Published in Science on September 28, 2001
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J (2005) 2.69
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 2.43
Global chromatin compaction limits the strength of the DNA damage response. J Cell Biol (2007) 2.40
Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Biol (2007) 2.24
Multiple roles for MRE11 at uncapped telomeres. Nature (2009) 2.18
Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions. Nat Struct Mol Biol (2009) 2.08
Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination. Nature (2015) 2.03
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J Exp Med (2003) 1.98
Apollo contributes to G overhang maintenance and protects leading-end telomeres. Mol Cell (2010) 1.97
Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells. Nucleic Acids Res (2004) 1.89
The nature of telomere fusion and a definition of the critical telomere length in human cells. Genes Dev (2007) 1.88
Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. Genes Dev (2005) 1.84
Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J (2009) 1.83
Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2. Genes Dev (2008) 1.80
Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. EMBO J (2002) 1.74
Telomeres, chromosome instability and cancer. Nucleic Acids Res (2006) 1.67
POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. EMBO J (2006) 1.66
Ku86 represses lethal telomere deletion events in human somatic cells. Proc Natl Acad Sci U S A (2009) 1.63
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Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells. Cancer Cell (2015) 1.52
Five dysfunctional telomeres predict onset of senescence in human cells. EMBO Rep (2011) 1.45
The V122I cardiomyopathy variant of transthyretin increases the velocity of rate-limiting tetramer dissociation, resulting in accelerated amyloidosis. Proc Natl Acad Sci U S A (2001) 1.45
Ku is required for telomeric C-rich strand maintenance but not for end-to-end chromosome fusions in Arabidopsis. Proc Natl Acad Sci U S A (2003) 1.42
Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging. EMBO J (2005) 1.38
The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres. EMBO Rep (2006) 1.36
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance. EMBO J (2002) 1.32
SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair. EMBO J (2010) 1.32
Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2. Mol Cell Biol (2004) 1.27
Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity. EMBO J (2013) 1.25
DNA damage-induced phosphorylation of the human telomere-associated protein TRF2. Proc Natl Acad Sci U S A (2005) 1.24
Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence. Cancer Res (2009) 1.23
The mre11 complex and the response to dysfunctional telomeres. Mol Cell Biol (2009) 1.22
Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in. Cell Res (2012) 1.20
Sister telomeres rendered dysfunctional by persistent cohesion are fused by NHEJ. J Cell Biol (2009) 1.11
Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication. EMBO J (2011) 1.11
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Protection and replication of telomeres in fission yeast. Biochem Cell Biol (2009) 1.10
Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability. Cancer Res (2012) 1.06
Hyper telomere recombination accelerates replicative senescence and may promote premature aging. Proc Natl Acad Sci U S A (2010) 1.05
Asynchronous replication timing of telomeres at opposite arms of mammalian chromosomes. Proc Natl Acad Sci U S A (2004) 1.01
Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo. Proc Natl Acad Sci U S A (2007) 1.00
Role of mammalian Rad54 in telomere length maintenance. Mol Cell Biol (2003) 0.99
Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs. Aging (Albany NY) (2010) 0.98
Chromosome end protection by blunt-ended telomeres. Genes Dev (2012) 0.97
Differential processing of leading- and lagging-strand ends at Saccharomyces cerevisiae telomeres revealed by the absence of Rad27p nuclease. Genetics (2002) 0.96
Yeast telomerase is specialized for C/A-rich RNA templates. Nucleic Acids Res (2003) 0.93
Telomere biology: integrating chromosomal end protection with DNA damage response. Chromosoma (2005) 0.92
Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability. Mol Cell Biol (2008) 0.92
The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres. Cell Cycle (2014) 0.89
Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds. Mol Cell (2015) 0.88
Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres. Cell Res (2013) 0.88
ATR contributes to telomere maintenance in human cells. Nucleic Acids Res (2010) 0.88
Mechanisms of telomere loss and their consequences for chromosome instability. Front Oncol (2012) 0.87
Defending the end zone: studying the players involved in protecting chromosome ends. FEBS Lett (2010) 0.86
Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle (2010) 0.86
BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres. EMBO J (2015) 0.86
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Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death. Cell Mol Life Sci (2011) 0.85
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A CO-FISH assay to assess sister chromatid segregation patterns in mitosis of mouse embryonic stem cells. Chromosome Res (2013) 0.84
The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers. Oncogene (2014) 0.83
DNA-PKcs phosphorylates hnRNP-A1 to facilitate the RPA-to-POT1 switch and telomere capping after replication. Nucleic Acids Res (2015) 0.83
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Trapping Rap1 at the telomere to prevent chromosome end fusions. EMBO J (2009) 0.77
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Chromosome end protection becomes even more complex. Nat Struct Mol Biol (2009) 0.75
Telomerase-dependent 3' G-strand overhang maintenance facilitates GTBP1-mediated telomere protection from misplaced homologous recombination. Plant Cell (2013) 0.75
53BP1 mediates the fusion of mammalian telomeres rendered dysfunctional by DNA-PKcs loss or inhibition. PLoS One (2014) 0.75
Cellular Homeostasis and Antioxidant Response in Epithelial HT29 Cells on Titania Nanotube Arrays Surface. Oxid Med Cell Longev (2017) 0.75
Loss of the tumor suppressor STAG2 promotes telomere recombination and extends the replicative lifespan of normal human cells. Cancer Res (2017) 0.75
The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells. Exp Cell Res (2017) 0.75
NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres. Mol Cell (2017) 0.75
Human Ribonuclease H1 resolves R loops and thereby enables progression of the DNA replication fork. J Biol Chem (2017) 0.75
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