PubRank

J R Nevins

Author PubWeight™ 368.54‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Predicting the clinical status of human breast cancer by using gene expression profiles. Proc Natl Acad Sci U S A 2001 13.30
2 The E2F transcription factor is a cellular target for the RB protein. Cell 1991 9.62
3 Mechanism of activation of early viral transcription by the adenovirus E1A gene product. Cell 1981 9.38
4 Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 1993 6.84
5 Induction of the synthesis of a 70,000 dalton mammalian heat shock protein by the adenovirus E1A gene product. Cell 1982 6.78
6 Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 2000 6.54
7 Identification of a cellular transcription factor involved in E1A trans-activation. Cell 1986 6.36
8 Steps in the processing of Ad2 mRNA: poly(A)+ nuclear sequences are conserved and poly(A) addition precedes splicing. Cell 1978 6.36
9 Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol Cell Biol 1995 6.26
10 The pathway of eukaryotic mRNA formation. Annu Rev Biochem 1983 6.16
11 Activation of gene expression by adenovirus and herpesvirus regulatory genes acting in trans and by a cis-acting adenovirus enhancer element. Cell 1983 5.91
12 Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl Acad Sci U S A 1997 5.83
13 The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev 1992 5.73
14 Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. Mol Cell Biol 2001 5.03
15 Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev 1994 4.93
16 Requirement of a downstream sequence for generation of a poly(A) addition site. Cell 1984 4.87
17 Common control of the heat shock gene and early adenovirus genes: evidence for a cellular E1A-like activity. Mol Cell Biol 1984 4.76
18 Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control. Proc Natl Acad Sci U S A 1987 4.68
19 Regulation of adenovirus-2 gene expression at the level of transcriptional termination and RNA processing. Nature 1981 4.46
20 The E2F1-3 transcription factors are essential for cellular proliferation. Nature 2001 4.37
21 Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc Natl Acad Sci U S A 1992 4.27
22 Transcriptional activation and subsequent control of the human heat shock gene during adenovirus infection. Mol Cell Biol 1983 4.15
23 Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell 1991 3.98
24 Regulation of the cyclin E gene by transcription factor E2F1. Proc Natl Acad Sci U S A 1995 3.95
25 Definition of multiple, functionally distinct TATA elements, one of which is a target in the hsp70 promoter for E1A regulation. Cell 1988 3.91
26 Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation. Cell 1990 3.77
27 E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor. Proc Natl Acad Sci U S A 1989 3.67
28 Definition and mapping of adenovirus 2 nuclear transcription. Methods Enzymol 1980 3.67
29 A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex. Cell 1992 3.64
30 E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J Virol 1995 3.55
31 E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev 1998 3.48
32 Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev 2001 3.41
33 Activation of early adenovirus transcription by the herpesvirus immediate early gene: evidence for a common cellular control factor. Proc Natl Acad Sci U S A 1982 3.29
34 Effect of adenovirus on metabolism of specific host mRNAs: transport control and specific translational discrimination. Mol Cell Biol 1983 3.25
35 An enhancer-like element in the adenovirus E2 promoter contains sequences essential for uninduced and E1A-induced transcription. Proc Natl Acad Sci U S A 1985 3.15
36 A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J 1990 3.07
37 An ordered pathway of assembly of components required for polyadenylation site recognition and processing. Genes Dev 1989 2.94
38 Regulation of the primary expression of the early adenovirus transcription units. J Virol 1979 2.92
39 Ras enhances Myc protein stability. Mol Cell 1999 2.91
