Published in Mol Cell Biol on November 17, 2008
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Chk2 activation dependence on Nbs1 after DNA damage. Mol Cell Biol (2001) 1.85
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DNA-PKcs is critical for telomere capping. Proc Natl Acad Sci U S A (2001) 1.64
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. Nature (2007) 1.58
Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm. Genes Dev (2000) 1.43
Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis. Curr Biol (2001) 1.38
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Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development. Proc Natl Acad Sci U S A (2005) 1.02
p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc. Mol Cancer Res (2006) 0.86
Identification of aneuploidy-selective antiproliferation compounds. Cell (2011) 4.45
The MRE11 complex: starting from the ends. Nat Rev Mol Cell Biol (2011) 3.83
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature (2002) 3.48
Aneuploidy: cells losing their balance. Genetics (2008) 3.48
Rag mutations reveal robust alternative end joining. Nature (2007) 3.29
The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat Genet (2002) 2.97
Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. Mol Cell (2010) 2.91
RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination. Cell (2004) 2.84
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DNA replication-dependent nuclear dynamics of the Mre11 complex. Mol Cancer Res (2003) 2.23
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol (2004) 2.23
The Rad50 hook domain is a critical determinant of Mre11 complex functions. Nat Struct Mol Biol (2005) 2.08
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell (2003) 2.08
A murine model of Nijmegen breakage syndrome. Curr Biol (2002) 1.96
Modernizing the nonhomologous end-joining repertoire: alternative and classical NHEJ share the stage. Annu Rev Genet (2013) 1.95
Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response. DNA Repair (Amst) (2009) 1.89
Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev (2002) 1.87
Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization. Mol Cell (2009) 1.73
Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates. Mol Cell (2009) 1.70
Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Mol Cell Biol (2005) 1.69
Target DNA structure plays a critical role in RAG transposition. PLoS Biol (2006) 1.61
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. Nature (2007) 1.58
Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance. DNA Repair (Amst) (2002) 1.57
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Mol Cell (2010) 1.51
G.O.D.'s Holy Grail: discovery of the RAG proteins. J Immunol (2008) 1.42
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev (2005) 1.37
Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev (2009) 1.36
Contribution of Vh gene replacement to the primary B cell repertoire. Immunity (2003) 1.32
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol Cell (2008) 1.30
The RAG2 C terminus suppresses genomic instability and lymphomagenesis. Nature (2011) 1.24
The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis. Curr Biol (2007) 1.23
Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage. Mol Cell Biol (2011) 1.23
The mre11 complex and the response to dysfunctional telomeres. Mol Cell Biol (2009) 1.22
Functional interactions between Sae2 and the Mre11 complex. Genetics (2008) 1.20
Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase. Mol Cell Biol (2002) 1.19
Targeted transposition by the V(D)J recombinase. Mol Cell Biol (2002) 1.18
ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over. PLoS Genet (2008) 1.18
The Rad50 coiled-coil domain is indispensable for Mre11 complex functions. Nat Struct Mol Biol (2011) 1.16
Amino acid residues in Rag1 crucial for DNA hairpin formation. Nat Struct Mol Biol (2006) 1.16
Methods for studying the cellular response to DNA damage: influence of the Mre11 complex on chromosome metabolism. Methods Enzymol (2006) 1.15
Rad50 is dispensable for the maintenance and viability of postmitotic tissues. Mol Cell Biol (2008) 1.13
Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway. Cancer Res (2009) 1.10
A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome. PLoS Genet (2013) 1.05
Rad50S alleles of the Mre11 complex: questions answered and questions raised. Exp Cell Res (2006) 1.02
Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication. DNA Repair (Amst) (2007) 0.99
The V(D)J recombinase efficiently cleaves and transposes signal joints. Mol Cell (2002) 0.98
DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions. Cancer Res (2008) 0.97
The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53. Proc Natl Acad Sci U S A (2007) 0.97
Base flipping in V(D)J recombination: insights into the mechanism of hairpin formation, the 12/23 rule, and the coordination of double-strand breaks. Mol Cell Biol (2009) 0.96
Distinct and opposite diversifying activities of terminal transferase splice variants. Nat Immunol (2002) 0.94
Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells. PLoS Genet (2012) 0.92
B-cell chronic lymphocytic leukaemia: a polymorphic family unified by genomic features. Lancet Oncol (2003) 0.92
The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage. Nat Commun (2013) 0.92
Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers. Cell Rep (2013) 0.90
Recent insights into the formation of RAG-induced chromosomal translocations. Adv Exp Med Biol (2009) 0.88
The Mre11 complex suppresses oncogene-driven breast tumorigenesis and metastasis. Mol Cell (2013) 0.87
V(D)J recombination: how to tame a transposase. Immunol Rev (2004) 0.87
Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways. Nucleic Acids Res (2010) 0.86
Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression. Proc Natl Acad Sci U S A (2012) 0.86
Distinct requirements for Ku in N nucleotide addition at V(D)J- and non-V(D)J-generated double-strand breaks. Nucleic Acids Res (2004) 0.85
A streamlined method for detecting structural variants in cancer genomes by short read paired-end sequencing. PLoS One (2012) 0.85
RAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability. Cell Rep (2013) 0.85
The Rad50 hook domain regulates DNA damage signaling and tumorigenesis. Genes Dev (2014) 0.83
Working together and apart: the twisted relationship of the Mre11 complex and Chk2 in apoptosis and tumor suppression. Cell Cycle (2008) 0.83
B cell development leads off with a base hit: dU:dG mismatches in class switching and hypermutation. Mol Cell (2004) 0.83
Modeling disease in the mouse: lessons from DNA damage response and cell cycle control genes. J Cell Biochem (2006) 0.83
Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition. Nucleic Acids Res (2008) 0.82
The Ku heterodimer and the metabolism of single-ended DNA double-strand breaks. Cell Rep (2013) 0.82
A recombinase diversified: new functions of the RAG proteins. Curr Opin Immunol (2002) 0.81
Chronic exposure to sublethal doses of radiation mimetic Zeocin selects for clones deficient in homologous recombination. Mutat Res (2006) 0.80
Division of labor: DNA repair and the cell cycle specific functions of the Mre11 complex. Cell Cycle (2009) 0.80
A RAG1 mutation found in Omenn syndrome causes coding flank hypersensitivity: a novel mechanism for antigen receptor repertoire restriction. J Immunol (2008) 0.79
V(D)J Recombination: Mechanism, Errors, and Fidelity. Microbiol Spectr (2014) 0.79
At the end, remodeling leads to eviction. Nat Struct Mol Biol (2005) 0.79
Murine models of Omenn syndrome. J Clin Invest (2007) 0.79
Excised V(D)J recombination byproducts threaten genomic integrity. Trends Immunol (2007) 0.78
Doing more with less in bacterial DNA repair. Nat Struct Mol Biol (2004) 0.78
NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication. DNA Repair (Amst) (2009) 0.78
New molecular markers in resistant B-CLL. Leuk Lymphoma (2006) 0.78
Paradigm switching in the germinal center. Nat Immunol (2004) 0.77
An unbiased method for detection of genome-wide off-target effects in cell lines treated with zinc finger nucleases. Methods Mol Biol (2014) 0.76
Identification of susceptibility loci in a mouse model of KRASG12D-driven pancreatic cancer. Cancer Res (2010) 0.76
Artemis: guarding small children and, now, the genome. J Clin Invest (2003) 0.75
TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding. Mol Cell (2016) 0.75