC-1) expression through mRNA stability. J Biol Chem (2013) 0.90
Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. Mol Cell Biol (2011) 0.90
Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. J Biol Chem (2013) 0.88
Senescence regulation by the p53 protein family. Methods Mol Biol (2013) 0.88
p53 transcription-dependent and -independent regulation of cerebellar neural precursor cell apoptosis. J Neuropathol Exp Neurol (2007) 0.88
DeltaNp73 modulates nerve growth factor-mediated neuronal differentiation through repression of TrkA. Mol Cell Biol (2007) 0.88
Poly (C)-binding protein 1 regulates p63 expression through mRNA stability. PLoS One (2013) 0.87
Glyoxalase II, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family. J Biol Chem (2006) 0.85
DEC1 and MIC-1: new players of p53-dependent cell fate decision. Cell Cycle (2012) 0.85
Arsenic suppresses cell survival via Pirh2-mediated proteasomal degradation of ΔNp63 protein. J Biol Chem (2012) 0.85
PUMA Cooperates with p21 to Regulate Mammary Epithelial Morphogenesis and Epithelial-To-Mesenchymal Transition. PLoS One (2013) 0.84
Tumor suppressor gene-inducible cell lines. Methods Mol Biol (2003) 0.84
G Protein-Coupled Receptor 87: a Promising Opportunity for Cancer Drug Discovery. Mol Cell Pharmacol (2010) 0.84
RNA-binding protein RBM24 regulates p63 expression via mRNA stability. Mol Cancer Res (2013) 0.82
Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality. Proc Natl Acad Sci U S A (2013) 0.82
HuR is necessary for mammary epithelial cell proliferation and polarity at least in part via ΔNp63. PLoS One (2012) 0.82
Fluoroquinolone-mediated inhibition of cell growth, S-G2/M cell cycle arrest, and apoptosis in canine osteosarcoma cell lines. PLoS One (2012) 0.82
TAp73 protein stability is controlled by histone deacetylase 1 via regulation of Hsp90 chaperone function. J Biol Chem (2013) 0.81
The p53 family: prospect for cancer gene therapy. Cancer Biol Ther (2007) 0.81
Serine 123 phosphorylation modulates p21 protein stability and activity by suppressing ubiquitin-independent proteasomal degradation. J Biol Chem (2012) 0.80
Development and characterization of 5 canine B-cell lymphoma cell lines. Leuk Res (2011) 0.79
Regulation of Mdm2 mRNA stability by RNA-binding protein RNPC1. Oncotarget (2013) 0.79
p19ras brings a new twist to the regulation of p73 by Mdm2. Sci STKE (2006) 0.79
Myosin VI is differentially regulated by DNA damage in p53- and cell type-dependent manners. J Biol Chem (2010) 0.78
Novel role of Wip1 in p53-mediated cell homeostasis under non-stress conditions. Cell Cycle (2011) 0.76
PPM1D regulates p21 expression via dephoshporylation at serine 123. Cell Cycle (2015) 0.76