40 Adenovirus 5 E2 transcription unit: an E1A-inducible promoter with an essential element that functions independently of position or orientation. Mol Cell Biol 1984 2.88
41 The adenovirus-inducible factor E2F stimulates transcription after specific DNA binding. Mol Cell Biol 1989 2.83
42 Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature 1997 2.78
43 Poly(A) site cleavage in a HeLa nuclear extract is dependent on downstream sequences. Cell 1985 2.72
44 Interactions of the p107 and Rb proteins with E2F during the cell proliferation response. EMBO J 1993 2.70
45 Sequences capable of restoring poly(A) site function define two distinct downstream elements. EMBO J 1986 2.69
46 Definition of essential sequences and functional equivalence of elements downstream of the adenovirus E2A and the early simian virus 40 polyadenylation sites. Mol Cell Biol 1985 2.65
47 E1A transcription induction: enhanced binding of a factor to upstream promoter sequences. Science 1986 2.49
48 E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol Cell 2000 2.48
49 The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state. Mol Cell Biol 1996 2.47
50 The stability of early adenovirus mRNA is controlled by the viral 72 kd DNA-binding protein. Cell 1981 2.44
51 Multiple factors are required for specific RNA cleavage at a poly(A) addition site. Genes Dev 1988 2.43
52 Regulation of early adenovirus transcription: a protein product of early region 2 specifically represses region 4 transcription. Proc Natl Acad Sci U S A 1980 2.42
53 Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc Natl Acad Sci U S A 1998 2.40
54 Identification of an E1A-inducible cellular factor that interacts with regulatory sequences within the adenovirus E4 promoter. EMBO J 1987 2.40
55 Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes. Genes Dev 1991 2.40
56 A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc Natl Acad Sci U S A 1996 2.36
57 Localization of the adenovirus E1Aa protein, a positive-acting transcriptional factor, in infected cells infected cells. Mol Cell Biol 1983 2.36
58 Poly(A) site efficiency reflects the stability of complex formation involving the downstream element. EMBO J 1991 2.30
59 Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complex. EMBO J 1987 2.30
60 Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proc Natl Acad Sci U S A 1996 2.30
61 Developmental control of a promoter-specific factor that is also regulated by the E1A gene product. Cell 1987 2.29
62 Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell 2001 2.29
63 Oncogenic capacity of the E2F1 gene. Proc Natl Acad Sci U S A 1994 2.24
64 Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. Mol Cell Biol 2000 2.24
65 Activation of a preexisting cellular factor as a basis for adenovirus E1A-mediated transcription control. Proc Natl Acad Sci U S A 1988 2.16
66 Molecular analyses of two poly(A) site-processing factors that determine the recognition and efficiency of cleavage of the pre-mRNA. Mol Cell Biol 1991 2.15
67 Transcription units of adenovirus type 2. Termination of transcription beyond the poly(A) addition site in early regions 2 and 4. J Mol Biol 1980 2.11
68 An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F. Proc Natl Acad Sci U S A 1990 2.09
69 Relative position and strengths of poly(A) sites as well as transcription termination are critical to membrane versus secreted mu-chain expression during B-cell development. Genes Dev 1987 2.07
70 Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev 1996 2.06
71 Groups of adenovirus type 2 mRNA's derived from a large primary transcript: probable nuclear origin and possible common 3' ends. J Virol 1978 2.06
72 The major late adenovirus type-2 transcription unit: termination is downstream from the last poly(A) site. J Mol Biol 1979 2.04
73 Cell cycle control of the human HSP70 gene: implications for the role of a cellular E1A-like function. Mol Cell Biol 1985 2.01
74 The HTLV-I Rex response element mediates a novel form of mRNA polyadenylation. Cell 1991 2.00
75 Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. Mol Cell Biol 1997 2.00
76 Anchorage-independent cell growth signature identifies tumors with metastatic potential. Oncogene 2009 1.99
77 E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ 1998 1.96
78 E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev 1995 1.95
79 Role of E2F transcription factor in E1A-mediated trans activation of cellular genes. J Virol 1991 1.92
80 Loss of E2F4 activity leads to abnormal development of multiple cellular lineages. Mol Cell 2000 1.86
81 Isolation and properties of the vaccinia virus DNA-dependent RNA polymerase. J Biol Chem 1977 1.85
82 Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1. J Biol Chem 2001 1.85
83 Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. Mol Cell Biol 1996 1.83
84 N-6-methyl-adenosine in adenovirus type 2 nuclear RNA is conserved in the formation of messenger RNA. J Mol Biol 1979 1.82
85 Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression. Proc Natl Acad Sci U S A 1995 1.81
86 A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor. Proc Natl Acad Sci U S A 1999 1.80
87 Newly formed mRNA lacking polyadenylic acid enters the cytoplasm and the polyribosomes but has a shorter half-life in the absence of polyadenylic acid. Mol Cell Biol 1982 1.79
88 Poly (A) sequences of vaccinia virus messenger RNA: nature, mode of addition and function during translation in vitra and in vivo. Virology 1975 1.79
89 Identification of distinct roles for separate E1A domains in disruption of E2F complexes. Mol Cell Biol 1993 1.75
90 Activation of the E2F transcription factor in adenovirus-infected cells involves E1A-dependent stimulation of DNA-binding activity and induction of cooperative binding mediated by an E4 gene product. J Virol 1990 1.70
91 A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4. Mol Cell Biol 1993 1.70
92 Functional properties of a Drosophila homolog of the E2F1 gene. Mol Cell Biol 1994 1.67
93 Metabolism of mRNA from the transforming region of adenovirus 2. Cold Spring Harb Symp Quant Biol 1980 1.66
94 Nuclear RNA is spliced in the absence of poly(A) addition. Cell 1981 1.64
95 DNA-binding activity of the adenovirus-induced E4F transcription factor is regulated by phosphorylation. Genes Dev 1989 1.61
96 Phosphorylation-dependent activation of the adenovirus-inducible E2F transcription factor in a cell-free system. Proc Natl Acad Sci U S A 1989 1.59
97 Multiple factors are required for poly(A) addition to a mRNA 3' end. Genes Dev 1988 1.58
98 Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism. J Virol 1991 1.54
99 The adenovirus E4 gene, in addition to the E1A gene, is important for trans-activation of E2 transcription and for E2F activation. J Virol 1989 1.50
100 Compensation and specificity of function within the E2F family. Oncogene 2006 1.48
101 Isolation and analysis of nuclear RNA. Methods Enzymol 1987 1.48
102 Poly(A) site choice rather than splice site choice governs the regulated production of IgM heavy-chain RNAs. Proc Natl Acad Sci U S A 1988 1.46
103 Selective induction of human heat shock gene transcription by the adenovirus E1A gene products, including the 12S E1A product. Mol Cell Biol 1987 1.40
104 Transcriptional regulation. A closer look at E2F. Nature 1992 1.39
105 Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains. Mol Cell Biol 1992 1.37
106 A role for Myc in facilitating transcription activation by E2F1. Oncogene 2008 1.35
107 Splice site selection dominates over poly(A) site choice in RNA production from complex adenovirus transcription units. EMBO J 1988 1.34
108 Regulation of early adenovirus gene expression. Microbiol Rev 1987 1.34
109 Collaborative role of E2F transcriptional activity and G1 cyclindependent kinase activity in the induction of S phase. Proc Natl Acad Sci U S A 1999 1.34
110 Complex transcriptional regulatory mechanisms control expression of the E2F3 locus. Mol Cell Biol 2000 1.32
111 Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A. Proc Natl Acad Sci U S A 1994 1.28
112 Control of cellular and viral transcription during adenovirus infection. CRC Crit Rev Biochem 1986 1.27
113 Identification of genes associated with ovarian cancer metastasis using microarray expression analysis. Int J Gynecol Cancer 2006 1.23
114 E4F and ATF, two transcription factors that recognize the same site, can be distinguished both physically and functionally: a role for E4F in E1A trans activation. Mol Cell Biol 1990 1.22
115 A factor discriminating between the wild-type and a mutant polyomavirus enhancer. Nature 1987 1.16
116 Processing of late adenovirus nuclear RNA to mRNA. Kinetics of formation of intermediates and demonstration that all events are nuclear. J Mol Biol 1979 1.15
117 Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth. Cell Growth Differ 1998 1.15
118 Early capping of transcripts from the adenovirus major late transcription unit. Nature 1980 1.15
119 Alternative poly(A) site utilization during adenovirus infection coincides with a decrease in the activity of a poly(A) site processing factor. Mol Cell Biol 1993 1.10
120 The Rb-related p107 protein can suppress E2F function independently of binding to cyclin A/cdk2. Mol Cell Biol 1995 1.09
121 E1A-dependent trans-activation of the c-fos promoter requires the TATAA sequence. Proc Natl Acad Sci U S A 1990 1.08
122 Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function. Nat Med 1996 1.08
123 Adenovirus gene expression: control at multiple steps of mRNA biogenesis. Cell 1982 1.06
124 Isolation and partial characterization of the poly(A) polymerases from HeLa cells infected with vaccinia virus. J Biol Chem 1977 1.04
125 Genetic analysis of the adenovirus E4 6/7 trans activator: interaction with E2F and induction of a stable DNA-protein complex are critical for activity. J Virol 1991 1.03
126 A role for a bent DNA structure in E2F-mediated transcription activation. Mol Cell Biol 1996 1.00
127 Adenovirus 12S E1A gene represses differentiation of F9 teratocarcinoma cells. Proc Natl Acad Sci U S A 1990 0.99
128 Identification of an activity in B-cell extracts that selectively impairs the formation of an immunoglobulin mu s poly(A) site processing complex. Mol Cell Biol 1995 0.96
129 A role for Mediator complex subunit MED13L in Rb/E2F-induced growth arrest. Oncogene 2012 0.95
130 A combinatorial mechanism for determining the specificity of E2F activation and repression. Oncogene 2009 0.94
131 Processing of adenovirus nuclear RNA to mRNA. Adv Virus Res 1981 0.94
132 Use of the E2F transcription factor by DNA tumor virus regulatory proteins. Curr Top Microbiol Immunol 1996 0.94
133 Adenovirus infection of differentiated F9 cells results in a global shut-off of differentiation-induced gene expression. Nucleic Acids Res 1990 0.92
134 Interacting domains of E2F1, DP1, and the adenovirus E4 protein. J Virol 1994 0.92
135 Adenovirus E1A-mediated negative control of genes activated during F9 differentiation. Mol Cell Biol 1989 0.91
136 Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway. Cell Growth Differ 2000 0.88
137 DNA octamer element can confer E1A trans-activation, and adenovirus infection results in a stimulation of the DNA-binding activity of OTF-1/NFIII factor. Proc Natl Acad Sci U S A 1990 0.86
138 Distinct DNA targets for trans-activation by HTLV-1 tax and adenovirus E1A. Virology 1991 0.83
139 Heterogeneity in MYC-induced mammary tumors contributes to escape from oncogene dependence. Oncogene 2011 0.83
140 Detection of an adenovirus E1A-like activity in mammalian cells. Curr Top Microbiol Immunol 1984 0.81
141 Variety in the mechanisms of adenovirus gene control. Ann N Y Acad Sci 1980 0.80
142 Role of the adenovirus 72-kDa DNA binding protein in the rapid decay of early viral mRNA. Virology 1988 0.79
143 Towards a genomic-based diagnosis. Lancet 2001 0.78
144 Alteration of cellular gene expression in adenovirus transformed cells by post-transcriptional mechanisms. Nucleic Acids Res 1986 0.77
145 ABCA1 single nucleotide polymorphisms. Snipping at the pathogenesis of atherosclerosis. Circ Res 2001 0.75
146 Transcription activation by viral and cellular oncogenes. Adv Cancer Res 1986 0.75
147 Role of the adenovirus transforming gene (E1A) in the general control of gene expression. Transplant Proc 1984 0.75